578 Astrazeneca jobs in the United Kingdom
Principal Scientist, Drug Discovery
SW1A 0AA London, London
£85000 Annually
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Our client is a world-leading biotechnology company at the forefront of pharmaceutical innovation. They are seeking an exceptional Principal Scientist to drive critical research initiatives within their drug discovery division. This is a fully remote position, offering a unique opportunity to shape the future of medicine from your home laboratory or office. You will be responsible for leading complex research projects, developing novel therapeutic strategies, and contributing to the advancement of our preclinical and clinical pipelines. Key responsibilities include designing and executing sophisticated experiments, analysing complex biological data, and interpreting results to guide project direction. You will be expected to identify and validate new drug targets, develop innovative assay methodologies, and contribute to the preclinical characterisation of drug candidates. Collaboration with internal multidisciplinary teams, including medicinal chemists, pharmacologists, and clinical researchers, as well as external academic partners, will be essential. The ideal candidate will possess a deep understanding of molecular biology, pharmacology, or a related field, with a strong publication record and extensive experience in drug discovery. Proven experience in leading research projects, mentoring junior scientists, and contributing to strategic R&D decisions is highly desirable. You should be adept at critical thinking, possess excellent problem-solving skills, and be passionate about scientific advancement. As a remote role, outstanding communication, presentation, and self-management skills are crucial for effective collaboration and leadership. This role offers a challenging and rewarding opportunity to make a significant impact on patient lives through cutting-edge scientific research.
Key Responsibilities:
Qualifications:
Key Responsibilities:
- Lead and design complex research projects in drug discovery.
- Develop and implement novel scientific methodologies and assays.
- Identify and validate potential drug targets and therapeutic strategies.
- Conduct in-depth analysis of biological and pharmacological data.
- Interpret experimental results and guide project progression.
- Collaborate with internal and external research teams and stakeholders.
- Mentor and supervise junior scientific staff.
- Contribute to the strategic direction of the R&D pipeline.
- Author scientific publications and present research findings.
- Ensure compliance with safety and ethical research standards.
Qualifications:
- PhD in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
- Minimum of 8 years of post-doctoral research experience in drug discovery or a related field.
- Proven track record of leading successful research projects and publications in high-impact journals.
- Extensive experience in experimental design, execution, and data analysis.
- Expertise in relevant therapeutic areas and/or scientific disciplines (e.g., oncology, immunology, neuroscience).
- Demonstrated leadership, mentoring, and project management skills.
- Excellent analytical, critical thinking, and problem-solving abilities.
- Outstanding written and verbal communication and presentation skills.
- Experience working independently and collaboratively in a remote research setting.
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Principal Scientist - Drug Discovery
DE1 2BU Derby, East Midlands
£70000 Annually
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Our client, a leading pharmaceutical innovator, is seeking an exceptional Principal Scientist to drive forward their early-stage drug discovery programs. This hybrid role offers a blend of remote flexibility and in-office collaboration, based in Derby, Derbyshire, UK . You will lead the design and execution of complex research projects, focusing on identifying and validating novel therapeutic targets for unmet medical needs. Responsibilities include directing medicinal chemistry efforts, overseeing in vitro and in vivo studies, interpreting experimental data, and contributing to the development of comprehensive research strategies. You will mentor and guide a team of talented scientists, foster a collaborative research environment, and engage with external partners and key opinion leaders. The successful candidate will possess a PhD in pharmacology, biochemistry, medicinal chemistry, or a related discipline, with a minimum of 8-10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry. A strong publication record, expertise in a specific therapeutic area (e.g., oncology, neuroscience, immunology), and a proven ability to manage projects from target identification through to lead optimization are essential. Experience with modern drug discovery technologies, including high-throughput screening and structure-based drug design, is highly desirable. This is a critical leadership role, offering the chance to make a significant impact on the future of medicine and contribute to the development of life-changing therapies.
