46 Astrazeneca jobs in Macclesfield
Principal Scientist - Drug Discovery
Posted 4 days ago
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Job Description
Responsibilities:
- Lead and manage complex drug discovery research projects.
- Design and execute sophisticated biological assays and experiments.
- Develop and validate new scientific methodologies and technologies.
- Interpret experimental data and draw scientifically sound conclusions.
- Collaborate with cross-functional teams, including medicinal chemists and pharmacologists.
- Mentor and guide junior research scientists and fellows.
- Contribute to research strategy and identify new opportunities.
- Prepare and present research findings at internal meetings and external conferences.
- Author scientific publications and contribute to patent applications.
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
- Extensive post-doctoral and/or industry experience in drug discovery.
- Demonstrated track record of scientific achievement, including publications and presentations.
- Expertise in relevant biological techniques and assay development.
- Strong understanding of drug discovery processes and principles.
- Excellent leadership, communication, and interpersonal skills.
- Proven ability to manage projects and mentor scientific staff.
- Experience in a specific therapeutic area (e.g., oncology, immunology) is a plus.
Principal Scientist, Drug Discovery
Posted 13 days ago
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Job Description
Responsibilities:
- Lead and manage drug discovery research programs and projects.
- Design, conduct, and interpret complex biological experiments.
- Identify and validate novel drug targets and therapeutic strategies.
- Advance lead compounds through the preclinical development pipeline.
- Mentor and guide junior scientists and research associates.
- Collaborate effectively with internal and external partners (chemists, clinicians, CROs).
- Analyze and present scientific data to senior management and project teams.
- Contribute to the strategic planning and decision-making for the drug discovery portfolio.
- Stay abreast of the latest scientific literature and technological advancements in the field.
- Author scientific publications and contribute to patent filings.
- PhD in Molecular Biology, Pharmacology, Biochemistry, or a related field.
- Extensive experience (8+ years) in drug discovery within the pharmaceutical or biotech industry.
- Proven track record of leading research projects and achieving key milestones.
- Deep expertise in relevant scientific disciplines and assay development.
- Experience in a specific therapeutic area (e.g., oncology, infectious diseases) is advantageous.
- Strong understanding of drug discovery processes and regulatory requirements.
- Excellent data analysis, interpretation, and presentation skills.
- Strong leadership, mentorship, and team collaboration abilities.
- Proficiency in relevant scientific software and tools.
- Excellent written and verbal communication skills.
Principal Scientist - Drug Discovery
Posted 15 days ago
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Job Description
Responsibilities:
- Lead and manage drug discovery projects from target identification through to lead optimization.
- Design, develop, and implement robust experimental assays and screening methodologies.
- Analyze complex biological and chemical data, drawing sound conclusions and making strategic recommendations.
- Collaborate closely with medicinal chemists, biologists, pharmacologists, and other scientific disciplines.
- Prepare high-quality scientific reports, presentations, and publications.
- Manage junior scientists and research associates, providing technical guidance and mentorship.
- Contribute to the strategic direction of the R&D department and identify new research opportunities.
- Ensure compliance with all relevant safety, ethical, and regulatory guidelines.
- Present research findings at internal and external scientific meetings.
- Ph.D. in a relevant scientific discipline such as Molecular Biology, Biochemistry, Pharmacology, or related field.
- Extensive experience in drug discovery, with a strong emphasis on small molecule or biologic therapeutics.
- Demonstrated expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience).
- Proven ability to design and execute complex research projects and interpret data.
- Excellent track record of scientific publications and presentations.
- Strong leadership, team management, and interpersonal skills.
- Proficiency in relevant laboratory techniques and data analysis software.
- Experience with in vivo models and pharmacokinetics is advantageous.
Principal Scientist, Drug Discovery
Posted 15 days ago
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Job Description
Key Responsibilities:
- Design and execute complex biological experiments to identify and validate novel drug targets for various diseases.
- Lead and mentor a team of research scientists, fostering a collaborative and innovative research culture.
