9 Astrazeneca jobs in the United Kingdom

About Us

Exscientia is an AI-driven precision medicine company committed to discovering, designing and developing the best possible drugs in the fastest and most effective manner. Exscientia developed the first-ever functional precision oncology platform to successfully guide treatment selection and improve patient outcomes in a prospective interventional clinical study, as well as to progress AI-designed small molecules into the clinical setting.

Our internal pipeline is focused on leveraging our precision medicine platform in oncology, while our partnered pipeline broadens our approach to other therapeutic areas. By pioneering a new approach to medicine creation, we believe the best ideas of science can rapidly become the best medicines for patients.

The Role

The Associate Director, Discovery Toxicologist will join the innovative Preclinical Development group and will provide project teams with scientific expertise and leadership for the safety assessment of Exscientia programs from early discovery, through to candidate selection and beyond. You will contribute to the assessment and selection of novel drug targets and optimisation of novel small molecule drug candidates using innovative molecular, cellular and in vivo technologies to maximise predictive safety science and investigative toxicology.

Please note this is a hybrid role and occasional travel is required to our offices in Oxford, UK (approximately 1-2 times per quarter), with flexibility to work from home in the UK the remaining time. We are a flexible working organisation and we’re willing to consider other options which would provide similar contact time with the team.

You will have the opportunity to:

• Represent Toxicology as the Subject Matter Expert on cross-functional project teams within the Discovery organisation. Opportunity to represent Toxicology in Development as the projects progress.
• Act as a key resource for early safety assessment during the drug discovery phase, providing scientific knowledge and expertise to cross-functional project teams.
• Use established toxicology screening strategies to predict, assess and mitigate target- and drug-related safety risks in support of the drug discovery portfolio.
• Refine and implement innovative experimental strategies and use the data to assess and /or provide mechanistic understanding of safety issues.
• Collaborate with CROs to ensure best practice for in vitro and/or in vivo safety assessment.
• Prepare verbal and written summaries for internal discussions. Work with the Discovery teams to develop optimal strategies to address specific safety issues within project teams. Present summary data to project teams, Exscientia senior leadership and external partners as needed.

Requirements

Essential skills:

• DVM, Pharm D, Ph.D in toxicology, Pathology, Physiology, Biochemistry or expertise in related biological scientific disciplines, with an emphasis on Oncology/Immunology is preferred. 10+ years’ experience in safety sciences in the Biotech/Pharma industry.
• Experience in project team membership as a Discovery toxicology representative in a matrix environment.
• Experience with in silico and in vitro safety assessment leading to an in-depth knowledge of small molecule discovery toxicology, and experience designing and critically evaluating results of exploratory toxicology studies.
• An understanding of in vitro to in vivo translation of potential toxicities and implications for human safety.
• Broad background in novel methods of identifying potential toxicities and developing risk mitigation plans.
• Highly motivated scientist, who can work independently, with excellent oral/written communication skills.

Desirable skills:

• Board Certification in Toxicology (DABT/ERT).
• Experience running in vivo safety assessment studies.
• Knowledge of secondary pharmacology assessment and mitigation of identified risks.
• Keen interest in artificial intelligence and its application to drug discovery. Experience with the use of AI-tools to predict toxicology endpoints.