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Principal Scientist - Drug Discovery
BD1 1AA Bradford, Yorkshire and the Humber
£80000 Annually
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Our client is searching for a distinguished Principal Scientist to lead critical initiatives in drug discovery, based in our state-of-the-art facilities in Bradford, West Yorkshire, UK . This senior role is integral to identifying and advancing novel therapeutic candidates. You will leverage your extensive expertise in pharmaceutical research, innovative experimental design, and in-depth biological understanding to drive projects from early-stage discovery through to preclinical development. The ideal candidate will be a thought leader with a proven track record of scientific innovation, a strong publication record, and a deep commitment to bringing life-changing medicines to patients.
Key Responsibilities:
Qualifications:
Key Responsibilities:
- Lead and manage complex drug discovery projects, defining strategic direction and experimental approaches.
- Design, execute, and interpret advanced experiments to identify and validate novel drug targets and lead compounds.
- Develop and optimise cutting-edge assays and methodologies in relevant therapeutic areas.
- Collaborate closely with multidisciplinary teams, including medicinal chemists, biologists, pharmacologists, and toxicologists.
- Provide scientific leadership and mentorship to research scientists and postdoctoral fellows.
- Analyse and interpret complex biological data, drawing robust conclusions and making informed recommendations.
- Contribute to the intellectual property strategy through invention disclosures and patent filings.
- Present research findings at internal meetings and external scientific conferences.
- Author high-impact scientific publications in peer-reviewed journals.
- Stay abreast of the latest scientific advancements and emerging technologies in drug discovery.
- Contribute to the strategic planning and portfolio management of the drug discovery pipeline.
- Ensure adherence to all safety, ethical, and regulatory guidelines.
Qualifications:
- Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
- Minimum of 10 years of relevant experience in drug discovery within the pharmaceutical or biotechnology industry.
- Demonstrated success in leading drug discovery programs and advancing candidates into development.
- Extensive knowledge of drug discovery processes, including target identification, validation, lead generation, and optimisation.
- Expertise in one or more therapeutic areas (e.g., oncology, immunology, neurology, infectious diseases).
- Proven ability to design and interpret complex biological experiments and data.
- Excellent track record of scientific publications and presentations.
- Strong leadership, mentoring, and team-building skills.
- Exceptional problem-solving abilities and strategic thinking.
- Proficiency in relevant scientific technologies and platforms.
- Strong written and verbal communication skills, with the ability to articulate complex scientific concepts effectively.
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2
Research Scientist - Drug Discovery
NG1 3DQ Nottingham, East Midlands
£55000 Annually
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Our client, a pioneering pharmaceutical company at the forefront of therapeutic innovation, is seeking a talented Research Scientist to join their dedicated Drug Discovery unit. This role is based at their state-of-the-art facility in Nottingham, Nottinghamshire, UK , with a hybrid working arrangement allowing for a balanced approach to research and personal life. You will play a critical role in identifying and validating novel drug targets and developing innovative small molecule therapeutics.
The successful candidate will design and execute complex biological assays, contribute to lead optimization efforts, and collaborate with multidisciplinary teams including medicinal chemists, pharmacologists, and DMPK scientists. Responsibilities include maintaining cell lines, performing high-throughput screening, analysing experimental data, interpreting results, and presenting findings at team meetings and scientific conferences. A strong background in molecular biology, biochemistry, or a related life science discipline is essential, along with hands-on experience in assay development and drug discovery methodologies. The ability to work effectively in a fast-paced, collaborative research environment is crucial.
Key Responsibilities:
The successful candidate will design and execute complex biological assays, contribute to lead optimization efforts, and collaborate with multidisciplinary teams including medicinal chemists, pharmacologists, and DMPK scientists. Responsibilities include maintaining cell lines, performing high-throughput screening, analysing experimental data, interpreting results, and presenting findings at team meetings and scientific conferences. A strong background in molecular biology, biochemistry, or a related life science discipline is essential, along with hands-on experience in assay development and drug discovery methodologies. The ability to work effectively in a fast-paced, collaborative research environment is crucial.
