What Jobs are available for Astrazeneca in the United Kingdom?
Showing 986 Astrazeneca jobs in the United Kingdom
Principal Scientist - Drug Discovery
BT2 7GS Belfast, Northern Ireland
£75000 Annually
WhatJobs Direct
Posted 1 day ago
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Job Description
A pioneering biotechnology company focused on developing novel therapeutics for unmet medical needs is seeking a highly skilled Principal Scientist to lead critical drug discovery programs. This role will be based in our state-of-the-art facility in Belfast, Northern Ireland, UK , operating on a hybrid model that blends cutting-edge laboratory work with strategic remote collaboration.
Position Overview:
The Principal Scientist will be instrumental in driving innovative research from target identification through to lead optimization. You will leverage your expertise in molecular biology, pharmacology, and assay development to design and execute complex experiments, interpret data, and guide research strategies. This role requires a strong scientific background, excellent problem-solving abilities, and the capacity to lead and mentor junior scientists.
Responsibilities:
Position Overview:
The Principal Scientist will be instrumental in driving innovative research from target identification through to lead optimization. You will leverage your expertise in molecular biology, pharmacology, and assay development to design and execute complex experiments, interpret data, and guide research strategies. This role requires a strong scientific background, excellent problem-solving abilities, and the capacity to lead and mentor junior scientists.
Responsibilities:
- Lead and manage multiple drug discovery projects, defining scientific strategy and overseeing experimental design and execution.
- Develop and validate novel biological assays for target engagement and efficacy screening.
- Design and conduct in vivo and in vitro studies to assess drug candidate properties.
- Analyze complex biological datasets, interpret results, and make critical decisions regarding project direction.
- Collaborate closely with chemists, computational biologists, and other cross-functional teams to advance programs.
- Prepare research reports, publications, and presentations for internal and external stakeholders.
- Contribute to intellectual property generation and patent filings.
- Mentor and supervise junior scientists and research associates.
- Stay abreast of the latest scientific advancements and technologies in relevant therapeutic areas.
- PhD in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
- Minimum of 7 years of post-doctoral and industry experience in drug discovery.
- Proven track record of successfully advancing drug candidates through the discovery pipeline.
- Extensive experience in assay development, screening, and data analysis.
- Expertise in one or more therapeutic areas relevant to the company's focus (e.g., oncology, immunology, neuroscience).
- Strong understanding of medicinal chemistry principles.
- Excellent leadership, communication, and interpersonal skills.
- Experience with hybrid work environments and remote collaboration tools.
- A strong publication record is highly desirable.
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0
Senior Biophysicist - Drug Discovery
BT7 1AA Belfast, Northern Ireland
£65000 Annually
WhatJobs Direct
Posted 1 day ago
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Job Description
Our client, a pioneering biopharmaceutical company, is seeking a highly motivated and experienced Senior Biophysicist to join their dynamic Drug Discovery team. This role will be integral to the identification and validation of novel therapeutic targets and the characterisation of drug candidates. You will leverage your expertise in biophysical techniques to support drug development programmes, working collaboratively with chemists, biologists, and pharmacologists. The company is at the forefront of scientific innovation, seeking to make a tangible impact on patient lives.
Responsibilities:
If you are a seasoned biophysicist eager to contribute to groundbreaking drug discovery efforts, we invite you to apply.
Responsibilities:
- Design and execute complex biophysical experiments using a variety of techniques (e.g., SPR, ITC, MST, FRET, DLS, HIC).
- Characterise the binding kinetics and thermodynamics of small molecules and biologics with target proteins.
- Develop and optimise novel biophysical assays for screening and hit-to-lead optimisation.
- Analyse and interpret experimental data, providing clear and concise reports to project teams.
- Troubleshoot experimental methodologies and instrumentation.
- Contribute to the strategic direction of biophysical approaches within the drug discovery pipeline.
- Collaborate with interdisciplinary teams to integrate biophysical data with other biological and chemical information.
