Principal Scientist - Drug Discovery

M1 4DT Manchester, North West £70000 Annually WhatJobs

Posted 4 days ago

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full-time
Our client, a leading pharmaceutical research organisation, is seeking an exceptional Principal Scientist to join their innovative Scientific Research & Development team in Manchester, Greater Manchester, UK . This is a pivotal role for an experienced scientist to lead and contribute to high-impact drug discovery projects. You will be responsible for designing, executing, and interpreting complex experiments, developing novel methodologies, and contributing to the strategic direction of research programs. The ideal candidate will possess a deep understanding of molecular biology, biochemistry, or a related discipline, with a strong publication record and a proven ability to drive research projects from conception through to key milestones. You will collaborate extensively with interdisciplinary teams, including chemists, pharmacologists, and computational biologists, fostering a collaborative and innovative research environment. This role requires a strategic thinker with excellent problem-solving skills and a passion for scientific discovery. You will be expected to mentor junior scientists, provide scientific leadership, and stay abreast of the latest advancements in the field. Experience with specific therapeutic areas or target classes relevant to the company's pipeline would be highly advantageous. The ability to secure internal funding for projects and contribute to external grant applications is also desirable. This is a challenging and rewarding opportunity for a seasoned scientist looking to make a significant contribution to the development of life-saving therapies.

Responsibilities:
  • Lead and manage complex drug discovery research projects.
  • Design and execute sophisticated biological assays and experiments.
  • Develop and validate new scientific methodologies and technologies.
  • Interpret experimental data and draw scientifically sound conclusions.
  • Collaborate with cross-functional teams, including medicinal chemists and pharmacologists.
  • Mentor and guide junior research scientists and fellows.
  • Contribute to research strategy and identify new opportunities.
  • Prepare and present research findings at internal meetings and external conferences.
  • Author scientific publications and contribute to patent applications.
Qualifications:
  • PhD in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
  • Extensive post-doctoral and/or industry experience in drug discovery.
  • Demonstrated track record of scientific achievement, including publications and presentations.
  • Expertise in relevant biological techniques and assay development.
  • Strong understanding of drug discovery processes and principles.
  • Excellent leadership, communication, and interpersonal skills.
  • Proven ability to manage projects and mentor scientific staff.
  • Experience in a specific therapeutic area (e.g., oncology, immunology) is a plus.
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Principal Scientist, Drug Discovery

M15 6BG Manchester, North West £70000 Annually WhatJobs

Posted 13 days ago

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full-time
Our client is seeking a highly accomplished Principal Scientist to join their innovative Drug Discovery team based in **Manchester, Greater Manchester, UK**. This senior role is integral to the early-stage development of novel therapeutics. You will lead significant research programs, design and execute complex experiments, and contribute to the strategic direction of our drug discovery efforts. This position requires a deep understanding of molecular biology, pharmacology, and cutting-edge drug discovery technologies. You will be responsible for interpreting experimental data, drawing robust conclusions, and presenting findings to scientific leadership and cross-functional teams. The ideal candidate will possess a PhD in a relevant scientific discipline, coupled with extensive post-doctoral and industry experience in drug discovery. Strong leadership, mentorship capabilities, and a proven track record of scientific publications and successful project contributions are essential. You will collaborate closely with chemists, biologists, and computational scientists to identify and validate novel drug targets and advance lead compounds through the pipeline. Expertise in specific therapeutic areas (e.g., oncology, immunology, neuroscience) is highly desirable. This role offers the opportunity to work on impactful projects, contribute to groundbreaking research, and influence the future direction of our client's therapeutic pipeline. You will foster a culture of scientific rigor, innovation, and collaboration within the team. A proactive approach to problem-solving and a passion for scientific advancement are crucial. Join a world-class research organization dedicated to bringing life-changing medicines to patients.

Responsibilities:
  • Lead and manage drug discovery research programs and projects.
  • Design, conduct, and interpret complex biological experiments.
  • Identify and validate novel drug targets and therapeutic strategies.
  • Advance lead compounds through the preclinical development pipeline.
  • Mentor and guide junior scientists and research associates.
  • Collaborate effectively with internal and external partners (chemists, clinicians, CROs).
  • Analyze and present scientific data to senior management and project teams.
  • Contribute to the strategic planning and decision-making for the drug discovery portfolio.
  • Stay abreast of the latest scientific literature and technological advancements in the field.
  • Author scientific publications and contribute to patent filings.
Qualifications:
  • PhD in Molecular Biology, Pharmacology, Biochemistry, or a related field.
  • Extensive experience (8+ years) in drug discovery within the pharmaceutical or biotech industry.
  • Proven track record of leading research projects and achieving key milestones.
  • Deep expertise in relevant scientific disciplines and assay development.
  • Experience in a specific therapeutic area (e.g., oncology, infectious diseases) is advantageous.
  • Strong understanding of drug discovery processes and regulatory requirements.
  • Excellent data analysis, interpretation, and presentation skills.
  • Strong leadership, mentorship, and team collaboration abilities.
  • Proficiency in relevant scientific software and tools.
  • Excellent written and verbal communication skills.
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Principal Scientist - Drug Discovery

