1,099 Astrazeneca jobs in the United Kingdom
Principal Scientist, Drug Discovery
RG1 1AA Reading, South East
£70000 Annually
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Our client, a pioneering pharmaceutical company, is actively recruiting for a highly experienced Principal Scientist to lead critical initiatives within their Drug Discovery department. This position is fully remote, offering the flexibility to work from anywhere while contributing to groundbreaking research. The role demands an exceptional level of scientific expertise and a proven track record in identifying and validating novel therapeutic targets. You will be responsible for driving the early-stage drug discovery pipeline, from target identification to lead optimization, utilizing cutting-edge methodologies and technologies.
Key responsibilities include:
The ideal candidate will hold a PhD in Pharmacology, Biochemistry, Molecular Biology, or a closely related discipline, with a minimum of 8-10 years of post-doctoral and industry experience in drug discovery. Demonstrated expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience) is essential. Proven experience in leading discovery projects from inception through to preclinical candidate nomination is required. Strong understanding of modern drug discovery paradigms, including target identification/validation, lead generation/optimization, and translational science, is crucial. Exceptional data analysis, critical thinking, and problem-solving skills are mandatory. Excellent communication, presentation, and interpersonal skills are needed to effectively lead a remote team and engage with a diverse scientific community. Experience with computational biology and cheminformatics tools is highly desirable. This remote role requires a self-motivated, innovative, and collaborative scientist eager to make a significant impact on patient lives through scientific excellence.
Key responsibilities include:
- Leading and managing research projects focused on the discovery and development of novel pharmaceuticals.
- Designing and executing complex experiments to identify and validate new drug targets.
- Developing and implementing innovative assays and screening platforms for high-throughput screening (HTS).
- Analyzing and interpreting complex biological and chemical data to inform drug design strategies.
- Collaborating extensively with internal teams (e.g., chemistry, biology, pharmacology) and external academic/industry partners.
- Mentoring and guiding junior scientists, fostering a collaborative and high-performance research environment.
- Staying at the forefront of scientific literature and emerging technologies in relevant therapeutic areas.
- Contributing to patent filings and scientific publications.
- Presenting research findings at internal meetings and external scientific conferences.
- Ensuring all research activities comply with ethical guidelines, regulatory requirements, and safety protocols.
The ideal candidate will hold a PhD in Pharmacology, Biochemistry, Molecular Biology, or a closely related discipline, with a minimum of 8-10 years of post-doctoral and industry experience in drug discovery. Demonstrated expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience) is essential. Proven experience in leading discovery projects from inception through to preclinical candidate nomination is required. Strong understanding of modern drug discovery paradigms, including target identification/validation, lead generation/optimization, and translational science, is crucial. Exceptional data analysis, critical thinking, and problem-solving skills are mandatory. Excellent communication, presentation, and interpersonal skills are needed to effectively lead a remote team and engage with a diverse scientific community. Experience with computational biology and cheminformatics tools is highly desirable. This remote role requires a self-motivated, innovative, and collaborative scientist eager to make a significant impact on patient lives through scientific excellence.
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Principal Scientist - Drug Discovery
ST1 1AA Staffordshire, West Midlands
£80000 Annually
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Our leading pharmaceutical client is looking for an innovative and experienced Principal Scientist to join their pioneering drug discovery team. This is a fully remote position, allowing you to contribute your scientific expertise to groundbreaking research from your home laboratory or office. You will be instrumental in driving the early-stage research and development of novel therapeutic agents.
The Principal Scientist will be responsible for designing and executing complex research projects, leading scientific initiatives, and developing novel approaches in drug discovery. This includes identifying and validating new drug targets, developing and optimizing assay systems, and characterizing lead compounds. You will analyze experimental data, interpret results, and draw conclusions to guide future research directions. The role involves staying abreast of the latest scientific literature and technological advancements in the field.
Key responsibilities include mentoring and guiding junior scientists, fostering a collaborative research environment, and contributing to the strategic planning of the drug discovery pipeline. You will present research findings at internal meetings and potentially at external scientific conferences. Collaboration with cross-functional teams, including medicinal chemistry, pharmacology, and biology, will be essential to advance projects from discovery through to pre-clinical development.