Key Responsibilities:
- Design, develop, and validate biochemical and cell-based assays for target identification and validation.
- Perform high-throughput screening (HTS) and subsequent hit-to-lead optimization studies.
- Cultivate and maintain mammalian cell lines, including stable transfections and primary cell culture.
- Conduct detailed data analysis and interpretation using appropriate statistical methods.
- Contribute to project strategy and experimental planning.
- Collaborate effectively with chemists, pharmacologists, and other research staff.
- Present research findings clearly and concisely in internal meetings and scientific publications/conferences.
- Maintain accurate and up-to-date laboratory notebooks and documentation.
- Stay current with scientific literature and new technologies in drug discovery.
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a closely related field.
- Postdoctoral experience or equivalent industry experience in drug discovery is highly desirable.
- Proven experience in assay development, including biochemical and cell-based assays.
- Hands-on experience with HTS, screening technologies, and data analysis software.
- Strong understanding of drug discovery processes and principles.
- Excellent analytical, problem-solving, and critical thinking skills.
- Strong communication and interpersonal skills, with the ability to work effectively in a team environment.
- Experience with molecular biology techniques (e.g., PCR, Western Blotting, ELISA) is a plus.
- Familiarity with GxP environments is advantageous.
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Principal Scientist - Drug Discovery
NG1 2GH Nottingham, East Midlands
£70000 Annually
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Our client is a cutting-edge pharmaceutical research organisation seeking a highly skilled and visionary Principal Scientist in Drug Discovery to join their team in **Nottingham, Nottinghamshire, UK**. This hybrid role combines essential in-lab research with strategic remote work, allowing for maximum impact and flexibility. You will be at the forefront of identifying and validating novel therapeutic targets, designing and synthesizing small molecule inhibitors, and optimizing lead compounds through iterative medicinal chemistry efforts. This position requires a PhD in Organic Chemistry, Medicinal Chemistry, Pharmacology, or a closely related field, with extensive post-doctoral experience and a demonstrable track record of success in drug discovery programs. You will lead a dedicated team of scientists, providing scientific direction, mentorship, and fostering a collaborative, innovative research environment. Responsibilities include developing and executing ambitious research strategies, managing project timelines, and staying abreast of the latest scientific literature and technological advancements. The ideal candidate will possess exceptional problem-solving skills, a deep understanding of modern drug discovery methodologies, and a proven ability to bring drug candidates from concept to preclinical development. Strong analytical, communication, and interpersonal skills are crucial for effectively presenting complex scientific data to internal teams and external collaborators. Experience with target identification, hit-to-lead optimization, and ADMET profiling is essential. You will play a critical role in shaping the company's pipeline and contributing to the development of life-changing medicines. We seek individuals who are passionate about science, driven by innovation, and committed to achieving breakthroughs in therapeutic areas. This is an unparalleled opportunity to influence the direction of drug discovery within a dynamic and supportive organization.
Key Responsibilities:
Key Responsibilities:
- Lead and contribute to early-stage drug discovery programs.
- Design and synthesize novel small molecules for therapeutic targets.
- Conduct hit-to-lead and lead optimization studies.
- Develop and implement innovative medicinal chemistry strategies.
- Collaborate with biologists, pharmacologists, and DMPK scientists.
- Mentor and guide junior scientists and research associates.
- Analyze and interpret complex experimental data.
- Present research findings at internal meetings and external conferences.
- Contribute to patent applications and scientific publications.
- Stay current with emerging technologies and therapeutic approaches.
- PhD in Medicinal Chemistry, Organic Chemistry, Pharmacology, or a related field.
- Significant experience (5+ years) in drug discovery within the pharmaceutical or biotech industry.
- Demonstrated success in bringing drug candidates through discovery phases.
- Expertise in synthetic organic chemistry and structure-activity relationships (SAR).
- Strong understanding of biological assays and target validation.
- Excellent problem-solving, analytical, and critical thinking skills.
- Exceptional communication, presentation, and interpersonal skills.
- Experience with various computational chemistry tools and databases.
