1,694 Pharmacokinetics jobs in the United Kingdom
Principal Scientist (Drug Metabolism and Pharmacokinetics)
CF10 1AA Cardiff, Wales
£75000 Annually
WhatJobs
Posted 2 days ago
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Job Description
Our client, a cutting-edge pharmaceutical company, is seeking a highly experienced Principal Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK) to join their remote-first research and development team. This is a critical role for driving the early stages of drug discovery and development.
Responsibilities:
Qualifications:
This is an outstanding opportunity to join a forward-thinking organization and make a significant impact on the development of life-saving medicines. The role is fully remote, allowing you to contribute from your home office while supporting key research initiatives for our client based in **Cardiff, Wales, UK**.
Responsibilities:
- Lead and execute studies to characterize the ADME (Absorption, Distribution, Metabolism, Excretion) properties of novel drug candidates.
- Design and oversee in vitro and in vivo DMPK studies, utilizing state-of-the-art methodologies.
- Develop and validate bioanalytical methods for the quantification of drug and metabolite concentrations in biological matrices.
- Interpret complex DMPK data to inform compound selection, dose prediction, and potential drug-drug interactions.
- Collaborate closely with medicinal chemists, pharmacologists, and toxicologists to integrate DMPK data into the drug discovery process.
- Prepare high-quality reports, contribute to regulatory filings (e.g., IND, NDA), and present findings at scientific meetings.
- Stay current with scientific advancements and innovative technologies in DMPK research.
- Mentor junior scientists and provide scientific leadership within the DMPK group.
- Manage external collaborations with CROs and academic partners.
- Ensure compliance with GLP standards and all relevant regulatory guidelines.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline with a strong focus on DMPK.
- Minimum of 10 years of experience in drug metabolism and pharmacokinetics within the pharmaceutical industry or a closely related field.
- Extensive hands-on experience with in vitro DMPK assays (e.g., metabolic stability, CYP inhibition/induction, transporter assays) and in vivo pharmacokinetic studies.
- Proficiency in bioanalytical techniques (e.g., LC-MS/MS) and data analysis software.
- Demonstrated expertise in interpreting DMPK data and contributing to preclinical development strategies.
- Excellent scientific communication skills, including writing publications and reports.
- Proven ability to lead research projects and mentor scientific staff.
- Strong problem-solving skills and a creative approach to scientific challenges.
- Ability to thrive in a fully remote, collaborative, and fast-paced research environment.
- Familiarity with regulatory requirements for drug development is essential.
This is an outstanding opportunity to join a forward-thinking organization and make a significant impact on the development of life-saving medicines. The role is fully remote, allowing you to contribute from your home office while supporting key research initiatives for our client based in **Cardiff, Wales, UK**.
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Principal Scientist - Drug Metabolism & Pharmacokinetics (DMPK)
DE1 3BW Derby, East Midlands
£75000 Annually
WhatJobs
Posted 18 days ago
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Job Description
Our client, a world-leading pharmaceutical company with a strong pipeline of innovative medicines, is seeking a highly accomplished Principal Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK) to join their cutting-edge research facility in Derby, Derbyshire, UK . This senior role offers the opportunity to lead critical DMPK strategies and contribute significantly to the preclinical development of novel therapeutics. You will be responsible for designing and overseeing in vitro and in vivo DMPK studies, interpreting complex data, and providing expert guidance on drug candidates' absorption, distribution, metabolism, and excretion (ADME) properties. The successful candidate will possess extensive experience in DMPK research, with a deep understanding of biochemical assays, analytical techniques (LC-MS/MS), and PK modeling. A proven ability to lead research projects, mentor junior scientists, and collaborate effectively with cross-functional teams, including medicinal chemistry, toxicology, and clinical pharmacology, is essential. You will play a key role in advancing drug candidates from discovery through to clinical development, contributing to regulatory submissions and scientific publications. Experience with various therapeutic areas and modalities is a plus. This position requires a strong scientific acumen, excellent problem-solving skills, and a commitment to scientific excellence and innovation. As this is a lab-based role critical for direct research operations, it requires a full-time, on-site presence to ensure seamless integration with experimental workflows and laboratory resources.
