598 Pharmaceutical Development jobs in the United Kingdom
Pharmaceutical Development Chemist
Posted 3 days ago
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Senior Formulation Scientist - Pharmaceutical Development
Posted 16 days ago
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Key Responsibilities:
- Lead the design, development, and optimisation of pharmaceutical formulations for solid oral dosage forms, sterile injectables, or other relevant dosage forms.
- Conduct pre-formulation studies, including API characterization, solubility enhancement, and stability assessments.
- Select appropriate excipients and determine their compatibility with the active pharmaceutical ingredient (API).
- Develop and validate analytical methods for the characterization of formulations and drug products.
- Scale-up formulations from laboratory to pilot and commercial manufacturing.
- Troubleshoot formulation-related issues and implement corrective actions.
- Prepare detailed formulation development reports, protocols, and regulatory submission documents (e.g., IND, NDA).
- Collaborate with analytical development, process chemistry, manufacturing, and regulatory affairs teams.
- Stay current with scientific literature, industry trends, and new technologies in pharmaceutical formulation.
- Mentor junior scientists and contribute to the scientific advancement of the formulation development group.
- PhD or Master's degree in Pharmaceutical Sciences, Pharmaceutics, Chemistry, Chemical Engineering, or a related discipline.
- Minimum of 5-7 years of hands-on experience in pharmaceutical formulation development within the pharmaceutical industry.
- Strong knowledge of solid dosage forms (tablets, capsules) and/or sterile injectables is essential.
- Experience with various formulation technologies and drug delivery systems.
- Proficiency in analytical techniques relevant to drug formulation (e.g., HPLC, dissolution testing, DSC, TGA).
- Familiarity with Good Manufacturing Practices (GMP) and regulatory guidelines (e.g., FDA, EMA).
- Excellent problem-solving, critical thinking, and scientific writing skills.
- Strong project management and leadership capabilities.
- Ability to work effectively in a cross-functional team environment.
Senior Formulation Scientist - Pharmaceutical Development
Posted 21 days ago
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Key Responsibilities:
- Lead the formulation development of new drug candidates, from early-stage pre-formulation studies through to clinical trial material manufacturing.
- Design and conduct experiments to evaluate drug substance properties, excipient compatibility, and develop stable, effective drug delivery systems.
- Develop and optimize formulations for various dosage forms, including oral solid dosage (tablets, capsules), parenteral, and topical preparations.
- Perform characterization of formulated products using analytical techniques such as dissolution testing, HPLC, DSC, TGA, and microscopy.
- Plan and oversee scale-up activities from laboratory bench to pilot plant and manufacturing, ensuring process robustness.
- Troubleshoot formulation and process-related issues, implementing effective solutions.
- Write detailed development reports, protocols, and validation documents suitable for regulatory submissions.
- Collaborate closely with analytical development, CMC, regulatory affairs, and manufacturing teams to ensure project timelines are met.
- Stay current with scientific literature, industry trends, and regulatory guidelines related to pharmaceutical formulation.
- Mentor junior scientists and contribute to the technical growth of the formulation team.
- MSc or PhD in Pharmaceutical Sciences, Pharmaceutics, Chemistry, or a related field.
- Minimum of 5-7 years of hands-on experience in pharmaceutical formulation development within the industry.
- Proven expertise in developing various dosage forms, with a strong emphasis on oral solid dosage and/or sterile injectables.
- Proficiency in pre-formulation techniques and the use of solid-state characterization methods.
- Experience with laboratory-scale formulation equipment and pilot plant operations.
- Knowledge of Good Manufacturing Practice (GMP) and regulatory requirements (e.g., ICH guidelines).
- Excellent analytical and problem-solving skills, with strong attention to detail.
- Strong written and verbal communication skills, with the ability to present complex data clearly.
- Ability to work independently and as part of a multidisciplinary team.
- Experience with formulation of biologics or complex molecules is an advantage.
- Familiarity with QbD (Quality by Design) principles in formulation development.
Senior Pharmaceutical Development Scientist (Formulation)
Posted 2 days ago
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About the Role:
The Senior Pharmaceutical Development Scientist will be responsible for the design, development, and optimization of drug product formulations across various dosage forms. You will play a critical role in pre-formulation studies, formulation development, stability testing, and scale-up activities, contributing to the successful progression of drug candidates through the development pipeline. The ideal candidate will possess strong scientific expertise in pharmaceutics, excellent analytical skills, and a deep understanding of regulatory requirements.
Key Responsibilities:
- Design and execute pre-formulation studies to characterise active pharmaceutical ingredients (APIs) and excipients.
- Develop and optimize formulations for various dosage forms, including oral solid dosage forms (tablets, capsules), semi-solids, and liquids.
- Plan and conduct stability studies according to ICH guidelines and relevant regulatory expectations.
- Perform analytical testing to support formulation development, including dissolution testing, content uniformity, and impurity profiling.
- Collaborate with analytical development teams to establish appropriate analytical methods.
- Support technology transfer activities and the scale-up of manufacturing processes from lab to pilot and commercial scales.
