598 Pharmaceutical Development jobs in the United Kingdom

Pharmaceutical Development Chemist

BS1 4RR Bristol, South West £40000 Annually WhatJobs

Posted 3 days ago

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full-time
Our client, a progressive pharmaceutical company committed to advancing healthcare solutions, is seeking a talented and dedicated Pharmaceutical Development Chemist. This role is situated in our laboratory facilities in **Bristol, South West England, UK**, and is integral to the drug development pipeline. You will be responsible for the synthesis, purification, and characterization of small molecules intended for therapeutic applications. This hands-on role requires a deep understanding of organic chemistry and synthetic methodologies, coupled with practical experience in a laboratory setting. Your responsibilities will include designing and executing synthetic routes, optimizing reaction conditions, and employing various purification techniques such as chromatography. You will also be involved in characterizing synthesized compounds using analytical instrumentation, including NMR, Mass Spectrometry, and HPLC. The ability to interpret analytical data and troubleshoot synthetic challenges is essential. You will collaborate with research scientists and other chemists to advance drug candidates through preclinical development. A strong focus on safety, meticulous record-keeping, and adherence to good laboratory practices (GLP) are paramount. The ideal candidate will possess excellent problem-solving skills, a keen attention to detail, and the ability to work effectively both independently and as part of a team. Experience with process development and scale-up of chemical syntheses would be a significant advantage. Our client values innovation and offers a stimulating work environment with opportunities for professional growth and development. This is an excellent opportunity for a motivated chemist to contribute to the development of life-changing medicines within a reputable pharmaceutical organization.
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Senior Formulation Scientist - Pharmaceutical Development

SO14 1AA Southampton, South East £60000 Annually WhatJobs

Posted 16 days ago

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full-time
Our client, a leading pharmaceutical company, is seeking a highly skilled Senior Formulation Scientist to join their innovative Research and Development team. This role, based in Southampton, Hampshire, UK , will focus on the development and optimisation of novel drug delivery systems and dosage forms for various therapeutic areas. The ideal candidate will have extensive experience in pharmaceutical formulation, excipient selection, and pre-formulation studies, with a strong understanding of regulatory requirements and quality standards. You will be responsible for leading formulation development projects, troubleshooting technical challenges, and contributing to the overall drug development pipeline.

Key Responsibilities:
  • Lead the design, development, and optimisation of pharmaceutical formulations for solid oral dosage forms, sterile injectables, or other relevant dosage forms.
  • Conduct pre-formulation studies, including API characterization, solubility enhancement, and stability assessments.
  • Select appropriate excipients and determine their compatibility with the active pharmaceutical ingredient (API).
  • Develop and validate analytical methods for the characterization of formulations and drug products.
  • Scale-up formulations from laboratory to pilot and commercial manufacturing.
  • Troubleshoot formulation-related issues and implement corrective actions.
  • Prepare detailed formulation development reports, protocols, and regulatory submission documents (e.g., IND, NDA).
  • Collaborate with analytical development, process chemistry, manufacturing, and regulatory affairs teams.
  • Stay current with scientific literature, industry trends, and new technologies in pharmaceutical formulation.
  • Mentor junior scientists and contribute to the scientific advancement of the formulation development group.
Qualifications and Experience:
  • PhD or Master's degree in Pharmaceutical Sciences, Pharmaceutics, Chemistry, Chemical Engineering, or a related discipline.
  • Minimum of 5-7 years of hands-on experience in pharmaceutical formulation development within the pharmaceutical industry.
  • Strong knowledge of solid dosage forms (tablets, capsules) and/or sterile injectables is essential.
  • Experience with various formulation technologies and drug delivery systems.
  • Proficiency in analytical techniques relevant to drug formulation (e.g., HPLC, dissolution testing, DSC, TGA).
  • Familiarity with Good Manufacturing Practices (GMP) and regulatory guidelines (e.g., FDA, EMA).
  • Excellent problem-solving, critical thinking, and scientific writing skills.
  • Strong project management and leadership capabilities.
  • Ability to work effectively in a cross-functional team environment.
This role is a hybrid position, offering flexibility for remote work combined with essential on-site laboratory and team collaboration. Join a company dedicated to improving patient lives through cutting-edge pharmaceutical innovation.
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Senior Formulation Scientist - Pharmaceutical Development