The ideal candidate will possess a Ph.D. in a relevant scientific discipline (e.g., pharmacology, biochemistry, molecular biology, or a related field) with a proven track record of successful drug discovery contributions in the pharmaceutical or biotechnology industry. Expertise in specific therapeutic areas, advanced assay development, and in vivo/in vitro pharmacology is highly desirable. Strong analytical, problem-solving, and critical thinking skills are a must. Excellent written and verbal communication skills are required for scientific reporting and presentations. Experience leading research projects and mentoring scientific staff is essential.
This is an exceptional opportunity for a seasoned scientist to make a significant impact on the development of new medicines. If you are a passionate researcher with a vision for the future of pharmaceutical innovation and thrive in a remote, collaborative setting, we encourage you to apply. Your scientific leadership will be crucial to our client's mission.
The Principal Scientist will be responsible for designing and executing complex research projects, leading scientific initiatives, and developing novel approaches in drug discovery. This includes identifying and validating new drug targets, developing and optimizing assay systems, and characterizing lead compounds. You will analyze experimental data, interpret results, and draw conclusions to guide future research directions. The role involves staying abreast of the latest scientific literature and technological advancements in the field.
Key responsibilities include mentoring and guiding junior scientists, fostering a collaborative research environment, and contributing to the strategic planning of the drug discovery pipeline. You will present research findings at internal meetings and potentially at external scientific conferences. Collaboration with cross-functional teams, including medicinal chemistry, pharmacology, and biology, will be essential to advance projects from discovery through to pre-clinical development.
The ideal candidate will possess a Ph.D. in a relevant scientific discipline (e.g., pharmacology, biochemistry, molecular biology, or a related field) with a proven track record of successful drug discovery contributions in the pharmaceutical or biotechnology industry. Expertise in specific therapeutic areas, advanced assay development, and in vivo/in vitro pharmacology is highly desirable. Strong analytical, problem-solving, and critical thinking skills are a must. Excellent written and verbal communication skills are required for scientific reporting and presentations. Experience leading research projects and mentoring scientific staff is essential.
This is an exceptional opportunity for a seasoned scientist to make a significant impact on the development of new medicines. If you are a passionate researcher with a vision for the future of pharmaceutical innovation and thrive in a remote, collaborative setting, we encourage you to apply. Your scientific leadership will be crucial to our client's mission.
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1
Principal Drug Discovery Scientist
OX1 2JD Oxford, South East
£80000 Annually
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Our client, a cutting-edge biopharmaceutical company renowned for its innovative approach to drug discovery, is seeking a highly experienced Principal Drug Discovery Scientist. This is a fully remote position, enabling you to drive significant advancements in therapeutic research from your dedicated home office. You will be at the forefront of identifying and validating novel drug targets and advancing potential therapeutics through the early stages of development.
As a Principal Scientist, you will lead ambitious research projects, conceptualize and execute groundbreaking experiments, and interpret complex biological and chemical data to shape the company's pipeline. Your role will involve strategic direction-setting for discovery programs, mentoring talented scientists, and fostering collaboration across diverse scientific disciplines, including medicinal chemistry, biology, and pharmacology. You will play a key role in advancing our client's mission to develop life-changing medicines, supporting their research initiatives connected to the vibrant scientific community in Oxford, Oxfordshire, UK .
Key Responsibilities:
The ideal candidate will possess a Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a related discipline, with a minimum of 7-10 years of relevant experience in the pharmaceutical or biotechnology industry, focused on small molecule or biologic drug discovery. A proven track record of successful project leadership and delivering preclinical candidates is essential. Expertise in specific therapeutic areas (e.g., oncology, neurodegenerative diseases, infectious diseases) is highly valued. Excellent leadership, communication, and problem-solving skills are critical. The ability to work independently, drive scientific innovation, and contribute effectively within a remote research environment is paramount.