- Stay abreast of the latest advancements in biophysical techniques and their applications in drug discovery.
- Contribute to manuscript preparation and patent applications.
- Mentor junior scientists and contribute to a collaborative laboratory environment.
- A PhD in Biophysics, Biochemistry, Physical Chemistry, or a related discipline with a strong focus on biophysical characterisation.
- A minimum of 5 years of post-doctoral or industry experience in biophysics within a drug discovery setting.
- Extensive hands-on experience with multiple biophysical techniques for protein-ligand interaction analysis.
- Proven ability to design, troubleshoot, and optimise complex biophysical assays.
- Strong understanding of protein biochemistry and molecular biology.
- Excellent analytical skills and experience in data interpretation and statistical analysis.
- Proficiency in relevant software packages for data analysis and modelling.
- Strong communication and presentation skills, with the ability to effectively communicate complex scientific concepts.
- Experience with automation and high-throughput screening methodologies is advantageous.
- A collaborative spirit and ability to work effectively in a multidisciplinary team.
If you are a seasoned biophysicist eager to contribute to groundbreaking drug discovery efforts, we invite you to apply.
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1
Principal Scientist, Drug Discovery
BS1 6DG Bristol, South West
£85000 Annually
WhatJobs Direct
Posted 1 day ago
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Job Description
Join our client, a pioneering pharmaceutical company, as a Principal Scientist in Drug Discovery. This is a fully remote position, offering a unique opportunity to contribute to cutting-edge research from anywhere. You will lead innovative research programs aimed at identifying and validating novel therapeutic targets and developing first-in-class medicines. As a Principal Scientist, you will be responsible for designing and executing complex experimental strategies, interpreting data, and presenting findings to internal and external stakeholders. Your expertise will guide project teams, foster scientific rigor, and contribute to the company's pipeline advancement. Key responsibilities include developing new assays, utilizing advanced biological techniques, and staying abreast of the latest scientific literature and technological advancements in drug discovery. You will play a critical role in intellectual property generation and publication strategies. The ideal candidate will have a PhD in a relevant life science discipline (e.g., molecular biology, biochemistry, pharmacology) with a minimum of 8 years of post-doctoral and/or industry experience in drug discovery. Demonstrated success in leading research projects, a strong publication record, and experience with various therapeutic areas are essential. Proficiency in modern drug discovery platforms, including high-throughput screening, target validation, and mechanism-of-action studies, is required. Excellent communication, leadership, and collaboration skills are vital for success in this remote environment. We are seeking a highly motivated and results-oriented scientist who is passionate about translating scientific discoveries into life-changing therapies. This role offers the chance to work with a world-class scientific team and make a significant impact on patient health, with the flexibility of remote working.
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2
Principal Scientist - Drug Discovery
WV1 1LR Wolverhampton, West Midlands
£75000 Annually
WhatJobs Direct
Posted 1 day ago
Job Viewed
Job Description
Our client is seeking a highly accomplished Principal Scientist to join their innovative, remote-first Scientific Research & Development division. This senior role is integral to driving forward groundbreaking research initiatives and contributing to the development of novel scientific solutions. You will spearhead complex research projects, mentor junior scientists, and collaborate with a global team of experts. This position is fully remote, offering the flexibility to work from any location within the UK.
Key Responsibilities:
Qualifications:
This exciting fully remote role, supporting our client's leading-edge research based out of Wolverhampton, West Midlands, UK , is ideal for a visionary scientist seeking to make a significant impact.
Key Responsibilities:
- Lead and manage key research projects from conceptualization to completion, ensuring scientific rigor and timely delivery.
- Design and execute complex experiments, analyse data, and interpret results to advance research objectives.
- Develop and implement innovative scientific methodologies and technologies.
- Mentor and guide junior scientists and research associates, fostering a collaborative and high-performance team environment.
- Prepare comprehensive research reports, scientific publications, and presentations for internal and external stakeholders.
- Stay at the forefront of scientific advancements in the relevant field, identifying new research opportunities.
