5,729 Drug Discovery Scientist jobs in the United Kingdom

Principal Drug Discovery Scientist

OX1 3PA Oxford, South East £75000 Annually WhatJobs

Posted 21 days ago

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full-time
Our client, a pioneering biopharmaceutical company, is seeking a highly accomplished and visionary Principal Drug Discovery Scientist to lead critical research initiatives. This fully remote position offers a unique opportunity to drive innovation from the forefront of pharmaceutical research, working on groundbreaking therapeutic targets. You will be responsible for setting the scientific direction for drug discovery programs, designing and executing complex experimental strategies, and translating novel biological insights into potential drug candidates. Key aspects of the role include leading multidisciplinary teams, managing external collaborations, and staying abreast of the latest scientific advancements and emerging technologies. The ideal candidate will possess a deep understanding of molecular biology, pharmacology, and medicinal chemistry, with a proven track record of success in bringing drug candidates from discovery through preclinical development. Expertise in specific therapeutic areas and experience with advanced screening platforms (e.g., high-throughput screening, AI-driven drug design) is highly desirable. This role demands exceptional leadership qualities, strategic thinking, and the ability to inspire and mentor a team of talented scientists. You will be instrumental in shaping the company's R&D pipeline and contributing to the development of life-changing medicines. The ability to communicate complex scientific information clearly and persuasively to both scientific and non-scientific audiences is crucial. We are looking for an independent, motivated individual who can thrive in a fast-paced, remote research environment and make significant contributions to drug discovery. Responsibilities:
  • Define and lead scientific strategy for drug discovery programs.
  • Design and oversee complex biological and pharmacological experiments.
  • Identify and validate novel drug targets and therapeutic hypotheses.
  • Guide the development of small molecules and/or biologics candidates.
  • Manage and mentor a team of research scientists.
  • Foster collaborations with academic institutions and industry partners.
  • Stay at the forefront of scientific advancements and implement new technologies.
  • Contribute to patent applications and scientific publications.
  • Present research findings to senior leadership and external stakeholders.
Qualifications:
  • PhD in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
  • 10+ years of progressive experience in drug discovery and development within the pharmaceutical or biotech industry.
  • Proven track record of successfully advancing drug candidates into preclinical and/or clinical development.
  • Deep expertise in relevant disease areas and drug discovery methodologies.
  • Exceptional leadership, team management, and strategic planning skills.
  • Strong understanding of medicinal chemistry, pharmacokinetics, and toxicology.
  • Excellent written and verbal communication and presentation skills.
  • Ability to thrive in a highly collaborative, remote research environment.
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Principal Drug Discovery Scientist - Oncology

MK9 2BN Milton Keynes, South East £80000 Annually WhatJobs

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full-time
Our client, an innovative and leading biopharmaceutical company at the forefront of developing novel therapies, is seeking a highly experienced and accomplished Principal Drug Discovery Scientist to join their cutting-edge oncology research team. This is a fully remote position, allowing you to contribute to groundbreaking research from the comfort of your home office. The ideal candidate will possess a strong scientific background, a deep understanding of oncology biology, and a proven track record in small molecule or antibody drug discovery. You will play a critical role in the design, execution, and interpretation of experiments aimed at identifying and validating new drug targets and developing promising drug candidates for cancer treatment. Responsibilities include leading research projects, managing external collaborations with academic institutions and contract research organisations (CROs), and contributing to the strategic direction of the oncology pipeline. You will be expected to analyse complex biological data, interpret experimental results, and present findings to internal stakeholders and potentially at scientific conferences. A key aspect of this role involves staying abreast of the latest advancements in oncology research, cancer biology, and medicinal chemistry, and integrating this knowledge into the company's drug discovery efforts. Mentoring junior scientists and contributing to a collaborative and dynamic research environment will also be integral. The successful applicant will hold a PhD in a relevant scientific discipline (e.g., Molecular Biology, Biochemistry, Pharmacology, Oncology) and have a minimum of 7-10 years of post-doctoral experience in drug discovery within the pharmaceutical or biotechnology industry. Expertise in cancer cell biology, signalling pathways, preclinical models of cancer, and relevant assay development is essential. Excellent written and verbal communication skills, strong leadership abilities, and a passion for translating scientific discoveries into life-saving medicines are paramount. This is an exceptional opportunity to drive innovation and make a significant impact in the fight against cancer.
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Senior Drug Discovery Scientist (Oncology)

