1,694 Pharmacokinetics jobs in the United Kingdom
Principal Scientist (Drug Metabolism and Pharmacokinetics)
Posted 2 days ago
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Job Description
Responsibilities:
- Lead and execute studies to characterize the ADME (Absorption, Distribution, Metabolism, Excretion) properties of novel drug candidates.
- Design and oversee in vitro and in vivo DMPK studies, utilizing state-of-the-art methodologies.
- Develop and validate bioanalytical methods for the quantification of drug and metabolite concentrations in biological matrices.
- Interpret complex DMPK data to inform compound selection, dose prediction, and potential drug-drug interactions.
- Collaborate closely with medicinal chemists, pharmacologists, and toxicologists to integrate DMPK data into the drug discovery process.
- Prepare high-quality reports, contribute to regulatory filings (e.g., IND, NDA), and present findings at scientific meetings.
- Stay current with scientific advancements and innovative technologies in DMPK research.
- Mentor junior scientists and provide scientific leadership within the DMPK group.
- Manage external collaborations with CROs and academic partners.
- Ensure compliance with GLP standards and all relevant regulatory guidelines.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline with a strong focus on DMPK.
- Minimum of 10 years of experience in drug metabolism and pharmacokinetics within the pharmaceutical industry or a closely related field.
- Extensive hands-on experience with in vitro DMPK assays (e.g., metabolic stability, CYP inhibition/induction, transporter assays) and in vivo pharmacokinetic studies.
- Proficiency in bioanalytical techniques (e.g., LC-MS/MS) and data analysis software.
- Demonstrated expertise in interpreting DMPK data and contributing to preclinical development strategies.
- Excellent scientific communication skills, including writing publications and reports.
- Proven ability to lead research projects and mentor scientific staff.
- Strong problem-solving skills and a creative approach to scientific challenges.
- Ability to thrive in a fully remote, collaborative, and fast-paced research environment.
- Familiarity with regulatory requirements for drug development is essential.
This is an outstanding opportunity to join a forward-thinking organization and make a significant impact on the development of life-saving medicines. The role is fully remote, allowing you to contribute from your home office while supporting key research initiatives for our client based in **Cardiff, Wales, UK**.
Principal Scientist - Drug Metabolism & Pharmacokinetics (DMPK)
Posted 18 days ago
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Job Description
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
Posted 7 days ago
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Job Description
Key Responsibilities:
- Design, oversee, and interpret in vitro and in vivo DMPK studies for small molecules and biologics.
- Develop and validate bioanalytical methods for quantifying drug and metabolite concentrations in biological matrices.
- Conduct pharmacokinetic (PK) and mass balance studies.
- Utilize modeling and simulation (PBPK, population PK) to predict human PK and guide dose selection.
- Assess drug-drug interaction (DDI) potential and understand relevant regulatory guidelines.
- Collaborate with medicinal chemists, pharmacologists, and toxicologists to integrate DMPK data into development strategies.
- Provide scientific leadership and mentorship to DMPK team members.
- Prepare high-quality reports, regulatory submissions, and present findings at scientific conferences.
- Stay abreast of cutting-edge advancements and novel technologies in DMPK and related fields.
- Contribute to strategic decision-making for drug candidate progression.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, or a related discipline.
- Minimum of 8 years of relevant industry experience in drug metabolism and pharmacokinetics.
- Extensive hands-on experience with in vitro ADME assays (e.g., metabolic stability, CYP inhibition/induction, transporter assays).
- Proficiency in PK analysis software (e.g., Phoenix WinNonlin) and modeling tools.
- Strong understanding of bioanalytical techniques (e.g., LC-MS/MS).
- Demonstrated experience in guiding DMPK strategy for preclinical and early clinical development.
- Excellent scientific communication (written and oral) and presentation skills.
- Proven ability to lead projects, mentor scientists, and collaborate effectively in a remote, cross-functional environment.
- Knowledge of regulatory guidelines related to DMPK is essential.