- Collaborate effectively with cross-functional teams, including chemistry, biology, and data science departments.
- Contribute to the strategic direction of the R&D department, identifying potential areas for innovation and intellectual property generation.
- Manage research budgets and ensure efficient use of resources.
- Ensure all research activities comply with ethical guidelines and regulatory requirements.
- Present findings at scientific conferences and engage with the wider scientific community.
Qualifications:
- Ph.D. in a relevant scientific discipline (e.g., Molecular Biology, Biochemistry, Chemistry, Pharmacology).
- A minimum of 10 years of post-doctoral research experience in an academic or industrial R&D setting.
- Proven track record of successful project leadership and scientific innovation, evidenced by publications and patents.
- Extensive experience in experimental design, data analysis, and interpretation using advanced statistical methods.
- Expertise in a specific area of scientific research relevant to the company's focus (e.g., genomics, proteomics, immunology, synthetic chemistry).
- Strong understanding of drug discovery or development processes.
- Exceptional leadership, mentoring, and team collaboration skills.
- Excellent written and verbal communication skills, with the ability to present complex scientific information clearly.
- Ability to think critically and solve complex scientific problems independently.
- Proficiency in relevant scientific software and databases.
- Demonstrated ability to work effectively in a remote, collaborative environment.
This exciting fully remote role, supporting our client's leading-edge research based out of Wolverhampton, West Midlands, UK , is ideal for a visionary scientist seeking to make a significant impact.
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3
Principal Scientist - Drug Discovery
LE5 5PH Leicester, East Midlands
£70000 Annually
WhatJobs Direct
Posted 1 day ago
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Job Description
Our client, a cutting-edge biotechnology company in Leicester, Leicestershire, UK , is seeking an accomplished Principal Scientist to join their innovative Drug Discovery division. This senior research role will focus on leading critical projects in the development of novel therapeutics. You will be responsible for designing and executing complex experiments, analysing and interpreting data, and contributing to the strategic direction of discovery programmes. The ideal candidate will possess a deep understanding of molecular biology, pharmacology, or a related life science discipline, coupled with a proven track record of delivering successful research outcomes. Expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience) and experience with relevant assay development and screening platforms are highly desirable. This role offers an exciting opportunity to work at the forefront of scientific innovation and make a significant impact on patient health.
Key Responsibilities:
We are seeking a PhD-qualified scientist with substantial post-doctoral and industry experience in drug discovery. A strong publication record and demonstrated success in managing research projects are essential. Expertise in areas such as target validation, hit-to-lead optimisation, or specific therapeutic modalities is required. Excellent communication, problem-solving, and leadership skills are paramount. This hybrid role offers the best of both worlds, combining critical lab-based research with the flexibility of remote work for data analysis, report writing, and strategic planning.
Key Responsibilities:
- Lead the design, optimisation, and execution of in vitro and/or in vivo experiments to identify and validate novel drug targets and lead compounds.
- Develop and implement cutting-edge biological assays and screening methodologies.
- Analyse, interpret, and present complex experimental data to internal teams and external collaborators.
- Contribute significantly to the strategic planning and intellectual property generation for discovery programmes.
- Mentor and guide junior scientists and research associates, fostering a collaborative and high-performing research environment.
- Stay abreast of the latest scientific literature, technological advancements, and competitive landscape in drug discovery.
- Collaborate effectively with cross-functional teams, including medicinal chemistry, DMPK, and translational sciences.
- Author research reports, protocols, and publications for scientific journals and conferences.
- Contribute to regulatory submissions and patent applications as required.
- Manage external collaborations with academic institutions and CROs.
We are seeking a PhD-qualified scientist with substantial post-doctoral and industry experience in drug discovery. A strong publication record and demonstrated success in managing research projects are essential. Expertise in areas such as target validation, hit-to-lead optimisation, or specific therapeutic modalities is required. Excellent communication, problem-solving, and leadership skills are paramount. This hybrid role offers the best of both worlds, combining critical lab-based research with the flexibility of remote work for data analysis, report writing, and strategic planning.