SW1A 0AA London, London £60000 Annually WhatJobs

Posted 11 days ago

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full-time
Our client, a pioneering biopharmaceutical company at the forefront of cancer research, is actively recruiting a Senior Drug Discovery Scientist specializing in Oncology to join their fully remote, world-class research team. This role is pivotal in advancing our pipeline of innovative cancer therapeutics, requiring a deep understanding of cancer biology, target validation, and early-stage drug discovery.

Responsibilities:
  • Lead and execute research projects focused on identifying novel oncology targets and developing targeted therapies.
  • Design and implement in vitro and ex vivo assays to evaluate drug candidates for efficacy and mechanism of action.
  • Utilize cutting-edge technologies and methodologies in cancer biology, genomics, and proteomics.
  • Collaborate with medicinal chemists and pharmacologists to optimize lead compounds.
  • Analyze and interpret complex biological data, drawing meaningful conclusions and making strategic recommendations.
  • Prepare high-quality scientific reports, manuscripts for publication, and presentations for internal and external forums.
  • Stay abreast of the latest advancements in oncology research and drug discovery through literature review and conference attendance.
  • Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
  • Contribute to the development of intellectual property, including patent filings.
  • Ensure meticulous experimental design, data integrity, and adherence to laboratory best practices.
Qualifications:
  • PhD in Cancer Biology, Molecular Biology, Pharmacology, or a closely related field.
  • A minimum of 5 years of post-doctoral or industry experience in oncology drug discovery.
  • Proven expertise in cancer cell biology, tumor microenvironment, or immunotherapy.
  • Hands-on experience with a variety of cellular assays, molecular biology techniques, and potentially in vivo models.
  • Strong understanding of small molecule and/or biologics drug discovery processes.
  • Demonstrated ability to design, execute, and interpret complex experiments.
  • Excellent analytical and problem-solving skills.
  • Exceptional written and oral communication skills, with a strong publication record in reputable journals.
  • Ability to work independently and lead projects in a remote setting.
  • A passion for advancing cancer treatment and a commitment to scientific rigor.
This fully remote position offers an exceptional opportunity to contribute to life-saving research, collaborate with leading experts, and drive innovation in the fight against cancer, all within a flexible and stimulating work environment.
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Lead Drug Discovery Scientist (Oncology)

EH7 5HB Edinburgh, Scotland £70000 Annually WhatJobs

Posted 13 days ago

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full-time
Our client, a pioneering pharmaceutical company, is seeking an experienced Lead Drug Discovery Scientist with a focus on Oncology to join their research team in a fully remote capacity. This senior role is integral to driving innovative oncology drug discovery programs from target identification through to pre-clinical development. You will lead a team of scientists, contribute to strategic research planning, and manage multiple research projects aimed at developing novel cancer therapies.

Key responsibilities include designing and executing cutting-edge research strategies, identifying and validating novel oncology targets, and developing small molecule or biologic drug candidates. You will collaborate closely with internal multidisciplinary teams, including medicinal chemists, pharmacologists, and translational scientists, as well as external academic and industry partners. The successful candidate will analyze complex biological data, interpret results, and make critical decisions to advance discovery projects. You will also contribute to the preparation of research publications, patent applications, and regulatory submissions.

This role demands a deep understanding of cancer biology, molecular pathways, and current therapeutic strategies in oncology. Strong leadership, project management, and communication skills are essential. You should be adept at mentoring junior scientists, fostering a collaborative and innovative research environment, and effectively communicating scientific findings to diverse audiences. The ability to critically evaluate scientific literature and emerging trends in oncology research is paramount. This is an exceptional opportunity to make a significant contribution to the fight against cancer by leading groundbreaking research initiatives from a remote work setting.

