6,828 Drug Metabolism jobs in the United Kingdom
Principal Research Scientist - Drug Metabolism
SO14 0AA Southampton, South East
£70000 Annually
WhatJobs
Posted 20 days ago
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Job Description
Our client, a globally recognized pharmaceutical company, is seeking a highly accomplished Principal Research Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK) to join their world-class research team. This fully remote position offers an exceptional opportunity to contribute to the discovery and development of innovative medicines. You will be responsible for leading critical DMPK studies, providing expert scientific guidance, and driving strategy for early-stage drug candidates. The role requires a deep understanding of metabolic pathways, drug transporters, bioanalysis, and in vitro/in vivo ADME (Absorption, Distribution, Metabolism, Excretion) models. You will collaborate extensively with medicinal chemists, toxicologists, and other R&D disciplines to optimize drug properties and ensure successful progression through the development pipeline.
Key Responsibilities:
Key Responsibilities:
- Design, execute, and interpret complex in vitro and in vivo DMPK studies.
- Develop and validate bioanalytical methods for quantifying drug and metabolite concentrations in biological matrices.
- Provide strategic DMPK input to drug discovery and development teams, guiding lead optimization and candidate selection.
- Characterize the metabolic fate and pharmacokinetic profiles of novel drug candidates.
- Assess drug-drug interaction (DDI) potential and investigate drug transporter roles.
- Utilize PBPK (Physiologically Based Pharmacokinetic) modeling to predict human pharmacokinetics and inform dosing strategies.
- Author high-quality study reports, regulatory documents, and scientific publications.
- Mentor and provide scientific leadership to junior scientists and research associates.
- Stay abreast of cutting-edge technologies and scientific advancements in DMPK and related fields.
- Present scientific findings at internal project meetings and external conferences.
- Ph.D. in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline.
- Minimum of 10 years of relevant industry experience in DMPK research.
- Demonstrated expertise in drug metabolism, pharmacokinetics, bioanalysis, and transporter science.
- Extensive experience with various in vitro ADME assays and bioanalytical techniques (e.g., LC-MS/MS).
- Proficiency in PBPK modeling software (e.g., Simcyp, GastroPlus) is highly desirable.
- Strong understanding of regulatory guidelines related to drug development.
- Excellent problem-solving, analytical, and critical thinking skills.
- Exceptional written and verbal communication skills, with a track record of scientific publications.
- Proven ability to lead scientific projects and collaborate effectively in a remote research environment.
- Experience working with diverse therapeutic areas is a plus.
This advertiser has chosen not to accept applicants from your region.
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Principal Research Scientist - Drug Metabolism & Pharmacokinetics (DMPK)
L1 8 Liverpool, North West
£75000 Annually
WhatJobs
Posted 14 days ago
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Job Description
Our client, a globally recognised pharmaceutical company at the forefront of medical innovation, is seeking an exceptional Principal Research Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK). This is a fully remote position, allowing you to contribute your extensive scientific expertise from your home office, driving critical research that underpins the development of life-saving medicines. You will be a key scientific leader, guiding the strategic direction of DMPK studies and contributing to the selection and advancement of drug candidates through the development pipeline. The company's primary research and development centres are located in Liverpool, Merseyside, UK .
Key Responsibilities:
Qualifications and Skills:
This is a pivotal remote role for a highly experienced DMPK scientist seeking to make a significant impact on the development of novel therapeutics.
Key Responsibilities:
- Lead and execute complex in vitro and in vivo DMPK studies to characterise the absorption, distribution, metabolism, and excretion (ADME) properties of drug candidates.
- Design and interpret DMPK studies to support compound selection, candidate progression, and regulatory filings.
- Develop and validate bioanalytical methods for the quantification of drugs and metabolites in biological matrices.
- Utilise modelling and simulation techniques (e.g., PBPK modelling) to predict human pharmacokinetics and inform dose selection.
- Collaborate closely with medicinal chemists, pharmacologists, toxicologists, and formulation scientists to integrate DMPK data into early drug discovery and development strategies.