As a Principal Scientist, you will lead ambitious research projects, conceptualize and execute groundbreaking experiments, and interpret complex biological and chemical data to shape the company's pipeline. Your role will involve strategic direction-setting for discovery programs, mentoring talented scientists, and fostering collaboration across diverse scientific disciplines, including medicinal chemistry, biology, and pharmacology. You will play a key role in advancing our client's mission to develop life-changing medicines, supporting their research initiatives connected to the vibrant scientific community in Oxford, Oxfordshire, UK .
Key Responsibilities:
- Leading the design and execution of innovative drug discovery projects.
- Identifying and validating novel therapeutic targets using a range of biological and biochemical techniques.
- Developing and implementing high-throughput screening (HTS) campaigns and hit-to-lead optimization strategies.
- Interpreting complex biological data and translating findings into actionable research plans.
- Mentoring and guiding a team of drug discovery scientists.
- Collaborating closely with medicinal chemists, pharmacologists, and other R&D professionals.
- Contributing to the strategic planning and prioritization of the company's R&D pipeline.
- Preparing compelling research reports, scientific publications, and patent applications.
- Presenting research findings effectively to internal stakeholders and at scientific conferences.
- Staying current with the latest advancements in drug discovery technologies and therapeutic modalities.
The ideal candidate will possess a Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a related discipline, with a minimum of 7-10 years of relevant experience in the pharmaceutical or biotechnology industry, focused on small molecule or biologic drug discovery. A proven track record of successful project leadership and delivering preclinical candidates is essential. Expertise in specific therapeutic areas (e.g., oncology, neurodegenerative diseases, infectious diseases) is highly valued. Excellent leadership, communication, and problem-solving skills are critical. The ability to work independently, drive scientific innovation, and contribute effectively within a remote research environment is paramount.
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2
Principal Scientist - Drug Discovery
LS1 6AE Leeds, Yorkshire and the Humber
£70000 annum + ben
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Our client, a pioneering biotechnology company at the forefront of innovative scientific research and development, is seeking an exceptional Principal Scientist to join their dedicated drug discovery team in Leeds, West Yorkshire, UK . This senior role is crucial for driving the identification, validation, and early-stage development of novel therapeutic candidates. You will lead cutting-edge research projects, mentor junior scientists, and collaborate with multidisciplinary teams to advance our pipeline towards clinical applications. The ideal candidate will possess a PhD in a relevant life science discipline, extensive experience in drug discovery, a strong publication record, and a passion for tackling complex biological challenges. Responsibilities include:
Qualifications:
This is an outstanding opportunity to contribute to the development of transformative medicines and advance your career within a leading R&D organization. The successful candidate will be at the forefront of scientific innovation, working in a stimulating environment with excellent career prospects.
- Designing and leading innovative research programs focused on target identification and validation for various disease areas.
- Developing and implementing cutting-edge experimental strategies and assays to assess drug candidate efficacy and safety.
- Managing research projects from inception to preclinical proof-of-concept, ensuring timely execution and data integrity.
- Interpreting complex biological data, drawing robust conclusions, and making strategic recommendations for project progression.
- Mentoring and guiding junior scientists, fostering their professional development and ensuring high scientific standards.
- Collaborating effectively with internal teams (e.g., chemistry, DMPK, pharmacology) and external partners to achieve research milestones.
- Staying abreast of the latest scientific advancements, technologies, and methodologies in drug discovery.
- Contributing to the company's intellectual property strategy through patent applications and publications.
- Presenting research findings at scientific conferences and in peer-reviewed journals.
- Ensuring compliance with all laboratory safety regulations and company policies.
Qualifications:
- PhD in Molecular Biology, Biochemistry, Pharmacology, Genetics, or a related life science discipline.
- Minimum of 7 years of post-doctoral research experience in drug discovery, preferably within a pharmaceutical or biotechnology company.
- Demonstrated expertise in target validation, assay development, and lead optimization.
- Proven track record of successfully managing research projects and delivering key milestones.
- Strong understanding of human disease biology and relevant therapeutic areas.
