5,751 Drug Metabolism jobs in the United Kingdom

Principal Research Scientist - Drug Metabolism

SO14 0AA Southampton, South East £70000 Annually WhatJobs

Posted 4 days ago

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full-time
Our client, a globally recognized pharmaceutical company, is seeking a highly accomplished Principal Research Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK) to join their world-class research team. This fully remote position offers an exceptional opportunity to contribute to the discovery and development of innovative medicines. You will be responsible for leading critical DMPK studies, providing expert scientific guidance, and driving strategy for early-stage drug candidates. The role requires a deep understanding of metabolic pathways, drug transporters, bioanalysis, and in vitro/in vivo ADME (Absorption, Distribution, Metabolism, Excretion) models. You will collaborate extensively with medicinal chemists, toxicologists, and other R&D disciplines to optimize drug properties and ensure successful progression through the development pipeline.

Key Responsibilities:
  • Design, execute, and interpret complex in vitro and in vivo DMPK studies.
  • Develop and validate bioanalytical methods for quantifying drug and metabolite concentrations in biological matrices.
  • Provide strategic DMPK input to drug discovery and development teams, guiding lead optimization and candidate selection.
  • Characterize the metabolic fate and pharmacokinetic profiles of novel drug candidates.
  • Assess drug-drug interaction (DDI) potential and investigate drug transporter roles.
  • Utilize PBPK (Physiologically Based Pharmacokinetic) modeling to predict human pharmacokinetics and inform dosing strategies.
  • Author high-quality study reports, regulatory documents, and scientific publications.
  • Mentor and provide scientific leadership to junior scientists and research associates.
  • Stay abreast of cutting-edge technologies and scientific advancements in DMPK and related fields.
  • Present scientific findings at internal project meetings and external conferences.
Qualifications:
  • Ph.D. in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline.
  • Minimum of 10 years of relevant industry experience in DMPK research.
  • Demonstrated expertise in drug metabolism, pharmacokinetics, bioanalysis, and transporter science.
  • Extensive experience with various in vitro ADME assays and bioanalytical techniques (e.g., LC-MS/MS).
  • Proficiency in PBPK modeling software (e.g., Simcyp, GastroPlus) is highly desirable.
  • Strong understanding of regulatory guidelines related to drug development.
  • Excellent problem-solving, analytical, and critical thinking skills.
  • Exceptional written and verbal communication skills, with a track record of scientific publications.
  • Proven ability to lead scientific projects and collaborate effectively in a remote research environment.
  • Experience working with diverse therapeutic areas is a plus.
Join a forward-thinking research organization committed to advancing human health through scientific excellence and innovation.
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Principal Pharmaceutical Scientist - Drug Metabolism

SW1A 0AA London, London £75000 Annually WhatJobs

Posted 1 day ago

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full-time
Our client, a prestigious pharmaceutical company, is seeking a highly accomplished Principal Pharmaceutical Scientist specializing in Drug Metabolism to join their world-class research and development team in London, England, UK . This hybrid role offers an exciting opportunity to lead critical research initiatives and shape the future of drug development. You will be responsible for designing and overseeing complex studies related to drug metabolism, pharmacokinetics (DMPK), and bioanalysis. The ideal candidate possesses deep expertise in ADME (Absorption, Distribution, Metabolism, Excretion) principles, a proven track record of scientific leadership, and experience in regulatory submissions. You will mentor junior scientists, collaborate with internal and external partners, and contribute significantly to the company's drug discovery pipeline. This is an exceptional opportunity for a senior scientist to drive innovation and make a substantial impact in the pharmaceutical industry.