Qualifications:
  • Ph.D. in Cancer Biology, Molecular Biology, Immunology, or a related life science discipline.
  • Minimum of 7 years of post-doctoral or industrial experience in oncology drug discovery.
  • Proven track record of leading successful drug discovery projects and contributing to pipeline advancement.
  • In-depth knowledge of cancer biology, signaling pathways, and therapeutic modalities.
  • Experience with various in vitro and in vivo preclinical models of cancer.
  • Proficiency in experimental design, data analysis, and interpretation.
  • Strong publication record and/or patent filings in oncology research.
  • Excellent leadership, mentorship, and project management skills.
  • Strong written and verbal communication skills, with experience in remote team collaboration.
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Lead Drug Discovery Scientist - Oncology

EH1 1BG Edinburgh, Scotland £85000 Annually WhatJobs

Posted 18 days ago

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full-time
Our client, a leading pharmaceutical innovator, is seeking a highly motivated and experienced Lead Drug Discovery Scientist specializing in Oncology. This is a fully remote, critical role focused on driving the early-stage discovery and development of novel cancer therapeutics. You will be responsible for leading a talented team of scientists, defining research strategies, and executing programs aimed at identifying and validating new drug targets and lead compounds. Your expertise will be crucial in advancing our client's oncology pipeline from target identification through to preclinical development.

Key responsibilities include designing and overseeing complex biological assays, managing external research collaborations, and interpreting sophisticated experimental data. You will play a pivotal role in setting the scientific vision for oncology drug discovery, ensuring alignment with the company's strategic goals. This involves staying abreast of the latest scientific advancements, competitive landscape, and regulatory requirements within the oncology field. You will be responsible for project management, resource allocation, and fostering a culture of scientific rigor and innovation within the discovery team. The ability to effectively communicate complex scientific concepts to diverse audiences, including senior management, regulatory bodies, and external partners, is essential.

The ideal candidate will possess a PhD in Molecular Biology, Pharmacology, Biochemistry, or a related discipline, with a minimum of 8 years of progressive experience in pharmaceutical R&D, with a significant focus on oncology drug discovery. Proven experience in leading research teams and managing drug discovery projects from inception to preclinical candidate selection is mandatory. A strong publication record in peer-reviewed journals and experience with small molecule and/or biologics discovery are highly desirable. This position is fully remote, requiring exceptional self-management, organizational skills, and the ability to collaborate effectively across distributed teams using advanced digital communication tools. We are looking for a strategic thinker with a passion for developing life-saving medicines and a deep commitment to scientific excellence. Your contributions will be instrumental in bringing transformative cancer treatments to patients.
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Principal Drug Discovery Scientist (Oncology)

M1 1AE Manchester, North West £75000 Annually WhatJobs

Posted 22 days ago

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full-time
Our client, a pioneering biopharmaceutical company at the forefront of innovative cancer therapies, is actively seeking an exceptional Principal Drug Discovery Scientist specializing in Oncology to join their world-class research team. This is a fully remote position, offering the flexibility to work from anywhere within the UK, while contributing to groundbreaking work that has the potential to transform patient lives. You will lead critical research initiatives, driving the identification and validation of novel therapeutic targets and the development of first-in-class small molecule and biologic drug candidates for various oncological indications. This role demands a deep understanding of cancer biology, extensive experience in medicinal chemistry or pharmacology, and a passion for scientific innovation.