- Excellent analytical, problem-solving, and critical thinking skills.
- Exceptional written and verbal communication skills, with the ability to publish and present scientific findings.
- Experience in mentoring and leading research teams.
- Proficiency in relevant laboratory techniques and data analysis software.
- A collaborative spirit and ability to work effectively in a multidisciplinary team environment.
This is an outstanding opportunity to contribute to the development of transformative medicines and advance your career within a leading R&D organization. The successful candidate will be at the forefront of scientific innovation, working in a stimulating environment with excellent career prospects.
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3
Senior Scientist, Drug Discovery
OX1 2AA Oxford, South East
£60000 Annually
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Our client, a world-renowned biopharmaceutical company at the forefront of medical innovation, is seeking a highly motivated Senior Scientist to join their elite Drug Discovery team in **Oxford, Oxfordshire, UK**. This pivotal role will involve leading and executing cutting-edge research projects aimed at identifying and validating novel therapeutic targets and developing innovative drug candidates. You will leverage your deep expertise in biological pathways, assay development, and preclinical models to drive the discovery pipeline forward.
The ideal candidate will possess a strong publication record, extensive hands-on experience in relevant scientific disciplines, and a passion for translating complex biological insights into potential life-saving medicines. You will work in a highly collaborative, state-of-the-art research environment, contributing to multidisciplinary teams focused on unmet medical needs. This position offers significant opportunities for scientific leadership, career advancement, and contribution to impactful drug development programmes.
Key Responsibilities:
The ideal candidate will possess a strong publication record, extensive hands-on experience in relevant scientific disciplines, and a passion for translating complex biological insights into potential life-saving medicines. You will work in a highly collaborative, state-of-the-art research environment, contributing to multidisciplinary teams focused on unmet medical needs. This position offers significant opportunities for scientific leadership, career advancement, and contribution to impactful drug development programmes.
Key Responsibilities:
- Lead and design experimental strategies for the discovery and validation of novel drug targets and biomarkers.
- Develop, optimise, and implement complex biochemical and cellular assays to support drug discovery campaigns.
- Conduct in vitro and ex vivo studies using a variety of techniques, including high-throughput screening (HTS), enzyme kinetics, cell-based assays, and molecular biology methods.
- Analyse and interpret experimental data, summarise findings, and present results clearly to project teams and senior management.
- Contribute to the design and execution of preclinical in vivo studies, working closely with the pharmacology team.
- Author and contribute to scientific publications, patent applications, and regulatory submissions.
- Mentor and guide junior scientists and research associates, fostering a culture of scientific rigor and innovation.
- Collaborate effectively with cross-functional teams, including medicinal chemistry, DMPK, and toxicology.
- Stay abreast of the latest scientific advancements and emerging technologies in drug discovery and relevant therapeutic areas.
- Maintain meticulous laboratory records and ensure compliance with company policies and safety regulations.
- Contribute to strategic planning and decision-making within the drug discovery unit.
- PhD in Molecular Biology, Pharmacology, Biochemistry, Immunology, or a related life sciences discipline.
- A minimum of 5 years of post-doctoral or industry experience in drug discovery or a related research field.
- Demonstrated expertise in at least one major therapeutic area (e.g., oncology, immunology, neuroscience).
- Proven experience in assay development and execution, including HTS and dose-response analysis.
- Strong understanding of target validation strategies and disease biology.
- Hands-on experience with a range of molecular and cell biology techniques.
- Excellent analytical, problem-solving, and critical thinking skills.
- Proficiency in data analysis software (e.g., GraphPad Prism, Spotfire) and scientific writing.
- Strong presentation skills and the ability to communicate complex scientific concepts effectively.
- Experience mentoring junior staff is highly desirable.
- Familiarity with biopharmaceutical R&D processes and regulatory requirements.
