1,125 Molecular Modeling jobs in the United Kingdom
Principal Scientist, Drug Discovery
Posted today
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Job Description
Responsibilities:
- Lead and design innovative drug discovery research programmes.
- Identify and validate novel therapeutic targets.
- Develop and execute experimental strategies for drug discovery and characterisation.
- Interpret complex biological and pharmacological data.
- Mentor and guide junior scientists and research associates.
- Collaborate effectively with internal teams, academic partners, and CROs.
- Contribute to patent filings and scientific publications.
- Stay abreast of scientific literature and emerging technologies in drug discovery.
- Contribute to strategic planning and decision-making for the R&D pipeline.
- PhD in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
- 10+ years of post-doctoral experience in drug discovery within the pharmaceutical or biotech industry.
- Demonstrated success in leading R&D projects from target identification to lead optimisation.
- Expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience).
- Proven ability to design and interpret complex biological experiments.
- Excellent scientific communication, presentation, and writing skills.
- Strong leadership and mentorship capabilities.
- Experience with remote collaboration tools and working autonomously.
- Publication record in high-impact scientific journals.
Principal Scientist, Drug Discovery
Posted 1 day ago
Job Viewed
Job Description
Key Responsibilities:
- Design, implement, and interpret complex biological assays and experiments to identify and validate novel drug targets and mechanisms of action.
- Lead cross-functional research teams in the discovery and optimization of small molecule or biologic drug candidates.
- Develop and implement cutting-edge research strategies aligned with therapeutic area objectives.
- Analyze and interpret large datasets using statistical and bioinformatics tools to guide experimental design and decision-making.
- Manage external collaborations with academic institutions and contract research organizations (CROs).
- Author high-quality research reports, manuscripts for publication, and presentations for scientific conferences.
- Contribute to the intellectual property strategy through invention disclosures and patent filings.
- Mentor and train junior scientists, fostering a collaborative and innovative research environment.
- Stay current with the latest scientific literature, technologies, and trends in drug discovery and relevant therapeutic areas.
- Ensure rigorous adherence to laboratory safety protocols and good experimental practices.
- Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
- A minimum of 8 years of post-doctoral and/or industry experience in drug discovery, with a strong publication record.
- Demonstrated expertise in a specific therapeutic area (e.g., oncology, immunology, neurology) and relevant disease biology.
- Proven track record of successfully leading drug discovery projects from target identification through lead optimization.
- Extensive experience with a range of biochemical, cellular, and phenotypic assay development and execution.
- Proficiency in data analysis software and bioinformatics tools.
- Excellent critical thinking, problem-solving, and experimental design skills.
- Strong written and verbal communication skills, with the ability to articulate complex scientific concepts to diverse audiences.
- Experience managing projects and mentoring scientific staff.
- Ability to thrive in a fast-paced, dynamic, and remote research environment.
Principal Scientist - Drug Discovery
Posted 1 day ago
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Job Description
Responsibilities include leading research projects, mentoring junior scientists, collaborating with cross-functional teams, and presenting findings at international conferences. You will be expected to develop and validate assays, interpret complex data sets, and contribute to the intellectual property portfolio. Exceptional analytical, problem-solving, and communication skills are paramount. You must be adept at scientific literature review, experimental design, and manuscript preparation. Experience with specific therapeutic areas (e.g., oncology, immunology) and proficiency in relevant scientific software and data analysis tools are highly desirable. This role demands a high degree of autonomy, creativity, and scientific rigor. Our client is committed to fostering a collaborative and innovative remote work environment, providing cutting-edge resources and opportunities for professional growth. You will be at the forefront of developing life-changing medicines, contributing significantly to global health.
Principal Scientist - Drug Discovery
Posted 1 day ago
Job Viewed
Job Description
Key responsibilities:
- Lead and manage complex drug discovery projects from target identification through to lead optimization.
- Develop and implement innovative research strategies to address unmet medical needs.