Benefits

• Join our inclusive, collaborative and intellectually stimulating organisation with an exciting mission and strong values.
• As a learning organisation, we provide access to learning and development opportunities and will place you at the forefront of your career growth at Exscientia.
• We employ brilliant people so we pay highly competitive salaries. Additionally, all our employees are eligible for a company-wide annual bonus and receive new joiner and annual share awards.
• Enjoy our generous 28 days holiday allowance plus public holidays, with flexibility to carry over or purchase extra holidays.
• We also offer flexible working to find a healthy work-life balance that works for you.
• Create amazing memories or progress your personal and professional development with our four-week paid sabbatical after four years of service.
• We’re leading the way in progressive leave offering enhanced policies so you feel supported no matter the life event. This includes generous parental, fertility, menopause and family emergency leave, and much more. 
• Additionally, we support childcare costs for children aged 0-5 through our affordable childcare scheme.
• Take advantage of two generous salary exchange schemes to claim discounts on a brand new electric vehicle and cycling equipment worth up to £3,500.
• As a healthcare company, we understand the importance of health and wellbeing so we provide comprehensive private health insurance, dental and vision benefits for you and your family.
• We also provide plenty of access to mental health support including therapy and counselling sessions plus an employee assistance program for help with lifestyle issues such as bereavement, family problems or money management.
• To help safeguard the future for you and your loved ones, we also offer pension and life cover.
• Have fun with colleagues at our in-person and remote social events! Get competitive at a quiz or bake off, or relax at a movie night or picnic - there’s something for everyone.
• Collaborate with your team at our uplifting offices and choose a design-led breakout space to inspire creativity. Help yourself to free drinks, snacks and freshly ground coffee in our fully stocked kitchens. Some of the best ideas start with a coffee break!
• Feel inspired in our high spec labs where you will use state-of-the-art equipment and instruments that empower you to do your best work.
• We’ll even support your home office environment with an allowance for furniture and equipment to make your space as comfortable and productive as possible.
• Learn more about why our team enjoy working at Exscientia here

DEIB

At Exscientia, we are committed to building a diverse, equitable, and inclusive environment where every employee belongs.

We celebrate and value the diversity of our team, recognising that our differences drive our creativity and innovation forward. This applies to differences in ethnicity, nationality, cultural heritage, age, religion, mental and physical ability, neurodiversity, gender identity and expression, sexual orientation, marital and civil partnership status, family status, and socioeconomic background.

We are committed to providing fair treatment, opportunity and advancement for all employees, and we strive to create an inclusive environment where everyone feels valued, respected and empowered to bring their best selves to work.

If you require any support or adjustments to interact with us, please email

Scientific Sales Manager - Drug Discovery Tools

Newton Colmore is working with an exciting biotech company in Cambridge who are looking to hire a Sales Manager to lead the commercialisation of their latest drug discovery tool.

As a Sales Manager in this growing company, you will be utilising your molecular biology or biochemistry expertise and sales acumen to identify and win new customers. This is a pivotal role for the company, and you will be responsible for building a new sales strategy, attending industry events, building new relationships and engaging with key stakeholders.

The company have developed a new desktop tool that aims to speed up and improve drug discovery outcomes with novel technology that is at the intersection of science and engineering.

You will be utilising your scientific commercial experience to interact directly with potential customers and to help them understand more about the technology and how it can improve their discovery capabilities.

To be considered for this exciting role you will need to have the following;

• Prior sales experience, ideally within a drug discovery setting.
• Biology or Biochemistry academics.
• Some knowledge of bioprocessing or protein assays would be ideal.
• Be a great communicator and enjoy travelling with work (around 30%).

The company are offering competitive salaries coupled with a strong benefits package as well as excellent growth opportunities in a fast-growing company. They will provide you with all the tools you need to make this role a success. Share options are also available.

The company have created a hierarchy-free environment that fosters innovation and progress, meaning you can make a real difference with your ideas.

This is an opportunity not to be missed so make an application now. For more details speak with Matthew Lowdon, medical devices recruitment specialist at Newton Colmore Consulting on (phone number removed).

Newton Colmore Consulting is a specialist recruitment consultancy operating within the medical devices and scientific engineering sectors. We conduct bespoke searches for our clients across the globe. We are continually running searches across R&D so take a look at our open roles on our website.

Scientific Sales Manager - Drug Discovery Tools

Newton Colmore is working with an exciting biotech company in Cambridge who are looking to hire a Sales Manager to lead the commercialisation of their latest drug discovery tool.

As a Sales Manager in this growing company, you will be utilising your molecular biology or biochemistry expertise and sales acumen to identify and win new customers. This is a pivotal role for the company, and you will be responsible for building a new sales strategy, attending industry events, building new relationships and engaging with key stakeholders.

