4,244 Backend Programming jobs in the United Kingdom
Senior Backend Software Engineer (API Development)
WV1 1AA Wolverhampton, West Midlands
£65000 Annually
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Our client is a rapidly expanding tech company focused on developing innovative SaaS solutions for the enterprise market. They are seeking a highly skilled Senior Backend Software Engineer to join their remote team. This is a fully remote position, offering the flexibility to work from anywhere in the UK. You will play a pivotal role in designing, developing, and maintaining robust, scalable, and high-performance APIs that power their core product offerings. Your contributions will be crucial in shaping the future of their platform and ensuring seamless integration with client systems.
Responsibilities:
Responsibilities:
- Design, develop, test, and deploy secure, efficient, and scalable backend APIs using modern programming languages and frameworks (e.g., Python/Django, Node.js/Express, Java/Spring Boot, C#/.NET Core).
- Collaborate with product managers, frontend engineers, and other stakeholders to define API requirements and technical specifications.
- Implement and maintain robust data models and database schemas for relational and NoSQL databases.
- Develop and integrate with third-party APIs and services.
- Write clean, well-documented, and maintainable code adhering to best practices and coding standards.
- Implement security best practices and data protection measures within API development.
- Optimise API performance and scalability to handle high volumes of traffic.
- Write comprehensive unit, integration, and end-to-end tests to ensure code quality and reliability.
- Participate in code reviews, providing constructive feedback to team members.
- Troubleshoot and resolve bugs and performance issues in production environments.
- Stay current with emerging backend technologies, tools, and industry trends.
- Contribute to architectural discussions and technical decision-making processes.
- Mentor junior engineers and share knowledge within the team.
- Develop and maintain CI/CD pipelines for automated testing and deployment.
- Bachelor's or Master's degree in Computer Science, Software Engineering, or a related field.
- A minimum of 5 years of professional experience in backend software development, with a strong focus on API design and development.
- Proficiency in at least one major backend programming language (e.g., Python, Java, C#, Node.js).
- Extensive experience with RESTful API design principles and best practices.
- Strong knowledge of database technologies (e.g., PostgreSQL, MySQL, MongoDB, Redis).
- Experience with microservices architecture and containerisation technologies (e.g., Docker, Kubernetes).
- Familiarity with cloud platforms (AWS, Azure, GCP) and related services.
- Understanding of software development methodologies, such as Agile/Scrum.
- Experience with version control systems (e.g., Git).
- Excellent problem-solving, debugging, and analytical skills.
- Strong written and verbal communication skills.
- Ability to work independently and collaborate effectively in a remote team environment.
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0
Senior Backend Engineer - API Development
S1 1AA Sheffield, Yorkshire and the Humber
£75000 Annually
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Our client, a rapidly growing tech company revolutionizing data analytics, is seeking a talented Senior Backend Engineer to join their remote-first engineering team. This role is focused on designing, developing, and maintaining high-performance, scalable APIs and backend services that form the core of our innovative platform. You will be instrumental in building robust, efficient, and secure solutions that handle complex data processing and integration challenges.
Key Responsibilities:
Key Responsibilities:
- Designing, developing, and implementing robust and scalable backend services and APIs using modern programming languages and frameworks (e.g., Python/Django, Node.js/Express, Go).
- Architecting and building RESTful or GraphQL APIs that are well-documented, performant, and maintainable.
- Working with various database technologies (e.g., PostgreSQL, MongoDB, Redis) to ensure efficient data storage and retrieval.
- Implementing and optimizing microservices architectures.
- Writing clean, efficient, and well-tested code, adhering to coding standards and best practices.
- Collaborating with frontend engineers, product managers, and other stakeholders to define API requirements and deliver features.
- Ensuring the security, scalability, and reliability of backend systems.
- Participating in code reviews, providing constructive feedback to peers.
- Troubleshooting and debugging complex issues in production environments.
- Contributing to architectural decisions and technology selection.