- Develop and optimize high-throughput screening (HTS) assays and other discovery platforms.
- Analyze and interpret complex biological data, translating findings into actionable insights for drug development strategies.
- Prepare scientific manuscripts for publication in peer-reviewed journals and present findings at international conferences.
- Collaborate closely with cross-functional teams, including medicinal chemistry, DMPK, and translational science, to advance drug candidates.
- Stay abreast of the latest scientific literature, technological advancements, and competitive landscape in relevant therapeutic areas.
- Contribute to the strategic direction of the company's drug discovery portfolio.
- Manage external collaborations with academic institutions and CROs.
- Ensure adherence to all laboratory safety regulations and ethical guidelines.
- Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
- A minimum of 8 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong track record of successful drug discovery projects.
- Demonstrated expertise in target identification, validation, and assay development.
- Proven experience in leading and managing scientific teams and projects.
- In-depth knowledge of modern drug discovery techniques and technologies.
- Excellent understanding of disease biology and therapeutic intervention strategies.
- Strong analytical skills with the ability to critically evaluate complex data sets.
- Exceptional written and verbal communication skills, with a proven ability to publish and present scientific findings.
- Experience with computational biology and bioinformatics tools is advantageous.
- A proactive, self-motivated individual with a passion for scientific innovation and a commitment to delivering life-changing medicines.
Principal Scientist, Drug Discovery
Posted 15 days ago
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Job Description
As a Principal Scientist, you will contribute significantly to the strategic direction of the research programs, identifying new areas of scientific inquiry and potential therapeutic targets. You will play a vital role in mentoring junior scientists, fostering a collaborative and innovative research environment, and promoting scientific rigor. The ability to effectively communicate complex scientific findings to diverse audiences, including cross-functional teams, senior management, and external collaborators, is essential. You will also be expected to contribute to patent applications and scientific publications, enhancing the company's intellectual property portfolio and scientific reputation.
The ideal candidate will possess a PhD in a relevant scientific discipline (e.g., Pharmacology, Molecular Biology, Biochemistry, Medicinal Chemistry) with a strong publication record and significant post-doctoral and/or industry experience in drug discovery. Demonstrated leadership in managing research projects and a deep understanding of modern drug discovery techniques are paramount. Expertise in specific therapeutic areas or target classes would be a significant advantage. You should possess excellent problem-solving skills, creativity, and the ability to work effectively in a fast-paced, team-oriented environment. This is an exceptional opportunity to make a tangible impact on patient lives by contributing to the development of life-changing medicines.
Location: Manchester, Greater Manchester, UK
Pharmaceutical Research Scientist, Drug Discovery
Posted 9 days ago
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Job Description
Responsibilities:
- Design, conduct, and interpret complex experiments in drug discovery and development.
- Identify and validate novel drug targets using a range of biological assays.
- Develop and optimize in vitro and in vivo models for preclinical research.
- Analyze and present experimental data to project teams and senior management.
- Collaborate with medicinal chemists to design and synthesize potential drug candidates.
- Stay abreast of the latest scientific literature and technological advancements in pharmaceutical research.
- Contribute to the strategic planning and direction of drug discovery projects.
- Maintain accurate and detailed laboratory notebooks and research records.
- Ensure compliance with all safety regulations and ethical guidelines.
- Mentor junior research staff and contribute to a collaborative research environment.
Qualifications:
- Ph.D. in Pharmacology, Biochemistry, Molecular Biology, or a related field.
- Proven experience in drug discovery and development within the pharmaceutical industry.
- Strong understanding of biological pathways and disease mechanisms.
- Expertise in relevant experimental techniques and assay development.
- Proficiency with data analysis software and scientific literature databases.
- Excellent analytical, problem-solving, and critical thinking skills.
- Strong written and verbal communication skills for scientific reporting.
- Ability to work independently and manage multiple research projects in a remote setting.
- Demonstrated publication record in reputable peer-reviewed journals.
- Experience in specific therapeutic areas (e.g., oncology, immunology) is a plus.