The company have developed a new desktop tool that aims to speed up and improve drug discovery outcomes with novel technology that is at the intersection of science and engineering.

You will be utilising your scientific commercial experience to interact directly with potential customers and to help them understand more about the technology and how it can improve their discovery capabilities.

To be considered for this exciting role you will need to have the following;

• Prior sales experience, ideally within a drug discovery setting.
• Biology or Biochemistry academics.
• Some knowledge of bioprocessing or protein assays would be ideal.
• Be a great communicator and enjoy travelling with work (around 30%).

The company are offering competitive salaries coupled with a strong benefits package as well as excellent growth opportunities in a fast-growing company. They will provide you with all the tools you need to make this role a success. Share options are also available.

The company have created a hierarchy-free environment that fosters innovation and progress, meaning you can make a real difference with your ideas.

This is an opportunity not to be missed so make an application now. For more details speak with Matthew Lowdon, medical devices recruitment specialist at Newton Colmore Consulting on (phone number removed).

Newton Colmore Consulting is a specialist recruitment consultancy operating within the medical devices and scientific engineering sectors. We conduct bespoke searches for our clients across the globe. We are continually running searches across R&D so take a look at our open roles on our website.

SandboxAQs AI Simulation group partners with global research teams to discover new drugs and materials using AI and physics-based computational solutions. We are seeking an experienced researcher to drive innovative and impactful projects leveraging cheminformatics, machine learning, and computational chemistry for drug discovery. The successful candidate will demonstrate strong abilities in cheminformatics and/or bioinformatics, including knowledge of established techniques and cutting-edge machine learning methods for modeling molecular properties and interactions with complex systems. They will also have experience with scientific programming and data science. These skills will be leveraged within a seasoned, agile, and multi-disciplinary group, including drug hunters with an excellent track record in drug discovery, computational chemists, physicists, AI experts, and software engineers.

What Youll Do

• Design and implement software that leverages informatics, machine learning, and computational chemistry to address unmet needs in drug discovery
• Contribute to ongoing research leveraging physics-based simulation, deep learning, and knowledge graphs for drug discovery applications
• Work closely with an interdisciplinary team of scientists to identify hits and optimize leads in ongoing drug discovery programs
• Leverage Bayesian optimization and active learning to improve experimental designs and make data-driven decisions
• Collaborate with computational chemistry experts and cross-functional teams to rapidly prototype and scale cutting-edge, impactful drug design solutions.
• Translate research and applications to maintainable software systems
• Contribute to the scientific community by writing patents / journal articles and presenting at conferences
• Translate insights from statistics, multimodal data analysis, and ML to actionable and testable drug discovery hypothesis
• This is an opportunity to directly contribute to the discovery of novel innovative medicines by applying computational chemistry techniques on teams with experienced multidisciplinary drug hunters

About You

• PhD in chemistry, biology, computer science, or a related discipline
• 1-5 years of relevant experience including hands-on experience with informatics, machine learning, and computational chemistry applied to drug discovery in the private sector, like biotech or pharma
• Experience with cheminformatics and bioinformatics methods (e.g., similarity / substructure searching, reaction-based enumeration, sequence alignment, etc.)
• Experience with molecular property prediction and multi-objective optimization using machine learning and / or deep learning methods
• Experienced with common python toolkits for scientific computing (e.g., numpy, pandas, scipy), machine learning (e.g., scikit-learn, pytorch), and cheminformatics / bioinformatics (e.g., rdkit, openeye, biotite, biopython)
• Familiarity running simulations and training models on high-performance computing (GPU) environments for corporate R&D, innovation labs, or academic research
• An interest in solving scientific problems in chemistry and biology via computational and data-driven methods
• A drive to cooperate with colleagues to identify problems and communicate technical solutions in an accessible manner
• Hands-on mentality & comfortable with getting deep into the technical weeds of highly complex problems, and a track record of driving projects to completion

The US base salary range for this full-time position is expected to be $142k $198k per year. Our salary ranges are determined by role and level. Within the range, individual pay is determined by factors including job-related skills, experience, and relevant education or training. This role may be eligible for annual discretionary bonuses and equity.

