740 Pharmaceutical Development jobs in the United Kingdom
Pharmaceutical Development Chemist
BS1 4RR Bristol, South West
£40000 Annually
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Posted 20 days ago
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Job Description
Our client, a progressive pharmaceutical company committed to advancing healthcare solutions, is seeking a talented and dedicated Pharmaceutical Development Chemist. This role is situated in our laboratory facilities in **Bristol, South West England, UK**, and is integral to the drug development pipeline. You will be responsible for the synthesis, purification, and characterization of small molecules intended for therapeutic applications. This hands-on role requires a deep understanding of organic chemistry and synthetic methodologies, coupled with practical experience in a laboratory setting. Your responsibilities will include designing and executing synthetic routes, optimizing reaction conditions, and employing various purification techniques such as chromatography. You will also be involved in characterizing synthesized compounds using analytical instrumentation, including NMR, Mass Spectrometry, and HPLC. The ability to interpret analytical data and troubleshoot synthetic challenges is essential. You will collaborate with research scientists and other chemists to advance drug candidates through preclinical development. A strong focus on safety, meticulous record-keeping, and adherence to good laboratory practices (GLP) are paramount. The ideal candidate will possess excellent problem-solving skills, a keen attention to detail, and the ability to work effectively both independently and as part of a team. Experience with process development and scale-up of chemical syntheses would be a significant advantage. Our client values innovation and offers a stimulating work environment with opportunities for professional growth and development. This is an excellent opportunity for a motivated chemist to contribute to the development of life-changing medicines within a reputable pharmaceutical organization.
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Principal Formulation Scientist - Pharmaceutical Development
NE1 1AA Newcastle upon Tyne, North East
£70000 Annually
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Posted 3 days ago
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Job Description
Our client is a leading pharmaceutical innovator seeking a highly skilled Principal Formulation Scientist to drive the development of novel drug delivery systems. This critical role is based at our state-of-the-art facility in Newcastle upon Tyne, Tyne and Wear, UK , and involves leading projects from concept through to clinical supply. The ideal candidate will possess extensive experience in pharmaceutical formulation, a deep understanding of drug delivery technologies, and a passion for bringing life-changing medicines to patients.
Responsibilities:
Responsibilities:
- Lead the formulation development of new chemical entities (NCEs) and complex dosage forms (e.g., oral solids, injectables, topical).
- Design and execute formulation studies, including pre-formulation, excipient compatibility, stability testing, and process development.
- Characterize drug substances and drug products using a range of analytical techniques.
- Develop and optimize manufacturing processes for pilot and commercial scale-up.
- Troubleshoot formulation and manufacturing issues, providing scientific expertise and solutions.
- Collaborate effectively with cross-functional teams, including analytical development, DMPK, regulatory affairs, and manufacturing.
- Author and review technical reports, development protocols, and regulatory submission documents.
- Stay abreast of scientific advancements, emerging technologies, and industry trends in pharmaceutical formulation and drug delivery.
- Mentor junior scientists and contribute to the scientific advancement and technical capabilities of the formulation department.
- Ensure all activities are conducted in compliance with GMP and relevant regulatory guidelines.
- PhD or Master's degree in Pharmaceutical Sciences, Pharmaceutics, Chemistry, Chemical Engineering, or a related field.
- Minimum of 8 years of hands-on experience in pharmaceutical formulation development within the industry.
- Proven track record in developing robust and scalable formulations for various dosage forms.
- In-depth knowledge of drug delivery principles, excipient science, and material characterization techniques.
- Experience with analytical techniques such as HPLC, DSC, TGA, XRPD, and dissolution testing.
- Familiarity with GMP requirements and regulatory guidelines (e.g., FDA, EMA).
- Strong understanding of process development and scale-up principles.
- Excellent analytical, problem-solving, and critical thinking skills.
- Superb written and verbal communication skills, with the ability to present complex scientific data clearly.
- Demonstrated leadership capabilities and the ability to manage multiple projects simultaneously.