- Ability to work effectively in a collaborative, cross-functional team environment.
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Principal Scientist - Drug Discovery
WV1 1AA Wolverhampton, West Midlands
£85000 Annually
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Our client, a pioneering biotechnology firm at the forefront of innovative therapeutic development, is seeking an exceptional Principal Scientist to lead critical drug discovery initiatives. This is a fully remote position, offering a unique opportunity to contribute to groundbreaking research from anywhere within the UK. You will spearhead research projects, mentor junior scientists, and drive the advancement of novel drug candidates from target identification through to pre-clinical development. Your expertise will be pivotal in shaping the future of our client's therapeutic pipeline.
Responsibilities:
Responsibilities:
- Lead and manage complex drug discovery research programs, from target validation to lead optimization.
- Design and execute innovative experimental strategies to identify and characterize novel therapeutic targets and drug candidates.
- Mentor and guide a team of talented research scientists, fostering scientific rigor and a collaborative research environment.
- Interpret experimental data, draw meaningful conclusions, and present findings to senior management, research teams, and at scientific conferences.
- Develop and implement robust assays and methodologies for drug discovery screening and characterization.
- Collaborate effectively with cross-functional teams, including chemistry, biology, pharmacology, and toxicology departments.
- Stay abreast of the latest scientific literature, technologies, and trends in drug discovery and relevant therapeutic areas.
- Contribute to intellectual property generation and patent filings.
- Manage external research collaborations with academic institutions and contract research organizations (CROs).
- Ensure compliance with all laboratory safety regulations and ethical guidelines.
- Contribute to the strategic direction of the company's research and development efforts.
- Author scientific publications and contribute to regulatory submissions.
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
- A minimum of 8-10 years of post-doctoral and industry experience in drug discovery, with a strong publication record and a deep understanding of therapeutic mechanisms.
- Proven experience in leading research projects and mentoring scientific teams.
- Expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience) is highly desirable.
- Proficiency in a broad range of molecular and cellular biology techniques, assay development, and data analysis.
- Excellent understanding of PK/PD relationships, ADME, and early toxicology principles.
- Strong analytical, problem-solving, and critical thinking skills.
- Exceptional written and verbal communication skills, with the ability to present complex scientific data clearly and concisely.
- Experience managing CROs and academic collaborations.
- This is a fully remote position, open to highly qualified scientists based within the UK.
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Principal Scientist - Drug Discovery
NR4 7UH Norwich, Eastern
£85000 Annually
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Our client, a renowned research and development organization, is seeking a highly skilled and innovative Principal Scientist to lead critical initiatives within their drug discovery department. Based in **Norwich, Norfolk, UK**, this senior role is integral to advancing our client's pipeline of novel therapeutics. You will be responsible for designing and executing cutting-edge research programs, mentoring a team of scientists, and driving the progression of drug candidates from early discovery through to preclinical development. The ideal candidate will possess a Ph.D. in a relevant life science discipline (e.g., Molecular Biology, Pharmacology, Biochemistry) and a substantial track record of success in drug discovery, with demonstrable expertise in specific therapeutic areas or target classes. Responsibilities include conceptualizing and planning complex research projects, overseeing experimental design and execution, interpreting complex data, and contributing to the development of robust scientific strategies. You will be expected to publish findings in high-impact journals, present at international conferences, and contribute to patent applications. Strong leadership, excellent communication, and collaborative skills are essential, as you will work closely with cross-functional teams, including chemistry, DMPK, and toxicology. This role requires a deep understanding of modern drug discovery technologies and methodologies, coupled with a creative and problem-solving mindset. The successful applicant will be passionate about scientific innovation and committed to bringing life-changing medicines to patients.
Responsibilities:
Responsibilities:
- Lead and direct innovative drug discovery research programs from target identification to lead optimization.
- Design and execute complex experimental studies to evaluate novel therapeutic candidates.
- Mentor and guide a team of research scientists, fostering a collaborative and high-performance environment.