- Provide strategic guidance on DMPK aspects of drug development programmes to project teams and senior management.
- Contribute to the preparation of scientific manuscripts, presentations, and regulatory documents.
- Mentor and guide junior scientists, fostering scientific excellence and professional development.
- Stay abreast of the latest advancements in DMPK science, technologies, and regulatory expectations.
- Ensure all research activities are conducted in compliance with ethical standards and relevant guidelines.
Qualifications and Skills:
- PhD in Pharmacology, Biochemistry, Pharmaceutical Sciences, Chemistry, or a related discipline with a focus on DMPK.
- A minimum of 10 years of progressive experience in drug metabolism and pharmacokinetics within the pharmaceutical or biotechnology industry.
- Demonstrated expertise in designing and interpreting a wide range of in vitro and in vivo ADME assays.
- Proficiency in bioanalytical method development and validation (e.g., LC-MS/MS).
- Strong understanding of drug transport mechanisms, enzyme kinetics, and drug-drug interaction studies.
- Experience with pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation is highly desirable.
- Proven ability to lead research projects, manage timelines, and contribute to strategic decision-making.
- Excellent written and verbal communication skills, with a strong track record of scientific publication and presentation.
- Demonstrated ability to work independently, manage multiple priorities, and collaborate effectively in a remote setting.
- A deep understanding of the drug development process from discovery through to clinical phases.
This is a pivotal remote role for a highly experienced DMPK scientist seeking to make a significant impact on the development of novel therapeutics.
This advertiser has chosen not to accept applicants from your region.
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Principal Pharmaceutical Scientist - Drug Metabolism
SW1A 0AA London, London
£75000 Annually
WhatJobs
Posted 20 days ago
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Job Description
Our client, a prestigious pharmaceutical company, is seeking a highly accomplished Principal Pharmaceutical Scientist specializing in Drug Metabolism to join their world-class research and development team in London, England, UK . This hybrid role offers an exciting opportunity to lead critical research initiatives and shape the future of drug development. You will be responsible for designing and overseeing complex studies related to drug metabolism, pharmacokinetics (DMPK), and bioanalysis. The ideal candidate possesses deep expertise in ADME (Absorption, Distribution, Metabolism, Excretion) principles, a proven track record of scientific leadership, and experience in regulatory submissions. You will mentor junior scientists, collaborate with internal and external partners, and contribute significantly to the company's drug discovery pipeline. This is an exceptional opportunity for a senior scientist to drive innovation and make a substantial impact in the pharmaceutical industry.
Key Responsibilities:
Key Responsibilities:
- Lead and direct research programs in drug metabolism and pharmacokinetics (DMPK).
- Design and interpret in vitro and in vivo studies to characterize drug candidates.
- Develop and validate bioanalytical methods for quantifying drugs and metabolites.
- Provide expert scientific guidance on DMPK issues to project teams.
- Stay abreast of the latest scientific advancements and regulatory requirements in drug metabolism.
- Mentor and guide junior scientists and research associates.
- Author and review scientific reports, publications, and regulatory documents.
- Collaborate with cross-functional teams, including discovery chemistry, toxicology, and clinical pharmacology.
- PhD in Pharmaceutical Sciences, Biochemistry, Chemistry, or a related field.
- Extensive experience in drug metabolism and pharmacokinetic research within the pharmaceutical industry.
- Demonstrated expertise in in vitro and in vivo ADME studies.
- Strong knowledge of bioanalytical techniques (e.g., LC-MS/MS).
- Proven leadership experience and ability to mentor scientific teams.
- Excellent scientific communication, presentation, and writing skills.
- Familiarity with regulatory guidelines for drug development (e.g., FDA, EMA).
This advertiser has chosen not to accept applicants from your region.
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Principal Scientist (Drug Metabolism and Pharmacokinetics)
CF10 1AA Cardiff, Wales
£75000 Annually
WhatJobs
Posted 2 days ago
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Job Description
Our client, a cutting-edge pharmaceutical company, is seeking a highly experienced Principal Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK) to join their remote-first research and development team. This is a critical role for driving the early stages of drug discovery and development.