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1
Senior Formulation Scientist - Pharmaceutical Development
LE2 0BB Leicester, East Midlands
£60000 Annually
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Posted 3 days ago
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Job Description
Our client, a leading pharmaceutical innovator, is seeking an experienced Senior Formulation Scientist to join their dynamic drug development team based in Leicester, Leicestershire, UK . This critical role will focus on the design, development, and optimization of novel drug delivery systems and pharmaceutical formulations. You will be responsible for leading formulation projects from early-stage research through to pre-clinical development, working collaboratively with cross-functional teams including analytical chemistry, pharmacology, and manufacturing. The ideal candidate will possess a strong understanding of pharmaceutical sciences, with extensive hands-on experience in various dosage forms (e.g., oral solids, injectables, topical). You will be adept at experimental design, data analysis, and troubleshooting formulation challenges. A proven ability to manage multiple projects, mentor junior scientists, and contribute to regulatory submissions is essential. This role requires a Ph.D. or Master's degree in Pharmaceutical Sciences, Chemistry, or a related field, coupled with a minimum of 5-7 years of relevant industry experience. Excellent communication, presentation, and problem-solving skills are paramount. You will be expected to stay abreast of the latest scientific advancements and regulatory guidelines. The position offers a competitive salary, comprehensive benefits, and the opportunity to make a significant impact on the development of life-changing medicines. While the role is primarily lab-based, a hybrid working model allows for some flexibility. You will have access to state-of-the-art facilities and a supportive research environment. The ability to interpret complex scientific data and translate it into actionable strategies for formulation development is key. Contribution to scientific publications and presentations at conferences is encouraged.
Key Responsibilities:
Key Responsibilities:
- Design and develop innovative pharmaceutical formulations for various therapeutic areas.
- Conduct pre-formulation studies, including material characterization and stability assessments.
- Optimize existing formulations to improve efficacy, safety, and patient compliance.
- Oversee the preparation of preclinical batches and support in vivo studies.
- Troubleshoot formulation-related issues and implement effective solutions.
- Collaborate with analytical teams to develop and validate analytical methods for formulation characterization.
- Mentor and guide junior scientists in formulation development techniques and best practices.
- Prepare detailed technical reports, development summaries, and contribute to regulatory filings.
- Stay current with scientific literature, industry trends, and regulatory requirements relevant to pharmaceutical formulation.
- Manage project timelines and resources effectively to ensure timely project completion.
- Ph.D. or M.S. in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
- Minimum of 5-7 years of progressive experience in pharmaceutical formulation development.
- Extensive knowledge of various dosage forms (e.g., tablets, capsules, injectables, sustained-release systems).
- Hands-on experience with formulation development equipment and techniques.
- Proficiency in statistical analysis and experimental design (DoE).
- Strong understanding of physical chemistry, material science, and drug delivery principles.
- Excellent written and verbal communication skills, with the ability to present complex data clearly.
- Proven project management skills and ability to lead scientific projects.
- Experience with regulatory guidelines (e.g., FDA, EMA) related to drug development.
- Ability to work effectively in a collaborative, multi-disciplinary team environment.
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2
Senior Formulation Scientist - Pharmaceutical Development
RG1 2AA Reading, South East
£65000 Annually
WhatJobs
Posted 4 days ago
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Job Description
Our client, a prominent pharmaceutical company, is seeking an experienced Senior Formulation Scientist to join their innovative Product Development department based in **Reading, Berkshire, UK**. This critical role involves the design, development, and optimization of robust pharmaceutical formulations for novel drug products, ensuring efficacy, safety, and manufacturability. The ideal candidate will possess a deep understanding of formulation science, solid dosage forms, and regulatory requirements.
Key Responsibilities:
Required Qualifications and Experience:
This hybrid role based in **Reading** offers an exciting opportunity to contribute to the development of life-changing medicines.
Key Responsibilities:
- Lead the development of new drug product formulations (e.g., tablets, capsules, injectables) from early-stage feasibility through to technology transfer.
- Design and execute formulation development studies, including pre-formulation, excipient compatibility, and stability testing.
- Characterize drug substances and formulated products using a range of analytical techniques (e.g., HPLC, dissolution testing, physical property analysis).
- Optimize formulations to achieve desired pharmacokinetic profiles, stability, and manufacturability.
- Troubleshoot formulation and process-related issues, providing expert scientific input.