- Troubleshoot formulation-related issues and propose scientifically sound solutions.
- Prepare technical reports, development summaries, and regulatory submission documents (e.g., IND, NDA sections).
- Stay abreast of scientific literature, new technologies, and industry trends in pharmaceutics and drug delivery.
- Work closely with cross-functional teams, including pre-clinical, clinical, regulatory affairs, and manufacturing.
- Mentor junior scientists and contribute to a culture of scientific excellence and innovation.
- Ensure all laboratory activities are conducted in compliance with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) principles.
- Ph.D. or Master's degree in Pharmaceutics, Pharmaceutical Sciences, Chemistry, or a related discipline.
- A minimum of 5-7 years of relevant experience in pharmaceutical formulation development within the pharmaceutical industry.
- Proven track record in developing and characterizing various dosage forms.
- Strong understanding of physicochemical principles, drug delivery systems, and material science.
- Hands-on experience with formulation development equipment and analytical instrumentation.
- Knowledge of ICH guidelines and regulatory requirements for drug product development.
- Excellent problem-solving, analytical, and critical thinking skills.
- Strong written and verbal communication skills, with the ability to document scientific findings clearly and concisely.
- Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
- Experience with statistical analysis and design of experiments (DoE) is a plus.
Senior Pharmaceutical Development Scientist (Formulation)
Posted 15 days ago
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Key Responsibilities:
- Design and develop robust oral solid dosage (OSD) and/or parenteral formulations for small molecules and/or biologics.
- Plan and execute pre-formulation studies, including physicochemical characterization, solubility enhancement, and excipient compatibility.
- Conduct formulation development experiments using various techniques (e.g., direct compression, wet granulation, spray drying, lyophilization, sterile filtration).
- Utilize specialized equipment for formulation development and characterization (e.g., mixers, tablet presses, dissolution testers, particle sizers).
- Prepare development reports, protocols, and presentations to document experimental findings and support regulatory filings.
- Collaborate closely with analytical development, DMPK, and regulatory affairs teams to ensure comprehensive product development.
- Troubleshoot formulation challenges and identify solutions to optimize drug product performance.
- Contribute to the scale-up of formulations from laboratory to pilot and manufacturing scale.
- Stay current with industry trends, regulatory guidelines (ICH, FDA, EMA), and new technologies in pharmaceutical formulation.
- Mentor junior scientists and contribute to the scientific growth of the department.
- Participate in project team meetings and provide scientific expertise on formulation development.
Qualifications:
- PhD or Master's degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
- A minimum of 5 years of relevant experience in pharmaceutical formulation development within the industry.
- Proven track record in developing OSD (tablets, capsules) and/or parenteral formulations.
- Hands-on experience with common formulation techniques and analytical characterization methods.
- Strong understanding of drug delivery principles, pharmacokinetics, and biopharmaceutics.
- Familiarity with regulatory requirements and ICH guidelines relevant to drug product development.
- Excellent problem-solving, analytical, and critical thinking skills.
- Strong written and verbal communication skills, with the ability to clearly document and present scientific data.
- Ability to work effectively both independently and as part of a cross-functional team in a hybrid environment.
- Experience with biologics formulation is a significant plus.
- Proficiency in statistical analysis software is advantageous.
Senior Pharmaceutical Development Scientist
Posted today
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Principal Pharmaceutical Development Scientist
Posted 1 day ago
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The Principal Scientist will be responsible for leading the design, execution, and interpretation of pre-formulation and formulation development studies for small molecules and/or biologics. You will leverage your extensive knowledge of solid-state chemistry, solubility enhancement techniques, drug delivery systems, and analytical characterization methods to overcome complex formulation challenges. This role involves defining critical quality attributes (CQAs) and establishing control strategies to ensure product robustness and manufacturability. You will also play a key role in scaling up formulations from laboratory to pilot and clinical manufacturing.
This is a fully remote role requiring close collaboration with internal R&D teams, CMC regulatory affairs, and manufacturing partners. The successful candidate will possess strong project management skills, the ability to independently manage multiple projects, and a track record of successfully advancing drug candidates from early development through to clinical trials. You will contribute to the preparation of regulatory submission documents (e.g., IND, NDA) and represent the company at scientific conferences and external meetings. Mentoring junior scientists and contributing to the strategic direction of the pharmaceutical development department will also be key responsibilities. A deep understanding of GMP requirements and ICH guidelines is essential.
Qualifications: PhD in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline. A minimum of 10 years of relevant industry experience in pharmaceutical formulation development. Demonstrated expertise in pre-formulation, formulation design (e.g., amorphous solid dispersions, lipid-based systems, parenteral formulations), and process development. Proficiency in various analytical techniques (e.g., HPLC, DSC, TGA, XRD, dissolution testing). Proven experience in leading formulation projects and contributing to regulatory filings. Excellent problem-solving skills, scientific rigor, and a strong publication record are desirable. Outstanding written and verbal communication skills, with the ability to effectively present complex scientific data. Ability to work autonomously and collaboratively in a virtual environment. This is a significant opportunity for a dedicated scientist to drive innovation and shape the future of drug development at a dynamic and growing company.