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1
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
B1 1AA Birmingham, West Midlands
£85000 Annually
WhatJobs
Posted 7 days ago
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Job Description
Our client, a globally leading biopharmaceutical company, is seeking a highly experienced Principal Scientist in Drug Metabolism and Pharmacokinetics (DMPK) to join their fully remote, innovative research and development team. This senior role is crucial for guiding and executing preclinical and early clinical DMPK strategies to advance drug candidates through the development pipeline. The Principal Scientist will be responsible for designing complex in vitro and in vivo studies to characterize the absorption, distribution, metabolism, and excretion (ADME) properties of novel drug molecules. You will interpret complex pharmacokinetic data, develop sophisticated modeling and simulation approaches, and provide critical data to inform drug development decisions. This position requires a deep scientific understanding of drug metabolism pathways, transporter interactions, and pharmacokinetic principles, as well as extensive experience with bioanalytical techniques and regulatory requirements. The ideal candidate will possess excellent leadership, communication, and collaboration skills, with a proven ability to mentor junior scientists and effectively influence cross-functional teams. This role is a unique opportunity to contribute to the discovery and development of life-saving medicines from a remote setting, working alongside a world-class team of scientists.
Key Responsibilities:
Qualifications:
Key Responsibilities:
- Design, oversee, and interpret in vitro and in vivo DMPK studies for small molecules and biologics.
- Develop and validate bioanalytical methods for quantifying drug and metabolite concentrations in biological matrices.
- Conduct pharmacokinetic (PK) and mass balance studies.
- Utilize modeling and simulation (PBPK, population PK) to predict human PK and guide dose selection.
- Assess drug-drug interaction (DDI) potential and understand relevant regulatory guidelines.
- Collaborate with medicinal chemists, pharmacologists, and toxicologists to integrate DMPK data into development strategies.
- Provide scientific leadership and mentorship to DMPK team members.
- Prepare high-quality reports, regulatory submissions, and present findings at scientific conferences.
- Stay abreast of cutting-edge advancements and novel technologies in DMPK and related fields.
- Contribute to strategic decision-making for drug candidate progression.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline.
- Minimum of 8 years of relevant industry experience in drug metabolism and pharmacokinetics.
- Extensive hands-on experience with in vitro ADME assays (e.g., metabolic stability, CYP inhibition/induction, transporter assays).
- Proficiency in PK analysis software (e.g., Phoenix WinNonlin) and modeling tools.
- Strong understanding of bioanalytical techniques (e.g., LC-MS/MS).
- Demonstrated experience in guiding DMPK strategy for preclinical and early clinical development.
- Excellent scientific communication (written and oral) and presentation skills.
- Proven ability to lead projects, mentor scientists, and collaborate effectively in a remote, cross-functional environment.
- Knowledge of regulatory guidelines related to DMPK is essential.
This advertiser has chosen not to accept applicants from your region.
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Principal Research Scientist - Drug Metabolism & Pharmacokinetics (DMPK)
L1 8 Liverpool, North West
£75000 Annually
WhatJobs
Posted 14 days ago
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Job Description
Our client, a globally recognised pharmaceutical company at the forefront of medical innovation, is seeking an exceptional Principal Research Scientist specializing in Drug Metabolism and Pharmacokinetics (DMPK). This is a fully remote position, allowing you to contribute your extensive scientific expertise from your home office, driving critical research that underpins the development of life-saving medicines. You will be a key scientific leader, guiding the strategic direction of DMPK studies and contributing to the selection and advancement of drug candidates through the development pipeline. The company's primary research and development centres are located in Liverpool, Merseyside, UK .
Key Responsibilities:
Qualifications and Skills:
This is a pivotal remote role for a highly experienced DMPK scientist seeking to make a significant impact on the development of novel therapeutics.
Key Responsibilities:
- Lead and execute complex in vitro and in vivo DMPK studies to characterise the absorption, distribution, metabolism, and excretion (ADME) properties of drug candidates.