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4
Principal Scientist, Drug Discovery
OX1 3PA Oxford, South East
£90000 Annually
WhatJobs Direct
Posted 1 day ago
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Job Description
Our client, a leading pharmaceutical research organization, is seeking an innovative and highly skilled Principal Scientist to drive critical advancements in drug discovery. This role offers a unique opportunity to lead research initiatives, contribute to groundbreaking therapeutic developments, and mentor a team of talented scientists. The position is based in the renowned scientific hub of Oxford, Oxfordshire, UK , but offers a significant degree of remote work flexibility for successful candidates who can demonstrate effective remote collaboration and project leadership. You will play a pivotal role in identifying and validating novel drug targets and developing early-stage therapeutic candidates.
Responsibilities:
Responsibilities:
- Lead and design innovative research programs focused on identifying and validating novel drug targets in specific therapeutic areas.
- Develop and implement cutting-edge methodologies and assays for drug discovery screening and characterization.
- Oversee laboratory-based research activities, ensuring scientific rigor, data integrity, and efficient resource allocation.
- Analyze and interpret complex experimental data, drawing conclusions and making strategic recommendations for project progression.
- Collaborate closely with cross-functional teams, including medicinal chemists, biologists, pharmacologists, and clinical development experts.
- Author high-quality scientific publications, patent applications, and regulatory documents.
- Mentor and provide scientific guidance to junior scientists and research associates.
- Stay abreast of the latest scientific literature, technological advancements, and emerging trends in pharmaceutical research and development.
- Contribute to the strategic direction of the drug discovery pipeline.
- Present research findings at internal and external scientific conferences.
- PhD in a relevant life science discipline (e.g., Molecular Biology, Pharmacology, Biochemistry, Immunology).
- Minimum of 8 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
- Demonstrated track record of successfully leading drug discovery projects from target identification through to candidate selection.
- Extensive expertise in relevant disease areas and biological pathways.
- Proficiency in a range of molecular and cellular biology techniques, assay development, and data analysis.
- Excellent leadership, communication, and interpersonal skills, with the ability to foster a collaborative and innovative research environment.
- Proven ability to publish in high-impact journals and present research findings effectively.
- Experience in managing projects and mentoring junior scientists.
- Familiarity with computational biology and bioinformatics tools is an advantage.
- Ability to work effectively in a hybrid or remote research setting, demonstrating strong self-management.
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5
Principal Scientist - Drug Discovery
BT1 1AA Belfast, Northern Ireland
£85000 Annually
WhatJobs Direct
Posted 2 days ago
Job Viewed
Job Description
Our client, a pioneering biopharmaceutical company, is seeking a highly accomplished Principal Scientist to lead critical research and development initiatives in drug discovery. This senior role, based in **Belfast, Northern Ireland, UK**, offers a unique opportunity to drive innovation in therapeutic areas and shape the future of medicine. You will be responsible for designing and executing complex experiments, leading cross-functional research teams, and contributing to the strategic direction of the R&D pipeline. The ideal candidate will possess a deep understanding of molecular biology, pharmacology, or a related discipline, coupled with a proven track record of successful drug discovery programs and a passion for scientific excellence.
Key Responsibilities:
Key Responsibilities:
- Design, implement, and interpret complex research projects aimed at identifying and validating novel drug targets.
- Lead and mentor a team of scientists and technicians, fostering a collaborative and innovative research environment.
- Develop and optimize experimental methodologies and assays relevant to drug discovery.
- Analyze and interpret large datasets to derive meaningful conclusions and guide research directions.
- Author and contribute to scientific publications, patents, and regulatory submissions.
- Collaborate effectively with internal teams (e.g., chemistry, toxicology) and external partners.
- Stay abreast of the latest scientific advancements, literature, and technologies in relevant therapeutic areas.
