3,370 Principal Investigator jobs in the United Kingdom
Principal Investigator
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Principal Investigator
Posted today
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Principal Investigator
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Principal Investigator
Posted 9 days ago
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Principal Investigator (PI) – Clinical Research Site Network - Multiple Locations
We are seeking experienced Principal Investigators (PIs) to join a brand new fast-growing clinical research site network across the UK and US. This is a chance to be part of an innovative organisation transforming trial delivery with modern infrastructure, operational excellence, and a collaborative investigator community.
As a PI, you will oversee clinical trials at your site, ensuring patient safety, data integrity, and regulatory compliance , supported by dedicated operations teams and a strong pipeline of diverse studies.
What It’s Like to Work Here
- Join a growing network committed to expanding patient access to research.
- Focus on science and patient care while we handle operations and compliance.
- Collaborate with leading investigators across multiple therapeutic areas.
- Access a steady stream of high-quality, industry-sponsored trials .
Responsibilities
- Provide medical leadership for trials and safeguard participant well-being.
- Ensure compliance with ICH-GCP, FDA, EMA/MHRA regulations .
- Supervise sub-investigators and site staff.
- Oversee accurate documentation, reporting, and regulatory submissions.
Qualifications
- Medical Degree (MD, DO, MBBS, or equivalent ) with active license.
- Prior clinical research experience (PI or Sub-Investigator).
- GCP certification and strong leadership skills.
What We Offer
- Competitive compensation with performance incentives.
- Centralised support in operations, regulatory, and recruitment .
- Opportunities to grow your research portfolio and shape the future of clinical trials.
Principal Investigator
Posted 9 days ago
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Job Description
We’re working with a leading, fully integrated Clinical Research Organization (CRO) in England, dedicated to advancing innovative medical treatments through exceptional patient care and the delivery of high-quality clinical data.
I’m currently partnering with several top-5 global pharmaceutical companies to identify an
experienced Principal Investigator for a high-profile clinical research program.
They are seeking an experienced Principal Investigator (PI) to join their expert team.
In this role, you will:
- Provide medical leadership and oversight across multiple clinical trials
- Ensure participant safety, regulatory compliance, and GCP adherence
- Collaborate closely with sponsors, CRO teams, and regulatory authorities
- Contribute to cutting-edge research that impacts global healthcare
What we’re looking for:
- Licensed physician (MD or equivalent)
- Proven experience as a Principal Investigator or Sub-Investigator
- Strong knowledge of clinical trial processes, GCP, and regulatory standards
- Passion for advancing medical innovation through clinical research
This is a fantastic opportunity to join a respected CRO at the forefront of clinical development.
Why Join Us?
- Opportunity to lead groundbreaking clinical research in a dynamic environment
- Competitive freelance/consulting terms
- Work with a dedicated team committed to scientific excellence and innovation
Principal Investigator
Posted 9 days ago
Job Viewed
Job Description
Principal Investigator – Clinical Development (Contract)
Location: London, UK
Employment type: Contract / Freelance ~ 12-16 month contract (possibility of extension)
We are seeking a highly skilled and motivated Principal Investigator (PI) to join a leading clinical research organization dedicated to advancing innovative medical treatments. This role offers the opportunity to be at the forefront of clinical development, working alongside an experienced research team to deliver high-quality data and exemplary patient care.
As a Principal Investigator, you will be entrusted with the conduct, oversight, and medical leadership of clinical trials at a site level. You will play a pivotal role in ensuring participant safety, maintaining compliance with Good Clinical Practice (GCP) guidelines, and driving the successful execution of studies. This position is ideal for physicians, scientists and pharmacists with a passion for clinical research who want to contribute directly to the progress of new therapies that have the potential to improve patient outcomes worldwide.
Key Responsibilities:
- Provide overall medical leadership and direction for assigned studies, ensuring strict adherence to study protocols and regulatory requirements.
- Safeguard the rights, safety, and well-being of all trial participants.
- Evaluate participant eligibility, conduct physical assessments, and perform study-specific procedures.
- Review and interpret diagnostic data, including lab work, ECGs, and imaging, as required.
- Oversee the administration of investigational products and ensure compliance with study protocols.
- Maintain accurate, complete, and timely documentation of study data and source records.
- Act as primary liaison with sponsors, monitors, and regulatory bodies, participating in audits and inspections as required.