M1 1AN Manchester, North West £65000 Annually WhatJobs

Posted 21 days ago

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full-time
Our client, a rapidly expanding pharmaceutical company located in the heart of Manchester, Greater Manchester, UK , is seeking an accomplished Senior Formulation Scientist to join their dedicated Product Development department. This role is crucial for the design, development, and optimization of innovative pharmaceutical formulations for a range of therapeutic areas. The ideal candidate will possess extensive expertise in pre-formulation, formulation development, and scale-up activities for various dosage forms.

Key Responsibilities:
  • Lead the formulation development of new drug candidates, from early-stage pre-formulation studies through to clinical trial material manufacturing.
  • Design and conduct experiments to evaluate drug substance properties, excipient compatibility, and develop stable, effective drug delivery systems.
  • Develop and optimize formulations for various dosage forms, including oral solid dosage (tablets, capsules), parenteral, and topical preparations.
  • Perform characterization of formulated products using analytical techniques such as dissolution testing, HPLC, DSC, TGA, and microscopy.
  • Plan and oversee scale-up activities from laboratory bench to pilot plant and manufacturing, ensuring process robustness.
  • Troubleshoot formulation and process-related issues, implementing effective solutions.
  • Write detailed development reports, protocols, and validation documents suitable for regulatory submissions.
  • Collaborate closely with analytical development, CMC, regulatory affairs, and manufacturing teams to ensure project timelines are met.
  • Stay current with scientific literature, industry trends, and regulatory guidelines related to pharmaceutical formulation.
  • Mentor junior scientists and contribute to the technical growth of the formulation team.
Qualifications and Experience:
  • MSc or PhD in Pharmaceutical Sciences, Pharmaceutics, Chemistry, or a related field.
  • Minimum of 5-7 years of hands-on experience in pharmaceutical formulation development within the industry.
  • Proven expertise in developing various dosage forms, with a strong emphasis on oral solid dosage and/or sterile injectables.
  • Proficiency in pre-formulation techniques and the use of solid-state characterization methods.
  • Experience with laboratory-scale formulation equipment and pilot plant operations.
  • Knowledge of Good Manufacturing Practice (GMP) and regulatory requirements (e.g., ICH guidelines).
  • Excellent analytical and problem-solving skills, with strong attention to detail.
  • Strong written and verbal communication skills, with the ability to present complex data clearly.
  • Ability to work independently and as part of a multidisciplinary team.
  • Experience with formulation of biologics or complex molecules is an advantage.
  • Familiarity with QbD (Quality by Design) principles in formulation development.
This role offers an exciting opportunity to contribute to the development of life-changing medicines and advance your career in a growing pharmaceutical company. Join our innovative team in Manchester, Greater Manchester, UK . A competitive salary and comprehensive benefits package are provided.
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Senior Pharmaceutical Development Scientist (Formulation)

WV1 2ST Wolverhampton, West Midlands £70000 Annually WhatJobs

Posted 2 days ago

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full-time
Our client, a leading pharmaceutical company, is seeking a highly skilled Senior Pharmaceutical Development Scientist specializing in formulation to join their innovative R&D team. This hybrid role offers a blend of on-site laboratory work and remote analysis/reporting, based in Wolverhampton, West Midlands, UK .

About the Role:
The Senior Pharmaceutical Development Scientist will be responsible for the design, development, and optimization of drug product formulations across various dosage forms. You will play a critical role in pre-formulation studies, formulation development, stability testing, and scale-up activities, contributing to the successful progression of drug candidates through the development pipeline. The ideal candidate will possess strong scientific expertise in pharmaceutics, excellent analytical skills, and a deep understanding of regulatory requirements.