M1 6EU Manchester, North West £70000 Annually WhatJobs

Posted 15 days ago

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full-time
Our client, a pioneering pharmaceutical research organization, is seeking a highly accomplished Principal Scientist to lead innovative drug discovery programs. This is a critical lab-based role focused on identifying novel therapeutic targets and developing cutting-edge small molecule or biologic drugs. You will be responsible for designing and executing complex experimental strategies, analyzing data, and contributing significantly to the preclinical development pipeline. The ideal candidate will possess a strong publication record, deep expertise in a relevant scientific discipline, and a proven track record of successfully advancing drug candidates.

Responsibilities:
  • Lead and manage drug discovery projects from target identification through to lead optimization.
  • Design, develop, and implement robust experimental assays and screening methodologies.
  • Analyze complex biological and chemical data, drawing sound conclusions and making strategic recommendations.
  • Collaborate closely with medicinal chemists, biologists, pharmacologists, and other scientific disciplines.
  • Prepare high-quality scientific reports, presentations, and publications.
  • Manage junior scientists and research associates, providing technical guidance and mentorship.
  • Contribute to the strategic direction of the R&D department and identify new research opportunities.
  • Ensure compliance with all relevant safety, ethical, and regulatory guidelines.
  • Present research findings at internal and external scientific meetings.
Qualifications:
  • Ph.D. in a relevant scientific discipline such as Molecular Biology, Biochemistry, Pharmacology, or related field.
  • Extensive experience in drug discovery, with a strong emphasis on small molecule or biologic therapeutics.
  • Demonstrated expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience).
  • Proven ability to design and execute complex research projects and interpret data.
  • Excellent track record of scientific publications and presentations.
  • Strong leadership, team management, and interpersonal skills.
  • Proficiency in relevant laboratory techniques and data analysis software.
  • Experience with in vivo models and pharmacokinetics is advantageous.
This demanding laboratory-based role is situated in Manchester, Greater Manchester, UK . We are looking for a visionary scientist ready to make a significant impact on the future of medicine within a highly collaborative and scientifically rigorous environment.
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Principal Scientist, Drug Discovery

M1 1AA Manchester, North West £85000 Annually WhatJobs

Posted 15 days ago

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full-time
Our client, a pioneering pharmaceutical company at the forefront of innovative drug development, is seeking a highly accomplished Principal Scientist to lead critical drug discovery initiatives. This role is fully remote, allowing talented scientists to contribute from anywhere, fostering a diverse and inclusive research environment. You will spearhead research programs, drive the identification and validation of novel therapeutic targets, and contribute significantly to the preclinical pipeline.

Key Responsibilities:
  • Design and execute complex biological experiments to identify and validate novel drug targets for various diseases.
  • Lead and mentor a team of research scientists, fostering a collaborative and innovative research culture.
  • Develop and optimize high-throughput screening (HTS) assays and other discovery platforms.
  • Analyze and interpret complex biological data, translating findings into actionable insights for drug development strategies.
  • Prepare scientific manuscripts for publication in peer-reviewed journals and present findings at international conferences.
  • Collaborate closely with cross-functional teams, including medicinal chemistry, DMPK, and translational science, to advance drug candidates.
  • Stay abreast of the latest scientific literature, technological advancements, and competitive landscape in relevant therapeutic areas.
  • Contribute to the strategic direction of the company's drug discovery portfolio.
  • Manage external collaborations with academic institutions and CROs.
  • Ensure adherence to all laboratory safety regulations and ethical guidelines.
Required Qualifications:
  • Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
  • A minimum of 8 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong track record of successful drug discovery projects.
  • Demonstrated expertise in target identification, validation, and assay development.
  • Proven experience in leading and managing scientific teams and projects.
  • In-depth knowledge of modern drug discovery techniques and technologies.
  • Excellent understanding of disease biology and therapeutic intervention strategies.
  • Strong analytical skills with the ability to critically evaluate complex data sets.
  • Exceptional written and verbal communication skills, with a proven ability to publish and present scientific findings.
  • Experience with computational biology and bioinformatics tools is advantageous.
  • A proactive, self-motivated individual with a passion for scientific innovation and a commitment to delivering life-changing medicines.
This remote position offers the unique opportunity to shape the future of medicine from the comfort of your home office, contributing to groundbreaking research in **Manchester, Greater Manchester, UK** (while working remotely). Join a team dedicated to tackling unmet medical needs through scientific excellence.
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Principal Scientist, Drug Discovery