Principal Research Scientist - Drug Metabolism & Pharmacokinetics (DMPK)
Posted 14 days ago
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Job Description
Key Responsibilities:
- Lead and execute complex in vitro and in vivo DMPK studies to characterise the absorption, distribution, metabolism, and excretion (ADME) properties of drug candidates.
- Design and interpret DMPK studies to support compound selection, candidate progression, and regulatory filings.
- Develop and validate bioanalytical methods for the quantification of drugs and metabolites in biological matrices.
- Utilise modelling and simulation techniques (e.g., PBPK modelling) to predict human pharmacokinetics and inform dose selection.
- Collaborate closely with medicinal chemists, pharmacologists, toxicologists, and formulation scientists to integrate DMPK data into early drug discovery and development strategies.
- Provide strategic guidance on DMPK aspects of drug development programmes to project teams and senior management.
- Contribute to the preparation of scientific manuscripts, presentations, and regulatory documents.
- Mentor and guide junior scientists, fostering scientific excellence and professional development.
- Stay abreast of the latest advancements in DMPK science, technologies, and regulatory expectations.
- Ensure all research activities are conducted in compliance with ethical standards and relevant guidelines.
Qualifications and Skills:
- PhD in Pharmacology, Biochemistry, Pharmaceutical Sciences, Chemistry, or a related discipline with a focus on DMPK.
- A minimum of 10 years of progressive experience in drug metabolism and pharmacokinetics within the pharmaceutical or biotechnology industry.
- Demonstrated expertise in designing and interpreting a wide range of in vitro and in vivo ADME assays.
- Proficiency in bioanalytical method development and validation (e.g., LC-MS/MS).
- Strong understanding of drug transport mechanisms, enzyme kinetics, and drug-drug interaction studies.
- Experience with pharmacokinetic/pharmacodynamic (PK/PD) modelling and simulation is highly desirable.
- Proven ability to lead research projects, manage timelines, and contribute to strategic decision-making.
- Excellent written and verbal communication skills, with a strong track record of scientific publication and presentation.
- Demonstrated ability to work independently, manage multiple priorities, and collaborate effectively in a remote setting.
- A deep understanding of the drug development process from discovery through to clinical phases.
This is a pivotal remote role for a highly experienced DMPK scientist seeking to make a significant impact on the development of novel therapeutics.
Principal Scientist, Drug Metabolism and Pharmacokinetics (DMPK)
Posted 20 days ago
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Job Description
Key Responsibilities:
- Design, execute, and oversee in vitro and in vivo DMPK studies to assess ADME characteristics of drug candidates.
- Develop and validate bioanalytical methods for quantifying drugs and metabolites in biological matrices.
- Interpret complex DMPK data, integrate findings with other preclinical and clinical data, and provide strategic recommendations.
- Contribute to the selection of development candidates based on robust DMPK assessments.
- Lead DMPK strategies for multiple drug discovery projects across various therapeutic areas.
- Prepare and review regulatory documents (e.g., IND, NDA sections) related to DMPK.
- Collaborate effectively with medicinal chemists, toxicologists, pharmacologists, and clinical teams in a remote environment.
- Stay abreast of cutting-edge technologies and methodologies in DMPK and related fields.
- Publish scientific findings in peer-reviewed journals and present at scientific conferences.
- Mentor and guide junior scientists, fostering their scientific and professional development.
- Contribute to the strategic direction of the DMPK department and the broader R&D organization.
- Ensure compliance with all relevant GLP and regulatory guidelines.
Qualifications:
- PhD in Pharmaceutical Sciences, Biochemistry, Pharmacology, Chemistry, or a related discipline.
- Minimum of 8-10 years of relevant industry experience in drug metabolism and pharmacokinetics.
- Demonstrated success in contributing to the advancement of drug candidates through preclinical and clinical development.
- Expertise in various in vitro and in vivo ADME techniques and assays.
