1,126 Drug jobs in the United Kingdom
Senior Formulation Scientist - Drug Development
OX1 3QG Oxford, South East
£65000 Annually
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Posted 7 days ago
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Job Description
Our client, a groundbreaking pharmaceutical company at the forefront of medical innovation, is seeking a highly experienced Senior Formulation Scientist to join their dynamic research and development team. This is a fully remote position, offering an exceptional opportunity to contribute to the development of novel drug delivery systems and pharmaceutical products from your home laboratory or approved remote workspace. You will play a critical role in designing, optimizing, and characterizing drug formulations to meet stringent efficacy, safety, and regulatory standards.
Responsibilities:
Responsibilities:
- Lead the design, development, and optimization of innovative drug formulations (e.g., oral solid dosage forms, injectables, topical applications) for various therapeutic areas.
- Conduct pre-formulation studies to understand drug-excipient compatibility, physicochemical properties, and stability.
- Develop and validate analytical methods for characterizing formulations and assessing drug release profiles.
- Oversee formulation scale-up activities, ensuring successful technology transfer from lab to pilot and manufacturing scales.
- Prepare comprehensive technical documentation, including formulation development reports, analytical method validation reports, and regulatory submission documents.
- Collaborate closely with cross-functional teams, including analytical chemistry, process development, quality assurance, and regulatory affairs.
- Troubleshoot formulation challenges and implement robust solutions to ensure product quality and performance.
- Stay abreast of the latest advancements in pharmaceutical formulation science, drug delivery technologies, and relevant regulatory guidelines.
- Mentor and guide junior scientists, fostering a culture of scientific excellence and continuous learning.
- Manage external contract research organizations (CROs) for specific formulation development activities, ensuring project timelines and deliverables are met.
- PhD or Master's degree in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, or a related discipline.
- Minimum of 7 years of hands-on experience in pharmaceutical formulation development, with a proven track record in bringing drug products from concept to clinical trial stages.
- In-depth knowledge of various drug delivery systems and formulation techniques.
- Proficiency in relevant analytical techniques (e.g., HPLC, GC, DSC, XRPD) for formulation characterization.
- Strong understanding of pharmaceutical manufacturing processes and GMP requirements.
- Experience with regulatory guidelines (e.g., ICH, FDA, EMA) pertaining to drug development.
- Excellent problem-solving skills, with a keen attention to detail and the ability to interpret complex data.
- Exceptional written and verbal communication skills, with the ability to effectively present scientific findings.
- Proven ability to work independently and manage multiple projects in a remote research environment.
- Experience with statistical analysis software and design of experiments (DoE) is advantageous.
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Principal Formulation Scientist - Drug Development
NG1 6AE Nottingham, East Midlands
£80000 Annually
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Posted 17 days ago
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Job Description
Our client, a leading pharmaceutical company dedicated to advancing healthcare through innovative drug development, is seeking an experienced and highly skilled Principal Formulation Scientist to join their dynamic R&D team in Nottingham, Nottinghamshire, UK . This critical role will involve leading the development of novel drug delivery systems and innovative formulations for a diverse pipeline of pharmaceutical products. You will be at the forefront of designing, optimizing, and scaling up formulations, ensuring product efficacy, stability, and bioavailability. The ideal candidate will possess a deep understanding of pharmaceutical sciences, particularly in pre-formulation, formulation development, and manufacturing processes. Responsibilities include conducting pre-formulation studies, designing and executing experiments for solid dosage forms, sterile injectables, or other relevant delivery routes, and characterizing formulation performance. You will lead the troubleshooting of formulation challenges and provide expert scientific guidance to project teams. The Principal Formulation Scientist will play a key role in the transition of formulations from laboratory scale to clinical manufacturing and beyond. Collaboration with cross-functional teams, including analytical development, DMPK, regulatory affairs, and manufacturing, is essential. You will also contribute to the scientific strategy of the formulation department, stay abreast of emerging technologies, and potentially mentor junior scientists. A strong publication record and experience with intellectual property development are desirable. This hybrid role offers a blend of essential lab-based work and remote strategic planning and analysis, providing a balanced and productive work environment. This is an excellent opportunity to contribute to life-changing medicines within a supportive and scientifically driven organization in Nottingham .