Key Responsibilities:
  • Lead and direct research programs in drug metabolism and pharmacokinetics (DMPK).
  • Design and interpret in vitro and in vivo studies to characterize drug candidates.
  • Develop and validate bioanalytical methods for quantifying drugs and metabolites.
  • Provide expert scientific guidance on DMPK issues to project teams.
  • Stay abreast of the latest scientific advancements and regulatory requirements in drug metabolism.
  • Mentor and guide junior scientists and research associates.
  • Author and review scientific reports, publications, and regulatory documents.
  • Collaborate with cross-functional teams, including discovery chemistry, toxicology, and clinical pharmacology.
Qualifications:
  • PhD in Pharmaceutical Sciences, Biochemistry, Chemistry, or a related field.
  • Extensive experience in drug metabolism and pharmacokinetic research within the pharmaceutical industry.
  • Demonstrated expertise in in vitro and in vivo ADME studies.
  • Strong knowledge of bioanalytical techniques (e.g., LC-MS/MS).
  • Proven leadership experience and ability to mentor scientific teams.
  • Excellent scientific communication, presentation, and writing skills.
  • Familiarity with regulatory guidelines for drug development (e.g., FDA, EMA).
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Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)

CV1 2DT Coventry, West Midlands £75000 Annually WhatJobs

Posted 3 days ago

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full-time
Our client is actively seeking a highly accomplished Principal Scientist to join their esteemed Drug Metabolism and Pharmacokinetics (DMPK) department. This is a fully remote, senior-level position, offering a unique opportunity to significantly influence the trajectory of drug development programs. The successful candidate will bring extensive expertise in designing and interpreting DMPK studies, contributing critical insights into drug absorption, distribution, metabolism, and excretion (ADME) properties. You will lead scientific initiatives, mentor junior colleagues, and collaborate closely with discovery and development teams to ensure compounds possess favorable pharmacokinetic profiles for clinical success. This role requires a profound scientific understanding, strategic thinking, and exceptional communication skills within a virtual setting.

Key Responsibilities:
  • Design, execute, and oversee in vitro and in vivo DMPK studies to assess ADME characteristics of drug candidates.
  • Develop and validate bioanalytical methods for quantifying drugs and metabolites in biological matrices.
  • Interpret complex DMPK data, integrate findings with other preclinical and clinical data, and provide strategic recommendations.
  • Contribute to the selection of development candidates based on robust DMPK assessments.
  • Lead DMPK strategies for multiple drug discovery projects across various therapeutic areas.
  • Prepare and review regulatory documents (e.g., IND, NDA sections) related to DMPK.
  • Collaborate effectively with medicinal chemists, toxicologists, pharmacologists, and clinical teams in a remote environment.
  • Stay abreast of cutting-edge technologies and methodologies in DMPK and related fields.
  • Publish scientific findings in peer-reviewed journals and present at scientific conferences.
  • Mentor and guide junior scientists, fostering their scientific and professional development.
  • Contribute to the strategic direction of the DMPK department and the broader R&D organization.
  • Ensure compliance with all relevant GLP and regulatory guidelines.

Qualifications:
  • PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, Chemistry, or a related discipline.
  • Minimum of 8-10 years of relevant industry experience in drug metabolism and pharmacokinetics.
  • Demonstrated success in contributing to the advancement of drug candidates through preclinical and clinical development.
  • Expertise in various in vitro and in vivo ADME techniques and assays.
  • Strong knowledge of bioanalytical methodologies (e.g., LC-MS/MS).
  • Proven experience in preparing regulatory submissions.
  • Excellent scientific judgment, problem-solving skills, and strategic thinking.
  • Outstanding written and verbal communication skills, with the ability to present complex data clearly and persuasively.
  • Ability to lead scientific projects and mentor team members effectively in a remote setting.
  • A proactive and collaborative approach to research and development.
  • Track record of scientific publications and presentations.
This role offers the chance to make a substantial impact on the development of innovative therapeutics, working remotely for a leading pharmaceutical organization. The role is based in Coventry, West Midlands, UK , with all work conducted remotely.
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Research Scientist (Drug Discovery)