Key Responsibilities:
  • Lead and execute cutting-edge drug discovery projects in oncology, from target identification through lead optimization.
  • Design and implement experimental strategies to validate novel therapeutic targets and pathways.
  • Oversee the synthesis and characterization of novel small molecule inhibitors and/or biologics.
  • Collaborate closely with internal and external partners, including academic institutions and contract research organizations (CROs).
  • Analyze and interpret complex biological and chemical data, making critical decisions to advance projects.
  • Develop and troubleshoot in vitro and in vivo assays to assess compound efficacy and mechanism of action.
  • Contribute to the strategic direction of the oncology discovery portfolio.
  • Mentor and guide junior scientists, fostering a collaborative and high-performing research environment.
  • Prepare high-quality scientific reports, publications, and patent applications.
  • Present research findings at scientific conferences and internal meetings.
  • Ensure compliance with all relevant safety and ethical guidelines.
  • Manage project timelines and resources effectively in a remote setting.
Qualifications:
  • Ph.D. in Molecular Biology, Pharmacology, Biochemistry, Chemistry, or a related life science field.
  • Minimum of 8 years of post-doctoral experience in drug discovery, with a significant focus on oncology research.
  • Demonstrated success in identifying and advancing oncology drug candidates.
  • Extensive experience in cancer biology, including signaling pathways, tumor microenvironment, and immunology.
  • Strong expertise in either medicinal chemistry, small molecule drug design, or biologics development (e.g., antibody engineering).
  • Proficiency in relevant experimental techniques (e.g., cell-based assays, molecular biology techniques, in vivo pharmacology models).
  • Proven ability to think critically, solve complex problems, and drive research independently.
  • Excellent leadership, communication, and interpersonal skills, essential for remote collaboration.
  • Track record of scientific publications and/or patents.
  • Experience managing CRO relationships and projects.
  • Must be comfortable working autonomously and managing workload in a remote-first environment.
This is a unique opportunity to join a dynamic and forward-thinking company and play a pivotal role in shaping the future of cancer treatment. We offer a competitive salary, excellent benefits, and a stimulating remote work environment.
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Lead Drug Discovery Scientist - AI Integration

EH1 1AA Edinburgh, Scotland £80000 Annually WhatJobs

Posted 5 days ago

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full-time
Our client, a forward-thinking pharmaceutical company, is seeking a highly accomplished Lead Drug Discovery Scientist to spearhead the integration of Artificial Intelligence and machine learning into their drug discovery pipeline. This is a fully remote position, offering the unique opportunity to shape the future of medicine from anywhere in the UK. You will be instrumental in identifying and implementing novel AI-driven strategies to accelerate the identification and optimization of therapeutic candidates. Your responsibilities will include collaborating closely with computational chemists, biologists, and data scientists to develop and validate predictive models for drug properties, target engagement, and efficacy. You will guide the application of AI/ML techniques to large-scale biological and chemical datasets, ensuring robust experimental design and data interpretation. The ideal candidate will possess a deep understanding of drug discovery principles coupled with significant experience in applying AI/ML to biological or chemical problems. You will lead cross-functional project teams, fostering innovation and driving scientific rigor. Strong communication and presentation skills are essential for articulating complex concepts to diverse audiences and for effective remote collaboration. This role demands a proactive approach to exploring new technologies and a passion for translating cutting-edge research into tangible therapeutic breakthroughs. You will contribute to strategic planning, proposal writing, and the dissemination of research findings through publications and conference presentations.

Responsibilities:
  • Lead the integration of AI/ML methodologies into drug discovery programs.
  • Collaborate with computational, biological, and data science teams.
  • Develop and validate predictive models for drug discovery and development.
  • Analyze and interpret complex biological and chemical datasets using AI/ML tools.
  • Design and oversee experimental validation of AI-generated hypotheses.
  • Drive innovation in target identification, lead generation, and optimization.
  • Communicate complex scientific findings to both technical and non-technical audiences.
  • Contribute to the strategic direction of the drug discovery portfolio.
  • Mentor junior scientists and foster a collaborative research environment.
  • Stay current with advancements in AI, machine learning, and pharmaceutical sciences.
Qualifications:
  • Ph.D. in Pharmacology, Cheminformatics, Computational Biology, or a related discipline.
  • Minimum of 7 years of experience in drug discovery, with a significant focus on AI/ML applications.
  • Demonstrated expertise in applying machine learning algorithms to biological or chemical data.
  • Strong understanding of pharmaceutical R&D processes.
  • Excellent programming skills (e.g., Python, R) and familiarity with relevant libraries.
  • Proven ability to lead and mentor scientific teams.
  • Exceptional problem-solving, analytical, and critical thinking skills.
  • Outstanding written and verbal communication abilities for remote settings.
  • Experience with cloud computing platforms and big data technologies is a plus.
  • A track record of scientific publications and presentations.
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Principal Drug Discovery Scientist - Small Molecules

