4,576 Backend Programming jobs in the United Kingdom
Senior Backend Software Engineer (API Development)
Posted 21 days ago
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Job Description
Responsibilities:
- Design, develop, test, and deploy secure, efficient, and scalable backend APIs using modern programming languages and frameworks (e.g., Python/Django, Node.js/Express, Java/Spring Boot, C#/.NET Core).
- Collaborate with product managers, frontend engineers, and other stakeholders to define API requirements and technical specifications.
- Implement and maintain robust data models and database schemas for relational and NoSQL databases.
- Develop and integrate with third-party APIs and services.
- Write clean, well-documented, and maintainable code adhering to best practices and coding standards.
- Implement security best practices and data protection measures within API development.
- Optimise API performance and scalability to handle high volumes of traffic.
- Write comprehensive unit, integration, and end-to-end tests to ensure code quality and reliability.
- Participate in code reviews, providing constructive feedback to team members.
- Troubleshoot and resolve bugs and performance issues in production environments.
- Stay current with emerging backend technologies, tools, and industry trends.
- Contribute to architectural discussions and technical decision-making processes.
- Mentor junior engineers and share knowledge within the team.
- Develop and maintain CI/CD pipelines for automated testing and deployment.
- Bachelor's or Master's degree in Computer Science, Software Engineering, or a related field.
- A minimum of 5 years of professional experience in backend software development, with a strong focus on API design and development.
- Proficiency in at least one major backend programming language (e.g., Python, Java, C#, Node.js).
- Extensive experience with RESTful API design principles and best practices.
- Strong knowledge of database technologies (e.g., PostgreSQL, MySQL, MongoDB, Redis).
- Experience with microservices architecture and containerisation technologies (e.g., Docker, Kubernetes).
- Familiarity with cloud platforms (AWS, Azure, GCP) and related services.
- Understanding of software development methodologies, such as Agile/Scrum.
- Experience with version control systems (e.g., Git).
- Excellent problem-solving, debugging, and analytical skills.
- Strong written and verbal communication skills.
- Ability to work independently and collaborate effectively in a remote team environment.
Senior Process Chemist - API Development
Posted 12 days ago
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Job Description
Key Responsibilities:
- Design, execute, and optimize synthetic routes for APIs, focusing on yield, purity, cost-effectiveness, and safety.
- Develop robust and scalable chemical processes suitable for pilot plant and commercial manufacturing.
- Perform process hazard analyses and implement appropriate safety measures.
- Investigate and troubleshoot process deviations, identifying root causes and implementing corrective actions.
- Characterize intermediates and final APIs using various analytical techniques (e.g., HPLC, GC, NMR, MS, XRPD).
- Transfer processes from laboratory scale to pilot plant and commercial manufacturing sites.
- Author and review process development reports, technical transfer documents, and regulatory filings (e.g., CMC sections).
- Collaborate effectively with cross-functional teams including R&D, manufacturing, quality assurance, and regulatory affairs.
- Ensure all activities comply with Good Manufacturing Practices (GMP) and relevant health and safety regulations.
- Manage external contract manufacturing organizations (CMOs) for specific process development activities.
- Mentor junior chemists and contribute to the technical training of the team.
- Evaluate and implement new technologies to improve process efficiency and sustainability.
- Contribute to the strategic planning of process development activities.
- PhD or MSc in Organic Chemistry, Process Chemistry, or a closely related field.
- Minimum of 5-7 years of relevant experience in pharmaceutical process development, with a strong focus on API synthesis.
- Demonstrated expertise in synthetic organic chemistry and reaction optimization.
- Hands-on experience with process scale-up, including pilot plant operations.
- Proficiency in analytical techniques for chemical characterization.
- Thorough understanding of GMP guidelines and regulatory requirements for pharmaceutical manufacturing.
- Excellent problem-solving, analytical, and critical thinking skills.
- Strong project management abilities and experience managing multiple priorities.
- Effective written and verbal communication skills, with the ability to present complex technical information clearly.
- Experience with process safety assessments (e.g., HAZOP).
- Ability to work collaboratively within a team environment and independently as required.
- Must be willing to work onsite at our facility in Coventry, West Midlands, UK .
Lead Backend Engineer (API Development)
Posted 13 days ago
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Job Description
Key Responsibilities:
- Lead the design, development, and implementation of robust and scalable backend services and APIs.
- Architect and build highly available and fault-tolerant systems.