- Prepare technical reports, development summaries, and relevant documentation for regulatory submissions.
- Collaborate closely with cross-functional teams, including analytical development, process development, manufacturing, and regulatory affairs.
- Evaluate and implement new formulation technologies and methodologies.
- Mentor junior scientists and contribute to the growth of the formulation development team.
Required Qualifications and Experience:
- MSc or PhD in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
- Minimum of 5-7 years of experience in pharmaceutical formulation development, preferably within the pharmaceutical industry.
- Proven experience with oral solid dosage forms (tablets, capsules) and/or parenteral formulations.
- Hands-on experience with common pharmaceutical formulation equipment and analytical instruments.
- Strong understanding of drug delivery principles, pharmacokinetics, and product performance.
- Knowledge of GMP guidelines and regulatory requirements (e.g., FDA, EMA) for drug product development.
- Excellent problem-solving, analytical, and critical thinking skills.
- Strong written and oral communication skills, with the ability to present complex scientific information clearly.
- Ability to work independently and as part of a team in a fast-paced environment.
This hybrid role based in **Reading** offers an exciting opportunity to contribute to the development of life-changing medicines.
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3
Senior Formulation Scientist - Pharmaceutical Development
SR5 2HX Sunderland, North East
£58000 Annually
WhatJobs
Posted 10 days ago
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Job Description
Our client, a highly respected pharmaceutical company based in Sunderland, Tyne and Wear, UK , is seeking an experienced Senior Formulation Scientist to join their innovative Drug Product Development department. This critical role involves the design, development, and optimization of novel drug formulations to support the company's pipeline of therapeutics. You will play a key role in translating preclinical and clinical data into robust, scalable, and effective drug products. The ideal candidate will possess a strong theoretical understanding and practical experience in various pharmaceutical formulation techniques, including solid dosage forms, oral liquids, or parenteral formulations, depending on the company's focus. Responsibilities include conducting pre-formulation studies, developing and optimizing formulations, executing stability studies, and troubleshooting formulation challenges. You will work closely with analytical chemists, process engineers, and project managers to ensure timely delivery of high-quality drug products for clinical trials and commercialization. A deep understanding of pharmaceutical excipients, drug delivery technologies, and relevant regulatory guidelines (e.g., ICH) is essential. This position requires excellent problem-solving skills, meticulous attention to detail, and strong scientific communication abilities, enabling you to effectively document and present your findings. If you are a passionate scientist eager to contribute to the advancement of pharmaceutical innovation, this is an exciting opportunity.
Responsibilities:
Responsibilities:
- Design, develop, and optimize pharmaceutical formulations for small molecules and/or biologics.
- Conduct pre-formulation studies, including solubility, stability, and compatibility assessments.
- Develop prototypes and perform formulation screening to identify optimal drug delivery systems.
- Execute and interpret stability studies according to ICH guidelines.
- Troubleshoot formulation-related issues and propose viable solutions.
- Collaborate with analytical development teams to define testing methods and specifications.
- Support scale-up activities and technology transfer to manufacturing.
- Prepare technical reports, development summaries, and regulatory documentation.
- Stay current with advancements in formulation science and drug delivery technologies.
- PhD or Master's degree in Pharmaceutical Sciences, Pharmaceutics, Chemistry, or a related discipline.
- Significant experience in pharmaceutical formulation development, ideally within a GMP environment.
- Proven expertise in the development of specific dosage forms (e.g., tablets, capsules, injectables).
- Strong understanding of drug delivery principles, excipient functionality, and manufacturing processes.
- Familiarity with ICH guidelines and regulatory requirements for drug product development.
- Excellent analytical, problem-solving, and experimental design skills.
- Proficiency in relevant laboratory equipment and analytical techniques.
- Strong written and verbal communication skills.
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4
Senior Pharmaceutical Development Scientist - Formulation
MK9 2EN Milton Keynes, South East
£70000 Annually
WhatJobs
Posted 7 days ago
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Job Description
Our client, a leading biopharmaceutical company dedicated to advancing healthcare, is seeking a highly skilled and innovative Senior Pharmaceutical Development Scientist specializing in Formulation to join their dynamic research and development team. This is a crucial, fully remote position focused on designing, developing, and optimising novel drug formulations to enhance efficacy, safety, and patient compliance. You will be at the forefront of transforming promising drug candidates into viable therapeutic products.