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4
Principal Scientist - Drug Discovery
ST4 2DP Staffordshire, West Midlands
£70000 Annually
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Our client, a groundbreaking biopharmaceutical company at the forefront of medical innovation, is actively seeking a Principal Scientist to join their fully remote Scientific Research & Development team. Based in **Stoke-on-Trent, Staffordshire, UK**, this role offers an exceptional opportunity for a highly experienced and motivated scientist to lead critical research initiatives in drug discovery and development. You will spearhead innovative projects, mentor junior scientists, and contribute significantly to the advancement of novel therapeutic agents. This is a remote-first position, designed to foster collaboration and allow scientists to contribute from anywhere, leveraging cutting-edge digital tools and virtual platforms.
Key Responsibilities:
The ideal candidate will hold a Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a closely related discipline, with a minimum of 8-10 years of post-doctoral and industry experience in drug discovery. A strong track record of success in leading research projects, evidenced by publications and patents, is essential. Expertise in a specific therapeutic area (e.g., oncology, immunology, neurology) is highly desirable. Proven experience in experimental design, data analysis, and interpretation is crucial. Excellent communication, leadership, and interpersonal skills are required for effective collaboration within a remote team. The ability to think critically, solve complex scientific problems, and drive innovation independently is paramount.
Key Responsibilities:
- Lead the design and execution of complex research projects focused on identifying and validating new drug targets and therapeutic modalities.
- Develop and optimise innovative experimental methodologies and assays to support drug discovery efforts.
- Interpret experimental data, draw meaningful conclusions, and present findings at internal and external scientific forums.
- Collaborate closely with cross-functional teams, including medicinal chemists, biologists, pharmacologists, and computational scientists, to drive project progression.
- Mentor and guide junior research staff, fostering a culture of scientific excellence and continuous learning.
- Contribute to the development of research strategies and the identification of new areas for scientific exploration.
- Manage external collaborations with academic institutions and CROs.
- Ensure rigorous adherence to scientific rigor, ethical standards, and safety protocols.
- Author scientific publications and patent applications.
- Stay abreast of the latest scientific literature, emerging technologies, and industry trends in relevant therapeutic areas.
The ideal candidate will hold a Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a closely related discipline, with a minimum of 8-10 years of post-doctoral and industry experience in drug discovery. A strong track record of success in leading research projects, evidenced by publications and patents, is essential. Expertise in a specific therapeutic area (e.g., oncology, immunology, neurology) is highly desirable. Proven experience in experimental design, data analysis, and interpretation is crucial. Excellent communication, leadership, and interpersonal skills are required for effective collaboration within a remote team. The ability to think critically, solve complex scientific problems, and drive innovation independently is paramount.
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5
Principal Scientist - Drug Discovery
SR1 2TB Sunderland, North East
£75000 Annually
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A leading pharmaceutical company renowned for its innovative research and development is seeking a highly accomplished Principal Scientist to join their cutting-edge drug discovery team in Sunderland, Tyne and Wear, UK . This senior role requires a deep scientific understanding, exceptional leadership skills, and a passion for advancing novel therapeutics. You will be instrumental in designing and executing complex research programs, mentoring junior scientists, and contributing to the strategic direction of the R&D pipeline.
Key Responsibilities:
Key Responsibilities:
- Lead the design, execution, and interpretation of complex biological experiments and research projects aimed at identifying and validating novel drug targets.
- Develop and implement innovative scientific strategies to accelerate drug discovery and development.
- Manage and mentor a team of scientists and research associates, providing technical guidance and career development support.
- Collaborate effectively with cross-functional teams, including medicinal chemistry, pharmacology, and clinical development.
- Stay at the forefront of scientific advancements in relevant therapeutic areas through literature review, conference participation, and scientific networking.
- Prepare high-quality scientific reports, presentations, and publications for internal and external dissemination.
- Contribute to the strategic planning and prioritization of the R&D portfolio.
- Ensure compliance with all relevant laboratory safety regulations and ethical guidelines.
- Play a key role in the evaluation of new technologies and research platforms.
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
- Extensive post-doctoral and industry experience (8+ years) in drug discovery, with a proven track record of leading successful research programs.
- Deep expertise in specific therapeutic areas (e.g., oncology, immunology, neuroscience).
- Demonstrated experience with various biological assays, molecular biology techniques, and data analysis tools.