- Report adverse events promptly in compliance with study-specific and regulatory reporting requirements.
- Provide scientific and medical input for new study feasibility assessments.
- Guide and support clinical research staff to ensure quality standards are consistently met.
Qualifications:
- M.D. or D.O. with active, unrestricted medical license in the state where research will be conducted.
- Board certification (or board eligibility) in a relevant specialty.
- Training and certification in Good Clinical Practice (GCP).
- Strong knowledge of clinical trial protocols, regulatory requirements, and biomedical research ethics.
- Excellent communication skills with the ability to collaborate cross-functionally.
- Demonstrated ability to critically evaluate clinical data and resolve challenges with sound judgment.
- Willingness to travel occasionally (up to 10%) for sponsor meetings, trainings, or professional conferences.
Tangible Benefits:
- Competitive compensation package with performance-based incentives.
- Medical, dental, and vision coverage.
- Retirement savings plan with employer contributions.
- Generous paid time off and recognized company holidays.
- Ongoing opportunities for career development, training, and advancement within clinical research.
Principal Forensic Investigator (Mechanical)

Posted 4 days ago
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Job Description
Newsweek Recognizes Sedgwick as America's Greatest Workplaces National Top Companies
Certified as a Great Place to Work®
Fortune Best Workplaces in Financial Services & Insurance
Principal Forensic Investigator (Mechanical)
**Job Location:** **UK wide**
**Job Type:** **Permanent**
**Remuneration** **: Competitive salary taking into account skills, experience and qualifications**
**Join EFI Global UK as a Principal Forensic Investigator and play a pivotal role in uncovering the causes behind complex incidents while shaping best practices in safety and forensic investigation.**
EFI Global UK, part of the internationally respected EFI Global Inc and Sedgwick Group, delivers impartial expert opinion in environmental consultancy and forensic investigations. With a client base that includes insurance companies, brokers, loss adjusters, government bodies, and private individuals, EFI Global UK is known for its technical excellence and commitment to service.
An exciting opportunity has arisen for a skilled Principal Forensic Investigator (Mechanical) to join the team. This is a dynamic and multifaceted role that combines technical investigation with strategic support for health and safety processes across the department and wider Sedgwick organisation. The successful candidate will be involved in examining a broad spectrum of incidents in both domestic and commercial environments-from routine insurance claims to complex, high-value cases such as large marine losses.
The role offers a hands-on investigative element, requiring visits to incident sites and laboratories to collect evidence, interview witnesses, and occasionally dismantle machinery or equipment to determine the root cause of incidents. You may also be called upon to design and conduct tests in collaboration with external agencies, adding a practical and experimental dimension to your work.
Beyond investigations, you'll play a key role in promoting health and safety best practices, supporting internal procedures, and contributing to the team's reputation for technical expertise. This position demands a blend of engineering knowledge, analytical thinking, and interpersonal skills, making it ideal for someone who thrives in a varied and intellectually stimulating environment.
**The skills you will have when you apply:**
+ **Educational background** : Degree-level qualification or equivalent experience - chartered status preferred, ideally supported by IOSH or NEBOSH certifications.
+ **Engineering expertise** : Strong understanding and practical application of engineering principles.
+ **Health and safety knowledge** : Proven experience in preparing and delivering health and safety processes and procedures.
+ **Expert witness experience** : Ideally has experience providing expert opinion in legal or insurance contexts.
+ **Regulatory familiarity** : Comfortable working with approved documents, codes, and standards relevant to the role.
+ **Interpersonal skills** : Able to motivate, inspire confidence, and communicate effectively with a range of stakeholders.
+ **Flexibility and resilience** : Willingness to work occasional long hours and maintain motivation in challenging situations.
+ **Organisational ability** : Strong planning and time management skills.
+ **Technical proficiency** : IT skills appropriate to the role, including report writing and data handling.
+ **Driving licence** : Full UK driving license is essential for travel to incident sites and laboratories.
+ **Insurance industry exposure** : Experience in the insurance sector is beneficial but not essential, as training will be provided.
