5,729 Drug Discovery Scientist jobs in the United Kingdom
Principal Drug Discovery Scientist
Posted 21 days ago
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Job Description
- Define and lead scientific strategy for drug discovery programs.
- Design and oversee complex biological and pharmacological experiments.
- Identify and validate novel drug targets and therapeutic hypotheses.
- Guide the development of small molecules and/or biologics candidates.
- Manage and mentor a team of research scientists.
- Foster collaborations with academic institutions and industry partners.
- Stay at the forefront of scientific advancements and implement new technologies.
- Contribute to patent applications and scientific publications.
- Present research findings to senior leadership and external stakeholders.
- PhD in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
- 10+ years of progressive experience in drug discovery and development within the pharmaceutical or biotech industry.
- Proven track record of successfully advancing drug candidates into preclinical and/or clinical development.
- Deep expertise in relevant disease areas and drug discovery methodologies.
- Exceptional leadership, team management, and strategic planning skills.
- Strong understanding of medicinal chemistry, pharmacokinetics, and toxicology.
- Excellent written and verbal communication and presentation skills.
- Ability to thrive in a highly collaborative, remote research environment.
Principal Drug Discovery Scientist - Oncology
Posted today
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Senior Drug Discovery Scientist (Oncology)
Posted 11 days ago
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Job Description
Responsibilities:
- Lead and execute research projects focused on identifying novel oncology targets and developing targeted therapies.
- Design and implement in vitro and ex vivo assays to evaluate drug candidates for efficacy and mechanism of action.
- Utilize cutting-edge technologies and methodologies in cancer biology, genomics, and proteomics.
- Collaborate with medicinal chemists and pharmacologists to optimize lead compounds.
- Analyze and interpret complex biological data, drawing meaningful conclusions and making strategic recommendations.
- Prepare high-quality scientific reports, manuscripts for publication, and presentations for internal and external forums.
- Stay abreast of the latest advancements in oncology research and drug discovery through literature review and conference attendance.
- Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
- Contribute to the development of intellectual property, including patent filings.
- Ensure meticulous experimental design, data integrity, and adherence to laboratory best practices.
- PhD in Cancer Biology, Molecular Biology, Pharmacology, or a closely related field.
- A minimum of 5 years of post-doctoral or industry experience in oncology drug discovery.
- Proven expertise in cancer cell biology, tumor microenvironment, or immunotherapy.
- Hands-on experience with a variety of cellular assays, molecular biology techniques, and potentially in vivo models.
- Strong understanding of small molecule and/or biologics drug discovery processes.
- Demonstrated ability to design, execute, and interpret complex experiments.
- Excellent analytical and problem-solving skills.
- Exceptional written and oral communication skills, with a strong publication record in reputable journals.
- Ability to work independently and lead projects in a remote setting.
- A passion for advancing cancer treatment and a commitment to scientific rigor.
Lead Drug Discovery Scientist (Oncology)
Posted 13 days ago
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Job Description
Key responsibilities include designing and executing cutting-edge research strategies, identifying and validating novel oncology targets, and developing small molecule or biologic drug candidates. You will collaborate closely with internal multidisciplinary teams, including medicinal chemists, pharmacologists, and translational scientists, as well as external academic and industry partners. The successful candidate will analyze complex biological data, interpret results, and make critical decisions to advance discovery projects. You will also contribute to the preparation of research publications, patent applications, and regulatory submissions.
This role demands a deep understanding of cancer biology, molecular pathways, and current therapeutic strategies in oncology. Strong leadership, project management, and communication skills are essential. You should be adept at mentoring junior scientists, fostering a collaborative and innovative research environment, and effectively communicating scientific findings to diverse audiences. The ability to critically evaluate scientific literature and emerging trends in oncology research is paramount. This is an exceptional opportunity to make a significant contribution to the fight against cancer by leading groundbreaking research initiatives from a remote work setting.
Qualifications:
- Ph.D. in Cancer Biology, Molecular Biology, Immunology, or a related life science discipline.
- Minimum of 7 years of post-doctoral or industrial experience in oncology drug discovery.
- Proven track record of leading successful drug discovery projects and contributing to pipeline advancement.
- In-depth knowledge of cancer biology, signaling pathways, and therapeutic modalities.
- Experience with various in vitro and in vivo preclinical models of cancer.
- Proficiency in experimental design, data analysis, and interpretation.
- Strong publication record and/or patent filings in oncology research.
- Excellent leadership, mentorship, and project management skills.
- Strong written and verbal communication skills, with experience in remote team collaboration.
Lead Drug Discovery Scientist - Oncology
Posted 18 days ago
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Job Description
Key responsibilities include designing and overseeing complex biological assays, managing external research collaborations, and interpreting sophisticated experimental data. You will play a pivotal role in setting the scientific vision for oncology drug discovery, ensuring alignment with the company's strategic goals. This involves staying abreast of the latest scientific advancements, competitive landscape, and regulatory requirements within the oncology field. You will be responsible for project management, resource allocation, and fostering a culture of scientific rigor and innovation within the discovery team. The ability to effectively communicate complex scientific concepts to diverse audiences, including senior management, regulatory bodies, and external partners, is essential.