- Staying up-to-date with industry trends and emerging technologies in backend development and API design.
- Bachelor's degree in Computer Science, Engineering, or a related field, or equivalent practical experience.
- 5+ years of professional experience in backend software development.
- Proven experience designing and building robust, scalable APIs.
- Strong proficiency in at least one modern backend programming language (e.g., Python, Java, Go, Node.js).
- Deep understanding of API design principles (REST, GraphQL) and best practices.
- Experience with relational databases (e.g., PostgreSQL, MySQL) and NoSQL databases (e.g., MongoDB).
- Familiarity with cloud platforms (AWS, Azure, GCP) and containerization technologies (Docker, Kubernetes).
- Experience with CI/CD pipelines and automated testing.
- Excellent problem-solving, analytical, and algorithmic thinking skills.
- Strong communication and collaboration skills, with the ability to thrive in a remote team environment.
- Experience with data processing and distributed systems is a plus.
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1
Principal Process Chemist - API Development
CB2 0AA Cambridge, Eastern
£70000 Annually
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Posted 2 days ago
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Our client, a leading pharmaceutical company at the forefront of drug discovery and development, is seeking a highly experienced Principal Process Chemist to join their dynamic R&D team in Cambridge . This role is crucial for developing and optimizing synthetic routes for Active Pharmaceutical Ingredients (APIs) from early-stage development through to commercial scale-up. You will lead complex projects, mentor junior scientists, and contribute significantly to the company's pipeline of innovative therapeutics.
As a Principal Process Chemist, you will be responsible for designing, executing, and troubleshooting synthetic processes, ensuring they are robust, scalable, cost-effective, and compliant with regulatory standards (e.g., GMP). Your expertise will be vital in identifying and resolving synthetic challenges, improving yields, and enhancing product purity. You will collaborate extensively with analytical chemists, formulation scientists, engineers, and regulatory affairs specialists. A strong understanding of process safety, analytical techniques, and technology transfer is essential. This position demands a deep scientific background, excellent problem-solving abilities, and leadership qualities. You will play a key role in the strategic direction of process development, driving innovation and ensuring the successful delivery of life-saving medicines.
Responsibilities:
As a Principal Process Chemist, you will be responsible for designing, executing, and troubleshooting synthetic processes, ensuring they are robust, scalable, cost-effective, and compliant with regulatory standards (e.g., GMP). Your expertise will be vital in identifying and resolving synthetic challenges, improving yields, and enhancing product purity. You will collaborate extensively with analytical chemists, formulation scientists, engineers, and regulatory affairs specialists. A strong understanding of process safety, analytical techniques, and technology transfer is essential. This position demands a deep scientific background, excellent problem-solving abilities, and leadership qualities. You will play a key role in the strategic direction of process development, driving innovation and ensuring the successful delivery of life-saving medicines.
Responsibilities:
- Lead the development and optimization of synthetic routes for novel APIs, from lab scale to pilot and commercial manufacturing.
- Design and execute experiments to understand reaction kinetics, thermodynamics, and impurity profiles.
- Develop robust and scalable chemical processes that meet safety, quality, and economic requirements.
- Troubleshoot and resolve complex chemical synthesis issues encountered during development and scale-up.
- Characterize reaction intermediates and final products using various analytical techniques (e.g., HPLC, GC, NMR, MS).
- Collaborate with analytical teams to develop and validate analytical methods.
- Prepare detailed process descriptions, development reports, and regulatory documentation.
- Provide technical guidance and mentorship to junior process chemists and technicians.
- Lead technology transfer activities to internal manufacturing sites or external contract manufacturing organizations (CMOs).
- Conduct thorough process safety assessments and implement appropriate control measures.
- Stay abreast of the latest advancements in synthetic chemistry and process development technologies.
- Contribute to the strategic planning and prioritization of process chemistry projects in Cambridge .
- PhD in Organic Chemistry, Process Chemistry, or a related field.