**What we'll give you for this role:**
**Remuneration & more**
+ Competitive salary taking into account skills, experience and qualifications
+ Fully funded company vehicle or cash in lieu allowance
+ A Self Invested Personal Pension Scheme (SIPP)
+ Holiday allowance of 25 days plus bank holidays
+ Flexible working from our office or your home
**Health & support**
+ Private healthcare plan (including pre-existing conditions)
+ Life assurance
+ Group Income Protection
**Other benefits**
+ Voluntary benefits - dental cover, cycle to work scheme, season ticket loan, wellbeing and digital GP applications
+ Employee assistance programme for employee wellbeing
+ Discounts on various products and services
**This isn't just a position, it's a pivotal role in shaping our industry**
At Sedgwick, not only will you be working behind the scenes for some of the UK's most trusted insurance brands helping to resolve millions of claims every year, you'll also be an architect of tomorrow's insurance landscape with Sedgwick University. Our proprietary offering is the most comprehensive training and development program in the industry with more than 15,000 courses on demand, training specific to roles, and opportunities to continue your formal education - all available to you starting from your very first day.
You'll join a community passionate about making a difference, where every role contributes to a larger mission; protecting people and businesses. This isn't just a job; it's an opportunity to shape the future of insurance.
**Next steps for you:**
**Think we'd be a great match? Apply now - we want to hear from you.**
If you're unsure whether you have all the skills needed then do apply - we are looking for all backgrounds from seasoned professionals to those returning to the workforce, and everyone in-between.
Not only that, we are proud to have a zero tolerance policy towards discrimination of any kind regardless of age, disability, gender identity, marital/ family status, race, religion, sex or sexual orientation.
After the closing date we will review all applications and may select some applicants for an interview (which may be virtual, or in-person).
#LI-HYBRID
Sedgwick is an Equal Opportunity Employer.
The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Sedgwick retains the discretion to add or to change the duties of the position at any time.
**Sedgwick is the world's leading risk and claims administration partner, which helps clients thrive by navigating the unexpected. The company's expertise, combined with the most advanced AI-enabled technology available, sets the standard for solutions in claims administration, loss adjusting, benefits administration, and product recall. With over 33,000 colleagues and 10,000 clients across 80 countries, Sedgwick provides unmatched perspective, caring that counts, and solutions for the rapidly changing and complex risk landscape. For more, see** **sedgwick.com**
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Principal Forensic Investigator (Mechanical)

Posted 4 days ago
Job Viewed
Job Description
IF YOU CARE, THERE'S A PLACE FOR YOU HERE
EFI Global is a full-service engineering, fire investigation, environmental, health and safety, and specialty consulting services firm serving a variety of industries in both the public and private sectors. Over the last four decades, we have grown from a boutique firm specializing in handling insurance fraud and arson cases and providing expert witness testimony, into a recognized global leader in engineering failure analysis, origin-and-cause investigations, environmental consulting, laboratory testing and specialty consulting. Our forensic investigation, engineering and environmental services teams around the world share a dedication to expertise, quality and demonstrating to customers that caring counts®. Each of our more than 700 professional engineers, fire investigators, architects and scientists was selected for their technical proficiency, in-depth industry knowledge and commitment to professional integrity. Together, our diverse backgrounds and collective insights empower clients to make better-informed business decisions. EFI's combination of global solutions and local expertise has earned the firm a reputation for delivering timely responses that consistently meet our clients' expectations-anytime, anywhere. Click here to learn more about EFI Global.
**Job Location:** **UK wide**
**Job Type:** **Permanent**
**Remuneration** **: Competitive salary taking into account skills, experience and qualifications**
**Join EFI Global UK as a Principal Forensic Investigator and play a pivotal role in uncovering the causes behind complex incidents while shaping best practices in safety and forensic investigation.**
EFI Global UK, part of the internationally respected EFI Global Inc and Sedgwick Group, delivers impartial expert opinion in environmental consultancy and forensic investigations. With a client base that includes insurance companies, brokers, loss adjusters, government bodies, and private individuals, EFI Global UK is known for its technical excellence and commitment to service.
An exciting opportunity has arisen for a skilled Principal Forensic Investigator (Mechanical) to join the team. This is a dynamic and multifaceted role that combines technical investigation with strategic support for health and safety processes across the department and wider Sedgwick organisation. The successful candidate will be involved in examining a broad spectrum of incidents in both domestic and commercial environments-from routine insurance claims to complex, high-value cases such as large marine losses.