- Analyze and interpret complex biological and pharmacological data, drawing robust conclusions.
- Develop and present scientific findings to internal committees, senior management, and external stakeholders.
- Contribute to intellectual property generation through patent filings and publications.
- Collaborate effectively with cross-functional teams (chemistry, DMPK, toxicology, clinical development).
- Stay abreast of the latest advancements in scientific literature, technologies, and methodologies in drug discovery.
- Manage research budgets and resources effectively.
- Ensure all research activities are conducted in compliance with ethical and regulatory guidelines.
- Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related field.
- Minimum of 8 years of post-doctoral research experience in drug discovery within the pharmaceutical or biotechnology industry.
- Proven track record of leading successful drug discovery projects and advancing candidates into preclinical development.
- Deep expertise in relevant scientific areas (e.g., oncology, immunology, neuroscience) and target classes.
- Extensive experience with a variety of in vitro and in vivo assays and technologies.
- Strong leadership, mentorship, and team management skills.
- Excellent scientific communication, presentation, and writing skills.
- Proficiency in data analysis software and scientific literature databases.
- Ability to think creatively and solve complex scientific problems.
- Demonstrated success in publishing in peer-reviewed journals and presenting at scientific conferences.
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Principal Scientist - Drug Discovery
BN1 1AB East Sussex, South East
£80000 Annually
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Our client is a leading biopharmaceutical company dedicated to groundbreaking scientific research and development. We are seeking a highly accomplished Principal Scientist to join our innovative Drug Discovery team. This role is based in Brighton, East Sussex, UK , and operates on a hybrid model, balancing essential lab-based work with remote research and analysis.
Key Responsibilities:
Key Responsibilities:
- Lead and execute complex research projects focused on identifying and validating novel drug targets and therapeutic modalities.
- Design and perform in vitro and in vivo experiments to assess the efficacy and safety of potential drug candidates.
- Develop and optimize cutting-edge biological assays and screening platforms.
- Interpret experimental data, draw robust conclusions, and present findings to scientific leadership and project teams.
- Contribute to the strategic direction of the drug discovery pipeline, identifying new research opportunities and technologies.
- Mentor and guide junior scientists, fostering a collaborative and intellectually stimulating research environment.
- Author scientific publications, present at conferences, and contribute to patent filings.
- Collaborate effectively with cross-functional teams, including chemistry, pharmacology, and translational science.
- Manage research budgets and resources efficiently.
- Maintain a high level of scientific rigor and adherence to ethical standards in all research activities.
- Participate in scientific review committees and contribute to peer review processes.
- Ph.D. in a relevant biological science (e.g., Molecular Biology, Pharmacology, Immunology, Biochemistry) with a strong publication record.
- Minimum of 8 years of post-doctoral and industry experience in drug discovery, with a focus on (Specify area, e.g., oncology, immunology, infectious diseases).
- Proven expertise in (mention specific techniques, e.g., target validation, high-throughput screening, cell-based assays, animal models).
- Demonstrated success in leading research projects from conception to preclinical development.
- Deep understanding of disease biology and drug discovery processes.
- Excellent analytical, critical thinking, and problem-solving skills.
- Outstanding written and oral communication skills, with the ability to present complex scientific information clearly.
- Experience with data analysis software and bioinformatics tools.
- Ability to work effectively both independently and collaboratively in a hybrid research setting.
- Experience managing and mentoring junior staff.
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7
Principal Scientist - Drug Discovery
PO1 3LZ Portsmouth, South East
£80000 Annually
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Posted 1 day ago
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Our client is a leading pharmaceutical research organization seeking an exceptional Principal Scientist to join their pioneering drug discovery team. This fully remote position offers a unique opportunity to contribute to groundbreaking therapeutic advancements from your home-based laboratory or office. You will play a critical role in identifying and validating novel drug targets, designing and executing complex experiments, and driving research programs from early discovery through to preclinical development. This role demands a high degree of scientific rigor, innovative thinking, and collaborative spirit, all within a remote-first operational framework.