- Minimum of 8 years of progressive experience in pharmaceutical process chemistry, with a focus on API development.
- Demonstrated expertise in designing and scaling up multi-step synthetic routes.
- Strong understanding of reaction mechanisms, kinetics, and thermodynamics.
- Proficiency in modern synthetic techniques and analytical methods.
- Experience with GMP guidelines and regulatory requirements for pharmaceutical manufacturing.
- Proven ability to lead projects, mentor junior scientists, and collaborate effectively in cross-functional teams.
- Excellent problem-solving, critical thinking, and decision-making skills.
- Strong written and verbal communication skills, with the ability to present complex scientific information clearly.
- Experience with statistical experimental design (DoE) is highly desirable.
- Familiarity with process safety evaluation techniques.
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2
Senior Process Chemist - API Development
L1 8JQ Liverpool, North West
£65000 Annually
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Posted 2 days ago
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Our client, a leading pharmaceutical manufacturer, is seeking a highly skilled Senior Process Chemist to join their Active Pharmaceutical Ingredient (API) development team. This role, based in Liverpool, Merseyside, UK , is crucial for optimizing and scaling up chemical synthesis processes for new drug candidates. The ideal candidate will possess extensive experience in organic synthesis, process development, and chemical engineering principles, with a strong emphasis on safety, efficiency, and regulatory compliance. You will be responsible for developing robust, reproducible, and cost-effective manufacturing processes.
Responsibilities:
Responsibilities:
- Develop and optimize synthetic routes for APIs, focusing on scalability, safety, and cost-effectiveness.
- Conduct process hazard assessments and implement safety protocols for all chemical reactions.
- Scale up laboratory procedures to pilot plant and commercial manufacturing scales.
- Troubleshoot and resolve issues encountered during process development and manufacturing.
- Characterize intermediates and final APIs using analytical techniques such as HPLC, GC, NMR, and MS.
- Write detailed process development reports, batch records, and technical transfer documents.
- Collaborate with formulation scientists, analytical chemists, and engineers to ensure seamless product development.
- Ensure all processes comply with Good Manufacturing Practices (GMP) and other relevant regulatory guidelines.
- Stay current with advancements in synthetic organic chemistry, process technology, and analytical methods.
- Manage external contract manufacturing organizations (CMOs) for process development and scale-up activities.
- Contribute to intellectual property development and patent filings.
- Mentor junior chemists and provide technical guidance.
- Optimize reaction conditions to improve yield, purity, and reduce waste.
- PhD or Master's degree in Organic Chemistry, Chemical Engineering, or a related field.
- Minimum of 7 years of hands-on experience in process chemistry, with a focus on API development in the pharmaceutical industry.
- Demonstrated expertise in route scouting, process optimization, and scale-up of complex organic syntheses.
- Strong understanding of reaction kinetics, thermodynamics, and chemical engineering principles.
- Proficiency in a wide range of analytical techniques for characterization and impurity profiling.
- In-depth knowledge of GMP and regulatory requirements for pharmaceutical manufacturing.
- Excellent problem-solving and troubleshooting skills.
- Strong written and verbal communication skills, with the ability to present complex technical information clearly.
- Experience with process safety management and risk assessment methodologies.
- Ability to work effectively in a team-oriented, fast-paced environment.
- Previous experience with CMO management is a plus.
