45 Astrazeneca jobs in Girton
Principal Scientist (Drug Discovery)
Posted 1 day ago
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Key responsibilities include developing and implementing cutting-edge research methodologies, overseeing experimental design and data analysis, and interpreting results to drive project progression. You will collaborate closely with internal research teams, external academic collaborators, and key opinion leaders to foster innovation and address challenging scientific questions. A significant aspect of this role involves staying at the forefront of scientific literature and emerging technologies within the pharmaceutical industry. You will present findings at scientific conferences and contribute to patent applications and regulatory submissions. Leadership in fostering a culture of scientific rigor, creativity, and collaboration is paramount.
We are seeking candidates with a PhD in Molecular Biology, Pharmacology, Biochemistry, or a related field, coupled with a minimum of 8-10 years of post-doctoral and industry experience in drug discovery. Demonstrable expertise in target validation, assay development, lead optimisation, and in vivo pharmacology is required. Strong experience with specific therapeutic modalities (e.g., small molecules, biologics, gene therapy) relevant to the company's focus is essential. Excellent communication, presentation, and project management skills are vital for success in this hybrid environment. If you are a passionate and innovative scientist looking to make a significant impact on human health from **Cambridge, Cambridgeshire, UK**, we invite you to apply.
Principal Scientist - Drug Discovery
Posted 2 days ago
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Key Responsibilities:
- Design and execute innovative research strategies to identify and validate novel drug targets and hit compounds.
- Lead and mentor a team of scientists, fostering a collaborative and high-performance research environment.
- Oversee the synthesis and characterization of small molecules and biologics, employing advanced chemical and biological techniques.
- Develop and implement high-throughput screening assays and phenotypic screening platforms.
- Manage external research collaborations with academic institutions and biotechnology partners.
- Interpret complex experimental data, draw sound scientific conclusions, and make strategic recommendations for project progression.
- Prepare and present scientific findings to internal stakeholders, including senior management and external collaborators.
- Contribute to the intellectual property strategy through invention disclosures and patent filings.
- Ensure compliance with all laboratory safety regulations and ethical guidelines.
- Stay abreast of the latest scientific advancements and emerging technologies in drug discovery.
- Ph.D. in Medicinal Chemistry, Pharmacology, Molecular Biology, Biochemistry, or a closely related field.
- Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
- Demonstrated success in leading drug discovery projects from target identification through to preclinical development.
- Expertise in one or more therapeutic areas is highly desirable.
- Proven experience in managing and mentoring scientific staff.
- Strong understanding of modern drug discovery methodologies, including AI/ML in drug design.
- Excellent track record of publications in peer-reviewed journals and presentations at international conferences.
- Exceptional problem-solving skills and a strategic mindset.
- Outstanding communication and interpersonal skills, with the ability to influence and collaborate effectively across disciplines.
- Familiarity with regulatory requirements for drug development.
Principal Scientist - Drug Discovery
Posted 4 days ago
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Job Description
As a Principal Scientist, you will be responsible for designing and executing complex research projects aimed at identifying and validating new drug targets and developing small molecule or biologic drug candidates. This involves leading a team of scientists, overseeing experimental design, data analysis, and interpretation. You will be expected to contribute to strategic planning, identify innovative research approaches, and stay abreast of the latest scientific advancements in your field. Close collaboration with cross-functional teams, including medicinal chemistry, pharmacology, and translational science, is essential. The role requires strong leadership capabilities, the ability to mentor junior researchers, and a proven track record of delivering high-impact research outcomes. Significant experience in contributing to IND-enabling studies is highly desirable.
We are seeking candidates with a PhD in a relevant life science discipline (e.g., Molecular Biology, Biochemistry, Pharmacology) and a minimum of 10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry. A deep understanding of disease biology, target validation, and drug development processes is essential. Demonstrated success in leading research projects and managing scientific teams, preferably in a remote or hybrid setting, is crucial. Exceptional analytical, problem-solving, and critical thinking skills are required. Excellent written and verbal communication skills, with a proven ability to present complex scientific data clearly and concisely, are a must. Experience with various assay technologies and biophysical techniques is also expected. This is an outstanding opportunity for a seasoned scientist to shape the future of medicine.