Responsibilities:
Responsibilities:
- Lead and manage early-stage drug discovery projects, contributing innovative ideas and scientific expertise.
- Design, optimize, and execute complex in vitro and in vivo experimental protocols to assess target validation and compound efficacy.
- Analyze and interpret experimental data, drawing meaningful conclusions and making strategic recommendations.
- Develop and implement cutting-edge assays and technologies to support drug discovery initiatives.
- Collaborate closely with internal multidisciplinary teams (chemistry, biology, pharmacology) and external partners.
- Stay abreast of the latest scientific literature and technological advancements in relevant therapeutic areas.
- Prepare and present research findings at internal meetings and external scientific conferences.
- Contribute to the preparation of scientific publications and patent applications.
- Mentor junior scientists and contribute to a culture of scientific excellence and innovation.
- Ensure rigorous adherence to experimental design, data integrity, and regulatory guidelines within a remote research setting.
- Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
- Minimum of 8 years of post-doctoral and/or industry experience in drug discovery.
- Proven track record of success in identifying and validating novel drug targets and advancing programs.
- Extensive hands-on experience with a variety of molecular and cellular biology techniques.
- Strong understanding of therapeutic areas relevant to the company's pipeline.
- Demonstrated ability to work independently and lead research initiatives in a remote environment.
- Excellent analytical, problem-solving, and critical thinking skills.
- Superb written and verbal communication skills, with the ability to clearly articulate complex scientific concepts.
- Experience with data analysis software and bioinformatics tools is a plus.
- Ability to foster strong collaborative relationships with remote colleagues and external collaborators.
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8
Principal Chemist - Drug Discovery
PL4 8AA Plymouth, South West
£70000 Annually
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Our client, a renowned pharmaceutical company committed to developing life-saving therapies, is seeking an exceptional Principal Chemist to join their dynamic Drug Discovery unit in **Plymouth, Devon, UK**. This senior role is critical in driving the early-stage discovery of novel small molecule therapeutics. You will leverage your extensive expertise in synthetic organic chemistry and medicinal chemistry to design, synthesize, and optimize potent and selective drug candidates. This is a unique opportunity to contribute to impactful research within a collaborative and innovative environment. Key Responsibilities:
- Lead the design and synthesis of novel chemical entities for therapeutic targets across various disease areas.
- Apply advanced medicinal chemistry principles to optimize lead compounds, improving potency, selectivity, pharmacokinetic properties, and safety profiles.
- Develop and implement innovative synthetic routes and strategies for complex molecules.
- Collaborate closely with biologists, pharmacologists, and DMPK scientists to advance drug discovery projects from hit identification through lead optimization.
- Manage research projects, set priorities, and mentor junior chemists.
- Oversee the procurement and management of chemical reagents and inventory.
- Interpret spectroscopic data (NMR, MS, etc.) and other analytical results to confirm compound structures and purity.
- Stay abreast of the latest advancements in synthetic and medicinal chemistry, as well as emerging therapeutic modalities.
- Prepare scientific reports, presentations, and contribute to patent filings and publications.
- Ensure adherence to all safety protocols and good laboratory practices (GLP).
- PhD in Organic Chemistry, Medicinal Chemistry, or a closely related field.
- Minimum of 7 years of relevant experience in pharmaceutical or biotechnology drug discovery, with a strong track record in small molecule synthesis and optimization.
- Expertise in modern synthetic organic chemistry techniques and methodologies.
- In-depth understanding of Structure-Activity Relationships (SAR) and Structure-Property Relationships (SPR).
- Proficiency in compound analysis using techniques such as NMR, LC-MS, and HPLC.
- Experience with computational chemistry tools for molecular design and property prediction is desirable.
- Excellent problem-solving abilities and a creative approach to synthetic challenges.
- Strong project management skills and the ability to work independently and lead teams.
- Outstanding communication and interpersonal skills, with the ability to effectively present complex scientific information to diverse audiences.
- A passion for drug discovery and a commitment to scientific rigor.
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