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Principal Scientist - Pharmaceutical Development
Posted 1 day ago
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The ideal candidate will possess a Ph.D. in a relevant scientific discipline (e.g., Pharmacology, Biochemistry, Medicinal Chemistry) with a minimum of 8-10 years of post-doctoral experience in the pharmaceutical industry. You should have a deep understanding of drug discovery processes, including lead identification, optimization, and preclinical development. Demonstrated experience in managing research teams, mentoring junior scientists, and successfully delivering on project milestones is essential. Strong analytical, problem-solving, and critical thinking skills are required, along with excellent written and verbal communication abilities for reporting and presentation to internal and external stakeholders. Experience with regulatory requirements and submission processes is a significant advantage. The ability to foster collaboration across diverse scientific disciplines and contribute to a high-performance research culture is paramount.
Key Responsibilities:
- Lead and manage complex R&D projects in pharmaceutical development.
- Design and execute innovative research strategies to identify and validate new drug candidates.
- Provide scientific expertise and mentorship to research teams.
- Interpret complex experimental data and draw robust conclusions.
- Collaborate with cross-functional teams, including chemistry, biology, and clinical development.
- Contribute to the development of regulatory submissions and scientific publications.
- Stay abreast of scientific advancements and emerging technologies in the pharmaceutical field.
- Manage external collaborations and key opinion leader relationships.
- Ensure adherence to GxP guidelines and laboratory safety standards.
This is a unique opportunity for a senior scientist to take on a leadership role within a dynamic and rapidly growing pharmaceutical organisation. You will be instrumental in shaping the future of drug development, working on challenging projects that have the potential to significantly improve patient outcomes. Join a team of passionate and talented scientists dedicated to making a difference in healthcare.
Lead Pharmaceutical Development Scientist
Posted 2 days ago
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Responsibilities:
- Lead the formulation development of small molecule and/or biologic drug candidates, encompassing pre-formulation studies, excipient selection, and dosage form design.
- Design and conduct experiments to optimize drug product performance, stability, and manufacturability.
- Characterise drug substances and drug products using a range of analytical techniques (e.g., HPLC, DSC, XRPD, dissolution testing).
- Develop and validate analytical methods for raw materials, in-process samples, and finished products.
- Oversee the preparation of materials for preclinical and early-phase clinical studies, ensuring adherence to GxP guidelines.
- Collaborate effectively with cross-functional teams, including medicinal chemistry, DMPK, manufacturing, and regulatory affairs.
- Prepare comprehensive technical reports, study protocols, and regulatory submission documents.
- Stay abreast of the latest scientific advancements, regulatory guidelines, and industry trends in pharmaceutical development.
- Mentor and guide junior scientists, fostering a culture of scientific excellence and innovation.
- Troubleshoot formulation and analytical challenges, providing effective solutions.
- Manage external collaborations with contract research organizations (CROs) as needed.
- PhD or Master's degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
- Minimum of 8 years of relevant industry experience in pharmaceutical formulation development and/or analytical development.
- Proven expertise in various dosage forms (e.g., oral solids, injectables, topical).
- Strong hands-on experience with analytical instrumentation and method development/validation.
- In-depth knowledge of GxP regulations and requirements for drug development.
- Excellent understanding of drug delivery principles and material science.
- Demonstrated leadership and project management skills, with the ability to lead complex projects.
- Strong scientific curiosity, problem-solving abilities, and attention to detail.
- Excellent written and verbal communication skills, with the ability to present complex data clearly.
- Willingness to travel to the Norwich, Norfolk, UK site as required for specific project needs and team collaboration.
Senior Pharmaceutical Development Scientist
Posted 3 days ago
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Key Responsibilities:
- Lead formulation development activities for new drug candidates, including pre-formulation studies.
- Design and optimize manufacturing processes for pharmaceutical products.
- Develop and validate analytical methods for raw materials, intermediates, and finished products.
- Conduct stability studies and interpret data to determine shelf-life and storage conditions.
- Troubleshoot formulation and process-related issues encountered during development.
- Prepare technical reports, development summaries, and relevant sections of regulatory submissions (e.g., IND, NDA).
- Collaborate with CMC, regulatory affairs, and manufacturing teams.
- Ensure all activities comply with Good Manufacturing Practices (GMP) and relevant regulatory guidelines.
- Stay informed about new technologies and scientific advancements in pharmaceutical development.
- Ph.D. or Master's degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline.
- Minimum of 5 years of experience in pharmaceutical research and development, with a focus on formulation and process development.
- Proven experience with various dosage forms and formulation techniques.
- In-depth knowledge of pharmaceutical analytical techniques (e.g., HPLC, GC, dissolution testing).
- Familiarity with GMP regulations and ICH guidelines.
- Excellent problem-solving, analytical, and data interpretation skills.
- Strong written and verbal communication abilities, with experience in technical writing.
- Ability to manage multiple projects and work effectively in a team environment.