- Define API standards and best practices, ensuring consistency and usability across the platform.
- Collaborate with front-end developers, product managers, and other stakeholders to understand requirements and deliver solutions.
- Write clean, efficient, and well-documented code in one or more backend languages (e.g., Python, Node.js, Java, Go).
- Implement security best practices and ensure data protection.
- Optimize backend performance and database queries.
- Mentor and guide junior backend engineers, fostering a culture of technical excellence.
- Conduct code reviews and provide constructive feedback to team members.
- Troubleshoot and resolve complex backend issues.
- Contribute to architectural discussions and technology selection.
- Stay current with emerging backend technologies and industry trends.
- Manage and maintain CI/CD pipelines for backend services.
Qualifications:
- Bachelor's degree in Computer Science, Software Engineering, or a related field, or equivalent experience.
- Minimum of 8 years of professional experience in backend development.
- Proven experience in designing and building RESTful APIs and microservices.
- Strong proficiency in at least one major backend programming language (e.g., Python, Node.js, Java, Go).
- Deep understanding of database design and management (SQL and NoSQL).
- Experience with cloud platforms (AWS, Azure, GCP) and related services.
- Familiarity with containerization technologies (Docker, Kubernetes).
- Experience with CI/CD tools and practices.
- Strong knowledge of software architecture patterns and best practices.
- Excellent problem-solving, debugging, and analytical skills.
- Demonstrated leadership and mentoring abilities.
- Strong communication and collaboration skills.
- Experience with performance tuning and optimization.
This is an exciting opportunity to shape the future of our technology and lead a talented engineering team.
Principal Process Chemist - API Development
Posted 14 days ago
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Job Description
Key Responsibilities:
- Lead the design, development, and validation of robust chemical processes for the synthesis of APIs, from laboratory scale to commercial manufacturing.
- Conduct comprehensive process research and development, including route scouting, optimisation of reaction conditions, and impurity profiling.
- Apply Quality by Design (QbD) principles and statistical methods to develop well-understood and controlled manufacturing processes.
- Troubleshoot and resolve complex technical issues arising during process development, scale-up, and manufacturing.
- Collaborate closely with analytical chemists, engineers, and regulatory affairs specialists to ensure seamless project progression.
- Author and review critical process documents, including development reports, validation protocols, and regulatory submission modules (e.g., CMC sections).
- Stay abreast of emerging technologies, green chemistry principles, and industry best practices in API process development.
- Mentor and guide junior process chemists and scientists, sharing expertise and fostering a culture of scientific excellence.
- Contribute to technology transfer activities to internal manufacturing sites or external contract manufacturing organisations (CMOs).
- Ensure all activities are conducted in strict accordance with cGMP guidelines and other relevant regulatory requirements.
Qualifications:
- A Ph.D. in Organic Chemistry, Process Chemistry, or a related discipline.
- A minimum of 8 years of progressive experience in pharmaceutical process chemistry, specifically focusing on API development and scale-up.
- Proven track record of successfully developing and implementing scalable, robust, and cost-effective synthetic routes for complex small molecules.
- In-depth understanding of reaction mechanisms, process safety, thermodynamics, and kinetics.
- Experience with QbD principles, Design of Experiments (DoE), and statistical process control.
- Familiarity with regulatory requirements for API manufacturing (e.g., FDA, EMA).
- Excellent problem-solving, analytical, and critical thinking skills.
- Strong written and verbal communication abilities, with experience authoring technical reports and regulatory documents.
- Ability to lead projects independently and work effectively within a dispersed, multidisciplinary team in a remote setting.
Senior Formulation Scientist - API Development
Posted 20 days ago
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Job Description
Responsibilities:
- Lead the design and execution of formulation development studies for small molecules and/or biologics.
- Develop and optimize robust formulations for various dosage forms, including oral solid dosage, injectables, and topical preparations.
- Conduct pre-formulation characterization of APIs, including solubility, stability, and solid-state properties.
- Develop and validate analytical methods for assessing formulation performance and quality.
- Plan and execute technology transfer activities to manufacturing sites.
- Collaborate closely with API synthesis, analytical development, and regulatory affairs teams.
- Troubleshoot formulation and process-related issues and implement effective solutions.
- Author and review development reports, technical summaries, and regulatory submission documents.
- Stay abreast of emerging drug delivery technologies and scientific advancements in pharmaceutical formulation.
- Mentor and guide junior scientists within the formulation development team.
