Chemical and Epigenetics Scientist (#17946322) 

Oxford, South East, United Kingdom

Summary of Major ResponsibilitiesA Ph.D. Scientist with experience in creating and developing chemistries for genetic and epigenetic analysis to join a highly skilled interdisciplinary team working at the interface of chemistry, molecular biology, and bioinformatics. You will focus on the enhancing and characterizing the TAPS chemistry further and developing the core laboratory workflows and reagents used to implement it.Essential Duties and ResponsibilitiesSpend a significant portion of time in the lab; design, develop, and commercialise groundbreaking epigenetic analysis chemistries in a fast-paced product development environment.Adapt and optimise existing chemistries for epigenetic analysis of DNA and create improved methods that significantly extend capabilities.Identify and source new active chemicals, additives, or formulations that enable improved assay performance, stability, robustness, or other desirable characteristics.Design NGS experiments and use NGS data in order to measure the performance of epigenetic analysis methods and chemistries.Deploy analytical methods and assays suitable for characterisation and QC of novel chemistries.Use deep expertise and systematic problem-solving methods to troubleshoot complex issues.Develop and document lab-scale processes for the formulation and QC of critical reagents to enable scalable manufacturing processes; support the transfer of new processes and products to manufacturing.Collaborate effectively with the broader R&D team and senior staff on project requirements, planning, execution, and reporting.Present results, recommendations, and progress reports regularly to senior staff, colleagues, and collaborators.Contribute to the documentation of experimental protocols.Collaborate in the preparation of scientific reports and journal articles.Uphold company mission and values through accountability, innovation, integrity, quality, and teamwork. Support and comply with the company’s Quality Management System policies and procedures. Regular and reliable attendance. Ability to work on a mobile device, tablet, or in front of a computer screen and/or perform typing for approximately 100% of a typical working day.Ability to comply with any applicable personal protective equipment requirements.Ability to use various types of laboratory equipment including microscopes, microtomes, blades, strainers, pipettes for extended periods of time. May perform repetitious actions using lab tools. Ability to use near vision to view samples at close range.May be exposed to hazardous materials, tissue specimens and instruments with moving parts, lasers, heating and freezing elements, and high-speed centrifugation. QualificationsMinimum QualificationsD. in Chemistry/Biochemistry/Molecular Biology or Genetics; or high school degree/general education diploma and 6 years of relevant experience in lieu of Ph.D. Background in chemistry coupled with experience of genetic analysis technologies will be particularly advantageous.Strong skills in chemical biology, nucleic acid chemistry, and molecular biology techniques. Experience with NGS or other genetic analysis methods.Strong theoretical and practical chemistry skills, especially as applied to DNA.Good knowledge of modern analytical methods (e.g., HPLC, Mass Spec, and NMR).Excellent team working skills with previous experience of completing collaborative projects on time and within budget.Demonstrable experience in conducting high-quality, independent research with proven ability to write-up scientific findings in peer-reviewed journals.Excellent communication skills (both written and oral) with the ability to communicate complicated ideas and information effectively at all levels.Demonstrated ability to perform the Essential Duties of the position with or without accommodation. EEO DisclosureWe are an equal employment opportunity employer. All qualified applicants will receive consideration for employment without regard to age, color, creed, disability, gender identity, national origin, protected veteran status, race, religion, sex, sexual orientation, and any other status protected by applicable local, state or federal law. Applicable portions of the Company’s affirmative action program are available to any applicant or employee for inspection upon request.Job SummaryReq No.: 2021-8096Category: Research & Development

Company Details

Company Name
Exact Sciences

Job Details

Job Location
City/Town
Oxford
State
South East
Country
United Kingdom