6,828 Drug Metabolism jobs in the United Kingdom
Principal Research Scientist - Drug Metabolism
Posted 20 days ago
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Job Description
Key Responsibilities:
- Design, execute, and interpret complex in vitro and in vivo DMPK studies.
- Develop and validate bioanalytical methods for quantifying drug and metabolite concentrations in biological matrices.
- Provide strategic DMPK input to drug discovery and development teams, guiding lead optimization and candidate selection.
- Characterize the metabolic fate and pharmacokinetic profiles of novel drug candidates.
- Assess drug-drug interaction (DDI) potential and investigate drug transporter roles.
- Utilize PBPK (Physiologically Based Pharmacokinetic) modeling to predict human pharmacokinetics and inform dosing strategies.
- Author high-quality study reports, regulatory documents, and scientific publications.
- Mentor and provide scientific leadership to junior scientists and research associates.
- Stay abreast of cutting-edge technologies and scientific advancements in DMPK and related fields.
- Present scientific findings at internal project meetings and external conferences.
- Ph.D. in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline.
- Minimum of 10 years of relevant industry experience in DMPK research.
- Demonstrated expertise in drug metabolism, pharmacokinetics, bioanalysis, and transporter science.
- Extensive experience with various in vitro ADME assays and bioanalytical techniques (e.g., LC-MS/MS).
- Proficiency in PBPK modeling software (e.g., Simcyp, GastroPlus) is highly desirable.
- Strong understanding of regulatory guidelines related to drug development.
- Excellent problem-solving, analytical, and critical thinking skills.
- Exceptional written and verbal communication skills, with a track record of scientific publications.
- Proven ability to lead scientific projects and collaborate effectively in a remote research environment.
- Experience working with diverse therapeutic areas is a plus.
Principal Research Scientist - Drug Metabolism & Pharmacokinetics (DMPK)
Posted 14 days ago
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Job Description
Key Responsibilities:
- Lead and execute complex in vitro and in vivo DMPK studies to characterise the absorption, distribution, metabolism, and excretion (ADME) properties of drug candidates.
- Design and interpret DMPK studies to support compound selection, candidate progression, and regulatory filings.
- Develop and validate bioanalytical methods for the quantification of drugs and metabolites in biological matrices.
- Utilise modelling and simulation techniques (e.g., PBPK modelling) to predict human pharmacokinetics and inform dose selection.
- Collaborate closely with medicinal chemists, pharmacologists, toxicologists, and formulation scientists to integrate DMPK data into early drug discovery and development strategies.
- Provide strategic guidance on DMPK aspects of drug development programmes to project teams and senior management.
- Contribute to the preparation of scientific manuscripts, presentations, and regulatory documents.
- Mentor and guide junior scientists, fostering scientific excellence and professional development.
- Stay abreast of the latest advancements in DMPK science, technologies, and regulatory expectations.
- Ensure all research activities are conducted in compliance with ethical standards and relevant guidelines.
Qualifications and Skills:
- PhD in Pharmacology, Biochemistry, Pharmaceutical Sciences, Chemistry, or a related discipline with a focus on DMPK.
- A minimum of 10 years of progressive experience in drug metabolism and pharmacokinetics within the pharmaceutical or biotechnology industry.
- Demonstrated expertise in designing and interpreting a wide range of in vitro and in vivo ADME assays.
- Proficiency in bioanalytical method development and validation (e.g., LC-MS/MS).
- Strong understanding of drug transport mechanisms, enzyme kinetics, and drug-drug interaction studies.
- Experience with pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation is highly desirable.
- Proven ability to lead research projects, manage timelines, and contribute to strategic decision-making.
- Excellent written and verbal communication skills, with a strong track record of scientific publication and presentation.
- Demonstrated ability to work independently, manage multiple priorities, and collaborate effectively in a remote setting.
- A deep understanding of the drug development process from discovery through to clinical phases.
This is a pivotal remote role for a highly experienced DMPK scientist seeking to make a significant impact on the development of novel therapeutics.
Principal Pharmaceutical Scientist - Drug Metabolism
Posted 20 days ago
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Job Description
Key Responsibilities:
- Lead and direct research programs in drug metabolism and pharmacokinetics (DMPK).
- Design and interpret in vitro and in vivo studies to characterize drug candidates.
- Develop and validate bioanalytical methods for quantifying drugs and metabolites.
- Provide expert scientific guidance on DMPK issues to project teams.