M1 2AA Manchester, North West £70000 Annually WhatJobs

Posted 15 days ago

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Job Description

full-time
Our client, a groundbreaking pharmaceutical company at the cutting edge of therapeutic innovation, is seeking a highly motivated and experienced Principal Scientist to join their esteemed Drug Discovery team. This senior role is central to driving the discovery and development of novel drug candidates for unmet medical needs. You will be responsible for leading ambitious research projects, from target identification and validation through to lead optimization, utilizing state-of-the-art methodologies and technologies. Your expertise will be crucial in designing and executing complex experiments, interpreting intricate data sets, and making critical decisions that advance the drug development pipeline.

As a Principal Scientist, you will contribute significantly to the strategic direction of the research programs, identifying new areas of scientific inquiry and potential therapeutic targets. You will play a vital role in mentoring junior scientists, fostering a collaborative and innovative research environment, and promoting scientific rigor. The ability to effectively communicate complex scientific findings to diverse audiences, including cross-functional teams, senior management, and external collaborators, is essential. You will also be expected to contribute to patent applications and scientific publications, enhancing the company's intellectual property portfolio and scientific reputation.

The ideal candidate will possess a PhD in a relevant scientific discipline (e.g., Pharmacology, Molecular Biology, Biochemistry, Medicinal Chemistry) with a strong publication record and significant post-doctoral and/or industry experience in drug discovery. Demonstrated leadership in managing research projects and a deep understanding of modern drug discovery techniques are paramount. Expertise in specific therapeutic areas or target classes would be a significant advantage. You should possess excellent problem-solving skills, creativity, and the ability to work effectively in a fast-paced, team-oriented environment. This is an exceptional opportunity to make a tangible impact on patient lives by contributing to the development of life-changing medicines.

Location: Manchester, Greater Manchester, UK
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Pharmaceutical Research Scientist, Drug Discovery

M1 2BG Manchester, North West £55000 Annually WhatJobs

Posted 9 days ago

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full-time
Our client, a leading innovator in pharmaceutical research, is seeking a highly motivated and skilled Pharmaceutical Research Scientist to join their cutting-edge drug discovery team. This is a fully remote position, offering the flexibility to work from anywhere in the UK. You will play a pivotal role in the identification and validation of novel therapeutic targets and the development of innovative drug candidates. Your responsibilities will include designing and executing complex in vitro and in vivo experiments, analyzing experimental data, and contributing to the interpretation of results within the context of drug discovery programs. The ideal candidate will possess a Ph.D. in Pharmacology, Biochemistry, Molecular Biology, or a related life science discipline, coupled with a strong publication record and demonstrated experience in drug discovery. Expertise in specific therapeutic areas (e.g., oncology, immunology, neurology) and proficiency with relevant assay development, screening technologies, and data analysis tools are highly desirable. You will collaborate closely with a multidisciplinary team of scientists, chemists, and clinicians, contributing to project strategy and decision-making. We are looking for an individual who is passionate about scientific exploration, possesses excellent problem-solving skills, and can work effectively both independently and as part of a virtual research team. Meticulous attention to detail, strong organizational skills, and the ability to manage multiple research projects concurrently are essential. This role offers an exciting opportunity to contribute to the development of life-changing medicines and advance your career in pharmaceutical R&D. The research focus will be related to initiatives stemming from Manchester, Greater Manchester, UK , but the work is performed entirely remotely. We value individuals who are proactive, innovative, and dedicated to scientific excellence. Your contributions will be integral to our client's mission of improving patient health globally.

Responsibilities:
  • Design, conduct, and interpret complex experiments in drug discovery and development.
  • Identify and validate novel drug targets using a range of biological assays.
  • Develop and optimize in vitro and in vivo models for preclinical research.
  • Analyze and present experimental data to project teams and senior management.
  • Collaborate with medicinal chemists to design and synthesize potential drug candidates.
  • Stay abreast of the latest scientific literature and technological advancements in pharmaceutical research.
  • Contribute to the strategic planning and direction of drug discovery projects.
  • Maintain accurate and detailed laboratory notebooks and research records.
  • Ensure compliance with all safety regulations and ethical guidelines.
  • Mentor junior research staff and contribute to a collaborative research environment.