The ideal candidate will possess a PhD in Molecular Biology, Pharmacology, Biochemistry, or a related discipline, with a minimum of 8 years of progressive experience in pharmaceutical R&D, with a significant focus on oncology drug discovery. Proven experience in leading research teams and managing drug discovery projects from inception to preclinical candidate selection is mandatory. A strong publication record in peer-reviewed journals and experience with small molecule and/or biologics discovery are highly desirable. This position is fully remote, requiring exceptional self-management, organizational skills, and the ability to collaborate effectively across distributed teams using advanced digital communication tools. We are looking for a strategic thinker with a passion for developing life-saving medicines and a deep commitment to scientific excellence. Your contributions will be instrumental in bringing transformative cancer treatments to patients.
Principal Drug Discovery Scientist (Oncology)
Posted 22 days ago
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Job Description
Key Responsibilities:
- Lead and execute cutting-edge drug discovery projects in oncology, from target identification through lead optimization.
- Design and implement experimental strategies to validate novel therapeutic targets and pathways.
- Oversee the synthesis and characterization of novel small molecule inhibitors and/or biologics.
- Collaborate closely with internal and external partners, including academic institutions and contract research organizations (CROs).
- Analyze and interpret complex biological and chemical data, making critical decisions to advance projects.
- Develop and troubleshoot in vitro and in vivo assays to assess compound efficacy and mechanism of action.
- Contribute to the strategic direction of the oncology discovery portfolio.
- Mentor and guide junior scientists, fostering a collaborative and high-performing research environment.
- Prepare high-quality scientific reports, publications, and patent applications.
- Present research findings at scientific conferences and internal meetings.
- Ensure compliance with all relevant safety and ethical guidelines.
- Manage project timelines and resources effectively in a remote setting.
- Ph.D. in Molecular Biology, Pharmacology, Biochemistry, Chemistry, or a related life science field.
- Minimum of 8 years of post-doctoral experience in drug discovery, with a significant focus on oncology research.
- Demonstrated success in identifying and advancing oncology drug candidates.
- Extensive experience in cancer biology, including signaling pathways, tumor microenvironment, and immunology.
- Strong expertise in either medicinal chemistry, small molecule drug design, or biologics development (e.g., antibody engineering).
- Proficiency in relevant experimental techniques (e.g., cell-based assays, molecular biology techniques, in vivo pharmacology models).
- Proven ability to think critically, solve complex problems, and drive research independently.
- Excellent leadership, communication, and interpersonal skills, essential for remote collaboration.
- Track record of scientific publications and/or patents.
- Experience managing CRO relationships and projects.
- Must be comfortable working autonomously and managing workload in a remote-first environment.
Lead Drug Discovery Scientist - AI Integration
Posted 5 days ago
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Job Description
Responsibilities:
- Lead the integration of AI/ML methodologies into drug discovery programs.
- Collaborate with computational, biological, and data science teams.
- Develop and validate predictive models for drug discovery and development.
- Analyze and interpret complex biological and chemical datasets using AI/ML tools.
- Design and oversee experimental validation of AI-generated hypotheses.
- Drive innovation in target identification, lead generation, and optimization.
- Communicate complex scientific findings to both technical and non-technical audiences.
- Contribute to the strategic direction of the drug discovery portfolio.
- Mentor junior scientists and foster a collaborative research environment.
- Stay current with advancements in AI, machine learning, and pharmaceutical sciences.
- Ph.D. in Pharmacology, Cheminformatics, Computational Biology, or a related discipline.
- Minimum of 7 years of experience in drug discovery, with a significant focus on AI/ML applications.
- Demonstrated expertise in applying machine learning algorithms to biological or chemical data.
- Strong understanding of pharmaceutical R&D processes.
- Excellent programming skills (e.g., Python, R) and familiarity with relevant libraries.
- Proven ability to lead and mentor scientific teams.
- Exceptional problem-solving, analytical, and critical thinking skills.
- Outstanding written and verbal communication abilities for remote settings.
- Experience with cloud computing platforms and big data technologies is a plus.
- A track record of scientific publications and presentations.
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Principal Drug Discovery Scientist - Small Molecules
Posted 15 days ago
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Key Responsibilities:
- Lead medicinal chemistry efforts in the design, synthesis, and optimisation of novel small molecule drug candidates.
- Drive research programs from hit identification through to lead optimisation and preclinical candidate selection.
- Develop and implement innovative synthetic strategies to access complex molecular architectures.
- Utilise structure-based drug design principles and computational chemistry tools to guide optimisation efforts.
- Collaborate effectively with biologists, pharmacologists, ADMET scientists, and other disciplines to advance drug discovery projects.
- Provide scientific leadership and mentorship to junior chemists and research associates.
- Interpret and present complex experimental data to project teams, management, and at scientific conferences.