- Strong knowledge of bioanalytical methodologies (e.g., LC-MS/MS).
- Proven experience in preparing regulatory submissions.
- Excellent scientific judgment, problem-solving skills, and strategic thinking.
- Outstanding written and verbal communication skills, with the ability to present complex data clearly and persuasively.
- Ability to lead scientific projects and mentor team members effectively in a remote setting.
- A proactive and collaborative approach to research and development.
- Track record of scientific publications and presentations.
Senior Formulation Scientist - Drug Development
Posted 10 days ago
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Job Description
Responsibilities:
- Lead the design, development, and optimization of innovative drug formulations (e.g., oral solid dosage forms, injectables, topical applications) for various therapeutic areas.
- Conduct pre-formulation studies to understand drug-excipient compatibility, physicochemical properties, and stability.
- Develop and validate analytical methods for characterizing formulations and assessing drug release profiles.
- Oversee formulation scale-up activities, ensuring successful technology transfer from lab to pilot and manufacturing scales.
- Prepare comprehensive technical documentation, including formulation development reports, analytical method validation reports, and regulatory submission documents.
- Collaborate closely with cross-functional teams, including analytical chemistry, process development, quality assurance, and regulatory affairs.
- Troubleshoot formulation challenges and implement robust solutions to ensure product quality and performance.
- Stay abreast of the latest advancements in pharmaceutical formulation science, drug delivery technologies, and relevant regulatory guidelines.
- Mentor and guide junior scientists, fostering a culture of scientific excellence and continuous learning.
- Manage external contract research organizations (CROs) for specific formulation development activities, ensuring project timelines and deliverables are met.
- PhD or Master's degree in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, or a related discipline.
- Minimum of 7 years of hands-on experience in pharmaceutical formulation development, with a proven track record in bringing drug products from concept to clinical trial stages.
- In-depth knowledge of various drug delivery systems and formulation techniques.
- Proficiency in relevant analytical techniques (e.g., HPLC, GC, DSC, XRPD) for formulation characterization.
- Strong understanding of pharmaceutical manufacturing processes and GMP requirements.
- Experience with regulatory guidelines (e.g., ICH, FDA, EMA) pertaining to drug development.
- Excellent problem-solving skills, with a keen attention to detail and the ability to interpret complex data.
- Exceptional written and verbal communication skills, with the ability to effectively present scientific findings.
- Proven ability to work independently and manage multiple projects in a remote research environment.
- Experience with statistical analysis software and design of experiments (DoE) is advantageous.
Principal Formulation Scientist - Drug Development
Posted 19 days ago
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Job Description
Qualifications:
- Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemistry, or a related field
- Minimum of 7 years of progressive experience in pharmaceutical formulation development
- Proven expertise in developing various dosage forms (e.g., oral solids, injectables, topical)
- Strong understanding of pre-formulation, excipient selection, and drug-excipient compatibility
- Hands-on experience with formulation characterization techniques (e.g., DSC, TGA, XRPD, dissolution)
- Experience with pilot-scale formulation manufacturing and technology transfer
- Knowledge of GMP guidelines and regulatory requirements for drug development
- Excellent problem-solving, analytical, and critical thinking skills
- Strong project management and organizational abilities
- Effective communication and interpersonal skills for cross-functional collaboration
- Ability to mentor junior scientists and contribute to scientific strategy
- Experience with specific therapeutic areas is a plus
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Pharmaceutical Formulation Scientist - Drug Development
Posted 20 days ago
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Job Description
- Designing, developing, and optimizing oral solid dosage forms (tablets, capsules) and potentially other dosage forms.
- Conducting pre-formulation studies to understand the physicochemical properties of active pharmaceutical ingredients (APIs) and excipients.
- Evaluating and selecting appropriate excipients to achieve desired drug release profiles and stability.
- Utilizing various laboratory techniques for formulation preparation and characterization (e.g., particle size analysis, dissolution testing, differential scanning calorimetry).
- Developing and validating analytical methods for drug product testing.