- Design and interpret DMPK studies to support compound selection, candidate progression, and regulatory filings.
- Develop and validate bioanalytical methods for the quantification of drugs and metabolites in biological matrices.
- Utilise modelling and simulation techniques (e.g., PBPK modelling) to predict human pharmacokinetics and inform dose selection.
- Collaborate closely with medicinal chemists, pharmacologists, toxicologists, and formulation scientists to integrate DMPK data into early drug discovery and development strategies.
- Provide strategic guidance on DMPK aspects of drug development programmes to project teams and senior management.
- Contribute to the preparation of scientific manuscripts, presentations, and regulatory documents.
- Mentor and guide junior scientists, fostering scientific excellence and professional development.
- Stay abreast of the latest advancements in DMPK science, technologies, and regulatory expectations.
- Ensure all research activities are conducted in compliance with ethical standards and relevant guidelines.
Qualifications and Skills:
- PhD in Pharmacology, Biochemistry, Pharmaceutical Sciences, Chemistry, or a related discipline with a focus on DMPK.
- A minimum of 10 years of progressive experience in drug metabolism and pharmacokinetics within the pharmaceutical or biotechnology industry.
- Demonstrated expertise in designing and interpreting a wide range of in vitro and in vivo ADME assays.
- Proficiency in bioanalytical method development and validation (e.g., LC-MS/MS).
- Strong understanding of drug transport mechanisms, enzyme kinetics, and drug-drug interaction studies.
- Experience with pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation is highly desirable.
- Proven ability to lead research projects, manage timelines, and contribute to strategic decision-making.
- Excellent written and verbal communication skills, with a strong track record of scientific publication and presentation.
- Demonstrated ability to work independently, manage multiple priorities, and collaborate effectively in a remote setting.
- A deep understanding of the drug development process from discovery through to clinical phases.
This is a pivotal remote role for a highly experienced DMPK scientist seeking to make a significant impact on the development of novel therapeutics.
This advertiser has chosen not to accept applicants from your region.
3
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
CV1 2DT Coventry, West Midlands
£75000 Annually
WhatJobs
Posted 20 days ago
Job Viewed
Job Description
Our client is actively seeking a highly accomplished Principal Scientist to join their esteemed Drug Metabolism and Pharmacokinetics (DMPK) department. This is a fully remote, senior-level position, offering a unique opportunity to significantly influence the trajectory of drug development programs. The successful candidate will bring extensive expertise in designing and interpreting DMPK studies, contributing critical insights into drug absorption, distribution, metabolism, and excretion (ADME) properties. You will lead scientific initiatives, mentor junior colleagues, and collaborate closely with discovery and development teams to ensure compounds possess favorable pharmacokinetic profiles for clinical success. This role requires a profound scientific understanding, strategic thinking, and exceptional communication skills within a virtual setting.
Key Responsibilities:
Qualifications:
Key Responsibilities:
- Design, execute, and oversee in vitro and in vivo DMPK studies to assess ADME characteristics of drug candidates.
- Develop and validate bioanalytical methods for quantifying drugs and metabolites in biological matrices.
- Interpret complex DMPK data, integrate findings with other preclinical and clinical data, and provide strategic recommendations.
- Contribute to the selection of development candidates based on robust DMPK assessments.
- Lead DMPK strategies for multiple drug discovery projects across various therapeutic areas.
- Prepare and review regulatory documents (e.g., IND, NDA sections) related to DMPK.
- Collaborate effectively with medicinal chemists, toxicologists, pharmacologists, and clinical teams in a remote environment.
- Stay abreast of cutting-edge technologies and methodologies in DMPK and related fields.
- Publish scientific findings in peer-reviewed journals and present at scientific conferences.
- Mentor and guide junior scientists, fostering their scientific and professional development.
- Contribute to the strategic direction of the DMPK department and the broader R&D organization.
- Ensure compliance with all relevant GLP and regulatory guidelines.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, Chemistry, or a related discipline.
- Minimum of 8-10 years of relevant industry experience in drug metabolism and pharmacokinetics.