- Strong understanding of target identification, validation, and preclinical development.
- Excellent leadership, mentorship, and team management skills.
- Exceptional scientific communication, presentation, and publication record.
- Proven ability to think critically, solve complex problems, and drive innovation.
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Principal Scientist, Drug Discovery
NG1 3DE Nottingham, East Midlands
£80000 Annually
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Our client, a leading pharmaceutical innovator with a fully remote R&D infrastructure, is seeking a highly skilled and experienced Principal Scientist, Drug Discovery to join their dedicated research team. This role, while conceptually linked to our operations in Nottingham, Nottinghamshire, UK , allows for complete remote work, offering flexibility and the chance to contribute to groundbreaking pharmaceutical research from anywhere. The ideal candidate will possess a deep understanding of modern drug discovery methodologies, a strong publication record, and a passion for translating scientific insights into novel therapeutics. You will lead critical research projects, mentor junior scientists, and contribute to the strategic direction of our discovery pipeline.
Responsibilities:
Qualifications:
Responsibilities:
- Lead and manage complex drug discovery projects from target identification through to lead optimization.
- Design and execute innovative experimental strategies to validate novel therapeutic targets and identify promising drug candidates.
- Develop and implement state-of-the-art biochemical and cellular assays to assess compound efficacy and safety.
- Analyze and interpret complex datasets, drawing insightful conclusions and making data-driven recommendations.
- Collaborate effectively with cross-functional teams, including medicinal chemistry, pharmacology, DMPK, and regulatory affairs.
- Stay at the forefront of scientific advancements in relevant therapeutic areas and drug discovery technologies.
- Author high-impact scientific publications and present research findings at international conferences.
- Mentor and guide junior scientists, fostering their professional development and research skills.
- Contribute to the strategic planning of the drug discovery portfolio, identifying new opportunities and innovative approaches.
- Manage external collaborations and vendor relationships to support research objectives.
Qualifications:
- Ph.D. in Pharmacology, Biochemistry, Molecular Biology, or a closely related life science discipline.
- Minimum of 8 years of post-doctoral experience in drug discovery within the pharmaceutical or biotechnology industry.
- Proven track record of successfully progressing drug candidates through the early stages of discovery.
- Extensive hands-on experience with a range of drug discovery technologies and methodologies.
- Strong understanding of disease biology and mechanisms of action in relevant therapeutic areas.
- Excellent analytical, critical thinking, and problem-solving skills.
- Demonstrated leadership capabilities and experience in mentoring scientific staff.
- Exceptional written and verbal communication skills, with a strong publication record.
- Ability to work independently and collaboratively in a fully remote scientific team environment.
- Proficiency in bioinformatics and relevant scientific software is a plus.
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7
Lead Biophysicist - Drug Discovery
PL1 2JP Plymouth, South West
£75000 Annually
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Our client, a pioneering biotechnology company based in **Plymouth, Devon, UK**, is seeking an accomplished Lead Biophysicist to spearhead their drug discovery efforts. This senior position is central to understanding the molecular interactions of novel therapeutic candidates and driving the development pipeline forward. The Lead Biophysicist will direct a team of scientists, design and execute complex biophysical assays, and contribute significantly to the strategic direction of research programmes. This role requires hands-on expertise, strong leadership capabilities, and a deep commitment to scientific innovation within the pharmaceutical sector. The position is laboratory-based, fostering close collaboration with chemists, biologists, and pharmacologists.
Responsibilities:
Responsibilities:
- Lead and mentor a team of biophysicists and research associates involved in drug discovery projects.
- Design, develop, and validate innovative biophysical assays to characterise drug-target interactions, including binding kinetics, thermodynamics, and protein conformation.
- Utilise a range of biophysical techniques such as SPR, ITC, MST, DSF, CD, and mass spectrometry.
- Interpret complex experimental data, draw meaningful conclusions, and communicate findings effectively to cross-functional teams and senior management.
- Contribute to the strategic planning and prioritisation of drug discovery programmes.