Responsibilities:
Qualifications:
This is an outstanding opportunity to join a forward-thinking organization and make a significant impact on the development of life-saving medicines. The role is fully remote, allowing you to contribute from your home office while supporting key research initiatives for our client based in **Cardiff, Wales, UK**.
Responsibilities:
- Lead and execute studies to characterize the ADME (Absorption, Distribution, Metabolism, Excretion) properties of novel drug candidates.
- Design and oversee in vitro and in vivo DMPK studies, utilizing state-of-the-art methodologies.
- Develop and validate bioanalytical methods for the quantification of drug and metabolite concentrations in biological matrices.
- Interpret complex DMPK data to inform compound selection, dose prediction, and potential drug-drug interactions.
- Collaborate closely with medicinal chemists, pharmacologists, and toxicologists to integrate DMPK data into the drug discovery process.
- Prepare high-quality reports, contribute to regulatory filings (e.g., IND, NDA), and present findings at scientific meetings.
- Stay current with scientific advancements and innovative technologies in DMPK research.
- Mentor junior scientists and provide scientific leadership within the DMPK group.
- Manage external collaborations with CROs and academic partners.
- Ensure compliance with GLP standards and all relevant regulatory guidelines.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline with a strong focus on DMPK.
- Minimum of 10 years of experience in drug metabolism and pharmacokinetics within the pharmaceutical industry or a closely related field.
- Extensive hands-on experience with in vitro DMPK assays (e.g., metabolic stability, CYP inhibition/induction, transporter assays) and in vivo pharmacokinetic studies.
- Proficiency in bioanalytical techniques (e.g., LC-MS/MS) and data analysis software.
- Demonstrated expertise in interpreting DMPK data and contributing to preclinical development strategies.
- Excellent scientific communication skills, including writing publications and reports.
- Proven ability to lead research projects and mentor scientific staff.
- Strong problem-solving skills and a creative approach to scientific challenges.
- Ability to thrive in a fully remote, collaborative, and fast-paced research environment.
- Familiarity with regulatory requirements for drug development is essential.
This is an outstanding opportunity to join a forward-thinking organization and make a significant impact on the development of life-saving medicines. The role is fully remote, allowing you to contribute from your home office while supporting key research initiatives for our client based in **Cardiff, Wales, UK**.
This advertiser has chosen not to accept applicants from your region.
3
Principal Scientist - Drug Metabolism & Pharmacokinetics (DMPK)
DE1 3BW Derby, East Midlands
£75000 Annually
WhatJobs
Posted 18 days ago
Job Viewed
Job Description
Our client, a world-leading pharmaceutical company with a strong pipeline of innovative medicines, is seeking a highly accomplished Principal Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK) to join their cutting-edge research facility in Derby, Derbyshire, UK . This senior role offers the opportunity to lead critical DMPK strategies and contribute significantly to the preclinical development of novel therapeutics. You will be responsible for designing and overseeing in vitro and in vivo DMPK studies, interpreting complex data, and providing expert guidance on drug candidates' absorption, distribution, metabolism, and excretion (ADME) properties. The successful candidate will possess extensive experience in DMPK research, with a deep understanding of biochemical assays, analytical techniques (LC-MS/MS), and PK modeling. A proven ability to lead research projects, mentor junior scientists, and collaborate effectively with cross-functional teams, including medicinal chemistry, toxicology, and clinical pharmacology, is essential. You will play a key role in advancing drug candidates from discovery through to clinical development, contributing to regulatory submissions and scientific publications. Experience with various therapeutic areas and modalities is a plus. This position requires a strong scientific acumen, excellent problem-solving skills, and a commitment to scientific excellence and innovation. As this is a lab-based role critical for direct research operations, it requires a full-time, on-site presence to ensure seamless integration with experimental workflows and laboratory resources.
This advertiser has chosen not to accept applicants from your region.