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3
Lead Process Chemist - API Development
NR1 1LL Norwich, Eastern
£55000 Annually
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Our client is seeking an accomplished Lead Process Chemist with extensive experience in Active Pharmaceutical Ingredient (API) development to join their dynamic pharmaceutical research and development department in Norwich, Norfolk, UK . This critical role involves leading the process chemistry team in the scale-up, optimization, and validation of synthetic routes for new drug candidates. You will be responsible for designing and executing laboratory experiments, troubleshooting complex synthetic challenges, and ensuring the development of robust, cost-effective, and environmentally sustainable manufacturing processes. A key aspect of this position is the rigorous application of quality control and compliance with Good Manufacturing Practices (GMP) and regulatory guidelines (e.g., FDA, EMA). You will be expected to mentor and guide junior chemists, foster a collaborative team environment, and manage project timelines effectively. This role requires a deep understanding of organic synthesis, reaction kinetics, process safety, and analytical techniques relevant to API characterization and impurity profiling. Experience with various purification techniques, crystallization studies, and solid-state characterization is essential. You will also be involved in the preparation of technical reports, regulatory submissions, and presentations to senior management and project teams. Collaboration with analytical development, formulation, and manufacturing departments is crucial for seamless technology transfer and successful drug product development. The ideal candidate will possess strong leadership capabilities, excellent problem-solving skills, and a meticulous attention to detail. A passion for pharmaceutical innovation and a commitment to delivering high-quality medicines are paramount. This is an excellent opportunity to make a significant impact within a growing pharmaceutical company.
Key Responsibilities:
Key Responsibilities:
- Lead and mentor a team of process chemists in API development projects.
- Develop, optimize, and scale-up synthetic routes for APIs.
- Conduct process hazard analyses and implement safety protocols.
- Perform and interpret analytical data (HPLC, GC, NMR, MS, XRPD).
- Manage crystallization studies and solid-state characterization.
- Ensure compliance with GMP, ICH, and regulatory requirements.
- Prepare comprehensive technical reports and regulatory documentation.
- Collaborate with cross-functional teams for technology transfer.
- Manage project timelines and resources effectively.
- PhD or MSc in Organic Chemistry, Process Chemistry, or a related field.
- Minimum of 8 years of experience in pharmaceutical process chemistry, with a focus on API development.
- Proven track record in scaling up complex synthetic routes from lab to pilot plant.
- Extensive knowledge of GMP, process safety, and regulatory affairs.
- Proficiency in various analytical techniques for compound characterization.
- Strong leadership, communication, and interpersonal skills.
- Experience with DOE (Design of Experiments) methodologies.
- Ability to troubleshoot complex chemical synthesis and scale-up challenges.
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4
Senior Process Chemist - API Development
LS1 1UR Leeds, Yorkshire and the Humber
£60000 Annually
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Our client, a leading pharmaceutical research and development company, is seeking a highly skilled and experienced Senior Process Chemist to join their innovative drug discovery and development team. This role operates on a hybrid model, offering a blend of on-site laboratory work at our facility in Leeds, West Yorkshire, UK , and flexible remote working. You will be instrumental in the development and optimisation of chemical processes for the synthesis of Active Pharmaceutical Ingredients (APIs), ensuring scalability, efficiency, and regulatory compliance. Your expertise will be crucial in translating laboratory-scale synthesis into robust manufacturing processes.
Key Responsibilities:
Key Responsibilities:
- Develop and optimise synthetic routes for small molecule APIs, focusing on yield improvement, cost reduction, and impurity profiling.
- Design and execute experiments to establish scalable, robust, and safe chemical processes suitable for pilot plant and commercial manufacturing.
- Utilise DoE (Design of Experiments) methodologies to efficiently explore process parameters and identify optimal operating conditions.
- Characterise intermediates and final APIs using a range of analytical techniques (e.g., HPLC, GC, NMR, MS, XRPD).
- Troubleshoot process-related issues encountered during scale-up and manufacturing.
- Write clear and comprehensive process development reports, batch records, and technical documentation.
- Ensure all laboratory activities and documentation comply with cGMP (current Good Manufacturing Practice) guidelines.
- Collaborate closely with analytical chemists, formulation scientists, and manufacturing teams.
- Conduct process hazard assessments and implement appropriate safety measures.
- Stay current with advancements in synthetic organic chemistry, process chemistry, and pharmaceutical manufacturing technologies.
- Contribute to the intellectual property portfolio through innovative process development.
- A PhD or Master's degree in Organic Chemistry, Process Chemistry, or a closely related discipline.