Job Title: Clinical Trials Manager

Location: London

Contract: 5 months

Hours: 14.5 hours per week (9-5 Mondays/Tuesday)

Rates: 22.79-23.97 p/h

Job Description

SRG are looking for a clinical trials manager to join a leading higher educations provider based in London. The primary role of the post holder is to set up and support a high quality clinical trial at the CCTU.

Duties and Responsibilities

• To establish and maintain effective management systems for the trial
• To act as the central Trials Unit contact for the Trial
• To work closely with the Chief Investigator, trial and IT staff to ensure the successful management of the Trial.
• Secure all necessary approvals for the trial and participating sites according to the UK regulations including UK Research Governance Framework
• Coordinate the design, printing and distribution of trial documentation
• Develop trial specific documentation that is compliant with the CCTU Policies and Standard Operating Procedures (SOPs) and ensure this is implemented and kept up to date.
• Ensure sites have appropriate training and maintain necessary records.
• Work within budget constraints in liaison with the Project Manager.
• Ensure that good communication is maintained between the CCTU and recruiting centre staff
• Provide updates on the progress of the trial at regular Trial Management Group meetings, to the Independent Data Monitoring and Trial Steering Committees and to the funder as required.
• Monitor the trial sites to assess compliance with the protocol and regulatory requirements.
• Prepare under the guidance of the Clinical Project Manager, the trial specifications for the Database.
• Undertake Risk Assessment of the trial and, with the Clinical Project Manager, propose appropriate mitigations.
• Minute trial related meetings.
• Supervise the data collected and enter data if required.
• Supervise the data cleaning and validation, including querying and chasing missing data in a timely manner.
• Monitor trial recruitment, providing support and motivation to recruiting staff as required.
• Ensure the timely submission and processing of data and documents from sites to the CTU including safety events. Prepare and submit the necessary reports to appropriate regulatory, ethical and other parties (such as submission of safety reports to the Ethics Committee).
• Represent the trial at conferences, meetings and internal unit meetings as appropriate.
• Keep the relevant literature searches up to date.
• Participate in university and the CCTU training and development initiatives.
• Carry out any other comparable tasks as required including being prepared to assist those working on other studies/trials as directed by the Head of Clinical Trial Operations.

Experience and Qualifications

• Degree and/or equivalent experience in Clinical Trials
• Experience of managing a clinical trial
• Experience of managing a trial of an investigational medicinal product
• Comprehensive understanding of UK Clinical Trials Regulations, ICH Good Clinical Practice, the European Directives on Clinical Trials and Good Clinical Practice and the Department of Health's Research Governance Framework
• Experience of monitoring
• Experience of using Pharmacovigilance systems
• Experience of working in an academic or similar institution
• Experience of public speaking and giving presentations
• Experience of data management
• Evidence of ability to set up and maintain effective management system in trials
• Excellent IT skills; MS Office Suite, Trial Databases and other Trial related systems (such as IMP management, Randomisation)
• Excellent communication and interpersonal skills
• A methodical and accurate approach to work with attention to detail
• The ability to make and carry out decisions and know when to confer with colleagues or refer matters onwards
• The ability to work without direct supervision; to manage own workload and display good organisational ability
• Take responsibility for setting and meeting targets for your own work and others
• Ability to evaluate risks inherent in clinical trials and decide those which should be prioritised to ensure that risks are properly managed
• Advanced organisational skills, managing several projects that are often time pressured, concurrently
• Ability to supervise other members of the team, promote good working relationships and resolve difficult situations
• Commitment to and knowledge of advancing equality, diversity and inclusion

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.