The successful candidate will hold a Master's or PhD degree in Pharmaceutical Sciences, Chemical Engineering, or a related discipline, with a minimum of 7 years of progressive experience in pharmaceutical formulation development. Proven experience with a variety of dosage forms and drug delivery technologies is essential. Strong understanding of GMP, ICH guidelines, and regulatory requirements for drug product development is mandatory. Excellent analytical, problem-solving, and communication skills are required. Experience with laboratory equipment such as particle size analyzers, dissolution apparatus, and rheometers is necessary. This role requires a dedicated professional to contribute significantly to our pipeline of innovative medicines at our Liverpool, Merseyside, UK facility.
Senior Backend Engineer - API Development
Posted 22 days ago
Job Viewed
Job Description
Key Responsibilities:
- Designing, developing, and implementing robust and scalable backend services and APIs using modern programming languages and frameworks (e.g., Python/Django, Node.js/Express, Go).
- Architecting and building RESTful or GraphQL APIs that are well-documented, performant, and maintainable.
- Working with various database technologies (e.g., PostgreSQL, MongoDB, Redis) to ensure efficient data storage and retrieval.
- Implementing and optimizing microservices architectures.
- Writing clean, efficient, and well-tested code, adhering to coding standards and best practices.
- Collaborating with frontend engineers, product managers, and other stakeholders to define API requirements and deliver features.
- Ensuring the security, scalability, and reliability of backend systems.
- Participating in code reviews, providing constructive feedback to peers.
- Troubleshooting and debugging complex issues in production environments.
- Contributing to architectural decisions and technology selection.
- Staying up-to-date with industry trends and emerging technologies in backend development and API design.
- Bachelor's degree in Computer Science, Engineering, or a related field, or equivalent practical experience.
- 5+ years of professional experience in backend software development.
- Proven experience designing and building robust, scalable APIs.
- Strong proficiency in at least one modern backend programming language (e.g., Python, Java, Go, Node.js).
- Deep understanding of API design principles (REST, GraphQL) and best practices.
- Experience with relational databases (e.g., PostgreSQL, MySQL) and NoSQL databases (e.g., MongoDB).
- Familiarity with cloud platforms (AWS, Azure, GCP) and containerization technologies (Docker, Kubernetes).
- Experience with CI/CD pipelines and automated testing.
- Excellent problem-solving, analytical, and algorithmic thinking skills.
- Strong communication and collaboration skills, with the ability to thrive in a remote team environment.
- Experience with data processing and distributed systems is a plus.
Principal Process Chemist - API Development
Posted 24 days ago
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Job Description
As a Principal Process Chemist, you will be responsible for designing, executing, and troubleshooting synthetic processes, ensuring they are robust, scalable, cost-effective, and compliant with regulatory standards (e.g., GMP). Your expertise will be vital in identifying and resolving synthetic challenges, improving yields, and enhancing product purity. You will collaborate extensively with analytical chemists, formulation scientists, engineers, and regulatory affairs specialists. A strong understanding of process safety, analytical techniques, and technology transfer is essential. This position demands a deep scientific background, excellent problem-solving abilities, and leadership qualities. You will play a key role in the strategic direction of process development, driving innovation and ensuring the successful delivery of life-saving medicines.
Responsibilities:
- Lead the development and optimization of synthetic routes for novel APIs, from lab scale to pilot and commercial manufacturing.
- Design and execute experiments to understand reaction kinetics, thermodynamics, and impurity profiles.
- Develop robust and scalable chemical processes that meet safety, quality, and economic requirements.
- Troubleshoot and resolve complex chemical synthesis issues encountered during development and scale-up.
- Characterize reaction intermediates and final products using various analytical techniques (e.g., HPLC, GC, NMR, MS).
- Collaborate with analytical teams to develop and validate analytical methods.
- Prepare detailed process descriptions, development reports, and regulatory documentation.
- Provide technical guidance and mentorship to junior process chemists and technicians.
- Lead technology transfer activities to internal manufacturing sites or external contract manufacturing organizations (CMOs).
- Conduct thorough process safety assessments and implement appropriate control measures.
- Stay abreast of the latest advancements in synthetic chemistry and process development technologies.
- Contribute to the strategic planning and prioritization of process chemistry projects in Cambridge .
- PhD in Organic Chemistry, Process Chemistry, or a related field.
- Minimum of 8 years of progressive experience in pharmaceutical process chemistry, with a focus on API development.
- Demonstrated expertise in designing and scaling up multi-step synthetic routes.