Key Responsibilities:
  • Design and execute pre-formulation studies to characterise active pharmaceutical ingredients (APIs) and excipients.
  • Develop and optimize formulations for various dosage forms, including oral solid dosage forms (tablets, capsules), semi-solids, and liquids.
  • Plan and conduct stability studies according to ICH guidelines and relevant regulatory expectations.
  • Perform analytical testing to support formulation development, including dissolution testing, content uniformity, and impurity profiling.
  • Collaborate with analytical development teams to establish appropriate analytical methods.
  • Support technology transfer activities and the scale-up of manufacturing processes from lab to pilot and commercial scales.
  • Troubleshoot formulation-related issues and propose scientifically sound solutions.
  • Prepare technical reports, development summaries, and regulatory submission documents (e.g., IND, NDA sections).
  • Stay abreast of scientific literature, new technologies, and industry trends in pharmaceutics and drug delivery.
  • Work closely with cross-functional teams, including pre-clinical, clinical, regulatory affairs, and manufacturing.
  • Mentor junior scientists and contribute to a culture of scientific excellence and innovation.
  • Ensure all laboratory activities are conducted in compliance with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) principles.
Qualifications:
  • Ph.D. or Master's degree in Pharmaceutics, Pharmaceutical Sciences, Chemistry, or a related discipline.
  • A minimum of 5-7 years of relevant experience in pharmaceutical formulation development within the pharmaceutical industry.
  • Proven track record in developing and characterizing various dosage forms.
  • Strong understanding of physicochemical principles, drug delivery systems, and material science.
  • Hands-on experience with formulation development equipment and analytical instrumentation.
  • Knowledge of ICH guidelines and regulatory requirements for drug product development.
  • Excellent problem-solving, analytical, and critical thinking skills.
  • Strong written and verbal communication skills, with the ability to document scientific findings clearly and concisely.
  • Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
  • Experience with statistical analysis and design of experiments (DoE) is a plus.
This is an exciting opportunity to contribute to the development of life-changing medicines. Join our research-focused team in Wolverhampton, West Midlands, UK .
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Senior Pharmaceutical Development Scientist (Formulation)

EH1 2HE Edinburgh, Scotland £60000 Annually WhatJobs

Posted 15 days ago

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full-time
Our client, a dynamic and innovative pharmaceutical company dedicated to improving global health, is seeking a highly skilled Senior Pharmaceutical Development Scientist with expertise in formulation. Based in Edinburgh, Scotland, UK , this hybrid role offers the opportunity to contribute to the development of novel drug products from early-stage formulation through to clinical trial supply. You will be a key member of the Pharmaceutical Development team, responsible for designing, executing, and optimizing drug formulations to ensure efficacy, safety, and stability.

Key Responsibilities:
  • Design and develop robust oral solid dosage (OSD) and/or parenteral formulations for small molecules and/or biologics.
  • Plan and execute pre-formulation studies, including physicochemical characterization, solubility enhancement, and excipient compatibility.
  • Conduct formulation development experiments using various techniques (e.g., direct compression, wet granulation, spray drying, lyophilization, sterile filtration).
  • Utilize specialized equipment for formulation development and characterization (e.g., mixers, tablet presses, dissolution testers, particle sizers).
  • Prepare development reports, protocols, and presentations to document experimental findings and support regulatory filings.
  • Collaborate closely with analytical development, DMPK, and regulatory affairs teams to ensure comprehensive product development.
  • Troubleshoot formulation challenges and identify solutions to optimize drug product performance.
  • Contribute to the scale-up of formulations from laboratory to pilot and manufacturing scale.
  • Stay current with industry trends, regulatory guidelines (ICH, FDA, EMA), and new technologies in pharmaceutical formulation.
  • Mentor junior scientists and contribute to the scientific growth of the department.
  • Participate in project team meetings and provide scientific expertise on formulation development.