4
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
B1 1AA Birmingham, West Midlands
£85000 Annually
WhatJobs
Posted 7 days ago
Job Viewed
Job Description
Our client, a globally leading biopharmaceutical company, is seeking a highly experienced Principal Scientist in Drug Metabolism and Pharmacokinetics (DMPK) to join their fully remote, innovative research and development team. This senior role is crucial for guiding and executing preclinical and early clinical DMPK strategies to advance drug candidates through the development pipeline. The Principal Scientist will be responsible for designing complex in vitro and in vivo studies to characterize the absorption, distribution, metabolism, and excretion (ADME) properties of novel drug molecules. You will interpret complex pharmacokinetic data, develop sophisticated modeling and simulation approaches, and provide critical data to inform drug development decisions. This position requires a deep scientific understanding of drug metabolism pathways, transporter interactions, and pharmacokinetic principles, as well as extensive experience with bioanalytical techniques and regulatory requirements. The ideal candidate will possess excellent leadership, communication, and collaboration skills, with a proven ability to mentor junior scientists and effectively influence cross-functional teams. This role is a unique opportunity to contribute to the discovery and development of life-saving medicines from a remote setting, working alongside a world-class team of scientists.
Key Responsibilities:
Qualifications:
Key Responsibilities:
- Design, oversee, and interpret in vitro and in vivo DMPK studies for small molecules and biologics.
- Develop and validate bioanalytical methods for quantifying drug and metabolite concentrations in biological matrices.
- Conduct pharmacokinetic (PK) and mass balance studies.
- Utilize modeling and simulation (PBPK, population PK) to predict human PK and guide dose selection.
- Assess drug-drug interaction (DDI) potential and understand relevant regulatory guidelines.
- Collaborate with medicinal chemists, pharmacologists, and toxicologists to integrate DMPK data into development strategies.
- Provide scientific leadership and mentorship to DMPK team members.
- Prepare high-quality reports, regulatory submissions, and present findings at scientific conferences.
- Stay abreast of cutting-edge advancements and novel technologies in DMPK and related fields.
- Contribute to strategic decision-making for drug candidate progression.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline.
- Minimum of 8 years of relevant industry experience in drug metabolism and pharmacokinetics.
- Extensive hands-on experience with in vitro ADME assays (e.g., metabolic stability, CYP inhibition/induction, transporter assays).
- Proficiency in PK analysis software (e.g., Phoenix WinNonlin) and modeling tools.
- Strong understanding of bioanalytical techniques (e.g., LC-MS/MS).
- Demonstrated experience in guiding DMPK strategy for preclinical and early clinical development.
- Excellent scientific communication (written and oral) and presentation skills.
- Proven ability to lead projects, mentor scientists, and collaborate effectively in a remote, cross-functional environment.
- Knowledge of regulatory guidelines related to DMPK is essential.
This advertiser has chosen not to accept applicants from your region.
5
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
CV1 2DT Coventry, West Midlands
£75000 Annually
WhatJobs
Posted 20 days ago
Job Viewed
Job Description
Our client is actively seeking a highly accomplished Principal Scientist to join their esteemed Drug Metabolism and Pharmacokinetics (DMPK) department. This is a fully remote, senior-level position, offering a unique opportunity to significantly influence the trajectory of drug development programs. The successful candidate will bring extensive expertise in designing and interpreting DMPK studies, contributing critical insights into drug absorption, distribution, metabolism, and excretion (ADME) properties. You will lead scientific initiatives, mentor junior colleagues, and collaborate closely with discovery and development teams to ensure compounds possess favorable pharmacokinetic profiles for clinical success. This role requires a profound scientific understanding, strategic thinking, and exceptional communication skills within a virtual setting.
Key Responsibilities:
Qualifications:
Key Responsibilities:
- Design, execute, and oversee in vitro and in vivo DMPK studies to assess ADME characteristics of drug candidates.
- Develop and validate bioanalytical methods for quantifying drugs and metabolites in biological matrices.