OX1 3PS Oxford, South East £80000 Annually WhatJobs

Posted 15 days ago

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full-time
Our client, a globally recognised pharmaceutical innovator, is seeking a highly skilled and experienced Principal Drug Discovery Scientist, specialising in small molecule development, to join their state-of-the-art research facility in **Oxford, Oxfordshire, UK**. This pivotal role involves leading cutting-edge research programmes aimed at identifying and optimising novel small molecule therapeutics for challenging diseases. You will be at the forefront of medicinal chemistry and drug design, working collaboratively within a world-class scientific team. This on-site position offers the opportunity to significantly impact the discovery of new medicines and contribute to advancing human health.

Key Responsibilities:
  • Lead medicinal chemistry efforts in the design, synthesis, and optimisation of novel small molecule drug candidates.
  • Drive research programs from hit identification through to lead optimisation and preclinical candidate selection.
  • Develop and implement innovative synthetic strategies to access complex molecular architectures.
  • Utilise structure-based drug design principles and computational chemistry tools to guide optimisation efforts.
  • Collaborate effectively with biologists, pharmacologists, ADMET scientists, and other disciplines to advance drug discovery projects.
  • Provide scientific leadership and mentorship to junior chemists and research associates.
  • Interpret and present complex experimental data to project teams, management, and at scientific conferences.
  • Stay abreast of the latest advancements in medicinal chemistry, synthetic organic chemistry, and relevant therapeutic areas.
  • Contribute to the strategic direction of the drug discovery portfolio and identify new opportunities.
  • Author high-impact scientific publications and patent applications.
  • Ensure compliance with all relevant safety, ethical, and regulatory guidelines.
  • Manage external collaborations and outsourced synthesis activities as needed.

Qualifications:
  • PhD in Organic Chemistry, Medicinal Chemistry, or a closely related field.
  • Minimum of 10 years of progressive experience in pharmaceutical drug discovery, with a strong focus on small molecule medicinal chemistry.
  • Demonstrated success in delivering preclinical drug candidates for development.
  • Expertise in synthetic organic chemistry, including route design and execution of complex syntheses.
  • In-depth understanding of structure-activity relationships (SAR) and structure-property relationships (SPR).
  • Experience with various drug discovery modalities and therapeutic areas is desirable.
  • Strong knowledge of computational chemistry and structure-based drug design techniques.
  • Proven ability to lead research projects and mentor scientific staff.
  • Excellent analytical, problem-solving, and critical thinking skills.
  • Outstanding oral and written communication skills, with a strong publication record.
  • Ability to work effectively in a highly collaborative, multidisciplinary team environment.
  • Familiarity with patent law and intellectual property strategies.

This is a distinguished opportunity for an accomplished Principal Scientist to shape the future of drug discovery within a leading organisation in **Oxford, Oxfordshire, UK**.
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Principal Scientist - Drug Discovery & Development

BD3 0HF Bradford, Yorkshire and the Humber £75000 Annually WhatJobs

Posted today

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full-time
Our client is a leading pharmaceutical innovator seeking a highly accomplished Principal Scientist to drive critical drug discovery and development initiatives within their state-of-the-art research facility located in **Bradford, West Yorkshire, UK**. This pivotal role involves leading complex research projects, from target identification and validation through to preclinical development, contributing significantly to the company's pipeline of novel therapeutics. You will leverage your deep scientific expertise and extensive experience to guide research strategies, foster innovation, and ensure the efficient progression of drug candidates.