Responsibilities:
Responsibilities:
- Lead the formulation development of small molecules and/or biologics for various dosage forms (e.g., oral, injectable, topical), ensuring stability, bioavailability, and manufacturability.
- Design and execute experimental studies to investigate drug-excipient compatibility, solubility enhancement, and drug delivery mechanisms.
- Utilise DoE (Design of Experiments) principles to efficiently optimise formulation parameters and manufacturing processes.
- Develop and validate analytical methods for characterising formulated products and assessing drug release profiles.
- Troubleshoot formulation challenges and provide innovative solutions to overcome development hurdles.
- Collaborate closely with pre-clinical, clinical, analytical, and manufacturing sciences teams to ensure seamless project progression.
- Prepare comprehensive technical reports, development summaries, and regulatory submission documents.
- Stay abreast of the latest scientific literature, technological advancements, and regulatory guidelines in pharmaceutical formulation.
- Mentor junior scientists and contribute to a culture of scientific excellence and continuous learning.
- Manage multiple development projects concurrently, ensuring adherence to timelines and budgets in a remote setting.
- Contribute to intellectual property generation and patent applications related to novel formulations.
- Evaluate and implement new formulation technologies and platforms.
- Communicate effectively with internal stakeholders and external partners regarding project status and technical findings.
- A Master's degree or PhD in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
- A minimum of 5-7 years of hands-on experience in pharmaceutical formulation development.
- Proven expertise in developing various dosage forms and understanding of their associated manufacturing processes.
- Strong knowledge of drug delivery systems, material science, and analytical techniques relevant to formulation characterisation.
- Experience with analytical instrumentation (e.g., HPLC, dissolution apparatus, DSC, TGA) is essential.
- Proficiency in statistical analysis software and DoE methodologies.
- Excellent problem-solving abilities and a systematic approach to experimental design and data interpretation.
- Strong written and verbal communication skills, with the ability to present complex scientific information clearly and concisely.
- Ability to work independently and collaboratively in a remote environment, demonstrating strong organisational and time management skills.
- Familiarity with regulatory requirements (e.g., ICH guidelines, FDA, EMA) pertaining to drug product development.
- Experience with biologics formulation is a significant plus.
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5
Principal Pharmaceutical Development Scientist (Formulation)
S1 4HG Sheffield, Yorkshire and the Humber
£85000 Annually
WhatJobs
Posted 18 days ago
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Job Description
Our client, a leading global pharmaceutical company, is seeking a highly skilled and innovative Principal Pharmaceutical Development Scientist specializing in Formulation to join their state-of-the-art research and development facility in **Sheffield, South Yorkshire, UK**. This senior role is crucial for driving the development of novel drug delivery systems and optimizing existing formulations to enhance therapeutic efficacy and patient compliance. The ideal candidate will possess extensive experience in solid dosage forms, a deep understanding of pre-formulation and formulation development, and a strong background in regulatory requirements.
Key Responsibilities:
Key Responsibilities:
- Lead the formulation development of new chemical entities (NCEs) and existing products, focusing on oral solid dosage forms (tablets, capsules).
- Design and execute pre-formulation studies, including physicochemical characterization, solubility enhancement techniques, and excipient compatibility.
- Develop robust, scalable, and manufacturable formulations, optimizing for dissolution, bioavailability, and stability.
- Plan and conduct pre-clinical and clinical formulation trials, ensuring timely delivery of materials.
- Troubleshoot formulation challenges and investigate root causes for product performance issues.
- Utilize advanced analytical techniques (e.g., HPLC, dissolution testing, DSC, TGA, XRPD) to characterize drug substances and formulated products.
- Collaborate closely with analytical development, process chemistry, manufacturing sciences, and regulatory affairs teams to ensure seamless project progression.
- Prepare comprehensive development reports, CMC documentation for regulatory submissions (IND, NDA), and present findings to internal and external stakeholders.
- Stay abreast of the latest advancements in pharmaceutical formulation, drug delivery technologies, and relevant scientific literature.