- Interpret complex DMPK data, integrate findings with other preclinical and clinical data, and provide strategic recommendations.
- Contribute to the selection of development candidates based on robust DMPK assessments.
- Lead DMPK strategies for multiple drug discovery projects across various therapeutic areas.
- Prepare and review regulatory documents (e.g., IND, NDA sections) related to DMPK.
- Collaborate effectively with medicinal chemists, toxicologists, pharmacologists, and clinical teams in a remote environment.
- Stay abreast of cutting-edge technologies and methodologies in DMPK and related fields.
- Publish scientific findings in peer-reviewed journals and present at scientific conferences.
- Mentor and guide junior scientists, fostering their scientific and professional development.
- Contribute to the strategic direction of the DMPK department and the broader R&D organization.
- Ensure compliance with all relevant GLP and regulatory guidelines.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, Chemistry, or a related discipline.
- Minimum of 8-10 years of relevant industry experience in drug metabolism and pharmacokinetics.
- Demonstrated success in contributing to the advancement of drug candidates through preclinical and clinical development.
- Expertise in various in vitro and in vivo ADME techniques and assays.
- Strong knowledge of bioanalytical methodologies (e.g., LC-MS/MS).
- Proven experience in preparing regulatory submissions.
- Excellent scientific judgment, problem-solving skills, and strategic thinking.
- Outstanding written and verbal communication skills, with the ability to present complex data clearly and persuasively.
- Ability to lead scientific projects and mentor team members effectively in a remote setting.
- A proactive and collaborative approach to research and development.
- Track record of scientific publications and presentations.
This advertiser has chosen not to accept applicants from your region.
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6
Research Scientist - Drug Discovery
BN1 1AA East Sussex, South East
£45000 Annually
WhatJobs
Posted 3 days ago
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Job Description
A pioneering biotechnology company at the forefront of innovative therapeutic development is seeking a talented Research Scientist to join their dynamic Scientific Research & Development team. This role is pivotal in advancing our drug discovery programs, contributing to the identification and validation of novel drug targets. You will be involved in designing and executing complex experiments, analysing experimental data, and interpreting results to inform strategic decisions. Responsibilities include conducting literature reviews, developing new assays, troubleshooting experimental protocols, and maintaining detailed laboratory records. Collaboration with cross-functional teams, including medicinal chemists, biologists, and pharmacologists, will be essential. The ideal candidate will have a PhD or a Master's degree in a relevant scientific discipline (e.g., Molecular Biology, Biochemistry, Pharmacology) with a strong background in drug discovery methodologies. Proven experience in cell culture, molecular biology techniques, and biochemical assays is required. Familiarity with target validation, lead optimization, or specific therapeutic areas is a plus.
We are looking for a highly motivated, detail-oriented individual with excellent analytical and problem-solving skills. Strong written and verbal communication abilities are essential for presenting findings and contributing to scientific publications and reports. This role operates on a hybrid model, combining essential laboratory-based research in our state-of-the-art facilities in Brighton, East Sussex, UK with remote work for data analysis, literature review, and report writing. You must be adept at working independently and as part of a collaborative team. A passion for scientific innovation and a commitment to advancing human health are key. This is an exceptional opportunity to make a significant contribution to the development of life-changing medicines.
We are looking for a highly motivated, detail-oriented individual with excellent analytical and problem-solving skills. Strong written and verbal communication abilities are essential for presenting findings and contributing to scientific publications and reports. This role operates on a hybrid model, combining essential laboratory-based research in our state-of-the-art facilities in Brighton, East Sussex, UK with remote work for data analysis, literature review, and report writing. You must be adept at working independently and as part of a collaborative team. A passion for scientific innovation and a commitment to advancing human health are key. This is an exceptional opportunity to make a significant contribution to the development of life-changing medicines.
This advertiser has chosen not to accept applicants from your region.