Qualifications:
  • Ph.D. in Pharmacology, Biochemistry, Molecular Biology, or a related field.
  • Proven experience in drug discovery and development within the pharmaceutical industry.
  • Strong understanding of biological pathways and disease mechanisms.
  • Expertise in relevant experimental techniques and assay development.
  • Proficiency with data analysis software and scientific literature databases.
  • Excellent analytical, problem-solving, and critical thinking skills.
  • Strong written and verbal communication skills for scientific reporting.
  • Ability to work independently and manage multiple research projects in a remote setting.
  • Demonstrated publication record in reputable peer-reviewed journals.
  • Experience in specific therapeutic areas (e.g., oncology, immunology) is a plus.
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Principal Pharmaceutical Scientist - Drug Discovery

M1 1 Manchester, North West £70000 Annually WhatJobs

Posted 10 days ago

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full-time
Our client, a pioneering biopharmaceutical company, is seeking an exceptional Principal Pharmaceutical Scientist to lead critical drug discovery initiatives. This fully remote position offers a unique opportunity to make a significant impact on the development of novel therapeutics from the comfort of your home office. You will be at the forefront of scientific innovation, driving research projects from initial concept through to pre-clinical stages. This role is ideal for a seasoned scientist with a deep understanding of drug discovery pipelines and a passion for tackling challenging diseases. While the role is remote, our client’s primary research hub is located in Manchester, Greater Manchester, UK .

Key Responsibilities:
  • Lead and manage multiple drug discovery projects, defining research strategies and objectives.
  • Design and execute complex experiments in areas such as medicinal chemistry, pharmacology, or biochemistry to identify and validate novel drug targets and lead compounds.
  • Interpret experimental data, identify key findings, and provide strategic recommendations for project progression.
  • Develop and implement robust assays for screening and characterisation of potential drug candidates.
  • Collaborate effectively with cross-functional teams, including biologists, chemists, toxicologists, and clinical development specialists, to advance projects through the pipeline.
  • Prepare high-quality scientific reports, presentations, and publications for internal and external audiences.
  • Contribute to the development of intellectual property, including patent filings.
  • Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
  • Stay abreast of the latest scientific advancements, technologies, and competitive landscape in relevant therapeutic areas.
  • Ensure all research activities are conducted in compliance with ethical guidelines and company policies.

Qualifications and Skills:
  • PhD in Pharmacology, Medicinal Chemistry, Biochemistry, or a related life science discipline.
  • A minimum of 8-10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry.
  • Demonstrated success in leading research projects and achieving key milestones in drug discovery.
  • Extensive hands-on experience with relevant experimental techniques and technologies (e.g., high-throughput screening, in vitro pharmacology, lead optimisation).
  • Strong understanding of disease biology and mechanisms of action for therapeutic interventions.
  • Excellent analytical, problem-solving, and critical thinking skills.
  • Exceptional written and verbal communication skills, with a proven ability to present complex scientific information clearly.
  • Demonstrated ability to work independently and manage multiple priorities in a remote setting.
  • Strong leadership and team management capabilities.
  • A passion for scientific discovery and a commitment to bringing new medicines to patients.

This is a critical role for an ambitious scientist looking to shape the future of medicine from a flexible, remote-first environment.
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Senior Research Scientist - Drug Discovery

M1 7EU Manchester, North West £60000 Annually WhatJobs

Posted 10 days ago

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full-time
Our client, a leading pharmaceutical innovator, is looking for a highly skilled Senior Research Scientist to join their cutting-edge drug discovery team. This position is based at their state-of-the-art facility in **Manchester, Greater Manchester, UK**. You will play a crucial role in identifying and validating novel therapeutic targets, designing and executing complex experiments, and contributing to the development of innovative new medicines. The ideal candidate will possess a deep understanding of molecular biology, biochemistry, or pharmacology, with a strong track record in medicinal chemistry and early-stage drug discovery. Key responsibilities include leading research projects, developing and optimizing assay methodologies, analyzing experimental data, and interpreting results to guide project strategy. You will collaborate closely with multidisciplinary teams, including medicinal chemists, biologists, and toxicologists, to advance drug candidates through the pipeline. Mentoring junior scientists and contributing to scientific publications and patent applications are also key aspects of this role. Qualifications include a PhD in a relevant scientific discipline (e.g., Molecular Biology, Biochemistry, Pharmacology, Chemistry) and a minimum of 5 years of post-doctoral research experience in the pharmaceutical or biotechnology industry. Proven expertise in at least one key therapeutic area (e.g., oncology, immunology, neuroscience) is highly desirable. Experience with high-throughput screening (HTS), compound library management, and lead optimization techniques is essential. Excellent written and verbal communication skills, strong analytical abilities, and a passion for scientific discovery are paramount. You should be adept at problem-solving, critical thinking, and presenting complex scientific information to diverse audiences. This role offers an exciting opportunity to contribute to groundbreaking research and make a tangible impact on patient health. Our client offers a competitive salary, comprehensive benefits package, and a dynamic, collaborative work environment with excellent opportunities for career growth.
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Senior Computational Scientist - Drug Discovery