- A minimum of 6 years of post-doctoral or industrial experience in process chemistry within the pharmaceutical industry.
- Proven track record in developing and scaling up synthetic processes for APIs.
- Strong understanding of reaction kinetics, thermodynamics, and physical organic chemistry.
- Proficiency with common laboratory equipment and analytical instrumentation.
- Experience with DoE software and statistical analysis.
- Knowledge of cGMP requirements and regulatory guidelines.
- Excellent problem-solving, analytical, and organisational skills.
- Strong written and verbal communication skills.
- Ability to work effectively both independently and as part of a collaborative team in a hybrid work environment.
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5
Senior Process Chemist (API Development)
NG1 1AA Nottingham, East Midlands
£60000 Annually
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Posted 3 days ago
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Our client, a prominent pharmaceutical research and development company, is seeking an experienced Senior Process Chemist to join their vital team in Nottingham, Nottinghamshire, UK . This role is central to the development and optimization of chemical processes for Active Pharmaceutical Ingredients (APIs). You will be responsible for designing, executing, and scaling up synthetic routes, ensuring safety, efficiency, and compliance with regulatory standards. This position demands a rigorous scientific approach, exceptional problem-solving skills, and a deep understanding of organic chemistry and chemical engineering principles.
The ideal candidate will have extensive experience in process chemistry, with a strong focus on API development and manufacturing. You should be proficient in route scouting, reaction optimization, impurity profiling, and analytical method development. Experience with hazardous reactions, process safety assessments (e.g., HAZOP), and scale-up challenges is essential. You will work closely with analytical chemists, formulation scientists, and regulatory affairs specialists to advance projects from laboratory scale to pilot plant and potentially commercial production. Strong documentation skills and familiarity with Good Manufacturing Practices (GMP) are required. This role offers the opportunity to make a significant contribution to the development of life-saving medicines.
Key responsibilities include:
Qualifications: A PhD or Master's degree in Organic Chemistry, Process Chemistry, or a related field. A minimum of 5-7 years of experience in pharmaceutical process development, with a focus on API synthesis. Strong knowledge of organic synthesis, reaction mechanisms, and purification techniques. Experience with process analytical technology (PAT) and Quality by Design (QbD) principles is advantageous. Familiarity with regulatory requirements (FDA, EMA) for pharmaceutical manufacturing. Excellent problem-solving, analytical, and communication skills. Ability to work independently and as part of a team in a fast-paced R&D environment. This is a key role within a leading pharmaceutical company.
The ideal candidate will have extensive experience in process chemistry, with a strong focus on API development and manufacturing. You should be proficient in route scouting, reaction optimization, impurity profiling, and analytical method development. Experience with hazardous reactions, process safety assessments (e.g., HAZOP), and scale-up challenges is essential. You will work closely with analytical chemists, formulation scientists, and regulatory affairs specialists to advance projects from laboratory scale to pilot plant and potentially commercial production. Strong documentation skills and familiarity with Good Manufacturing Practices (GMP) are required. This role offers the opportunity to make a significant contribution to the development of life-saving medicines.
Key responsibilities include:
- Designing and optimizing synthetic routes for APIs.
- Conducting laboratory-scale experiments and process development studies.
- Performing reaction kinetics studies and impurity profiling.
- Developing and validating analytical methods for process monitoring and control.
- Scaling up chemical processes from laboratory to pilot plant and manufacturing scale.
- Conducting process safety assessments and implementing appropriate safety measures.
- Troubleshooting and resolving issues encountered during process development and scale-up.
- Collaborating with cross-functional teams, including analytical, formulation, and regulatory departments.
- Ensuring compliance with GMP, EHS, and other relevant regulatory guidelines.
- Documenting all experimental work and process development activities thoroughly.