- Demonstrated success in contributing to the advancement of drug candidates through preclinical and clinical development.
- Expertise in various in vitro and in vivo ADME techniques and assays.
- Strong knowledge of bioanalytical methodologies (e.g., LC-MS/MS).
- Proven experience in preparing regulatory submissions.
- Excellent scientific judgment, problem-solving skills, and strategic thinking.
- Outstanding written and verbal communication skills, with the ability to present complex data clearly and persuasively.
- Ability to lead scientific projects and mentor team members effectively in a remote setting.
- A proactive and collaborative approach to research and development.
- Track record of scientific publications and presentations.
This advertiser has chosen not to accept applicants from your region.
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Senior Formulation Scientist - Drug Development
OX1 3QG Oxford, South East
£65000 Annually
WhatJobs
Posted 10 days ago
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Job Description
Our client, a groundbreaking pharmaceutical company at the forefront of medical innovation, is seeking a highly experienced Senior Formulation Scientist to join their dynamic research and development team. This is a fully remote position, offering an exceptional opportunity to contribute to the development of novel drug delivery systems and pharmaceutical products from your home laboratory or approved remote workspace. You will play a critical role in designing, optimizing, and characterizing drug formulations to meet stringent efficacy, safety, and regulatory standards.
Responsibilities:
Responsibilities:
- Lead the design, development, and optimization of innovative drug formulations (e.g., oral solid dosage forms, injectables, topical applications) for various therapeutic areas.
- Conduct pre-formulation studies to understand drug-excipient compatibility, physicochemical properties, and stability.
- Develop and validate analytical methods for characterizing formulations and assessing drug release profiles.
- Oversee formulation scale-up activities, ensuring successful technology transfer from lab to pilot and manufacturing scales.
- Prepare comprehensive technical documentation, including formulation development reports, analytical method validation reports, and regulatory submission documents.
- Collaborate closely with cross-functional teams, including analytical chemistry, process development, quality assurance, and regulatory affairs.
- Troubleshoot formulation challenges and implement robust solutions to ensure product quality and performance.
- Stay abreast of the latest advancements in pharmaceutical formulation science, drug delivery technologies, and relevant regulatory guidelines.
- Mentor and guide junior scientists, fostering a culture of scientific excellence and continuous learning.
- Manage external contract research organizations (CROs) for specific formulation development activities, ensuring project timelines and deliverables are met.
- PhD or Master's degree in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, or a related discipline.
- Minimum of 7 years of hands-on experience in pharmaceutical formulation development, with a proven track record in bringing drug products from concept to clinical trial stages.
- In-depth knowledge of various drug delivery systems and formulation techniques.
- Proficiency in relevant analytical techniques (e.g., HPLC, GC, DSC, XRPD) for formulation characterization.
- Strong understanding of pharmaceutical manufacturing processes and GMP requirements.
- Experience with regulatory guidelines (e.g., ICH, FDA, EMA) pertaining to drug development.
- Excellent problem-solving skills, with a keen attention to detail and the ability to interpret complex data.
- Exceptional written and verbal communication skills, with the ability to effectively present scientific findings.
- Proven ability to work independently and manage multiple projects in a remote research environment.
- Experience with statistical analysis software and design of experiments (DoE) is advantageous.
This advertiser has chosen not to accept applicants from your region.