- Strong understanding of reaction mechanisms, kinetics, and thermodynamics.
- Proficiency in modern synthetic techniques and analytical methods.
- Experience with GMP guidelines and regulatory requirements for pharmaceutical manufacturing.
- Proven ability to lead projects, mentor junior scientists, and collaborate effectively in cross-functional teams.
- Excellent problem-solving, critical thinking, and decision-making skills.
- Strong written and verbal communication skills, with the ability to present complex scientific information clearly.
- Experience with statistical experimental design (DoE) is highly desirable.
- Familiarity with process safety evaluation techniques.
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Senior Process Chemist - API Development
Posted 24 days ago
Job Viewed
Job Description
Responsibilities:
- Develop and optimize synthetic routes for APIs, focusing on scalability, safety, and cost-effectiveness.
- Conduct process hazard assessments and implement safety protocols for all chemical reactions.
- Scale up laboratory procedures to pilot plant and commercial manufacturing scales.
- Troubleshoot and resolve issues encountered during process development and manufacturing.
- Characterize intermediates and final APIs using analytical techniques such as HPLC, GC, NMR, and MS.
- Write detailed process development reports, batch records, and technical transfer documents.
- Collaborate with formulation scientists, analytical chemists, and engineers to ensure seamless product development.
- Ensure all processes comply with Good Manufacturing Practices (GMP) and other relevant regulatory guidelines.
- Stay current with advancements in synthetic organic chemistry, process technology, and analytical methods.
- Manage external contract manufacturing organizations (CMOs) for process development and scale-up activities.
- Contribute to intellectual property development and patent filings.
- Mentor junior chemists and provide technical guidance.
- Optimize reaction conditions to improve yield, purity, and reduce waste.
- PhD or Master's degree in Organic Chemistry, Chemical Engineering, or a related field.
- Minimum of 7 years of hands-on experience in process chemistry, with a focus on API development in the pharmaceutical industry.
- Demonstrated expertise in route scouting, process optimization, and scale-up of complex organic syntheses.
- Strong understanding of reaction kinetics, thermodynamics, and chemical engineering principles.
- Proficiency in a wide range of analytical techniques for characterization and impurity profiling.
- In-depth knowledge of GMP and regulatory requirements for pharmaceutical manufacturing.
- Excellent problem-solving and troubleshooting skills.
- Strong written and verbal communication skills, with the ability to present complex technical information clearly.
- Experience with process safety management and risk assessment methodologies.
- Ability to work effectively in a team-oriented, fast-paced environment.
- Previous experience with CMO management is a plus.
Senior Pharmaceutical Development Scientist - API
Posted 21 days ago
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Job Description
Key Responsibilities:
- Lead the development and characterization of Active Pharmaceutical Ingredients (APIs).
- Design and execute API synthesis and purification experiments.
- Perform comprehensive analytical characterization of APIs.
- Optimize chemical processes for scalability and regulatory compliance.
- Troubleshoot synthesis and process-related issues.
- Collaborate with multidisciplinary R&D and CMC teams.
- Prepare documentation for regulatory submissions (e.g., IND).
- Ensure adherence to GMP and other industry standards.
Senior Process Development Scientist (API)
Posted 24 days ago
Job Viewed
Job Description
Key Responsibilities:
- Develop, optimize, and scale-up chemical processes for API manufacturing.
- Design and execute experimental plans to investigate process variables and identify critical parameters.
- Utilize Design of Experiments (DoE) methodologies for efficient process optimization.
- Troubleshoot and resolve technical challenges in process development.
- Characterize intermediates and final products to ensure quality and purity.
- Collaborate with analytical teams to develop and validate analytical methods.
- Prepare comprehensive technical reports and documentation for regulatory submissions.
- Mentor and guide junior scientists and technicians in the laboratory.
- Ensure compliance with all relevant safety, environmental, and GMP regulations.
- PhD in Organic Chemistry, Chemical Engineering, or a closely related field.
- Minimum of 5 years of post-doctoral or industry experience in pharmaceutical process development.
- Extensive knowledge of synthetic organic chemistry and process scale-up.
- Experience with GMP manufacturing environments and regulatory requirements.
- Proficiency in analytical techniques (e.g., HPLC, GC, MS, NMR).
- Proven ability to manage projects and work effectively in a hybrid team setting.
- Excellent problem-solving, data analysis, and critical thinking skills.
- Strong scientific writing and presentation abilities.