Job Title: Clinical Trials Manager

Location: London

Contract: 5 months

Hours: 14.5 hours per week (9-5 Mondays/Tuesday)

Rates: 22.79-23.97 p/h

Job Description

SRG are looking for a clinical trials manager to join a leading higher educations provider based in London. The primary role of the post holder is to set up and support a high quality clinical trial at the CCTU.

Duties and Responsibilities

• To establish and maintain effective management systems for the trial
• To act as the central Trials Unit contact for the Trial
• To work closely with the Chief Investigator, trial and IT staff to ensure the successful management of the Trial.
• Secure all necessary approvals for the trial and participating sites according to the UK regulations including UK Research Governance Framework
• Coordinate the design, printing and distribution of trial documentation
• Develop trial specific documentation that is compliant with the CCTU Policies and Standard Operating Procedures (SOPs) and ensure this is implemented and kept up to date.
• Ensure sites have appropriate training and maintain necessary records.
• Work within budget constraints in liaison with the Project Manager.
• Ensure that good communication is maintained between the CCTU and recruiting centre staff
• Provide updates on the progress of the trial at regular Trial Management Group meetings, to the Independent Data Monitoring and Trial Steering Committees and to the funder as required.
• Monitor the trial sites to assess compliance with the protocol and regulatory requirements.
• Prepare under the guidance of the Clinical Project Manager, the trial specifications for the Database.
• Undertake Risk Assessment of the trial and, with the Clinical Project Manager, propose appropriate mitigations.
• Minute trial related meetings.
• Supervise the data collected and enter data if required.
• Supervise the data cleaning and validation, including querying and chasing missing data in a timely manner.
• Monitor trial recruitment, providing support and motivation to recruiting staff as required.
• Ensure the timely submission and processing of data and documents from sites to the CTU including safety events. Prepare and submit the necessary reports to appropriate regulatory, ethical and other parties (such as submission of safety reports to the Ethics Committee).
• Represent the trial at conferences, meetings and internal unit meetings as appropriate.
• Keep the relevant literature searches up to date.
• Participate in university and the CCTU training and development initiatives.
• Carry out any other comparable tasks as required including being prepared to assist those working on other studies/trials as directed by the Head of Clinical Trial Operations.

Experience and Qualifications

• Degree and/or equivalent experience in Clinical Trials
• Experience of managing a clinical trial
• Experience of managing a trial of an investigational medicinal product
• Comprehensive understanding of UK Clinical Trials Regulations, ICH Good Clinical Practice, the European Directives on Clinical Trials and Good Clinical Practice and the Department of Health's Research Governance Framework
• Experience of monitoring
• Experience of using Pharmacovigilance systems
• Experience of working in an academic or similar institution
• Experience of public speaking and giving presentations
• Experience of data management
• Evidence of ability to set up and maintain effective management system in trials
• Excellent IT skills; MS Office Suite, Trial Databases and other Trial related systems (such as IMP management, Randomisation)
• Excellent communication and interpersonal skills
• A methodical and accurate approach to work with attention to detail
• The ability to make and carry out decisions and know when to confer with colleagues or refer matters onwards
• The ability to work without direct supervision; to manage own workload and display good organisational ability
• Take responsibility for setting and meeting targets for your own work and others
• Ability to evaluate risks inherent in clinical trials and decide those which should be prioritised to ensure that risks are properly managed
• Advanced organisational skills, managing several projects that are often time pressured, concurrently
• Ability to supervise other members of the team, promote good working relationships and resolve difficult situations
• Commitment to and knowledge of advancing equality, diversity and inclusion

Carbon60, Lorien & SRG - The Impellam Group STEM Portfolio are acting as an Employment Business in relation to this vacancy.

Your new company
A leading biotech company, with a well-established presence in multiple therapy areas is looking to hire a Lead Statistical Genetics Scientist to support the further development of their products.They have a track record of innovation and a highly collaborative, cross-functional work environment.You would be joining an established team with significant expertise within genetics an.

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