Qualifications: A PhD or Master's degree in Organic Chemistry, Process Chemistry, or a related field. A minimum of 5-7 years of experience in pharmaceutical process development, with a focus on API synthesis. Strong knowledge of organic synthesis, reaction mechanisms, and purification techniques. Experience with process analytical technology (PAT) and Quality by Design (QbD) principles is advantageous. Familiarity with regulatory requirements (FDA, EMA) for pharmaceutical manufacturing. Excellent problem-solving, analytical, and communication skills. Ability to work independently and as part of a team in a fast-paced R&D environment. This is a key role within a leading pharmaceutical company.
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6
Senior Pharmaceutical Research Scientist - API Development
ST1 2JZ Staffordshire, West Midlands
£70000 Annually
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Posted 2 days ago
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Our client, a pioneering pharmaceutical company dedicated to advancing global health, is seeking an experienced Senior Pharmaceutical Research Scientist to join their state-of-the-art laboratories in **Stoke-on-Trent, Staffordshire, UK**. This critical role focuses on the development and optimisation of Active Pharmaceutical Ingredients (APIs), playing a vital part in bringing life-changing medications to patients. You will conduct cutting-edge research, contribute to process development, and ensure the highest standards of quality and regulatory compliance.
Responsibilities:
Responsibilities:
- Lead and execute research projects focused on the synthesis, characterisation, and optimisation of APIs.
- Develop and validate robust analytical methods for API characterisation and quality control.
- Design and perform experiments to identify and resolve complex challenges in API manufacturing processes.
- Collaborate with formulation scientists to ensure API properties are suitable for drug product development.
- Conduct literature reviews and stay abreast of the latest scientific advancements in pharmaceutical chemistry and process development.
- Author detailed research reports, protocols, and scientific publications.
- Ensure all laboratory activities comply with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) guidelines.
- Work closely with regulatory affairs teams to prepare documentation for regulatory submissions.
- Troubleshoot and resolve issues encountered during API synthesis and scale-up.
- Mentor junior scientists and contribute to a culture of scientific excellence and innovation.
- Participate in cross-functional team meetings to provide expert input on API development.
- Contribute to the selection and evaluation of new technologies and equipment for the R&D department.
- Ph.D. in Organic Chemistry, Pharmaceutical Chemistry, or a closely related field.
- Minimum of 5-7 years of post-doctoral or industrial experience in pharmaceutical R&D, with a strong focus on API development.
- Expertise in synthetic organic chemistry and medicinal chemistry.
- Hands-on experience with analytical techniques such as HPLC, GC, MS, NMR, and IR spectroscopy.
- Familiarity with process chemistry, scale-up, and manufacturing principles in a pharmaceutical context.
- Strong understanding of regulatory requirements (e.g., ICH guidelines, FDA, EMA).
- Excellent problem-solving, critical thinking, and experimental design skills.
- Proven ability to work independently and as part of a collaborative research team.
- Strong written and verbal communication skills, with the ability to present complex scientific information clearly.
- Experience working in a GLP/GMP compliant environment.
- Candidates must be based in or willing to relocate to the **Stoke-on-Trent, Staffordshire, UK** area to perform the laboratory-based duties.
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7
Remote Senior Backend Engineer (API Development)
PL1 2AA Plymouth, South West
£70000 Annually
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Posted 3 days ago
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We are searching for a highly skilled and experienced Senior Backend Engineer to join our innovative technology team, operating entirely remotely. This role is crucial for designing, developing, and maintaining robust, scalable, and high-performance backend systems and APIs that power our cutting-edge digital products. As a remote-first organization, we thrive on asynchronous communication, collaboration across time zones, and empowering our engineers with the autonomy to deliver exceptional work from anywhere. You will play a key role in architectural decisions, code quality, and mentoring junior developers.
Key Responsibilities:
Key Responsibilities:
- Design, build, and maintain efficient, reusable, and reliable code for our core backend services and APIs using modern languages and frameworks (e.g., Python/Django, Node.js/Express, Go, Java/Spring).
- Develop and implement robust API endpoints, ensuring scalability, security, and optimal performance.
- Collaborate closely with frontend developers, product managers, and other stakeholders to understand requirements and translate them into technical solutions.