7
Research Scientist - Drug Discovery
SO15 0AA Southampton, South East
£55000 Annually
WhatJobs
Posted 4 days ago
Job Viewed
Job Description
Our client, a dynamic pharmaceutical company, is seeking a dedicated Research Scientist to join their drug discovery team in Southampton, Hampshire, UK . This role offers a hybrid working arrangement, allowing for a blend of laboratory-based research and remote data analysis and reporting. The successful candidate will contribute to the identification and development of novel therapeutic agents. You will be involved in experimental design, execution, data analysis, and interpretation within a collaborative research environment. The ideal candidate will possess a strong background in molecular biology, biochemistry, or a related life science discipline, with hands-on experience in relevant laboratory techniques. A passion for scientific innovation and a commitment to advancing healthcare are essential. Responsibilities include:
Qualifications:
This is an exciting opportunity for a talented scientist to contribute to the development of life-saving medicines from our state-of-the-art facilities in Southampton.
- Designing and conducting in vitro and in vivo experiments to support drug discovery programs.
- Utilising a range of molecular biology, cell biology, and biochemical techniques.
- Analysing and interpreting complex experimental data, preparing comprehensive reports.
- Collaborating with cross-functional teams, including chemists, pharmacologists, and clinicians.
- Contributing to the development of new research methodologies and protocols.
- Maintaining accurate and detailed laboratory notebooks and research records.
- Staying abreast of scientific literature and emerging trends in pharmaceutical research.
- Presenting research findings at internal and external scientific meetings.
- Assisting in the identification and validation of new drug targets.
- Ensuring compliance with all safety and regulatory guidelines in the laboratory.
Qualifications:
- A PhD or MSc in Molecular Biology, Biochemistry, Pharmacology, or a related field.
- Proven experience in drug discovery research, preferably within the pharmaceutical or biotech industry.
- Hands-on experience with relevant laboratory techniques such as cell culture, Western blotting, ELISA, PCR, and flow cytometry.
- Strong analytical and problem-solving skills.
- Excellent written and oral communication skills.
- Ability to work effectively both independently and as part of a multidisciplinary team.
- Experience with data analysis software (e.g., GraphPad Prism, R) is a plus.
- Familiarity with assay development and validation.
- A proactive approach to research and a commitment to scientific rigor.
This is an exciting opportunity for a talented scientist to contribute to the development of life-saving medicines from our state-of-the-art facilities in Southampton.
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8
Research Scientist - Drug Discovery
SR3 3PX Sunderland, North East
£50000 Annually
WhatJobs
Posted 9 days ago
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Job Description
Our client, a leading pharmaceutical innovator based in Sunderland, is seeking a talented Research Scientist to join their cutting-edge Drug Discovery division. This hybrid role offers a compelling blend of in-lab experimentation and remote data analysis, contributing to the development of novel therapeutics. You will be instrumental in designing and executing complex biological assays, investigating novel targets, and contributing to lead optimization campaigns. Your responsibilities will include performing cell-based assays, biochemical assays, and phenotypic screening to evaluate the efficacy and safety of new drug candidates. You will meticulously document experimental procedures and results, maintaining high standards of scientific rigor. Data analysis, interpretation, and presentation of findings to the research team and cross-functional collaborators will be a key aspect of your role. You will also stay abreast of the latest scientific literature and technological advancements relevant to drug discovery. The ideal candidate will possess a PhD or Master's degree in a relevant biological science (e.g., Pharmacology, Molecular Biology, Biochemistry) with a strong publication record and hands-on experience in small molecule or biologics drug discovery. Expertise in specific assay development, high-throughput screening, and molecular biology techniques is essential. Experience with data analysis software (e.g., GraphPad Prism, Spotfire) and a good understanding of medicinal chemistry principles are highly desirable. Strong problem-solving skills, excellent communication abilities, and the capacity to work independently as well as collaboratively in a dynamic, fast-paced research environment are crucial. This is an exceptional opportunity to make a significant contribution to advancing human health, working within a state-of-the-art facility and a team of dedicated scientists. Embrace the opportunity to shape the future of medicine in a role that combines focused lab work with the flexibility of remote contribution.
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