Research And Development Scientist

Full Job Description

Job Title: Senior/Research Scientist – Mass spec

Contract: 12 months

Location: Slough

Salary: £28.09 – 33.58 PAYE, £38.24 Umbrella

SRG are working with a Global Biopharmaceutical company to help them find a Senior/Research Scientist to join their busy team.

This is an exciting opportunity for an individual experienced in HDX-MS to join the Mass Spectrometry team within the Protein Structure and Biophysics Group.

Key Responsibilities will include:

• and mechanistic understanding of target and therapeutic molecule interactions are driven by our department using Mass Spectrometry, Cryo-EM, X-ray crystallography, SAXS, NMR and other biophysical techniques.
• track record in the design and execution of HDX-MS experiments with a contextual understanding of their results alongside other structural data.
• and prioritise the demands from multiple projects.

Essential Requirements:

• or BSc with 5+ years of relevant laboratory-based experience in the design, execution and analysis of HDX-MS experiments for antibody/protein/ligand interactions.
• with Waters data processing software packages (PLGS) and DynamX™.
• knowledge Waters HDX-MS system.
• of structural visualisation tools (PyMOL, Chimera or similar).
• with HDX-MS experiments using NBE and NCE molecules.
• organisational, communication, record keeping and team-working abilities.

Desirable Requirements:

• analysis of membrane proteins.
• and maintenance of Waters LC/MS equipment.
• ability with Native MS, ion mobility MS, SEC-MS or intact mass LC/MS.
• track record of publications related to mass spectrometry in peer reviewed journals.
• of recombinant protein expression systems and PTMs.
• knowledge of Thermo Scientific Orbitrap MS systems.