Qualifications:
Qualifications:
- Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemistry, or a related field
- Minimum of 7 years of progressive experience in pharmaceutical formulation development
- Proven expertise in developing various dosage forms (e.g., oral solids, injectables, topical)
- Strong understanding of pre-formulation, excipient selection, and drug-excipient compatibility
- Hands-on experience with formulation characterization techniques (e.g., DSC, TGA, XRPD, dissolution)
- Experience with pilot-scale formulation manufacturing and technology transfer
- Knowledge of GMP guidelines and regulatory requirements for drug development
- Excellent problem-solving, analytical, and critical thinking skills
- Strong project management and organizational abilities
- Effective communication and interpersonal skills for cross-functional collaboration
- Ability to mentor junior scientists and contribute to scientific strategy
- Experience with specific therapeutic areas is a plus
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Pharmaceutical Formulation Scientist - Drug Development
MK9 2EZ Milton Keynes, South East
£60000 Annually
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Posted 17 days ago
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Job Description
Our client, a leading pharmaceutical company dedicated to advancing healthcare solutions, is seeking a skilled and innovative Pharmaceutical Formulation Scientist to join their research and development team in Milton Keynes, Buckinghamshire, UK . This role is pivotal in the early-stage development of novel drug formulations, contributing to the creation of effective and patient-centric medicines. The ideal candidate will possess a strong background in pharmaceutical sciences, with hands-on experience in formulation development and characterization. Responsibilities will include:
- Designing, developing, and optimizing oral solid dosage forms (tablets, capsules) and potentially other dosage forms.
- Conducting pre-formulation studies to understand the physicochemical properties of active pharmaceutical ingredients (APIs) and excipients.
- Evaluating and selecting appropriate excipients to achieve desired drug release profiles and stability.
- Utilizing various laboratory techniques for formulation preparation and characterization (e.g., particle size analysis, dissolution testing, differential scanning calorimetry).
- Developing and validating analytical methods for drug product testing.
- Conducting stability studies to assess the shelf-life and performance of formulations under various conditions.
- Troubleshooting formulation challenges and proposing innovative solutions.
- Collaborating with analytical development, process development, and regulatory affairs teams.
- Documenting experimental procedures, results, and reports in accordance with company standards and regulatory guidelines.
- Staying current with scientific literature and industry trends in pharmaceutical formulation and drug delivery.
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Senior Formulation Scientist - Innovative Drug Development
LE2 0AA Leicester, East Midlands
£55000 Annually
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Posted 1 day ago
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Job Description
Our client, a leading innovator in pharmaceutical research and development, is seeking a highly skilled and motivated Senior Formulation Scientist to join their dynamic team. This is an exciting opportunity to contribute to the development of cutting-edge therapeutic agents from pre-clinical stages through to clinical trials. The role will involve extensive laboratory work, data analysis, and collaboration with cross-functional teams.
Key Responsibilities:
Key Responsibilities:
- Design, develop, and optimize novel drug delivery systems and formulations for various routes of administration (e.g., oral, injectable, topical).
- Conduct pre-formulation studies, including API characterization, solubility enhancement, and stability assessment.
- Perform compatibility studies and develop analytical methods for drug substance and drug product characterization.
- Utilize a range of formulation technologies and equipment, including granulation, coating, lyophilization, and sterile manufacturing processes.
- Execute experiments meticulously, document all findings accurately in laboratory notebooks and reports, and present results to project teams and management.
- Troubleshoot formulation challenges and propose innovative solutions.
- Collaborate closely with analytical chemists, process engineers, and clinical development teams to ensure successful project progression.
- Stay abreast of the latest scientific literature, regulatory guidelines, and industry trends in pharmaceutical formulation.
- Contribute to the preparation of regulatory submission documents (e.g., IND, NDA).
- PhD or MSc in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related field.
- Minimum of 5 years of relevant experience in pharmaceutical formulation development, preferably within an R&D setting.
- Proven track record in developing various dosage forms, with a strong understanding of formulation science principles.
- Hands-on experience with laboratory equipment for formulation development and characterization.
- Proficiency in relevant analytical techniques (e.g., HPLC, GC, DSC, TGA, XRPD).
- Excellent understanding of Good Manufacturing Practice (GMP) and regulatory requirements.
- Strong problem-solving skills, attention to detail, and ability to work independently and as part of a team.
- Effective communication and interpersonal skills.