- Conducting stability studies to assess the shelf-life and performance of formulations under various conditions.
- Troubleshooting formulation challenges and proposing innovative solutions.
- Collaborating with analytical development, process development, and regulatory affairs teams.
- Documenting experimental procedures, results, and reports in accordance with company standards and regulatory guidelines.
- Staying current with scientific literature and industry trends in pharmaceutical formulation and drug delivery.
Senior Formulation Scientist - Innovative Drug Development
Posted 4 days ago
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Job Description
Key Responsibilities:
- Design, develop, and optimize novel drug delivery systems and formulations for various routes of administration (e.g., oral, injectable, topical).
- Conduct pre-formulation studies, including API characterization, solubility enhancement, and stability assessment.
- Perform compatibility studies and develop analytical methods for drug substance and drug product characterization.
- Utilize a range of formulation technologies and equipment, including granulation, coating, lyophilization, and sterile manufacturing processes.
- Execute experiments meticulously, document all findings accurately in laboratory notebooks and reports, and present results to project teams and management.
- Troubleshoot formulation challenges and propose innovative solutions.
- Collaborate closely with analytical chemists, process engineers, and clinical development teams to ensure successful project progression.
- Stay abreast of the latest scientific literature, regulatory guidelines, and industry trends in pharmaceutical formulation.
- Contribute to the preparation of regulatory submission documents (e.g., IND, NDA).
- PhD or MSc in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related field.
- Minimum of 5 years of relevant experience in pharmaceutical formulation development, preferably within an R&D setting.
- Proven track record in developing various dosage forms, with a strong understanding of formulation science principles.
- Hands-on experience with laboratory equipment for formulation development and characterization.
- Proficiency in relevant analytical techniques (e.g., HPLC, GC, DSC, TGA, XRPD).
- Excellent understanding of Good Manufacturing Practice (GMP) and regulatory requirements.
- Strong problem-solving skills, attention to detail, and ability to work independently and as part of a team.
- Effective communication and interpersonal skills.
Senior Clinical Research Scientist - Oncology Drug Development
Posted 2 days ago
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Job Description
Key Responsibilities:
- Design and develop clinical trial protocols for oncology assets, ensuring scientific rigor and regulatory compliance.
- Oversee the execution of clinical studies, providing scientific and medical expertise to cross-functional teams.
- Analyze and interpret complex clinical trial data, including efficacy and safety endpoints.
- Collaborate with regulatory affairs, statistics, and medical writing teams to prepare submissions and publications.
- Stay abreast of the latest scientific advancements, emerging trends, and competitive landscape in oncology drug development.
- Identify and engage with key opinion leaders (KOLs) and investigators in the field.
- Contribute to the strategic planning and decision-making processes for the oncology portfolio.
- Develop and present scientific data internally and externally at conferences and meetings.
- Ensure adherence to Good Clinical Practice (GCP) guidelines and all relevant regulations.
- Mentor junior scientists and contribute to the growth of the research department.
Qualifications and Experience:
- Ph.D. or M.D. in a relevant life science discipline (e.g., Oncology, Immunology, Pharmacology).
- Minimum of 5-7 years of experience in clinical research and drug development, with a significant focus on oncology.
- Demonstrated experience in designing and managing complex clinical trials (Phase I-III).
- In-depth knowledge of oncology disease areas, drug mechanisms, and current treatment paradigms.
- Strong understanding of regulatory requirements (FDA, EMA) and GCP.
- Excellent analytical, statistical interpretation, and problem-solving skills.
- Exceptional written and verbal communication skills, with a proven track record of scientific publications and presentations.
- Ability to work effectively in a remote, fast-paced, and collaborative environment.
- Experience with data management systems and statistical analysis software is a plus.
- Strong leadership potential and ability to influence cross-functional teams.
This is a crucial role for an accomplished scientist passionate about making a difference in the fight against cancer. Join our innovative client and shape the future of oncology treatments.