5
Principal Formulation Scientist - Drug Development
NG1 6AE Nottingham, East Midlands
£80000 Annually
WhatJobs
Posted 19 days ago
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Job Description
Our client, a leading pharmaceutical company dedicated to advancing healthcare through innovative drug development, is seeking an experienced and highly skilled Principal Formulation Scientist to join their dynamic R&D team in Nottingham, Nottinghamshire, UK . This critical role will involve leading the development of novel drug delivery systems and innovative formulations for a diverse pipeline of pharmaceutical products. You will be at the forefront of designing, optimizing, and scaling up formulations, ensuring product efficacy, stability, and bioavailability. The ideal candidate will possess a deep understanding of pharmaceutical sciences, particularly in pre-formulation, formulation development, and manufacturing processes. Responsibilities include conducting pre-formulation studies, designing and executing experiments for solid dosage forms, sterile injectables, or other relevant delivery routes, and characterizing formulation performance. You will lead the troubleshooting of formulation challenges and provide expert scientific guidance to project teams. The Principal Formulation Scientist will play a key role in the transition of formulations from laboratory scale to clinical manufacturing and beyond. Collaboration with cross-functional teams, including analytical development, DMPK, regulatory affairs, and manufacturing, is essential. You will also contribute to the scientific strategy of the formulation department, stay abreast of emerging technologies, and potentially mentor junior scientists. A strong publication record and experience with intellectual property development are desirable. This hybrid role offers a blend of essential lab-based work and remote strategic planning and analysis, providing a balanced and productive work environment. This is an excellent opportunity to contribute to life-changing medicines within a supportive and scientifically driven organization in Nottingham .
Qualifications:
Qualifications:
- Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemistry, or a related field
- Minimum of 7 years of progressive experience in pharmaceutical formulation development
- Proven expertise in developing various dosage forms (e.g., oral solids, injectables, topical)
- Strong understanding of pre-formulation, excipient selection, and drug-excipient compatibility
- Hands-on experience with formulation characterization techniques (e.g., DSC, TGA, XRPD, dissolution)
- Experience with pilot-scale formulation manufacturing and technology transfer
- Knowledge of GMP guidelines and regulatory requirements for drug development
- Excellent problem-solving, analytical, and critical thinking skills
- Strong project management and organizational abilities
- Effective communication and interpersonal skills for cross-functional collaboration
- Ability to mentor junior scientists and contribute to scientific strategy
- Experience with specific therapeutic areas is a plus
This advertiser has chosen not to accept applicants from your region.
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6
Pharmaceutical Formulation Scientist - Drug Development
MK9 2EZ Milton Keynes, South East
£60000 Annually
WhatJobs
Posted 20 days ago
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Job Description
Our client, a leading pharmaceutical company dedicated to advancing healthcare solutions, is seeking a skilled and innovative Pharmaceutical Formulation Scientist to join their research and development team in Milton Keynes, Buckinghamshire, UK . This role is pivotal in the early-stage development of novel drug formulations, contributing to the creation of effective and patient-centric medicines. The ideal candidate will possess a strong background in pharmaceutical sciences, with hands-on experience in formulation development and characterization. Responsibilities will include:
- Designing, developing, and optimizing oral solid dosage forms (tablets, capsules) and potentially other dosage forms.
- Conducting pre-formulation studies to understand the physicochemical properties of active pharmaceutical ingredients (APIs) and excipients.
- Evaluating and selecting appropriate excipients to achieve desired drug release profiles and stability.
- Utilizing various laboratory techniques for formulation preparation and characterization (e.g., particle size analysis, dissolution testing, differential scanning calorimetry).
- Developing and validating analytical methods for drug product testing.
- Conducting stability studies to assess the shelf-life and performance of formulations under various conditions.
- Troubleshooting formulation challenges and proposing innovative solutions.
- Collaborating with analytical development, process development, and regulatory affairs teams.
- Documenting experimental procedures, results, and reports in accordance with company standards and regulatory guidelines.
- Staying current with scientific literature and industry trends in pharmaceutical formulation and drug delivery.
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Senior Formulation Scientist - Innovative Drug Development
LE2 0AA Leicester, East Midlands
£55000 Annually
WhatJobs
Posted 4 days ago
Job Viewed
Job Description
Our client, a leading innovator in pharmaceutical research and development, is seeking a highly skilled and motivated Senior Formulation Scientist to join their dynamic team. This is an exciting opportunity to contribute to the development of cutting-edge therapeutic agents from pre-clinical stages through to clinical trials. The role will involve extensive laboratory work, data analysis, and collaboration with cross-functional teams.
Key Responsibilities:
Key Responsibilities:
- Design, develop, and optimize novel drug delivery systems and formulations for various routes of administration (e.g., oral, injectable, topical).