- Stay abreast of the latest advancements in medicinal chemistry, synthetic organic chemistry, and relevant therapeutic areas.
- Contribute to the strategic direction of the drug discovery portfolio and identify new opportunities.
- Author high-impact scientific publications and patent applications.
- Ensure compliance with all relevant safety, ethical, and regulatory guidelines.
- Manage external collaborations and outsourced synthesis activities as needed.
Qualifications:
- PhD in Organic Chemistry, Medicinal Chemistry, or a closely related field.
- Minimum of 10 years of progressive experience in pharmaceutical drug discovery, with a strong focus on small molecule medicinal chemistry.
- Demonstrated success in delivering preclinical drug candidates for development.
- Expertise in synthetic organic chemistry, including route design and execution of complex syntheses.
- In-depth understanding of structure-activity relationships (SAR) and structure-property relationships (SPR).
- Experience with various drug discovery modalities and therapeutic areas is desirable.
- Strong knowledge of computational chemistry and structure-based drug design techniques.
- Proven ability to lead research projects and mentor scientific staff.
- Excellent analytical, problem-solving, and critical thinking skills.
- Outstanding oral and written communication skills, with a strong publication record.
- Ability to work effectively in a highly collaborative, multidisciplinary team environment.
- Familiarity with patent law and intellectual property strategies.
This is a distinguished opportunity for an accomplished Principal Scientist to shape the future of drug discovery within a leading organisation in **Oxford, Oxfordshire, UK**.
Principal Scientist - Drug Discovery & Development
Posted today
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Job Description
Key Responsibilities:
- Lead and manage multiple drug discovery projects from concept to preclinical candidate selection.
- Design and execute complex biological experiments to investigate disease mechanisms and identify novel therapeutic targets.
- Develop and optimize assay development strategies for high-throughput screening and compound characterization.
- Analyze and interpret experimental data, making critical decisions on project direction and go/no-go criteria.
- Collaborate closely with internal teams (e.g., medicinal chemistry, pharmacology, DMPK) and external partners to advance drug candidates.
- Stay current with scientific literature and emerging technologies in relevant therapeutic areas and drug discovery methodologies.
- Prepare and present research findings to senior management, scientific committees, and at external conferences.
- Contribute to the development of intellectual property and regulatory submissions.
- Mentor and guide junior scientists, fostering a culture of scientific excellence and collaboration.
- Ensure compliance with all relevant safety, ethical, and regulatory guidelines.
- Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a closely related life science discipline.
- A minimum of 8-10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
- Demonstrated success in leading drug discovery projects and bringing candidates into preclinical development.
- Extensive knowledge of various drug discovery platforms and modalities (e.g., small molecules, biologics).
- Proficiency in experimental design, data analysis, and interpretation using relevant software.
- Excellent understanding of relevant therapeutic areas (e.g., oncology, immunology, neuroscience).
- Strong leadership, project management, and communication skills.
- Proven ability to work effectively in a multidisciplinary, matrixed environment.
- Experience with manuscript preparation and scientific presentation is essential.
- A strong publication record in peer-reviewed journals is highly desirable.
Principal Scientist - Drug Discovery & Development
Posted 14 days ago
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Job Description
Key Responsibilities:
- Lead and manage cutting-edge research projects focused on the discovery and development of novel therapeutics for unmet medical needs.
- Design and implement innovative experimental strategies to identify and validate drug targets.
- Oversee the synthesis, characterization, and optimization of potential drug candidates, utilizing expertise in medicinal chemistry or pharmacology.
- Provide scientific leadership and mentorship to a team of research scientists and technicians.
- Develop and maintain strong collaborations with internal R&D teams, external academic institutions, and CROs.
- Interpret complex scientific data, draw conclusions, and make strategic recommendations for project progression.
- Prepare high-quality research reports, publications, and patent applications.
- Ensure all research activities adhere to stringent quality, safety, and regulatory standards.
- Contribute to the strategic direction of the drug discovery portfolio.
- Present research findings at internal reviews and external scientific conferences.
- Manage budgets and resources allocated to research projects.
- Stay abreast of the latest scientific advancements and emerging technologies in relevant therapeutic areas.
- PhD in Pharmacology, Medicinal Chemistry, Biochemistry, Molecular Biology, or a closely related field.
- Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
- Demonstrated success in leading drug discovery programs from target identification to pre-clinical candidate selection.
- Extensive knowledge of drug discovery processes, including target validation, lead identification, and lead optimization.
- Proven expertise in a specific therapeutic area (e.g., oncology, immunology, CNS).
- Strong understanding of modern drug discovery technologies and methodologies.
- Excellent leadership, team management, and mentoring skills.
- Exceptional analytical, problem-solving, and critical thinking abilities.
- Strong publication record and experience with patent filings.
- Excellent written and verbal communication skills, with the ability to effectively present complex scientific information.
- Experience working within a GLP environment is advantageous.
This is a unique opportunity to shape the future of medicine within a world-class research environment in Manchester.