- Design and conduct experiments using cutting-edge techniques in molecular biology, biochemistry, pharmacology, or related fields.
- Analyze and interpret complex datasets, drawing meaningful conclusions to guide research direction.
- Identify and validate novel drug targets and pathways relevant to various disease areas.
- Design and synthesize potential drug molecules, or oversee their design and synthesis by external partners.
- Contribute to the preparation of regulatory submissions and scientific publications.
- Mentor and provide technical guidance to junior scientists and research associates.
- Foster a collaborative research environment and build strong relationships with academic institutions and industry partners.
- Stay at the forefront of scientific literature and emerging technologies in drug discovery and development.
- Manage project budgets and resources effectively, ensuring timely project completion.
The ideal candidate will possess:
- A PhD in a relevant scientific discipline such as Molecular Biology, Biochemistry, Pharmacology, Medicinal Chemistry, or a related field.
- A minimum of 8-10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry.
- A proven track record of successfully advancing drug candidates through the preclinical stages.
- Extensive experience in experimental design, data analysis, and interpretation.
- Deep understanding of disease biology and drug discovery principles.
- Expertise in one or more therapeutic areas (e.g., oncology, immunology, neurology, infectious diseases).
- Strong leadership, project management, and communication skills.
- Demonstrated ability to mentor and develop scientific talent.
- Excellent track record of scientific publications and presentations.
- Experience with external collaborations and partnership management is highly desirable.
- Ability to thrive in a remote-first, highly collaborative team environment.
Principal Scientist, Drug Discovery
Posted 2 days ago
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Job Description
The Principal Scientist will lead and execute complex research projects aimed at identifying and validating novel drug targets and developing small molecule therapeutics. This role requires a deep understanding of modern drug discovery principles, including target identification and validation, hit-to-lead optimisation, and preclinical development. You will be responsible for designing and interpreting experiments, analysing complex datasets, and contributing to the strategic direction of the drug discovery pipeline. Expertise in relevant therapeutic areas (e.g., oncology, immunology, neurology) is highly desirable. The ideal candidate will have a proven track record of scientific leadership, excellent problem-solving skills, and the ability to mentor junior scientists. We are looking for an individual who is passionate about scientific excellence and driven by the potential to impact patient lives.
Key Responsibilities:
- Lead and manage multiple drug discovery projects from inception to preclinical candidate nomination.
- Design, execute, and interpret complex experiments in areas such as medicinal chemistry, pharmacology, and biology.
- Identify and validate novel drug targets and therapeutic pathways.
- Drive hit identification and lead optimisation campaigns for small molecule therapeutics.
- Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
- Author scientific publications, patent applications, and regulatory documents.
- Present research findings at internal meetings and external scientific conferences.
- Collaborate effectively with cross-functional teams, including biology, chemistry, DMPK, and toxicology.
- Contribute to the strategic planning and decision-making for the drug discovery portfolio.
- PhD in Pharmacology, Biochemistry, Molecular Biology, Medicinal Chemistry, or a related field.
- 10+ years of progressive experience in pharmaceutical or biotechnology drug discovery.
- Demonstrated success in leading discovery projects and delivering preclinical candidates.
- Expertise in a specific therapeutic area (e.g., oncology, infectious diseases, neuroscience) is highly advantageous.
- Strong understanding of assay development, screening technologies, and structure-activity relationships.
- Excellent written and verbal communication skills, with a strong publication record.
- Proven ability to manage projects, mentor staff, and work effectively in a remote team environment.
Principal Scientist - Drug Discovery
Posted 2 days ago
Job Viewed
Job Description
- Leading and managing drug discovery projects from target identification to preclinical candidate selection.
- Designing and overseeing experimental strategies to validate novel therapeutic targets and mechanisms of action.
- Applying expertise in medicinal chemistry, pharmacology, and biology to optimize lead compounds.
- Developing and implementing cutting-edge assays and screening methodologies.