LE1 1AA Leicester, East Midlands £55000 Annually WhatJobs

Posted 7 days ago

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full-time
Our client is at the forefront of pharmaceutical innovation and is seeking a highly motivated and skilled Research Scientist to contribute to their drug discovery efforts in a fully remote capacity. This role is ideal for a passionate scientist with a strong background in molecular biology, biochemistry, or a related discipline, eager to drive groundbreaking research from concept to preclinical development. As a Research Scientist, you will design and execute experiments to identify and validate novel drug targets and therapeutic candidates. Your responsibilities will include developing and implementing in vitro and ex vivo assays, analyzing complex biological data, and interpreting experimental results to guide research strategies. You will collaborate closely with a multidisciplinary team of chemists, biologists, and pharmacologists, contributing your scientific expertise to cross-functional drug discovery programs. Staying abreast of the latest scientific literature, technological advancements, and emerging trends in pharmaceutical research will be essential. You will be expected to troubleshoot experimental challenges, optimize protocols, and contribute to the development of robust and reproducible assays. Maintaining meticulous laboratory records and preparing scientific reports, presentations, and potentially manuscripts for publication will be a key aspect of your role. The ability to work independently, manage multiple research projects simultaneously, and contribute effectively within a remote collaborative environment is crucial. This position offers a unique opportunity to contribute to the development of life-changing medicines within a dynamic and innovative research setting.
Responsibilities:
  • Design, optimize, and execute complex biological assays for drug target identification and validation.
  • Conduct experiments using molecular biology, biochemistry, and cell-based techniques.
  • Analyze and interpret experimental data, drawing scientifically sound conclusions.
  • Collaborate with cross-functional teams to advance drug discovery projects.
  • Troubleshoot experimental issues and develop solutions to overcome technical challenges.
  • Maintain accurate and detailed experimental records and documentation.
  • Prepare scientific reports, presentations, and contribute to publications.
  • Stay current with scientific literature and emerging trends in pharmaceutical research.
  • Contribute to the development of innovative research methodologies and technologies.
  • Ensure compliance with laboratory safety and ethical guidelines.
Qualifications:
  • PhD in Molecular Biology, Biochemistry, Pharmacology, or a closely related field.
  • Proven experience in drug discovery or relevant biomedical research.
  • Expertise in designing and performing in vitro and ex vivo biological assays.
  • Strong understanding of molecular mechanisms of disease and target validation.
  • Proficiency in data analysis software and techniques.
  • Excellent written and verbal communication skills.
  • Ability to work independently and manage multiple research projects.
  • Experience with mammalian cell culture and relevant molecular biology techniques.
  • Demonstrated ability to work effectively in a collaborative, remote team environment.
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Research Scientist - Drug Discovery

RG1 1AA Reading, South East £50000 Annually WhatJobs

Posted 8 days ago

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full-time
Our client, a leading pharmaceutical innovator, is seeking a highly skilled and dedicated Research Scientist to join their dynamic Drug Discovery team in Reading, Berkshire, UK . This role offers an exciting opportunity to contribute to the development of novel therapeutics by designing and executing cutting-edge experiments. The successful candidate will play a crucial role in identifying and validating new drug targets, characterizing potential drug candidates, and advancing early-stage discovery projects towards clinical development. This position requires a deep understanding of molecular biology, pharmacology, and a passion for translating scientific discoveries into life-changing medicines. The hybrid nature of this role allows for a balance between essential laboratory work and strategic planning/analysis.

Key Responsibilities:
  • Design, perform, and interpret experiments to identify and validate novel drug targets.
  • Characterize the biological activity and mechanisms of action of potential therapeutic compounds.
  • Develop and optimize in vitro and in vivo assays relevant to disease areas of interest.
  • Utilize advanced molecular and cellular biology techniques.
  • Analyze and interpret complex experimental data using appropriate statistical methods.
  • Prepare detailed reports, presentations, and scientific publications.
  • Collaborate effectively with cross-functional teams, including medicinal chemists, pharmacologists, and toxicologists.
  • Stay abreast of the latest scientific literature and technological advancements in drug discovery.
  • Contribute to the strategic direction of research projects.
  • Maintain accurate and up-to-date laboratory notebooks and records.
  • Contribute to the troubleshooting and optimization of experimental protocols.
  • Present research findings at internal and external scientific meetings.
  • Support the transition of promising drug candidates into pre-clinical development.
  • Ensure compliance with all laboratory safety regulations and protocols.
Qualifications and Experience:
  • PhD in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
  • Minimum of 3 years of post-doctoral or industry experience in drug discovery.
  • Proven track record of successfully designing and executing complex biological experiments.
  • Extensive hands-on experience with a range of molecular and cellular biology techniques (e.g., Western blotting, ELISA, qPCR, cell culture, flow cytometry).
  • Experience in assay development and validation.
  • Strong understanding of disease mechanisms and target identification/validation.
  • Proficiency in data analysis software and statistical methodologies.
  • Excellent written and verbal communication skills, with the ability to present complex scientific information clearly.
  • Ability to work independently and collaboratively in a fast-paced research environment.
  • Experience with in vivo models is a plus.
  • Knowledge of small molecule or biologic drug discovery processes.
This is a unique opportunity to join a highly respected pharmaceutical company and make a significant contribution to the advancement of healthcare. If you are a passionate scientist driven by innovation, apply today.
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Research Scientist - Drug Discovery