Qualifications:
  • PhD or Master's degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
  • A minimum of 5 years of relevant experience in pharmaceutical formulation development within the industry.
  • Proven track record in developing OSD (tablets, capsules) and/or parenteral formulations.
  • Hands-on experience with common formulation techniques and analytical characterization methods.
  • Strong understanding of drug delivery principles, pharmacokinetics, and biopharmaceutics.
  • Familiarity with regulatory requirements and ICH guidelines relevant to drug product development.
  • Excellent problem-solving, analytical, and critical thinking skills.
  • Strong written and verbal communication skills, with the ability to clearly document and present scientific data.
  • Ability to work effectively both independently and as part of a cross-functional team in a hybrid environment.
  • Experience with biologics formulation is a significant plus.
  • Proficiency in statistical analysis software is advantageous.
This hybrid role offers a competitive salary, comprehensive benefits package, and the opportunity to contribute to the development of life-changing medicines.
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Senior Pharmaceutical Development Scientist

NR1 1HN Norwich, Eastern £60000 Annually WhatJobs

Posted today

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full-time
A leading pharmaceutical research and development organization in Norwich, Norfolk, UK is seeking an experienced Senior Pharmaceutical Development Scientist to join their dynamic team. This role is central to the advancement of innovative drug products from concept through to clinical trials and potential commercialization. The successful candidate will be responsible for leading formulation development, process optimization, and analytical characterization of new drug entities. You will contribute to the design and execution of experimental plans, troubleshoot complex formulation challenges, and ensure robust and scalable manufacturing processes. Collaboration is key, and you will work closely with discovery teams, manufacturing personnel, and regulatory affairs specialists to ensure seamless project progression. Key responsibilities include maintaining high scientific standards, documenting experimental results meticulously, preparing technical reports and regulatory submissions, and potentially mentoring junior scientists. The ideal candidate will possess a PhD or Master's degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a closely related field, with significant hands-on experience in drug product formulation and development. Expertise in various dosage forms (e.g., oral solid dosage, injectables) and experience with relevant analytical techniques (e.g., HPLC, dissolution testing) are essential. A strong understanding of GMP principles and regulatory guidelines is required. This is an outstanding opportunity to contribute to the development of life-changing medicines within a stimulating and collaborative scientific environment.
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Principal Pharmaceutical Development Scientist

LS2 9AE Leeds, Yorkshire and the Humber £80000 Annually WhatJobs

Posted 1 day ago

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full-time
Our client, a pioneering biopharmaceutical company at the forefront of (Therapeutic Area) research, is seeking a highly innovative and experienced Principal Pharmaceutical Development Scientist to join their state-of-the-art facilities in **Leeds, West Yorkshire, UK**. This senior role is critical to the advancement of our drug discovery and development pipeline, focusing on the formulation and characterization of novel therapeutic entities.

The Principal Scientist will be responsible for leading the design, execution, and interpretation of pre-formulation and formulation development studies for small molecules and/or biologics. You will leverage your extensive knowledge of solid-state chemistry, solubility enhancement techniques, drug delivery systems, and analytical characterization methods to overcome complex formulation challenges. This role involves defining critical quality attributes (CQAs) and establishing control strategies to ensure product robustness and manufacturability. You will also play a key role in scaling up formulations from laboratory to pilot and clinical manufacturing.

This is a fully remote role requiring close collaboration with internal R&D teams, CMC regulatory affairs, and manufacturing partners. The successful candidate will possess strong project management skills, the ability to independently manage multiple projects, and a track record of successfully advancing drug candidates from early development through to clinical trials. You will contribute to the preparation of regulatory submission documents (e.g., IND, NDA) and represent the company at scientific conferences and external meetings. Mentoring junior scientists and contributing to the strategic direction of the pharmaceutical development department will also be key responsibilities. A deep understanding of GMP requirements and ICH guidelines is essential.