- Mentor and guide junior scientists, fostering a culture of scientific excellence and innovation.
- Contribute to strategic decision-making regarding drug development pipeline prioritization and technology platform selection.
- Ensure all activities are conducted in compliance with GMP and relevant regulatory guidelines.
- PhD in Pharmaceutics, Pharmaceutical Sciences, Chemistry, or a related discipline.
- A minimum of 10 years of hands-on experience in pharmaceutical formulation development, with a strong emphasis on solid dosage forms.
- Proven expertise in pre-formulation, formulation design, process development, and scale-up.
- In-depth knowledge of excipient science, drug-excipient interactions, and various drug delivery technologies.
- Experience with Good Manufacturing Practices (GMP) and regulatory guidelines (FDA, EMA).
- Proficiency in analytical techniques for characterization of drug substances and products.
- Excellent problem-solving skills and a systematic approach to experimental design and data analysis.
- Strong leadership, communication, and interpersonal skills, with the ability to influence and collaborate effectively across functions.
- Demonstrated ability to manage multiple projects and prioritize effectively.
- Experience with patent literature and intellectual property considerations is desirable.
- Must be eligible to work in the UK.
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Senior Pharmaceutical Development Scientist (Formulation)
WV1 2ST Wolverhampton, West Midlands
£70000 Annually
WhatJobs
Posted 20 days ago
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Job Description
Our client, a leading pharmaceutical company, is seeking a highly skilled Senior Pharmaceutical Development Scientist specializing in formulation to join their innovative R&D team. This hybrid role offers a blend of on-site laboratory work and remote analysis/reporting, based in Wolverhampton, West Midlands, UK .
About the Role:
The Senior Pharmaceutical Development Scientist will be responsible for the design, development, and optimization of drug product formulations across various dosage forms. You will play a critical role in pre-formulation studies, formulation development, stability testing, and scale-up activities, contributing to the successful progression of drug candidates through the development pipeline. The ideal candidate will possess strong scientific expertise in pharmaceutics, excellent analytical skills, and a deep understanding of regulatory requirements.
Key Responsibilities:
About the Role:
The Senior Pharmaceutical Development Scientist will be responsible for the design, development, and optimization of drug product formulations across various dosage forms. You will play a critical role in pre-formulation studies, formulation development, stability testing, and scale-up activities, contributing to the successful progression of drug candidates through the development pipeline. The ideal candidate will possess strong scientific expertise in pharmaceutics, excellent analytical skills, and a deep understanding of regulatory requirements.
Key Responsibilities:
- Design and execute pre-formulation studies to characterise active pharmaceutical ingredients (APIs) and excipients.
- Develop and optimize formulations for various dosage forms, including oral solid dosage forms (tablets, capsules), semi-solids, and liquids.
- Plan and conduct stability studies according to ICH guidelines and relevant regulatory expectations.
- Perform analytical testing to support formulation development, including dissolution testing, content uniformity, and impurity profiling.
- Collaborate with analytical development teams to establish appropriate analytical methods.
- Support technology transfer activities and the scale-up of manufacturing processes from lab to pilot and commercial scales.
- Troubleshoot formulation-related issues and propose scientifically sound solutions.
- Prepare technical reports, development summaries, and regulatory submission documents (e.g., IND, NDA sections).
- Stay abreast of scientific literature, new technologies, and industry trends in pharmaceutics and drug delivery.
- Work closely with cross-functional teams, including pre-clinical, clinical, regulatory affairs, and manufacturing.
- Mentor junior scientists and contribute to a culture of scientific excellence and innovation.
- Ensure all laboratory activities are conducted in compliance with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) principles.
- Ph.D. or Master's degree in Pharmaceutics, Pharmaceutical Sciences, Chemistry, or a related discipline.
- A minimum of 5-7 years of relevant experience in pharmaceutical formulation development within the pharmaceutical industry.
- Proven track record in developing and characterizing various dosage forms.
- Strong understanding of physicochemical principles, drug delivery systems, and material science.
- Hands-on experience with formulation development equipment and analytical instrumentation.
- Knowledge of ICH guidelines and regulatory requirements for drug product development.
- Excellent problem-solving, analytical, and critical thinking skills.