- Contribute to the strategic planning and prioritization of the R&D pipeline.
- Present research findings at scientific conferences and to internal stakeholders.
- Ensure compliance with all laboratory safety and ethical standards.
- Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a closely related scientific field.
- 10+ years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry.
- Demonstrated success in leading R&D projects from target identification through preclinical development.
- Expertise in relevant therapeutic areas and disease mechanisms.
- Proven experience with a range of in vitro and in vivo pharmacology techniques.
- Strong track record of scientific publications and presentations.
- Experience in managing and mentoring scientific staff.
- Excellent analytical, problem-solving, and critical thinking skills.
- Exceptional communication, collaboration, and leadership abilities.
- Proficiency in data analysis software and scientific literature databases.
- Experience with grant writing and securing external funding is a plus.
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Principal Scientist - Drug Discovery
BN1 1BB East Sussex, South East
£70000 Annually
WhatJobs Direct
Posted 2 days ago
Job Viewed
Job Description
Our client, a leading pharmaceutical research company, is seeking an accomplished Principal Scientist to spearhead innovative drug discovery initiatives. This vital role involves leading a team of researchers in the identification, validation, and optimization of novel therapeutic targets and drug candidates. Based in our state-of-the-art facilities in Brighton, East Sussex, UK , you will be instrumental in driving forward our pipeline of groundbreaking medicines. The ideal candidate will possess extensive expertise in a relevant therapeutic area (e.g., oncology, immunology, neuroscience) and a deep understanding of modern drug discovery methodologies, including medicinal chemistry, pharmacology, and preclinical development. Responsibilities include designing and executing complex experimental strategies, interpreting data, and making critical decisions regarding project direction. You will also be responsible for mentoring junior scientists, fostering a collaborative and scientifically rigorous research environment, and staying abreast of the latest scientific literature and technological advancements. Collaboration with cross-functional teams, including clinical development, regulatory affairs, and business development, is crucial. The Principal Scientist will contribute to the strategic planning of the R&D portfolio, identify new research opportunities, and represent the company at scientific conferences. A Ph.D. in a relevant life science discipline (e.g., molecular biology, biochemistry, pharmacology, medicinal chemistry) and a minimum of 8 years of post-doctoral and industry experience in drug discovery are required. A strong publication record and a proven ability to deliver successful drug discovery projects are essential. Excellent leadership, communication, and project management skills are mandatory. This is an exceptional opportunity for a motivated and experienced scientist to make a significant impact on patient health by contributing to the development of novel therapies. The role is located in Brighton, East Sussex, UK , and requires full-time on-site presence.
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7
Principal Scientist - Drug Discovery
NG1 1AA Nottingham, East Midlands
£80000 Annually
WhatJobs Direct
Posted 2 days ago
Job Viewed
Job Description
Our client, a pioneering pharmaceutical research company, is seeking a highly accomplished Principal Scientist to lead critical drug discovery initiatives. This senior role is based in our state-of-the-art research facility in Nottingham, Nottinghamshire, UK . The successful candidate will spearhead innovative research programs, contribute to strategic decision-making, and mentor a team of talented scientists. This position offers a unique opportunity to make a significant impact on the development of novel therapeutics for unmet medical needs.
Responsibilities:
Responsibilities:
- Design and execute complex biological experiments to identify and validate novel drug targets.
- Lead and manage multiple drug discovery projects from early discovery through to pre-clinical development.
- Develop and implement innovative scientific strategies and methodologies to advance research programs.
- Analyze and interpret complex datasets, drawing meaningful conclusions and making data-driven recommendations.
- Supervise, mentor, and guide a team of research scientists and associates, fostering a collaborative and high-performing environment.
- Prepare and present research findings at internal meetings, scientific conferences, and in peer-reviewed publications.
- Collaborate effectively with internal departments (e.g., chemistry, DMPK, toxicology) and external partners, including academic institutions and CROs.
- Contribute to the strategic direction of the drug discovery portfolio and identify new research opportunities.