- Conduct pre-formulation studies, including API characterization, solubility enhancement, and stability assessment.
- Perform compatibility studies and develop analytical methods for drug substance and drug product characterization.
- Utilize a range of formulation technologies and equipment, including granulation, coating, lyophilization, and sterile manufacturing processes.
- Execute experiments meticulously, document all findings accurately in laboratory notebooks and reports, and present results to project teams and management.
- Troubleshoot formulation challenges and propose innovative solutions.
- Collaborate closely with analytical chemists, process engineers, and clinical development teams to ensure successful project progression.
- Stay abreast of the latest scientific literature, regulatory guidelines, and industry trends in pharmaceutical formulation.
- Contribute to the preparation of regulatory submission documents (e.g., IND, NDA).
- PhD or MSc in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related field.
- Minimum of 5 years of relevant experience in pharmaceutical formulation development, preferably within an R&D setting.
- Proven track record in developing various dosage forms, with a strong understanding of formulation science principles.
- Hands-on experience with laboratory equipment for formulation development and characterization.
- Proficiency in relevant analytical techniques (e.g., HPLC, GC, DSC, TGA, XRPD).
- Excellent understanding of Good Manufacturing Practice (GMP) and regulatory requirements.
- Strong problem-solving skills, attention to detail, and ability to work independently and as part of a team.
- Effective communication and interpersonal skills.
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Senior Clinical Research Scientist - Oncology Drug Development
M1 1AA Manchester, North West
£70000 Annually
WhatJobs
Posted 2 days ago
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Job Description
Our client, a leading biopharmaceutical innovator, is seeking a highly motivated Senior Clinical Research Scientist to join their cutting-edge oncology research team. This fully remote position offers the unique opportunity to contribute significantly to the development of novel cancer therapies from anywhere in the UK. You will be at the forefront of scientific advancement, playing a pivotal role in the design, execution, and interpretation of clinical trials that have the potential to transform patient lives.
Key Responsibilities:
Qualifications and Experience:
This is a crucial role for an accomplished scientist passionate about making a difference in the fight against cancer. Join our innovative client and shape the future of oncology treatments.
Key Responsibilities:
- Design and develop clinical trial protocols for oncology assets, ensuring scientific rigor and regulatory compliance.
- Oversee the execution of clinical studies, providing scientific and medical expertise to cross-functional teams.
- Analyze and interpret complex clinical trial data, including efficacy and safety endpoints.
- Collaborate with regulatory affairs, statistics, and medical writing teams to prepare submissions and publications.
- Stay abreast of the latest scientific advancements, emerging trends, and competitive landscape in oncology drug development.
- Identify and engage with key opinion leaders (KOLs) and investigators in the field.
- Contribute to the strategic planning and decision-making processes for the oncology portfolio.
- Develop and present scientific data internally and externally at conferences and meetings.
- Ensure adherence to Good Clinical Practice (GCP) guidelines and all relevant regulations.
- Mentor junior scientists and contribute to the growth of the research department.
Qualifications and Experience:
- Ph.D. or M.D. in a relevant life science discipline (e.g., Oncology, Immunology, Pharmacology).
- Minimum of 5-7 years of experience in clinical research and drug development, with a significant focus on oncology.
- Demonstrated experience in designing and managing complex clinical trials (Phase I-III).
- In-depth knowledge of oncology disease areas, drug mechanisms, and current treatment paradigms.
- Strong understanding of regulatory requirements (FDA, EMA) and GCP.
- Excellent analytical, statistical interpretation, and problem-solving skills.
- Exceptional written and verbal communication skills, with a proven track record of scientific publications and presentations.
- Ability to work effectively in a remote, fast-paced, and collaborative environment.
- Experience with data management systems and statistical analysis software is a plus.
- Strong leadership potential and ability to influence cross-functional teams.
This is a crucial role for an accomplished scientist passionate about making a difference in the fight against cancer. Join our innovative client and shape the future of oncology treatments.
This advertiser has chosen not to accept applicants from your region.
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