L1 1AA Liverpool, North West £50000 Annually WhatJobs

Posted 8 days ago

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full-time
Our client, a pioneering pharmaceutical company at the forefront of medical innovation, is seeking a highly motivated and accomplished Research Scientist to join their esteemed Drug Discovery team in Liverpool, Merseyside, UK . This role is integral to the identification and validation of novel therapeutic targets and the development of groundbreaking new medicines. The successful candidate will conduct cutting-edge research, design and execute experiments, and contribute to the overall strategy of early-stage drug discovery programs. This hybrid position offers a blend of laboratory-based research and remote data analysis and collaboration. Key Responsibilities:
  • Design, optimize, and perform in vitro and in vivo experiments to assess the efficacy and safety of potential drug candidates.
  • Develop and validate novel assays for target identification and characterization.
  • Analyze experimental data using statistical methods and present findings to the research team and project leadership.
  • Contribute to the interpretation of research results and the formulation of scientific hypotheses.
  • Collaborate effectively with cross-functional teams, including medicinal chemists, biologists, and pharmacologists.
  • Maintain detailed and accurate laboratory notebooks and contribute to scientific publications and patent applications.
  • Stay abreast of the latest scientific literature and technological advancements in relevant therapeutic areas.
  • Participate in project meetings, providing critical scientific input and contributing to strategic planning.
  • Troubleshoot experimental issues and develop innovative solutions to research challenges.
  • Ensure compliance with all laboratory safety protocols and regulatory guidelines.
Qualifications:
  • PhD in Molecular Biology, Pharmacology, Biochemistry, or a closely related life science discipline.
  • Minimum of 3-5 years of post-doctoral or industry research experience in drug discovery.
  • Proven track record of designing and executing complex biological experiments.
  • Hands-on experience with a range of molecular and cellular biology techniques (e.g., cell culture, ELISA, Western blotting, PCR, flow cytometry).
  • Experience in target validation, assay development, and early-stage drug screening is highly desirable.
  • Strong analytical skills with the ability to interpret complex datasets and draw meaningful conclusions.
  • Excellent written and verbal communication skills, with experience presenting scientific data.
  • Ability to work independently and collaboratively in a team-oriented environment.
  • Proficiency in data analysis software and literature search tools.
  • Familiarity with specific therapeutic areas such as oncology, immunology, or neuroscience is a plus.
This hybrid role requires a commitment to working in our Liverpool laboratory for a significant portion of the week, with the flexibility for remote work on other days. Our client offers a competitive salary, a comprehensive benefits package, and an environment that fosters scientific excellence and career growth. If you are a passionate researcher dedicated to making a difference in patient lives, we encourage you to apply.
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Research Scientist - Drug Discovery

NG1 3DQ Nottingham, East Midlands £55000 Annually WhatJobs

Posted 10 days ago

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full-time
Our client, a pioneering pharmaceutical company at the forefront of therapeutic innovation, is seeking a talented Research Scientist to join their dedicated Drug Discovery unit. This role is based at their state-of-the-art facility in Nottingham, Nottinghamshire, UK , with a hybrid working arrangement allowing for a balanced approach to research and personal life. You will play a critical role in identifying and validating novel drug targets and developing innovative small molecule therapeutics.

The successful candidate will design and execute complex biological assays, contribute to lead optimization efforts, and collaborate with multidisciplinary teams including medicinal chemists, pharmacologists, and DMPK scientists. Responsibilities include maintaining cell lines, performing high-throughput screening, analysing experimental data, interpreting results, and presenting findings at team meetings and scientific conferences. A strong background in molecular biology, biochemistry, or a related life science discipline is essential, along with hands-on experience in assay development and drug discovery methodologies. The ability to work effectively in a fast-paced, collaborative research environment is crucial.