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3
Senior Clinical Research Scientist - Oncology Drug Development
M1 1AA Manchester, North West
£70000 Annually
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Posted today
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Our client, a leading biopharmaceutical innovator, is seeking a highly motivated Senior Clinical Research Scientist to join their cutting-edge oncology research team. This fully remote position offers the unique opportunity to contribute significantly to the development of novel cancer therapies from anywhere in the UK. You will be at the forefront of scientific advancement, playing a pivotal role in the design, execution, and interpretation of clinical trials that have the potential to transform patient lives.
Key Responsibilities:
Qualifications and Experience:
This is a crucial role for an accomplished scientist passionate about making a difference in the fight against cancer. Join our innovative client and shape the future of oncology treatments.
Key Responsibilities:
- Design and develop clinical trial protocols for oncology assets, ensuring scientific rigor and regulatory compliance.
- Oversee the execution of clinical studies, providing scientific and medical expertise to cross-functional teams.
- Analyze and interpret complex clinical trial data, including efficacy and safety endpoints.
- Collaborate with regulatory affairs, statistics, and medical writing teams to prepare submissions and publications.
- Stay abreast of the latest scientific advancements, emerging trends, and competitive landscape in oncology drug development.
- Identify and engage with key opinion leaders (KOLs) and investigators in the field.
- Contribute to the strategic planning and decision-making processes for the oncology portfolio.
- Develop and present scientific data internally and externally at conferences and meetings.
- Ensure adherence to Good Clinical Practice (GCP) guidelines and all relevant regulations.
- Mentor junior scientists and contribute to the growth of the research department.
Qualifications and Experience:
- Ph.D. or M.D. in a relevant life science discipline (e.g., Oncology, Immunology, Pharmacology).
- Minimum of 5-7 years of experience in clinical research and drug development, with a significant focus on oncology.
- Demonstrated experience in designing and managing complex clinical trials (Phase I-III).
- In-depth knowledge of oncology disease areas, drug mechanisms, and current treatment paradigms.
- Strong understanding of regulatory requirements (FDA, EMA) and GCP.
- Excellent analytical, statistical interpretation, and problem-solving skills.
- Exceptional written and verbal communication skills, with a proven track record of scientific publications and presentations.
- Ability to work effectively in a remote, fast-paced, and collaborative environment.
- Experience with data management systems and statistical analysis software is a plus.
- Strong leadership potential and ability to influence cross-functional teams.
This is a crucial role for an accomplished scientist passionate about making a difference in the fight against cancer. Join our innovative client and shape the future of oncology treatments.
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4
Principal Clinical Research Scientist - Oncology Drug Development
G1 1AA Glasgow, Scotland
£90000 Annually
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Posted 7 days ago
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Job Description
Our client, a leading pharmaceutical innovator, is seeking a highly accomplished Principal Clinical Research Scientist to spearhead critical oncology drug development programs. This role requires a deep scientific understanding of cancer biology, extensive experience in clinical trial design and execution, and a passion for bringing life-changing therapies to patients. You will collaborate with world-class researchers and clinicians to advance novel treatments from early-stage research through to regulatory submission.
Responsibilities:
Responsibilities:
- Lead the scientific strategy and design of Phase I-III clinical trials for novel oncology therapeutics.
- Oversee the development of clinical protocols, investigator brochures, and other essential study documents.
- Provide scientific and clinical expertise to cross-functional teams, including clinical operations, data management, regulatory affairs, and biomarker development.
- Analyze and interpret complex clinical trial data, translating findings into strategic recommendations for drug development.
- Prepare high-quality scientific publications, abstracts, and presentations for key medical conferences and journals.
- Engage with key opinion leaders (KOLs) in oncology to gather insights and foster collaboration.
- Contribute to regulatory submissions (e.g., IND, NDA) by preparing relevant clinical sections.
- Stay abreast of the latest advancements in oncology research, emerging therapeutic modalities, and competitive landscape.
- Mentor and guide junior scientists and clinical development professionals.
- Ensure all clinical research activities comply with GCP, regulatory guidelines, and company policies.
- Ph.D. or M.D. in a relevant life sciences discipline (e.g., Oncology, Immunology, Molecular Biology).
- Minimum of 10 years of experience in clinical drug development, with a strong focus on oncology.
- Demonstrated success in designing and leading complex clinical trials.
- Expertise in cancer biology, tumor microenvironment, and current therapeutic strategies.
- In-depth knowledge of GCP, regulatory requirements, and clinical trial methodologies.
- Proven ability to analyze and interpret clinical data effectively.