Qualifications: PhD in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline. A minimum of 10 years of relevant industry experience in pharmaceutical formulation development. Demonstrated expertise in pre-formulation, formulation design (e.g., amorphous solid dispersions, lipid-based systems, parenteral formulations), and process development. Proficiency in various analytical techniques (e.g., HPLC, DSC, TGA, XRD, dissolution testing). Proven experience in leading formulation projects and contributing to regulatory filings. Excellent problem-solving skills, scientific rigor, and a strong publication record are desirable. Outstanding written and verbal communication skills, with the ability to effectively present complex scientific data. Ability to work autonomously and collaboratively in a virtual environment. This is a significant opportunity for a dedicated scientist to drive innovation and shape the future of drug development at a dynamic and growing company.
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Principal Scientist - Pharmaceutical Development

BD1 5TD Bradford, Yorkshire and the Humber £75000 Annually WhatJobs

Posted 1 day ago

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full-time
Our client, a cutting-edge pharmaceutical company, is seeking an exceptional Principal Scientist to lead critical research and development initiatives within their state-of-the-art facilities in Bradford, West Yorkshire, UK . This is an office-based role requiring a dedicated individual with extensive expertise in pharmaceutical sciences. As a Principal Scientist, you will be responsible for driving innovation in drug discovery and development, from early-stage research through to clinical trial support. You will provide scientific leadership, manage complex research projects, and contribute to the strategic direction of the R&D pipeline. Your expertise will be crucial in identifying and validating novel therapeutic targets, designing robust experimental strategies, and interpreting complex data sets.

The ideal candidate will possess a Ph.D. in a relevant scientific discipline (e.g., Pharmacology, Biochemistry, Medicinal Chemistry) with a minimum of 8-10 years of post-doctoral experience in the pharmaceutical industry. You should have a deep understanding of drug discovery processes, including lead identification, optimization, and preclinical development. Demonstrated experience in managing research teams, mentoring junior scientists, and successfully delivering on project milestones is essential. Strong analytical, problem-solving, and critical thinking skills are required, along with excellent written and verbal communication abilities for reporting and presentation to internal and external stakeholders. Experience with regulatory requirements and submission processes is a significant advantage. The ability to foster collaboration across diverse scientific disciplines and contribute to a high-performance research culture is paramount.

Key Responsibilities:
  • Lead and manage complex R&D projects in pharmaceutical development.
  • Design and execute innovative research strategies to identify and validate new drug candidates.
  • Provide scientific expertise and mentorship to research teams.
  • Interpret complex experimental data and draw robust conclusions.
  • Collaborate with cross-functional teams, including chemistry, biology, and clinical development.
  • Contribute to the development of regulatory submissions and scientific publications.
  • Stay abreast of scientific advancements and emerging technologies in the pharmaceutical field.
  • Manage external collaborations and key opinion leader relationships.
  • Ensure adherence to GxP guidelines and laboratory safety standards.

This is a unique opportunity for a senior scientist to take on a leadership role within a dynamic and rapidly growing pharmaceutical organisation. You will be instrumental in shaping the future of drug development, working on challenging projects that have the potential to significantly improve patient outcomes. Join a team of passionate and talented scientists dedicated to making a difference in healthcare.
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Lead Pharmaceutical Development Scientist

NR4 7TJ Norwich, Eastern £75000 Annually WhatJobs

Posted 2 days ago

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full-time
Our client, a highly respected pharmaceutical research and development company, is seeking an innovative and experienced Lead Pharmaceutical Development Scientist. This hybrid role is based near Norwich, Norfolk, UK , offering a unique opportunity to lead critical drug development projects from discovery through to clinical trials. You will be at the forefront of designing and executing formulation development strategies, characterising drug substances, and ensuring the successful translation of preclinical candidates into viable pharmaceutical products.