- Stay abreast of the latest scientific advancements and regulatory requirements in drug metabolism.
- Mentor and guide junior scientists and research associates.
- Author and review scientific reports, publications, and regulatory documents.
- Collaborate with cross-functional teams, including discovery chemistry, toxicology, and clinical pharmacology.
- PhD in Pharmaceutical Sciences, Biochemistry, Chemistry, or a related field.
- Extensive experience in drug metabolism and pharmacokinetic research within the pharmaceutical industry.
- Demonstrated expertise in in vitro and in vivo ADME studies.
- Strong knowledge of bioanalytical techniques (e.g., LC-MS/MS).
- Proven leadership experience and ability to mentor scientific teams.
- Excellent scientific communication, presentation, and writing skills.
- Familiarity with regulatory guidelines for drug development (e.g., FDA, EMA).
Principal Scientist (Drug Metabolism and Pharmacokinetics)
Posted 2 days ago
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Job Description
Responsibilities:
- Lead and execute studies to characterize the ADME (Absorption, Distribution, Metabolism, Excretion) properties of novel drug candidates.
- Design and oversee in vitro and in vivo DMPK studies, utilizing state-of-the-art methodologies.
- Develop and validate bioanalytical methods for the quantification of drug and metabolite concentrations in biological matrices.
- Interpret complex DMPK data to inform compound selection, dose prediction, and potential drug-drug interactions.
- Collaborate closely with medicinal chemists, pharmacologists, and toxicologists to integrate DMPK data into the drug discovery process.
- Prepare high-quality reports, contribute to regulatory filings (e.g., IND, NDA), and present findings at scientific meetings.
- Stay current with scientific advancements and innovative technologies in DMPK research.
- Mentor junior scientists and provide scientific leadership within the DMPK group.
- Manage external collaborations with CROs and academic partners.
- Ensure compliance with GLP standards and all relevant regulatory guidelines.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline with a strong focus on DMPK.
- Minimum of 10 years of experience in drug metabolism and pharmacokinetics within the pharmaceutical industry or a closely related field.
- Extensive hands-on experience with in vitro DMPK assays (e.g., metabolic stability, CYP inhibition/induction, transporter assays) and in vivo pharmacokinetic studies.
- Proficiency in bioanalytical techniques (e.g., LC-MS/MS) and data analysis software.
- Demonstrated expertise in interpreting DMPK data and contributing to preclinical development strategies.
- Excellent scientific communication skills, including writing publications and reports.
- Proven ability to lead research projects and mentor scientific staff.
- Strong problem-solving skills and a creative approach to scientific challenges.
- Ability to thrive in a fully remote, collaborative, and fast-paced research environment.
- Familiarity with regulatory requirements for drug development is essential.
This is an outstanding opportunity to join a forward-thinking organization and make a significant impact on the development of life-saving medicines. The role is fully remote, allowing you to contribute from your home office while supporting key research initiatives for our client based in **Cardiff, Wales, UK**.
Principal Scientist - Drug Metabolism & Pharmacokinetics (DMPK)
Posted 18 days ago
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Job Description
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
Posted 7 days ago
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Job Description
Key Responsibilities:
- Design, oversee, and interpret in vitro and in vivo DMPK studies for small molecules and biologics.
- Develop and validate bioanalytical methods for quantifying drug and metabolite concentrations in biological matrices.
- Conduct pharmacokinetic (PK) and mass balance studies.
- Utilize modeling and simulation (PBPK, population PK) to predict human PK and guide dose selection.
- Assess drug-drug interaction (DDI) potential and understand relevant regulatory guidelines.
- Collaborate with medicinal chemists, pharmacologists, and toxicologists to integrate DMPK data into development strategies.
- Provide scientific leadership and mentorship to DMPK team members.
- Prepare high-quality reports, regulatory submissions, and present findings at scientific conferences.
- Stay abreast of cutting-edge advancements and novel technologies in DMPK and related fields.
- Contribute to strategic decision-making for drug candidate progression.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline.
- Minimum of 8 years of relevant industry experience in drug metabolism and pharmacokinetics.
- Extensive hands-on experience with in vitro ADME assays (e.g., metabolic stability, CYP inhibition/induction, transporter assays).
- Proficiency in PK analysis software (e.g., Phoenix WinNonlin) and modeling tools.
- Strong understanding of bioanalytical techniques (e.g., LC-MS/MS).