Key Responsibilities:
  • Design, develop, and validate biochemical and cell-based assays for target identification and validation.
  • Perform high-throughput screening (HTS) and subsequent hit-to-lead optimization studies.
  • Cultivate and maintain mammalian cell lines, including stable transfections and primary cell culture.
  • Conduct detailed data analysis and interpretation using appropriate statistical methods.
  • Contribute to project strategy and experimental planning.
  • Collaborate effectively with chemists, pharmacologists, and other research staff.
  • Present research findings clearly and concisely in internal meetings and scientific publications/conferences.
  • Maintain accurate and up-to-date laboratory notebooks and documentation.
  • Stay current with scientific literature and new technologies in drug discovery.
Qualifications:
  • PhD in Molecular Biology, Biochemistry, Pharmacology, or a closely related field.
  • Postdoctoral experience or equivalent industry experience in drug discovery is highly desirable.
  • Proven experience in assay development, including biochemical and cell-based assays.
  • Hands-on experience with HTS, screening technologies, and data analysis software.
  • Strong understanding of drug discovery processes and principles.
  • Excellent analytical, problem-solving, and critical thinking skills.
  • Strong communication and interpersonal skills, with the ability to work effectively in a team environment.
  • Experience with molecular biology techniques (e.g., PCR, Western Blotting, ELISA) is a plus.
  • Familiarity with GxP environments is advantageous.
Join a dynamic team committed to advancing human health through innovative pharmaceutical research. This role offers the chance to contribute to meaningful discoveries in a supportive and intellectually stimulating environment.
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Research Scientist - Drug Discovery

BS1 3BG Bristol, South West £60000 Annually WhatJobs

Posted 11 days ago

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full-time
Our client, a pioneering biopharmaceutical company, is seeking a highly motivated and innovative Research Scientist to join their cutting-edge, fully remote drug discovery team. This is a unique opportunity to contribute to the development of novel therapeutics by applying advanced scientific methodologies and experimental techniques. You will be at the forefront of scientific innovation, working on challenging projects that have the potential to significantly impact human health.

As a Research Scientist, your primary responsibility will be to design, execute, and interpret experiments aimed at identifying and validating new drug targets and therapeutic candidates. You will conduct literature reviews, develop hypotheses, and plan experimental strategies to address key scientific questions. This role involves extensive laboratory work (where applicable for remote collaboration and data analysis), data analysis, and the interpretation of results using sophisticated analytical tools and software. You will be expected to collaborate effectively with cross-functional teams, including medicinal chemists, biologists, and pharmacologists, to advance research programs. Maintaining accurate and detailed experimental records, and preparing scientific reports, presentations, and publications are integral parts of the role. The ability to troubleshoot experimental issues and propose alternative approaches is crucial. You will also contribute to the ongoing development of novel assay technologies and methodologies within the R&D department.

The ideal candidate will possess a Ph.D. in a relevant life science discipline (e.g., Molecular Biology, Biochemistry, Pharmacology, Genetics) and a minimum of 3 years of post-doctoral or industry research experience in drug discovery. A strong publication record demonstrating expertise in your field is required. Proficiency in a range of molecular and cellular biology techniques, experience with bioinformatics tools, and a solid understanding of disease mechanisms relevant to the company's therapeutic areas are essential. Excellent analytical, critical thinking, and problem-solving skills are paramount. Exceptional written and verbal communication abilities are necessary for effective remote collaboration and knowledge sharing. If you are passionate about scientific discovery and eager to make a difference in a dynamic, remote-first research environment based in Bristol , we encourage you to apply.
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Research Scientist - Drug Discovery

CB2 1GA Cambridge, Eastern £50000 Annually WhatJobs

Posted 11 days ago

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full-time
Our client, a leading pharmaceutical research organisation based in **Cambridge, Cambridgeshire, UK**, is seeking a dedicated and innovative Research Scientist to join their burgeoning drug discovery team. This hybrid role offers the exciting opportunity to contribute to the development of novel therapeutics that address unmet medical needs.