Responsibilities:
  • Lead the formulation development of small molecule and/or biologic drug candidates, encompassing pre-formulation studies, excipient selection, and dosage form design.
  • Design and conduct experiments to optimize drug product performance, stability, and manufacturability.
  • Characterise drug substances and drug products using a range of analytical techniques (e.g., HPLC, DSC, XRPD, dissolution testing).
  • Develop and validate analytical methods for raw materials, in-process samples, and finished products.
  • Oversee the preparation of materials for preclinical and early-phase clinical studies, ensuring adherence to GxP guidelines.
  • Collaborate effectively with cross-functional teams, including medicinal chemistry, DMPK, manufacturing, and regulatory affairs.
  • Prepare comprehensive technical reports, study protocols, and regulatory submission documents.
  • Stay abreast of the latest scientific advancements, regulatory guidelines, and industry trends in pharmaceutical development.
  • Mentor and guide junior scientists, fostering a culture of scientific excellence and innovation.
  • Troubleshoot formulation and analytical challenges, providing effective solutions.
  • Manage external collaborations with contract research organizations (CROs) as needed.
Qualifications:
  • PhD or Master's degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
  • Minimum of 8 years of relevant industry experience in pharmaceutical formulation development and/or analytical development.
  • Proven expertise in various dosage forms (e.g., oral solids, injectables, topical).
  • Strong hands-on experience with analytical instrumentation and method development/validation.
  • In-depth knowledge of GxP regulations and requirements for drug development.
  • Excellent understanding of drug delivery principles and material science.
  • Demonstrated leadership and project management skills, with the ability to lead complex projects.
  • Strong scientific curiosity, problem-solving abilities, and attention to detail.
  • Excellent written and verbal communication skills, with the ability to present complex data clearly.
  • Willingness to travel to the Norwich, Norfolk, UK site as required for specific project needs and team collaboration.
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Senior Pharmaceutical Development Scientist

DE1 1AA Derby, East Midlands £55000 Annually WhatJobs

Posted 3 days ago

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full-time
Our client, a dynamic pharmaceutical organization, is actively seeking a highly skilled Senior Pharmaceutical Development Scientist to join their innovative team in **Derby, Derbyshire, UK**. This crucial role focuses on advancing drug candidates from discovery through to clinical trials, involving formulation development, process optimization, and analytical characterization. You will be instrumental in designing and executing studies to establish robust and scalable manufacturing processes for new pharmaceutical products. The ideal candidate will possess a deep understanding of pharmaceutical sciences, including formulation development, drug delivery systems, and analytical chemistry. Proven experience in working with various dosage forms (e.g., oral solid dose, sterile injectables) and a strong command of relevant regulatory guidelines (e.g., ICH, FDA, EMA) are essential. Responsibilities include leading formulation development projects, troubleshooting formulation and process-related issues, developing and validating analytical methods, and preparing comprehensive technical reports and regulatory documentation. You will collaborate closely with chemists, biologists, regulatory affairs specialists, and manufacturing personnel to ensure seamless project progression. We are looking for a scientifically rigorous, creative problem-solver with excellent organizational and communication skills, dedicated to advancing pharmaceutical innovation. This is an exceptional opportunity to contribute to the development of critical medicines and impact patient lives within a progressive company.

Key Responsibilities:
  • Lead formulation development activities for new drug candidates, including pre-formulation studies.
  • Design and optimize manufacturing processes for pharmaceutical products.
  • Develop and validate analytical methods for raw materials, intermediates, and finished products.
  • Conduct stability studies and interpret data to determine shelf-life and storage conditions.
  • Troubleshoot formulation and process-related issues encountered during development.
  • Prepare technical reports, development summaries, and relevant sections of regulatory submissions (e.g., IND, NDA).
  • Collaborate with CMC, regulatory affairs, and manufacturing teams.
  • Ensure all activities comply with Good Manufacturing Practices (GMP) and relevant regulatory guidelines.
  • Stay informed about new technologies and scientific advancements in pharmaceutical development.
Qualifications:
  • Ph.D. or Master's degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
  • Minimum of 5 years of experience in pharmaceutical research and development, with a focus on formulation and process development.
  • Proven experience with various dosage forms and formulation techniques.
  • In-depth knowledge of pharmaceutical analytical techniques (e.g., HPLC, GC, dissolution testing).
  • Familiarity with GMP regulations and ICH guidelines.
  • Excellent problem-solving, analytical, and data interpretation skills.
  • Strong written and verbal communication abilities, with experience in technical writing.
  • Ability to manage multiple projects and work effectively in a team environment.
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