M1 6FQ Manchester, North West £70000 Annually WhatJobs

Posted 12 days ago

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full-time
Join our pioneering pharmaceutical research company as a Senior Computational Scientist, operating entirely remotely. We are at the forefront of drug discovery, leveraging advanced computational techniques to accelerate the identification and development of novel therapeutics. This is a unique opportunity for a highly skilled and motivated scientist to contribute to life-changing innovations from the convenience of their home office.

As a Senior Computational Scientist, you will be responsible for applying computational chemistry, bioinformatics, and data science methodologies to complex biological and chemical problems. You will design and implement computational strategies to support target identification, lead optimisation, and drug design efforts. A significant part of your role will involve collaborating with experimental biologists, medicinal chemists, and other computational scientists to interpret results, generate hypotheses, and drive research projects forward.

Key Responsibilities:
  • Develop and apply computational models and algorithms for drug discovery, including molecular docking, virtual screening, QSAR, and pharmacophore modelling.
  • Analyse large-scale biological and chemical datasets using bioinformatics and data mining techniques.
  • Design and interpret computational experiments to support target validation and lead optimisation.
  • Collaborate with experimental teams to integrate computational findings with empirical data.
  • Develop and maintain computational workflows and pipelines for high-throughput analysis.
  • Communicate complex scientific findings effectively to both computational and non-computational audiences.
  • Stay abreast of the latest advancements in computational chemistry, cheminformatics, bioinformatics, and machine learning.
  • Mentor junior computational scientists and contribute to the team's technical development.
  • Contribute to the strategic planning of computational drug discovery efforts.

We require a PhD in Computational Chemistry, Cheminformatics, Bioinformatics, Computer Science, or a related field. A minimum of 5 years of post-doctoral or industry experience in computational drug discovery is essential. Proven expertise in applying computational techniques to solve biological problems and a strong understanding of drug discovery processes are mandatory. Proficiency in programming languages such as Python or R, along with experience in molecular modelling software (e.g., Schrödinger, MOE, OpenEye) and databases, is required. Excellent problem-solving, analytical, and communication skills are vital for this remote position. The ability to work independently, manage multiple projects, and collaborate effectively in a virtual team environment is crucial. If you are passionate about applying cutting-edge computational science to develop new medicines, we encourage you to apply.
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Pharmaceutical Research Scientist - Drug Discovery

M1 2EH Manchester, North West £55000 Annually WhatJobs

Posted 13 days ago

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full-time
Our client, a leading pharmaceutical company, is seeking a highly motivated and accomplished Pharmaceutical Research Scientist specializing in Drug Discovery. This role offers a hybrid work model, blending essential in-lab research with remote data analysis and collaboration. You will be at the forefront of identifying and developing novel therapeutic agents, contributing to the company's pipeline of innovative medicines. Your responsibilities will include designing and executing in vitro and in vivo experiments, analysing complex biological and chemical data, and contributing to the interpretation of results. You will work collaboratively with a multidisciplinary team of chemists, biologists, and pharmacologists to advance drug candidates through the discovery process. Key activities involve assay development and validation, high-throughput screening, mechanism of action studies, and data interpretation. The ideal candidate will hold a PhD or MSc in Pharmacology, Biochemistry, Molecular Biology, or a related life science discipline, with a proven track record in drug discovery research. Experience with various assay technologies, cell culture, molecular biology techniques, and statistical analysis is essential. Strong scientific curiosity, excellent problem-solving skills, and the ability to work effectively in both independent and team-oriented settings are crucial. Proficiency in data analysis software and a thorough understanding of the drug discovery process are required. You will also contribute to scientific publications and presentations. This role provides an exciting opportunity to make a significant impact on human health by contributing to the development of life-changing therapies. The hybrid structure supports a dynamic research approach, ensuring both hands-on scientific work and flexible analytical contributions. Join a world-class research environment and advance your career in pharmaceutical innovation. Your expertise will be vital in bringing new medicines from concept to clinic.
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