- Write comprehensive unit, integration, and end-to-end tests to ensure code quality and system stability.
- Optimize application performance, identify bottlenecks, and implement solutions for improved efficiency.
- Contribute to architectural discussions and decision-making, helping to shape the future of our technology stack.
- Mentor and guide junior engineers, providing technical leadership and fostering best practices in coding, testing, and deployment.
- Participate in code reviews, offering constructive feedback to peers and maintaining high standards of code quality.
- Troubleshoot, debug, and resolve complex technical issues in production environments.
- Stay up-to-date with emerging technologies and industry trends, evaluating and recommending new tools and approaches.
- Contribute to documentation of APIs, system designs, and technical processes.
- Actively participate in remote team meetings and contribute to a collaborative and positive remote work culture.
- Bachelor's or Master's degree in Computer Science, Engineering, or a related field, or equivalent practical experience.
- 5+ years of professional experience in backend software development, with a strong focus on API design and implementation (RESTful, GraphQL).
- Proficiency in at least one major backend programming language (e.g., Python, Go, Java, Node.js) and associated frameworks.
- Extensive experience with database technologies (SQL and/or NoSQL), including schema design and query optimization.
- Solid understanding of cloud platforms (AWS, Azure, GCP) and containerization technologies (Docker, Kubernetes).
- Experience with message queues (e.g., Kafka, RabbitMQ) and caching mechanisms (e.g., Redis).
- Strong grasp of software design principles, data structures, algorithms, and architectural patterns.
- Excellent problem-solving and analytical skills.
- Proven ability to work independently and collaboratively in a remote team environment.
- Exceptional communication skills, both written and verbal, for effective remote collaboration.
- Experience with CI/CD pipelines and automated testing frameworks.
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8
Senior Pharmaceutical Development Scientist - API
SW1A 0AA London, London
£70000 Annually
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Our client, a distinguished biopharmaceutical company, is seeking a Senior Pharmaceutical Development Scientist specializing in Active Pharmaceutical Ingredient (API) development. This is a fully remote position, offering significant flexibility. You will be instrumental in the early-stage development and characterization of novel APIs, driving projects from discovery through to preclinical stages. Responsibilities include designing and executing laboratory experiments for API synthesis, purification, and formulation. You will perform detailed analytical characterization of APIs, utilizing techniques such as HPLC, GC, MS, NMR, and XRPD. A key aspect of this role involves troubleshooting synthesis routes, optimizing chemical processes for scalability, and ensuring compliance with Good Manufacturing Practices (GMP) and other relevant regulatory guidelines. The Senior Pharmaceutical Development Scientist will work collaboratively with medicinal chemists, analytical scientists, and CMC (Chemistry, Manufacturing, and Controls) teams to advance drug candidates. You will also be involved in the preparation of regulatory documentation, including IND (Investigational New Drug) filings. The ideal candidate will hold a Ph.D. or Master's degree in Organic Chemistry, Pharmaceutical Sciences, or a closely related field, with at least 5 years of relevant industry experience in API development. Proven expertise in synthetic organic chemistry and a strong understanding of physical and chemical characterization techniques are essential. Familiarity with process development and scale-up principles is highly desirable. Excellent scientific acumen, problem-solving abilities, and strong written and verbal communication skills are required to effectively present data and contribute to project strategy. This is a challenging and rewarding opportunity to contribute to the development of life-changing medicines.
Key Responsibilities:
Key Responsibilities:
- Lead the development and characterization of Active Pharmaceutical Ingredients (APIs).
- Design and execute API synthesis and purification experiments.
- Perform comprehensive analytical characterization of APIs.
- Optimize chemical processes for scalability and regulatory compliance.
- Troubleshoot synthesis and process-related issues.
- Collaborate with multidisciplinary R&D and CMC teams.
- Prepare documentation for regulatory submissions (e.g., IND).
- Ensure adherence to GMP and other industry standards.
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