Key Responsibilities:
  • Lead and manage multiple drug discovery projects from concept to preclinical candidate selection.
  • Design and execute complex biological experiments to investigate disease mechanisms and identify novel therapeutic targets.
  • Develop and optimize assay development strategies for high-throughput screening and compound characterization.
  • Analyze and interpret experimental data, making critical decisions on project direction and go/no-go criteria.
  • Collaborate closely with internal teams (e.g., medicinal chemistry, pharmacology, DMPK) and external partners to advance drug candidates.
  • Stay current with scientific literature and emerging technologies in relevant therapeutic areas and drug discovery methodologies.
  • Prepare and present research findings to senior management, scientific committees, and at external conferences.
  • Contribute to the development of intellectual property and regulatory submissions.
  • Mentor and guide junior scientists, fostering a culture of scientific excellence and collaboration.
  • Ensure compliance with all relevant safety, ethical, and regulatory guidelines.
Required Qualifications:
  • Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a closely related life science discipline.
  • A minimum of 8-10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
  • Demonstrated success in leading drug discovery projects and bringing candidates into preclinical development.
  • Extensive knowledge of various drug discovery platforms and modalities (e.g., small molecules, biologics).
  • Proficiency in experimental design, data analysis, and interpretation using relevant software.
  • Excellent understanding of relevant therapeutic areas (e.g., oncology, immunology, neuroscience).
  • Strong leadership, project management, and communication skills.
  • Proven ability to work effectively in a multidisciplinary, matrixed environment.
  • Experience with manuscript preparation and scientific presentation is essential.
  • A strong publication record in peer-reviewed journals is highly desirable.
This is a challenging and rewarding role for a seasoned scientist eager to make a substantial impact on the development of life-saving medicines. Join a dynamic team dedicated to advancing pharmaceutical science in **Bradford, West Yorkshire, UK**.
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Principal Scientist - Drug Discovery & Development

M1 1JN Manchester, North West £80000 Annually WhatJobs

Posted 14 days ago

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full-time
Our client, a leading global pharmaceutical company at the forefront of developing life-changing therapies, is seeking an exceptional Principal Scientist to drive innovation within their Drug Discovery & Development division. Based at their state-of-the-art research facility in Manchester, Greater Manchester, UK , this senior role requires a visionary leader with extensive expertise in identifying, validating, and advancing novel drug targets. You will be responsible for conceptualizing and executing complex research programs, leading a team of talented scientists, and collaborating across multidisciplinary teams to accelerate the pipeline from early discovery through to pre-clinical development. The ideal candidate will possess a deep scientific understanding, a proven track record in medicinal chemistry or pharmacology, and a passion for pushing the boundaries of pharmaceutical research.

Key Responsibilities:
  • Lead and manage cutting-edge research projects focused on the discovery and development of novel therapeutics for unmet medical needs.
  • Design and implement innovative experimental strategies to identify and validate drug targets.
  • Oversee the synthesis, characterization, and optimization of potential drug candidates, utilizing expertise in medicinal chemistry or pharmacology.
  • Provide scientific leadership and mentorship to a team of research scientists and technicians.
  • Develop and maintain strong collaborations with internal R&D teams, external academic institutions, and CROs.
  • Interpret complex scientific data, draw conclusions, and make strategic recommendations for project progression.
  • Prepare high-quality research reports, publications, and patent applications.
  • Ensure all research activities adhere to stringent quality, safety, and regulatory standards.
  • Contribute to the strategic direction of the drug discovery portfolio.
  • Present research findings at internal reviews and external scientific conferences.
  • Manage budgets and resources allocated to research projects.
  • Stay abreast of the latest scientific advancements and emerging technologies in relevant therapeutic areas.
Qualifications and Experience:
  • PhD in Pharmacology, Medicinal Chemistry, Biochemistry, Molecular Biology, or a closely related field.
  • Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
  • Demonstrated success in leading drug discovery programs from target identification to pre-clinical candidate selection.
  • Extensive knowledge of drug discovery processes, including target validation, lead identification, and lead optimization.
  • Proven expertise in a specific therapeutic area (e.g., oncology, immunology, CNS).
  • Strong understanding of modern drug discovery technologies and methodologies.
  • Excellent leadership, team management, and mentoring skills.
  • Exceptional analytical, problem-solving, and critical thinking abilities.
  • Strong publication record and experience with patent filings.
  • Excellent written and verbal communication skills, with the ability to effectively present complex scientific information.
  • Experience working within a GLP environment is advantageous.

This is a unique opportunity to shape the future of medicine within a world-class research environment in Manchester.
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