- Interpreting complex experimental data, drawing insightful conclusions, and making strategic recommendations.
- Managing, mentoring, and developing a team of research scientists.
- Collaborating closely with cross-functional teams, including bioinformatics, DMPK, and toxicology.
- Authoring scientific publications, patent applications, and internal reports.
- Representing the company at scientific conferences and engaging with external collaborators.
- Ensuring compliance with all relevant laboratory safety and ethical guidelines.
Principal Drug Discovery Scientist
Posted 2 days ago
Job Viewed
Job Description
Key Responsibilities:
- Lead and design innovative drug discovery projects from target validation through to preclinical candidate nomination.
- Develop and implement robust experimental strategies utilizing state-of-the-art biological assays and techniques.
- Critically evaluate and interpret complex biological data, identifying key trends and making informed decisions.
- Collaborate closely with medicinal chemists, pharmacologists, DMPK scientists, and other R&D functions.
- Manage external research collaborations and CRO relationships effectively.
- Stay abreast of the latest scientific advancements and emerging technologies in relevant therapeutic areas and drug discovery.
- Mentor and provide scientific guidance to junior scientists and research associates.
- Contribute to the strategic planning and prioritization of the drug discovery portfolio.
- Prepare high-quality research reports, manuscripts for publication, and presentations for internal and external audiences.
- Ensure compliance with all laboratory safety and regulatory guidelines.
- Ph.D. in Molecular Biology, Pharmacology, Biochemistry, Immunology, or a related life science discipline.
- A minimum of 10 years of post-doctoral research experience in drug discovery, preferably within the pharmaceutical or biotech industry.
- Proven track record of successfully advancing drug candidates into preclinical development.
- Extensive experience in assay development, target validation, and small molecule/biologics discovery.
- Expertise in specific therapeutic areas (e.g., oncology, immunology, CNS) is highly desirable.
- Strong understanding of medicinal chemistry, pharmacokinetics, and pharmacodynamics principles.
- Excellent analytical, problem-solving, and critical-thinking skills.
- Exceptional communication, presentation, and interpersonal skills.
- Demonstrated leadership capabilities and experience mentoring scientific teams.
- Proven ability to manage complex projects and drive results in a fast-paced environment.
- Experience working in a fully remote R&D setting is essential.
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Principal Scientist - Drug Discovery
Posted 2 days ago
Job Viewed
Job Description
Key Responsibilities:
- Lead and execute complex research projects focused on small molecule or biologic drug discovery.
- Design and implement innovative experimental strategies to assess target validation and drug efficacy.
- Utilize a range of cutting-edge technologies and assays relevant to medicinal chemistry, biology, pharmacology, or DMPK.
- Analyze and interpret complex biological and chemical data, drawing sound conclusions and making data-driven recommendations.
- Collaborate effectively with cross-functional teams, including medicinal chemists, biologists, pharmacologists, and computational scientists.
- Mentor and guide junior scientists, fostering a culture of scientific excellence and continuous learning.
- Stay abreast of the latest scientific literature, industry trends, and emerging technologies in drug discovery.
- Prepare high-quality research reports, presentations, and contribute to patent filings and scientific publications.
- Manage external collaborations and CROs as required.
- Contribute to the strategic direction of the drug discovery pipeline.
- Ensure rigorous adherence to safety protocols and laboratory best practices.
Required Qualifications:
- PhD in Molecular Biology, Biochemistry, Pharmacology, Medicinal Chemistry, or a related life science discipline.
- A minimum of 8 years of progressive drug discovery experience within the pharmaceutical or biotechnology industry.
- Proven track record of successfully contributing to the progression of drug candidates.
- Deep understanding of disease biology and mechanism of action relevant to therapeutic areas.
- Extensive experience with key drug discovery disciplines (e.g., target validation, assay development, screening, lead optimization).
- Strong analytical and problem-solving skills with meticulous attention to detail.
- Excellent communication, presentation, and interpersonal skills, essential for effective remote collaboration.