- Strong written and verbal communication skills, with the ability to document scientific findings clearly and concisely.
- Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
- Experience with statistical analysis and design of experiments (DoE) is a plus.
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7
Senior Pharmaceutical Development Scientist
SW1A 0AA London, London
£75000 Annually
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Posted today
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Job Description
Our client, a cutting-edge pharmaceutical company, is seeking a highly accomplished Senior Pharmaceutical Development Scientist to join their innovative team. This is a fully remote position, allowing you to contribute your expertise from anywhere within the UK. You will be at the forefront of drug development, focusing on formulation development, process optimization, and scale-up of novel therapeutic agents. Your role will involve designing and executing experiments to characterize drug substances and develop robust, stable, and bioavailable dosage forms. You will be responsible for leading formulation strategies, troubleshooting formulation challenges, and ensuring that development activities align with regulatory requirements (e.g., FDA, EMA). Key responsibilities include evaluating and selecting appropriate excipients, developing manufacturing processes, and conducting pre-formulation studies. You will work closely with analytical development teams to establish appropriate analytical methods for product characterization and release testing. A significant aspect of this role involves collaborating with project management, manufacturing, and regulatory affairs teams to ensure seamless project progression from early-stage development through to clinical trials and commercialization. You will be expected to stay abreast of the latest scientific advancements and regulatory guidelines in pharmaceutical development. The ability to interpret complex scientific data, present findings clearly, and make data-driven decisions is essential. Strong problem-solving skills and a meticulous approach to experimental design and execution are paramount. As a remote role, exceptional communication skills, self-discipline, and the ability to manage your time effectively are crucial. Proficiency in relevant software for experimental design, data analysis, and report writing is expected. This is a unique opportunity for a dedicated scientist to significantly impact the development of life-changing medicines while enjoying the flexibility of a remote work environment.
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8
Senior Pharmaceutical Development Scientist
NR3 1AA Norwich, Eastern
£60000 Annually
WhatJobs
Posted 1 day ago
Job Viewed
Job Description
Our client, a leading pharmaceutical research and development company, is seeking a highly skilled Senior Pharmaceutical Development Scientist to join their innovative team. This is a fully remote position, offering the flexibility to work from anywhere in the UK. You will play a pivotal role in the formulation and development of novel drug candidates.
Responsibilities:
Responsibilities:
- Lead the formulation development of new drug products, from pre-clinical through to early clinical stages.
- Design and execute experiments to characterize drug substances and optimize formulations, ensuring stability, bioavailability, and manufacturability.
- Develop and validate analytical methods for assessing drug product quality and performance.
- Troubleshoot formulation-related issues and provide scientific expertise to manufacturing and regulatory teams.
- Interpret experimental data, draw scientifically sound conclusions, and prepare comprehensive reports for internal review and regulatory submissions.
- Stay abreast of the latest scientific literature, industry trends, and regulatory guidelines relevant to pharmaceutical development.
- Collaborate effectively with cross-functional teams, including medicinal chemists, process engineers, quality assurance, and regulatory affairs, in a remote setting.
- Contribute to the development of intellectual property and strategic research planning.
- Mentor junior scientists and contribute to a culture of scientific excellence and continuous improvement.
- Ensure all research activities comply with company policies, ethical standards, and regulatory requirements (e.g., GMP).
- Ph.D. or M.S. in Pharmaceutical Sciences, Pharmaceutics, Chemistry, or a related field.
- Minimum of 5 years of experience in pharmaceutical formulation development, with a strong understanding of drug delivery systems.
- Proven experience in designing and conducting formulation studies for various dosage forms (e.g., oral, injectable, topical).
- Proficiency in relevant analytical techniques (e.g., HPLC, GC, dissolution testing, DSC).
- Excellent understanding of physicochemical properties of drugs and their impact on formulation.
- Strong knowledge of regulatory requirements (e.g., ICH guidelines, GMP) for drug development.
- Exceptional problem-solving, analytical, and critical thinking skills.
- Effective written and verbal communication skills, with the ability to present complex data clearly.
- Demonstrated ability to work independently and collaboratively within a remote team environment.
- Experience with pre-formulation studies and excipient selection is highly desirable.
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