- Ensure compliance with all laboratory safety protocols, ethical guidelines, and regulatory requirements.
- Manage project budgets and resources efficiently.
- Stay abreast of the latest scientific literature, technological advancements, and industry trends in relevant therapeutic areas.
- Contribute to intellectual property generation through patent applications.
- Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
- Extensive post-doctoral and industry experience (minimum 8-10 years) in drug discovery, with a proven track record of successfully advancing compounds.
- Deep understanding of specific therapeutic areas (e.g., oncology, immunology, neuroscience) and associated biological pathways.
- Demonstrated expertise in a range of experimental techniques relevant to drug discovery (e.g., cell-based assays, target validation, high-throughput screening).
- Proven leadership and team management skills, with the ability to inspire and motivate scientific staff.
- Excellent scientific communication, presentation, and writing skills.
- Strong strategic thinking and problem-solving abilities.
- Experience in collaborating with multidisciplinary teams and external partners.
- Familiarity with hybrid work models and effective remote collaboration tools.
- Publication record in high-impact scientific journals.
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8
Senior Biophysicist - Drug Discovery
WC2N 5DU London, London
£75000 Annually
WhatJobs Direct
Posted 2 days ago
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Job Description
Our client, a groundbreaking biotechnology company at the forefront of pharmaceutical innovation, is seeking a highly skilled Senior Biophysicist to contribute to their fully remote drug discovery efforts. This role is pivotal in elucidating molecular mechanisms and guiding therapeutic development.
As a Senior Biophysicist, you will be responsible for designing and executing sophisticated biophysical experiments to characterize drug-target interactions, understand protein dynamics, and assess the efficacy of potential drug candidates. You will utilize a range of cutting-edge biophysical techniques and play a key role in the early stages of the drug discovery pipeline. This remote position offers the flexibility to work from an optimized home laboratory or collaborate virtually with research teams.
Key Responsibilities:
As a Senior Biophysicist, you will be responsible for designing and executing sophisticated biophysical experiments to characterize drug-target interactions, understand protein dynamics, and assess the efficacy of potential drug candidates. You will utilize a range of cutting-edge biophysical techniques and play a key role in the early stages of the drug discovery pipeline. This remote position offers the flexibility to work from an optimized home laboratory or collaborate virtually with research teams.
Key Responsibilities:
- Design, optimize, and perform complex biophysical experiments to study molecular interactions, binding kinetics, and thermodynamics (e.g., SPR, ITC, MST, CD, fluorescence).
- Analyze and interpret large datasets generated from biophysical assays, providing critical insights into drug-target engagement and mechanism of action.
- Develop and validate novel biophysical assays for screening and characterization of small molecules and biologics.
- Collaborate closely with medicinal chemists, structural biologists, and pharmacologists to integrate biophysical data into drug discovery programs.
- Contribute to the strategic direction of drug discovery projects by providing robust biophysical data and expert interpretation.
- Prepare detailed technical reports, presentations, and manuscripts for internal and external dissemination.
- Stay current with advancements in biophysical techniques, instrumentation, and their applications in drug discovery.
- Mentor junior scientists and contribute to the scientific development of the research team.
- Troubleshoot experimental challenges and propose innovative solutions.
- PhD in Biophysics, Biochemistry, Chemistry, or a related life science discipline.
- A minimum of 5-7 years of postdoctoral and/or industry experience in biophysics, with a strong focus on drug discovery.
- Extensive hands-on experience with a variety of biophysical techniques (SPR, ITC, MST, FRET, SAXS, etc.).
- Proficiency in data analysis software and statistical methods relevant to biophysical data.
- Demonstrated ability to design and execute complex experimental plans independently.
- Excellent problem-solving skills and a meticulous approach to experimentation.
- Strong written and verbal communication skills, with the ability to present complex scientific findings clearly.
- Experience working effectively in a remote research environment and utilizing collaboration tools.
- A strong publication record in peer-reviewed journals is highly desirable.
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