- Demonstrated ability to lead projects, manage teams, and mentor junior scientists.
- Proficiency in data analysis software and a strong understanding of relevant scientific literature.
- Experience with biologics or antibody discovery is a significant advantage.
This is an exceptional opportunity for a seasoned drug discovery scientist to make a significant impact on human health, working remotely from Reading, Berkshire, UK or any other UK location. Our client is dedicated to innovation and creating a supportive virtual work environment.
Principal Scientist, Drug Discovery
Posted 2 days ago
Job Viewed
Job Description
Key Responsibilities:
- Lead and manage drug discovery research programs, from target identification to lead optimization.
- Design and execute complex experiments using state-of-the-art techniques in molecular biology, cell biology, and biochemistry.
- Analyze and interpret large datasets, draw meaningful conclusions, and make data-driven decisions.
- Supervise, mentor, and develop a team of research scientists and technicians.
- Contribute to the development of intellectual property through patent filings.
- Collaborate with internal and external partners, including academic institutions and CROs.
- Prepare scientific reports, publications, and presentations for internal and external audiences.
- Stay abreast of the latest scientific literature and technological advancements in drug discovery.
- Contribute to strategic planning for the R&D department.
- Ensure compliance with laboratory safety regulations and ethical guidelines.
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a related life science field.
- Minimum of 10 years of post-doctoral experience in drug discovery within the pharmaceutical or biotechnology industry.
- Proven track record of leading successful drug discovery projects and bringing candidates into development.
- Extensive hands-on experience with a variety of drug discovery techniques and technologies.
- Strong understanding of disease mechanisms and therapeutic development pathways.
- Excellent leadership, team management, and interpersonal skills.
- Strong scientific writing and presentation abilities.
- Proficiency in data analysis software and bioinformatics tools.
- Experience in a specific therapeutic area (e.g., oncology, neurology, infectious diseases) is a significant advantage.
Senior Pharmacologist - Drug Discovery
Posted 3 days ago
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Job Description
Key responsibilities will encompass:
- Designing, executing, and interpreting in vitro and in vivo pharmacological studies to assess the efficacy and safety of potential drug candidates.
- Developing and validating novel assays for target engagement, mechanism of action, and pharmacokinetic profiling.
- Collaborating closely with medicinal chemists, biologists, and other research scientists to integrate pharmacological data into drug design strategies.
- Analyzing complex experimental data, troubleshooting assays, and ensuring the highest standards of scientific rigor.
- Contributing to the strategic planning and prioritization of drug discovery projects.
- Writing comprehensive study reports, research summaries, and contributing to the preparation of regulatory documents.
- Keeping abreast of the latest scientific literature, industry trends, and technological advancements in pharmacology and related fields.
- Presenting research findings at internal team meetings and external scientific conferences.
- Mentoring junior scientists and contributing to a collaborative and innovative research environment.
- Ensuring all research activities are conducted in compliance with relevant ethical guidelines and regulatory standards.
- Managing external collaborations and contract research organizations (CROs) as needed.
The ideal candidate will hold a PhD in Pharmacology, Toxicology, or a closely related life science discipline, with a minimum of 5-7 years of post-doctoral or industry experience in drug discovery. A deep understanding of pharmacokinetic (PK) and pharmacodynamic (PD) principles is essential. Demonstrated experience with a range of in vitro and in vivo pharmacological techniques relevant to specific therapeutic areas (e.g., oncology, immunology, neuroscience) is highly desirable. Proficiency in data analysis software (e.g., GraphPad Prism, R) and a strong understanding of statistical methods are required. Excellent written and verbal communication skills are necessary for effective scientific reporting and collaboration. The ability to work independently, manage multiple projects simultaneously, and thrive in a remote team setting is crucial. Experience with regulatory submissions (e.g., IND, NDA) is a significant advantage. This role offers a unique opportunity to make a substantial impact on the development of life-changing medicines.