Principal Scientist - Drug Discovery
Posted 24 days ago
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Job Description
Responsibilities:
- Lead the design, execution, and interpretation of complex in vitro and/or in vivo studies to identify and validate new therapeutic targets and drug candidates.
- Develop and implement innovative experimental strategies and methodologies to advance drug discovery programs.
- Critically evaluate scientific data, propose hypotheses, and guide research directions.
- Optimise lead compounds for potency, selectivity, pharmacokinetics, and safety.
- Collaborate effectively with cross-functional teams, including medicinal chemists, biologists, toxicologists, and clinical development experts.
- Stay abreast of the latest scientific advancements, literature, and technologies in relevant therapeutic areas and drug discovery.
- Author high-quality scientific reports, publications, and regulatory submissions.
- Present research findings at internal meetings and external scientific conferences.
- Contribute to the strategic planning and pipeline development of the drug discovery portfolio.
- Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
- Ensure all research activities comply with relevant ethical guidelines, regulatory requirements, and company policies.
- Manage external collaborations with academic institutions and CROs.
- Contribute to intellectual property generation and patent filings.
- PhD in Pharmacology, Biochemistry, Molecular Biology, Medicinal Chemistry, or a closely related life science discipline.
- Minimum of 7-10 years of progressive drug discovery experience in the pharmaceutical or biotechnology industry.
- Demonstrated track record of success in identifying and advancing novel drug candidates through the pre-clinical stages.
- Deep expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience) is highly desirable.
- Proven ability to design and interpret complex biological assays and PK/PD studies.
- Strong understanding of drug development processes and regulatory requirements.
- Excellent analytical, problem-solving, and critical thinking skills.
- Outstanding written and verbal communication skills, with a proven ability to publish and present scientific work.
- Experience with remote collaboration tools and working effectively in a distributed research setting.
- A proactive, self-motivated individual with a strong commitment to scientific excellence and teamwork.
Senior Research Scientist - Drug Discovery
Posted today
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Job Description
Key Responsibilities:
- Design, execute, and interpret complex biological experiments to identify and validate drug targets.
- Develop and optimize in vitro and in vivo assays for compound screening and characterization.
- Contribute to the design and synthesis strategy for novel drug candidates.
- Analyze and present research data to internal teams and external collaborators.
- Manage research projects, ensuring timely delivery of milestones.
- Mentor and supervise junior research scientists and technicians.
- Stay abreast of the latest scientific literature and technological advancements in drug discovery.
- Contribute to the strategic planning and decision-making process for drug discovery programs.
- Ensure compliance with laboratory safety protocols and regulatory guidelines.
- PhD in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
- Minimum of 5 years of post-doctoral or industry research experience in drug discovery.
- Extensive experience in assay development, high-throughput screening, and data analysis.
- Proven ability to design and conduct complex biological experiments.
- Strong understanding of disease mechanisms and target validation.
- Excellent written and verbal communication skills.
- Demonstrated ability to work independently and collaboratively in a multidisciplinary team.
- Experience with biopharmaceutical R&D processes is a strong advantage.
Principal Research Scientist, Drug Discovery
Posted 1 day ago
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Job Description
Responsibilities:
- Lead and design innovative research projects in drug discovery, from target identification through to lead optimization.
- Develop and implement cutting-edge experimental strategies and assays to evaluate novel drug candidates.
- Analyze complex biological data, interpret results, and make data-driven decisions to advance research programs.
- Stay abreast of the latest scientific literature and technological advancements in relevant therapeutic areas and drug discovery methodologies.
- Collaborate effectively with cross-functional teams, including biology, chemistry, DMPK, and translational sciences, to achieve project milestones.
- Mentor and guide junior research scientists, providing technical expertise and career development support.
- Prepare high-quality scientific reports, presentations, and publications for internal and external audiences.
- Contribute to the intellectual property strategy through patent applications and publications.
- Present research findings at national and international scientific conferences.