Key Responsibilities:
  • Design and execute in vitro and in vivo experiments to evaluate potential drug candidates.
  • Develop and optimize assays for target identification and validation.
  • Analyse experimental data, interpret results, and contribute to the scientific interpretation of findings.
  • Collaborate closely with cross-functional teams, including chemists, biologists, and pharmacologists, to advance projects from discovery to preclinical development.
  • Maintain detailed experimental records and contribute to the preparation of reports, publications, and presentations.
  • Stay current with the latest scientific literature and technological advancements in relevant therapeutic areas.
  • Contribute to the strategic direction of drug discovery programs.
  • Ensure compliance with all laboratory safety regulations and company policies.

Required Qualifications:
  • Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
  • Minimum of 2-3 years of post-doctoral or industry experience in drug discovery.
  • Proven expertise in designing and conducting biological assays (e.g., enzyme activity, cell-based assays, receptor binding).
  • Strong understanding of disease biology and relevant therapeutic areas.
  • Proficiency in data analysis software (e.g., GraphPad Prism) and statistical methods.
  • Excellent written and verbal communication skills, with the ability to present complex scientific information clearly.
  • Demonstrated ability to work effectively in a collaborative, team-oriented environment.
  • Experience with high-throughput screening (HTS) methodologies is a plus.
  • Familiarity with bioinformatics tools and techniques is desirable.

This position offers a competitive salary, comprehensive benefits package, and the chance to work at the forefront of pharmaceutical innovation. Successful candidates will be required to spend a portion of their week on-site at our state-of-the-art facilities in **Cambridge**. If you are a passionate scientist driven by the pursuit of novel medicines, we encourage you to apply.
Location: Cambridge, Cambridgeshire, UK (Hybrid)
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Research Scientist - Drug Discovery

M1 1AA Manchester, North West £50000 Annually WhatJobs

Posted 15 days ago

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full-time
Our client, a leading innovator in the pharmaceutical sector, is seeking a highly skilled Research Scientist specializing in Drug Discovery to join their cutting-edge team in Manchester, Greater Manchester, UK . This role is integral to our client's mission of developing novel therapeutics to address unmet medical needs. The successful candidate will be instrumental in designing, executing, and analyzing experiments aimed at identifying and validating new drug targets and lead compounds. You will leverage your expertise in molecular biology, biochemistry, or pharmacology to drive research projects from initial hypothesis through to preclinical development. Responsibilities include developing and optimizing assay methodologies, conducting high-throughput screening campaigns, characterizing promising candidates, and collaborating with cross-functional teams including medicinal chemistry, DMPK, and clinical development. We are looking for a scientist with a strong publication record, a deep understanding of modern drug discovery paradigms, and a passion for scientific rigor and innovation. The ability to critically evaluate data, propose creative solutions to complex biological problems, and communicate findings effectively to both scientific and non-scientific audiences is essential. This position offers an exciting opportunity to contribute to impactful research in a collaborative and dynamic environment.

Key Responsibilities:
  • Design and conduct in vitro and in vivo experiments to identify and validate drug targets.
  • Develop and optimize biochemical and cellular assays for compound screening.
  • Execute high-throughput screening (HTS) campaigns and analyze resulting data.
  • Characterize the mechanism of action and potency of lead compounds.
  • Collaborate closely with medicinal chemists to guide structure-activity relationship (SAR) studies.
  • Contribute to the planning and execution of preclinical drug development studies.
  • Analyze and interpret complex datasets, presenting findings clearly and concisely.
  • Maintain detailed experimental records and contribute to scientific publications and patents.
  • Stay abreast of the latest scientific literature and technological advancements in drug discovery.
  • Participate in team meetings and present research progress and findings.
Qualifications:
  • PhD in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
  • Minimum of 3-5 years of post-doctoral or industry experience in drug discovery.
  • Proven experience with assay development, screening, and data analysis.
  • Strong understanding of common drug discovery platforms and methodologies.
  • Excellent analytical and problem-solving skills.
  • Proficiency in relevant scientific software and databases.
  • Strong written and verbal communication skills, with a track record of scientific publications.
  • Ability to work independently and as part of a multidisciplinary team.
  • Experience with biostatistics and data visualization tools.
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