- Collaborate closely with medicinal chemists and biologists to guide lead optimisation efforts.
- Oversee the maintenance and operational excellence of biophysical instrumentation and laboratory facilities.
- Stay abreast of the latest advancements in biophysics, structural biology, and drug discovery technologies.
- Contribute to scientific publications and presentations at international conferences.
- PhD in Biophysics, Biochemistry, or a closely related field with a strong emphasis on molecular interactions and drug discovery.
- A minimum of 8 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a significant portion dedicated to drug discovery.
- Demonstrated experience in leading and managing scientific teams.
- Expertise in a broad range of biophysical techniques and instrumentation relevant to drug discovery.
- Proven track record of successfully applying biophysical methods to solve complex drug discovery challenges.
- Excellent analytical, problem-solving, and critical thinking skills.
- Outstanding communication, interpersonal, and presentation skills.
- Experience with protein expression, purification, and characterisation is highly desirable.
- A strong publication record in reputable peer-reviewed journals.
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8
Principal Scientist - Drug Discovery
WV1 1TT Wolverhampton, West Midlands
£75000 Annually
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Job Description
Join a pioneering pharmaceutical company at the forefront of developing life-changing medicines. We are seeking a highly accomplished Principal Scientist with a specialization in Drug Discovery to lead innovative research initiatives. This is a fully remote position, allowing you to contribute your expertise from a dedicated home laboratory or office space, anywhere within the UK. Our client is committed to leveraging cutting-edge science and technology to address unmet medical needs.
The Role:
As a Principal Scientist, you will drive the discovery and early development of novel therapeutic agents. You will design and execute complex experiments, analyse data, and interpret results to advance drug candidates through the pipeline. This role involves leading and mentoring a team of research scientists, fostering a collaborative and innovative research environment. You will be expected to stay abreast of the latest scientific advancements, propose novel research strategies, and contribute significantly to the company's R&D objectives. Collaboration with internal cross-functional teams and external partners will be crucial for success.
Key Responsibilities:
The Role:
As a Principal Scientist, you will drive the discovery and early development of novel therapeutic agents. You will design and execute complex experiments, analyse data, and interpret results to advance drug candidates through the pipeline. This role involves leading and mentoring a team of research scientists, fostering a collaborative and innovative research environment. You will be expected to stay abreast of the latest scientific advancements, propose novel research strategies, and contribute significantly to the company's R&D objectives. Collaboration with internal cross-functional teams and external partners will be crucial for success.
Key Responsibilities:
- Lead and manage research projects focused on identifying and validating novel drug targets and developing small molecule or biologic therapeutics.
- Design, optimize, and execute complex in vitro and in vivo experimental assays relevant to drug discovery.
- Critically analyze, interpret, and present experimental data to project teams and senior management.
- Develop and implement innovative research strategies to overcome scientific challenges.
- Mentor and guide junior scientists, fostering their scientific growth and productivity.
- Contribute to the preparation of scientific publications, patents, and regulatory filings.
- Collaborate effectively with colleagues in chemistry, biology, pharmacology, and clinical development.
- Manage external research collaborations and partnerships.
- Ensure adherence to all laboratory safety protocols and ethical guidelines.
- Contribute to the strategic direction of the drug discovery portfolio.
- PhD in a relevant biological science (e.g., Pharmacology, Biochemistry, Molecular Biology, Immunology).
- Minimum of 8 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong track record in drug discovery.
- Extensive experience in a specific therapeutic area (e.g., oncology, immunology, CNS) is highly desirable.
- Proven expertise in designing and executing key drug discovery assays (e.g., target-based screening, cell-based assays, ADME studies).
- Demonstrated experience in leading research projects and managing scientific teams.
- Strong understanding of medicinal chemistry, pharmacokinetics, and pharmacodynamics.
- Excellent analytical, problem-solving, and critical thinking skills.
- Exceptional written and verbal communication skills, essential for remote collaboration and scientific reporting.
- Ability to work independently, manage multiple projects, and thrive in a fast-paced research environment.
- Experience with bioinformatics tools and data analysis platforms.
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