- Contribute to the overall scientific vision and strategy of the drug discovery unit.
- PhD in Molecular Biology, Pharmacology, Biochemistry, or a related life sciences discipline.
- Minimum of 8 years of post-doctoral research experience in drug discovery, with a proven track record of success in leading research projects and delivering results.
- Extensive experience in (Specific Area relevant to the job, e.g., small molecule drug discovery, antibody engineering, gene therapy).
- Deep understanding of disease biology and relevant target classes.
- Proficiency in a broad range of modern molecular and cellular biology techniques and assay development.
- Demonstrated ability to design and execute complex experiments, interpret data, and troubleshoot effectively.
- Strong publication record in peer-reviewed journals and experience presenting at scientific meetings.
- Excellent leadership, communication, and interpersonal skills, with the ability to inspire and guide a team.
- Experience with computational biology tools and data analysis platforms is a plus.
- A proactive, curious, and highly motivated scientific leader with a passion for innovation and patient benefit.
Principal Scientist - Drug Discovery (Oncology)
Posted 2 days ago
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Job Description
Key Responsibilities:
- Design and execute complex biological experiments to identify and validate novel oncology drug targets and pathways.
- Lead cross-functional teams in the discovery and optimization of small molecule and/or biologic drug candidates.
- Develop and implement cutting-edge in vitro and in vivo models to assess drug efficacy and mechanism of action.
- Analyze and interpret complex experimental data, drawing robust conclusions and formulating strategic recommendations for project progression.
- Author high-quality scientific publications, patent applications, and regulatory submissions.
- Present research findings at internal project meetings, scientific conferences, and to external collaborators.
- Manage external research collaborations with academic institutions and CROs.
- Contribute to the strategic direction of the Oncology discovery portfolio, identifying new research opportunities and therapeutic modalities.
- Mentor and guide junior scientists, fostering scientific rigor and a collaborative research environment.
- Ensure compliance with all company policies, safety regulations, and ethical standards.
- Ph.D. in Molecular Biology, Oncology, Pharmacology, or a related life science discipline.
- A minimum of 8 years of post-doctoral and/or industry experience in drug discovery, with a strong focus on oncology.
- Proven track record of success in identifying and advancing drug candidates through preclinical development.
- Deep expertise in cancer biology, tumor microenvironment, immunology, or related fields.
- Hands-on experience with a broad range of molecular and cellular biology techniques, including genomics, proteomics, cell-based assays, and advanced microscopy.
- Experience with in vivo pharmacology models and study design.
- Excellent leadership, communication, and project management skills.
- Demonstrated ability to think creatively, solve complex problems, and drive innovation.
- Strong publication record in peer-reviewed journals.
- Experience in managing CROs and academic collaborations is a plus.
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Principal Formulation Scientist - Drug Discovery
Posted 4 days ago
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Job Description
Responsibilities:
- Lead the design, development, and optimization of pharmaceutical formulations for various therapeutic modalities.
- Conduct comprehensive physicochemical characterization of drug substances and drug products.
- Develop and execute experimental plans for formulation and drug delivery studies.
- Evaluate drug product stability under various conditions according to ICH guidelines.
- Investigate and resolve complex formulation-related challenges.
- Collaborate with analytical development teams to establish appropriate testing methods.
- Provide scientific leadership and mentorship to formulation scientists and technicians.
- Prepare and review scientific reports, protocols, and regulatory documents.
- Present research findings and strategic recommendations to senior management and cross-functional teams.
- Stay abreast of emerging trends and technologies in pharmaceutical formulation and drug delivery.
- Contribute to the intellectual property portfolio through invention disclosures and patent applications.
- Ensure compliance with all relevant GxP regulations and company policies.
Qualifications:
- Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemistry, Chemical Engineering, or a related field.
- 10+ years of progressive experience in pharmaceutical formulation development.
- Proven track record in developing diverse dosage forms (e.g., tablets, capsules, injectables, extended-release formulations).
- In-depth knowledge of drug delivery technologies, excipients, and manufacturing processes.
- Expertise in physicochemical characterization techniques (e.g., DSC, TGA, XRD, particle size analysis).