Principal Pharmaceutical Scientist - Drug Discovery
Posted 10 days ago
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Job Description
Key Responsibilities:
- Lead and manage multiple drug discovery projects, defining research strategies and objectives.
- Design and execute complex experiments in areas such as medicinal chemistry, pharmacology, or biochemistry to identify and validate novel drug targets and lead compounds.
- Interpret experimental data, identify key findings, and provide strategic recommendations for project progression.
- Develop and implement robust assays for screening and characterisation of potential drug candidates.
- Collaborate effectively with cross-functional teams, including biologists, chemists, toxicologists, and clinical development specialists, to advance projects through the pipeline.
- Prepare high-quality scientific reports, presentations, and publications for internal and external audiences.
- Contribute to the development of intellectual property, including patent filings.
- Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
- Stay abreast of the latest scientific advancements, technologies, and competitive landscape in relevant therapeutic areas.
- Ensure all research activities are conducted in compliance with ethical guidelines and company policies.
Qualifications and Skills:
- PhD in Pharmacology, Medicinal Chemistry, Biochemistry, or a related life science discipline.
- A minimum of 8-10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry.
- Demonstrated success in leading research projects and achieving key milestones in drug discovery.
- Extensive hands-on experience with relevant experimental techniques and technologies (e.g., high-throughput screening, in vitro pharmacology, lead optimisation).
- Strong understanding of disease biology and mechanisms of action for therapeutic interventions.
- Excellent analytical, problem-solving, and critical thinking skills.
- Exceptional written and verbal communication skills, with a proven ability to present complex scientific information clearly.
- Demonstrated ability to work independently and manage multiple priorities in a remote setting.
- Strong leadership and team management capabilities.
- A passion for scientific discovery and a commitment to bringing new medicines to patients.
This is a critical role for an ambitious scientist looking to shape the future of medicine from a flexible, remote-first environment.
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Senior Research Scientist - Drug Discovery
Posted 10 days ago
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Senior Computational Scientist - Drug Discovery
Posted 12 days ago
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Job Description
As a Senior Computational Scientist, you will be responsible for applying computational chemistry, bioinformatics, and data science methodologies to complex biological and chemical problems. You will design and implement computational strategies to support target identification, lead optimisation, and drug design efforts. A significant part of your role will involve collaborating with experimental biologists, medicinal chemists, and other computational scientists to interpret results, generate hypotheses, and drive research projects forward.
Key Responsibilities:
- Develop and apply computational models and algorithms for drug discovery, including molecular docking, virtual screening, QSAR, and pharmacophore modelling.
- Analyse large-scale biological and chemical datasets using bioinformatics and data mining techniques.
- Design and interpret computational experiments to support target validation and lead optimisation.
- Collaborate with experimental teams to integrate computational findings with empirical data.
- Develop and maintain computational workflows and pipelines for high-throughput analysis.
- Communicate complex scientific findings effectively to both computational and non-computational audiences.
- Stay abreast of the latest advancements in computational chemistry, cheminformatics, bioinformatics, and machine learning.
- Mentor junior computational scientists and contribute to the team's technical development.
- Contribute to the strategic planning of computational drug discovery efforts.
We require a PhD in Computational Chemistry, Cheminformatics, Bioinformatics, Computer Science, or a related field. A minimum of 5 years of post-doctoral or industry experience in computational drug discovery is essential. Proven expertise in applying computational techniques to solve biological problems and a strong understanding of drug discovery processes are mandatory. Proficiency in programming languages such as Python or R, along with experience in molecular modelling software (e.g., Schrödinger, MOE, OpenEye) and databases, is required. Excellent problem-solving, analytical, and communication skills are vital for this remote position. The ability to work independently, manage multiple projects, and collaborate effectively in a virtual team environment is crucial. If you are passionate about applying cutting-edge computational science to develop new medicines, we encourage you to apply.
Pharmaceutical Research Scientist - Drug Discovery
Posted 13 days ago
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