Group Leader, Tumour Profiling (Translational Sciences)

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GROUP LEADER, TUMOUR PROFILINGTRANSLATIONAL SCIENCESABINGDON, OXFORDSHIRE, UKGROUP OVERVIEWThis is a senior role in the Translational Sciences team which functions out of both our UK and USA sites, providing broad translational sciences support to Adaptimmune’s clinical programs, and to the research teams. The Translational Sciences team remit is to support exploration of the mechanism of action of Adaptimmune’s cell therapy products, providing a better understanding of the drivers of safety, efficacy and durability, and guiding identification of biomarkers of response and indication selection. The team also provides valuable insights into tumor immune evasion mechanisms, guiding development of next generation products and provides support to pre-clinical research programs.ROLE OVERVIEWThe candidate will work collaboratively with diverse functional groups within Adaptimmune and across external partnerships to accomplish translational science objectives. The primary responsibility will be to lead the Tumour Profiling group within Translational Sciences, responsible for the profiling of clinical biopsy samples across all clinical trials and to manage a group of translational scientists specialising in histology and imaging. This will involve CRO management to deliver data, including tumor molecular profiling, for analysis, interpretation and communication to multiple stakeholders, and following up on learnings. A significant responsibility will be to manage a key partnership with a major clinical site to foster excellent relationships and data flows, including biopsy sc RNA seq and WES analysis. The candidate will also act as the tumour profiling expert for our clinical trials, working closely with other translational workstream leads, our clinical teams and external investigators/advisors, participating in authoring relevant sections pertaining to translational science/ correlative studies in documentation for regulatory submissions to governmental regulatory agencies, and will contribute to external publications.  KEY RESPONSIBILITIES• Work closely with all clinical development and research stakeholders, taking responsibility for setting experimental strategy and delivering data. â€¢ Lead a team of scientists specialising in histology and imaging.• Contribute to the function and performance of the TSG group as a member of the TSG leadership team.• Develop the biopsy profiling capabilities of the team in line with new products and expansion of the clinical studies.• Manage key research partnership and profiling activities.• Manage and monitor ongoing external CRO partnerships, ensuring high quality data is delivered on time, and set up new CRO partnerships as required.• Manage, collate, analyse, interpret and communicate high quality translational data to multiple stakeholders, including the clinical development teams, in a timely fashion.• Develop good scientific relationships with Investigators and clinical site personnel, presenting data and ensuring good communication.• Contribute to protocols and regulatory documents as required.• Represent the company at conferences, advisory boards and scientific meetings externally, making presentations and preparing publications. â€¢ Stay abreast of the literature in immune cell therapy and clinical biomarkers and communicate internally.QUALIFICATIONS & EXPERIENCERequired• PhD in immunology, cell therapy for cancer or a related field.• Industry experience within a pharma or biotech.• Experience in immunohistochemistry and tumour biopsy profiling.• Experience in managing a team of scientists.• Experience in translational sciences in the immuno-oncology field.• Experience in clinical research, with good understanding of the collection, handling and processing of tumour specimens.Desirable• Experience in adoptive cell therapy for cancer in a biotech or pharma or CRO environment.SKILLS & COMPETENCIESRequired• Excellent team leadership skills.• Excellent scientific knowledge and drive. â€¢ Ability to make sound and timely strategic decisions, prioritise, plan projects and deliver to timelines. â€¢ Strong team player with ability to work in cross-functional teams and a highly matrixed environment. â€¢ Excellent communication skills (both written and verbal).• High attention to detail, good time management skills. â€¢ Excellent numeracy and English language skills (both written and verbal).• Proven project management skills.• Computer literate and ability to familiarise with different IT systems.• Advanced histology and imaging expertise, including: Development and validation of novel multiplex immunohistochemistry (IHC), immunofluorescence, in situ hybridization (ISH) and IHC/ISH protocols on automated slide-based tissue platforms & support the use of digital imaging and apply advanced image analysis algorithms using commercially available platforms (e.g.: HALO).At Adaptimmune we embrace diversity and equality of opportunity. We believe that the more inclusive we are, the better our work will be. We welcome applications to join our team from all qualified candidates, regardless of age, colour, disability, marital status, national origin, race, religion, gender, sexual orientation, gender identity, veteran status or other legally protected category. It is our intent that all qualified applicants will receive equal consideration for employment.Powered by JazzHR

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