- Strong understanding of GMP, ICH guidelines, and regulatory requirements.
- Demonstrated scientific leadership, project management, and problem-solving skills.
- Excellent written and verbal communication skills, with experience presenting scientific data.
- Ability to work independently and effectively in a remote, collaborative research environment.
- Experience with biologics formulation is a significant asset.
This is a fully remote position, with the successful candidate ideally situated within reach of our research facilities near Cambridge, Cambridgeshire, UK for occasional key meetings.
Senior Research Scientist - Drug Discovery
Posted 4 days ago
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Job Description
You will play a pivotal role in the early stages of drug discovery, identifying and validating novel therapeutic targets, designing and implementing complex biological assays, and analyzing experimental data to drive project progression. This role requires a highly analytical and scientifically rigorous individual who can work independently and collaboratively within a virtual team environment. Experience in specific therapeutic areas such as oncology, immunology, or neuroscience is a significant advantage.
Key Responsibilities:
- Design, develop, and optimize robust biological assays to support target validation and compound screening.
- Conduct in vitro and ex vivo experiments to assess drug efficacy and mechanism of action.
- Analyze and interpret complex experimental data, generating clear and concise reports for project teams.
- Collaborate with medicinal chemists, pharmacologists, and other scientists to advance drug candidates through the discovery pipeline.
- Stay current with the latest scientific literature and technological advancements in drug discovery.
- Contribute to the strategic planning and execution of research projects.
- Present findings at internal team meetings and potentially at scientific conferences.
- Mentor and guide junior research associates.
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
- Minimum of 5 years of post-doctoral or industry experience in drug discovery.
- Proven expertise in assay development (e.g., HTS, ELISA, Western Blot, flow cytometry).
- Hands-on experience with relevant biological models and techniques.
- Strong analytical and problem-solving skills with meticulous attention to detail.
- Excellent written and verbal communication skills, with the ability to effectively communicate complex scientific information.
- Demonstrated ability to work independently and manage multiple projects in a remote setting.
- Experience with data analysis software (e.g., GraphPad Prism, R) is preferred.
Principal Research Scientist - Drug Discovery
Posted 4 days ago
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Job Description
Key Responsibilities:
- Lead and manage innovative drug discovery projects from conception to preclinical development.
- Design, optimise, and execute complex experimental protocols in areas such as molecular biology, biochemistry, and cell biology.
- Analyse and interpret large datasets, drawing robust conclusions and making data-driven recommendations.
- Identify and validate novel drug targets and therapeutic strategies.
- Oversee the development of assays for screening and evaluating potential drug candidates.
- Collaborate with cross-functional teams, including medicinal chemists, pharmacologists, and toxicologists.
- Stay abreast of the latest scientific literature, technological advancements, and industry trends in drug discovery.
- Mentor and guide junior scientists, fostering a collaborative and high-performance research environment.
- Prepare scientific manuscripts for publication in peer-reviewed journals and present findings at international conferences.
- Contribute to the strategic planning and direction of the company's R&D pipeline.
- Ensure all research activities are conducted in compliance with ethical standards and regulatory requirements.
Qualifications and Experience:
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a closely related field.
- Minimum of 10 years of post-doctoral research experience in drug discovery within the pharmaceutical or biotechnology industry.
- Proven track record of success in leading R&D projects and delivering preclinical candidates.
- Extensive experience in target validation, assay development, and high-throughput screening.
- Deep understanding of disease mechanisms and therapeutic intervention strategies.
- Proficiency in relevant scientific techniques and instrumentation.
- Excellent analytical, problem-solving, and critical thinking skills.
- Exceptional written and verbal communication skills, with the ability to present complex scientific information clearly.
- Demonstrated ability to work independently and collaboratively in a virtual team setting.
- Strong publication record in reputable scientific journals.
- Experience with data analysis software and bioinformatics tools is advantageous.
This is a unique opportunity to lead groundbreaking research and shape the future of medicine within a globally recognised organisation that embraces cutting-edge remote work practices. Join a team of world-class scientists and contribute to developing life-changing therapies from your home.