- Excellent scientific writing and communication skills, with a track record of publications and presentations.
- Strong leadership capabilities and experience working in a matrixed environment.
- Ability to travel to Glasgow, Scotland, UK as required for key meetings and site visits.
- Experience with immuno-oncology and targeted therapies is highly desirable.
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5
Principal Scientist - Drug Discovery & Development
MK9 2EB Milton Keynes, South East
£70000 Annually
WhatJobs
Posted 3 days ago
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Job Description
Our client, a pioneering biotechnology company at the forefront of therapeutic innovation, is seeking a highly accomplished Principal Scientist to lead critical research initiatives within their Drug Discovery & Development division. Based in Milton Keynes, Buckinghamshire, UK , this role is integral to advancing novel treatment modalities from early-stage research through to preclinical development. The successful candidate will bring a wealth of scientific expertise, a proven track record in research leadership, and a passion for translating scientific breakthroughs into life-changing medicines. This is a lab-based role requiring hands-on involvement and direct oversight of research activities.
Key Responsibilities:
Key Responsibilities:
- Design, execute, and interpret complex experiments to drive drug discovery programmes forward.
- Lead and mentor a team of talented research scientists and technicians, fostering a culture of scientific excellence and collaboration.
- Develop and validate novel assays and technologies to support drug discovery efforts.
- Identify and evaluate promising therapeutic targets and lead compounds.
- Oversee preclinical studies, including in vitro and in vivo models, to assess compound efficacy and safety.
- Collaborate effectively with cross-functional teams, including chemistry, pharmacology, toxicology, and translational science.
- Author high-quality scientific reports, manuscripts, and patent applications.
- Present research findings at internal meetings and external scientific conferences.
- Manage external collaborations with academic institutions and contract research organizations (CROs).
- Contribute to strategic planning for the R&D pipeline and portfolio management.
- Ensure compliance with all relevant laboratory safety regulations and best practices.
- Stay abreast of the latest scientific advancements and competitive landscape in relevant therapeutic areas.
- Ph.D. in Pharmacology, Molecular Biology, Biochemistry, Immunology, or a related life science discipline.
- Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong focus on drug discovery.
- Demonstrated leadership experience in managing scientific teams and projects.
- Deep expertise in (Specific therapeutic area relevant to fictional company, e.g., oncology, infectious diseases, neuroscience) and associated drug discovery methodologies.
- Proficiency in a wide range of in vitro and in vivo experimental techniques.
- Proven ability to design and execute complex research strategies and troubleshoot effectively.
- Excellent analytical, problem-solving, and critical thinking skills.
- Exceptional written and verbal communication skills, with a track record of publications and presentations.
- Experience with biostatistics and data analysis software.
- Strong project management skills and the ability to manage multiple priorities.
- A passion for scientific innovation and a commitment to developing novel therapeutics.
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6
Principal Scientist - Drug Discovery & Development
G2 1EU Glasgow, Scotland
£80000 Annually
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Posted 7 days ago
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Job Description
Our client, a renowned pharmaceutical research and development company located in Glasgow, Scotland, UK , is seeking a highly accomplished Principal Scientist to lead critical initiatives in drug discovery and development. This senior role is responsible for driving innovation, designing experimental strategies, and executing complex research projects aimed at identifying and advancing novel therapeutic candidates. You will play a key part in shaping the company's R&D pipeline, leveraging your deep scientific expertise to overcome research challenges and accelerate the progression of drug candidates through preclinical and early clinical stages. The ideal candidate will possess a strong track record in medicinal chemistry, pharmacology, or a related discipline, with a comprehensive understanding of the drug discovery process from target identification to candidate selection. Proven experience in leading scientific teams, managing research projects, and mentoring junior scientists is essential. You must demonstrate excellent analytical and problem-solving skills, with the ability to interpret complex data, draw insightful conclusions, and make critical research decisions. Strong communication and presentation skills are required to effectively convey scientific findings to internal stakeholders, including senior management and cross-functional teams, as well as external collaborators. Proficiency with relevant laboratory techniques, data analysis software, and scientific literature databases is expected. This hybrid position offers the benefit of collaborative laboratory work and team meetings, combined with the flexibility of focused remote work. We are looking for a visionary scientific leader with a passion for innovation and a commitment to developing life-changing medicines. A Ph.D. in a relevant scientific field (e.g., Pharmacology, Medicinal Chemistry, Biochemistry) and a minimum of 10 years of progressive experience in the pharmaceutical industry are required. Join our esteemed team in Glasgow and make a significant impact on global health.