- Demonstrated experience in guiding DMPK strategy for preclinical and early clinical development.
- Excellent scientific communication (written and oral) and presentation skills.
- Proven ability to lead projects, mentor scientists, and collaborate effectively in a remote, cross-functional environment.
- Knowledge of regulatory guidelines related to DMPK is essential.
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
Posted 20 days ago
Job Viewed
Job Description
Key Responsibilities:
- Design, execute, and oversee in vitro and in vivo DMPK studies to assess ADME characteristics of drug candidates.
- Develop and validate bioanalytical methods for quantifying drugs and metabolites in biological matrices.
- Interpret complex DMPK data, integrate findings with other preclinical and clinical data, and provide strategic recommendations.
- Contribute to the selection of development candidates based on robust DMPK assessments.
- Lead DMPK strategies for multiple drug discovery projects across various therapeutic areas.
- Prepare and review regulatory documents (e.g., IND, NDA sections) related to DMPK.
- Collaborate effectively with medicinal chemists, toxicologists, pharmacologists, and clinical teams in a remote environment.
- Stay abreast of cutting-edge technologies and methodologies in DMPK and related fields.
- Publish scientific findings in peer-reviewed journals and present at scientific conferences.
- Mentor and guide junior scientists, fostering their scientific and professional development.
- Contribute to the strategic direction of the DMPK department and the broader R&D organization.
- Ensure compliance with all relevant GLP and regulatory guidelines.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, Chemistry, or a related discipline.
- Minimum of 8-10 years of relevant industry experience in drug metabolism and pharmacokinetics.
- Demonstrated success in contributing to the advancement of drug candidates through preclinical and clinical development.
- Expertise in various in vitro and in vivo ADME techniques and assays.
- Strong knowledge of bioanalytical methodologies (e.g., LC-MS/MS).
- Proven experience in preparing regulatory submissions.
- Excellent scientific judgment, problem-solving skills, and strategic thinking.
- Outstanding written and verbal communication skills, with the ability to present complex data clearly and persuasively.
- Ability to lead scientific projects and mentor team members effectively in a remote setting.
- A proactive and collaborative approach to research and development.
- Track record of scientific publications and presentations.
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Research Scientist - Drug Discovery
Posted 3 days ago
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Job Description
We are looking for a highly motivated, detail-oriented individual with excellent analytical and problem-solving skills. Strong written and verbal communication abilities are essential for presenting findings and contributing to scientific publications and reports. This role operates on a hybrid model, combining essential laboratory-based research in our state-of-the-art facilities in Brighton, East Sussex, UK with remote work for data analysis, literature review, and report writing. You must be adept at working independently and as part of a collaborative team. A passion for scientific innovation and a commitment to advancing human health are key. This is an exceptional opportunity to make a significant contribution to the development of life-changing medicines.
Research Scientist - Drug Discovery
Posted 4 days ago
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Job Description
- Designing and conducting in vitro and in vivo experiments to support drug discovery programs.
- Utilising a range of molecular biology, cell biology, and biochemical techniques.
- Analysing and interpreting complex experimental data, preparing comprehensive reports.
- Collaborating with cross-functional teams, including chemists, pharmacologists, and clinicians.
- Contributing to the development of new research methodologies and protocols.
- Maintaining accurate and detailed laboratory notebooks and research records.
- Staying abreast of scientific literature and emerging trends in pharmaceutical research.
- Presenting research findings at internal and external scientific meetings.
- Assisting in the identification and validation of new drug targets.
- Ensuring compliance with all safety and regulatory guidelines in the laboratory.
Qualifications:
- A PhD or MSc in Molecular Biology, Biochemistry, Pharmacology, or a related field.
- Proven experience in drug discovery research, preferably within the pharmaceutical or biotech industry.
- Hands-on experience with relevant laboratory techniques such as cell culture, Western blotting, ELISA, PCR, and flow cytometry.
- Strong analytical and problem-solving skills.
- Excellent written and oral communication skills.
- Ability to work effectively both independently and as part of a multidisciplinary team.
- Experience with data analysis software (e.g., GraphPad Prism, R) is a plus.
- Familiarity with assay development and validation.
- A proactive approach to research and a commitment to scientific rigor.
This is an exciting opportunity for a talented scientist to contribute to the development of life-saving medicines from our state-of-the-art facilities in Southampton.
Research Scientist - Drug Discovery
Posted 9 days ago
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