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7
Principal Scientist - Drug Discovery & Development
ST1 5NB Staffordshire, West Midlands
£75000 Annually
WhatJobs
Posted 7 days ago
Job Viewed
Job Description
Our client, a rapidly growing pharmaceutical company dedicated to discovering and developing life-changing medicines, is seeking a highly accomplished Principal Scientist to join their remote-first research team. This pivotal role is essential for driving innovation in drug discovery and development. You will leverage your deep scientific expertise to design and execute complex research projects, mentor junior scientists, and contribute to strategic decision-making. This is an exceptional opportunity to make a tangible impact on patient lives from the comfort of your home office.
Key Responsibilities:
Key Responsibilities:
- Lead and execute complex research projects focused on novel therapeutic targets and drug candidates.
- Design and implement in vitro and in vivo experimental studies to assess drug efficacy, safety, and pharmacokinetics.
- Analyze and interpret complex biological data, drawing insightful conclusions and proposing next steps.
- Develop and validate new assays and methodologies to support drug discovery programs.
- Collaborate effectively with internal teams (chemistry, biology, DMPK) and external partners to advance pipeline projects.
- Provide scientific leadership and mentorship to junior scientists and research associates.
- Stay at the forefront of scientific literature, identifying emerging trends and opportunities in pharmaceutical research.
- Prepare high-quality scientific reports, presentations, and manuscripts for internal and external dissemination.
- Contribute to the strategic direction of the company's research pipeline and portfolio.
- PhD in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
- 10+ years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
- Proven track record of successfully leading drug discovery projects from target identification through preclinical development.
- Extensive experience with various biological assays, molecular biology techniques, and cell-based models.
- Strong understanding of immunology, oncology, or other relevant therapeutic areas.
- Demonstrated ability to design, execute, and interpret complex experiments.
- Exceptional critical thinking, problem-solving, and analytical skills.
- Excellent written and verbal communication skills, with a talent for presenting complex scientific information.
- Experience mentoring and managing scientific staff is essential.
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8
Principal Scientist - Drug Discovery & Development
BD3 0HF Bradford, Yorkshire and the Humber
£75000 Annually
WhatJobs
Posted 17 days ago
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Job Description
Our client is a leading pharmaceutical innovator seeking a highly accomplished Principal Scientist to drive critical drug discovery and development initiatives within their state-of-the-art research facility located in **Bradford, West Yorkshire, UK**. This pivotal role involves leading complex research projects, from target identification and validation through to preclinical development, contributing significantly to the company's pipeline of novel therapeutics. You will leverage your deep scientific expertise and extensive experience to guide research strategies, foster innovation, and ensure the efficient progression of drug candidates.
Key Responsibilities:
Key Responsibilities:
- Lead and manage multiple drug discovery projects from concept to preclinical candidate selection.
- Design and execute complex biological experiments to investigate disease mechanisms and identify novel therapeutic targets.
- Develop and optimize assay development strategies for high-throughput screening and compound characterization.
- Analyze and interpret experimental data, making critical decisions on project direction and go/no-go criteria.
- Collaborate closely with internal teams (e.g., medicinal chemistry, pharmacology, DMPK) and external partners to advance drug candidates.
- Stay current with scientific literature and emerging technologies in relevant therapeutic areas and drug discovery methodologies.
- Prepare and present research findings to senior management, scientific committees, and at external conferences.
- Contribute to the development of intellectual property and regulatory submissions.
- Mentor and guide junior scientists, fostering a culture of scientific excellence and collaboration.
- Ensure compliance with all relevant safety, ethical, and regulatory guidelines.
- Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a closely related life science discipline.
- A minimum of 8-10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
- Demonstrated success in leading drug discovery projects and bringing candidates into preclinical development.
- Extensive knowledge of various drug discovery platforms and modalities (e.g., small molecules, biologics).
- Proficiency in experimental design, data analysis, and interpretation using relevant software.
- Excellent understanding of relevant therapeutic areas (e.g., oncology, immunology, neuroscience).
- Strong leadership, project management, and communication skills.
- Proven ability to work effectively in a multidisciplinary, matrixed environment.
- Experience with manuscript preparation and scientific presentation is essential.
- A strong publication record in peer-reviewed journals is highly desirable.
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