The role offers a hands-on investigative element, requiring visits to incident sites and laboratories to collect evidence, interview witnesses, and occasionally dismantle machinery or equipment to determine the root cause of incidents. You may also be called upon to design and conduct tests in collaboration with external agencies, adding a practical and experimental dimension to your work.
Beyond investigations, you'll play a key role in promoting health and safety best practices, supporting internal procedures, and contributing to the team's reputation for technical expertise. This position demands a blend of engineering knowledge, analytical thinking, and interpersonal skills, making it ideal for someone who thrives in a varied and intellectually stimulating environment.
**The skills you will have when you apply:**
+ **Educational background** : Degree-level qualification or equivalent experience - chartered status preferred, ideally supported by IOSH or NEBOSH certifications.
+ **Engineering expertise** : Strong understanding and practical application of engineering principles.
+ **Health and safety knowledge** : Proven experience in preparing and delivering health and safety processes and procedures.
+ **Expert witness experience** : Ideally has experience providing expert opinion in legal or insurance contexts.
+ **Regulatory familiarity** : Comfortable working with approved documents, codes, and standards relevant to the role.
+ **Interpersonal skills** : Able to motivate, inspire confidence, and communicate effectively with a range of stakeholders.
+ **Flexibility and resilience** : Willingness to work occasional long hours and maintain motivation in challenging situations.
+ **Organisational ability** : Strong planning and time management skills.
+ **Technical proficiency** : IT skills appropriate to the role, including report writing and data handling.
+ **Driving licence** : Full UK driving license is essential for travel to incident sites and laboratories.
+ **Insurance industry exposure** : Experience in the insurance sector is beneficial but not essential, as training will be provided.
**What we'll give you for this role:**
**Remuneration & more**
+ Competitive salary taking into account skills, experience and qualifications
+ Fully funded company vehicle or cash in lieu allowance
+ A Self Invested Personal Pension Scheme (SIPP)
+ Holiday allowance of 25 days plus bank holidays
+ Flexible working from our office or your home
**Health & support**
+ Private healthcare plan (including pre-existing conditions)
+ Life assurance
+ Group Income Protection
**Other benefits**
+ Voluntary benefits - dental cover, cycle to work scheme, season ticket loan, wellbeing and digital GP applications
+ Employee assistance programme for employee wellbeing
+ Discounts on various products and services
**This isn't just a position, it's a pivotal role in shaping our industry**
At Sedgwick, not only will you be working behind the scenes for some of the UK's most trusted insurance brands helping to resolve millions of claims every year, you'll also be an architect of tomorrow's insurance landscape with Sedgwick University. Our proprietary offering is the most comprehensive training and development program in the industry with more than 15,000 courses on demand, training specific to roles, and opportunities to continue your formal education - all available to you starting from your very first day.
You'll join a community passionate about making a difference, where every role contributes to a larger mission; protecting people and businesses. This isn't just a job; it's an opportunity to shape the future of insurance.
**Next steps for you:**
**Think we'd be a great match? Apply now - we want to hear from you.**
If you're unsure whether you have all the skills needed then do apply - we are looking for all backgrounds from seasoned professionals to those returning to the workforce, and everyone in-between.
Not only that, we are proud to have a zero tolerance policy towards discrimination of any kind regardless of age, disability, gender identity, marital/ family status, race, religion, sex or sexual orientation.
After the closing date we will review all applications and may select some applicants for an interview (which may be virtual, or in-person).
#LI-HYBRID
The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or to change the duties of the position at any time.
Sedgwick is an Equal Opportunity Employer and a Drug-Free Workplace
Our business is founded on people with the best technical skills and outstanding industry knowledge and we strive to employ and retain exceptional talent. EFI Global is an equal opportunity employer welcoming applications from all qualified persons.
If you are interested in working for us, please visit our job board.
Research Project Assistant
Posted 4 days ago
Job Viewed
Job Description
Research Project Assistant
Salary: £15,960 p.a.
Location: Hybrid Working - Remote / London
Contract Type: Permanent, Part Time (21 hours; 3 days)
How to Apply
If you believe that you are the right person for this role, please submit your CV and Cover Letter by Friday, 07 October 2025.
Please note that the close date could be subject to change depending on the success of the recruitment process.
About You
The successful candidate will have experience in managing multiple administrative tasks and can prioritise their workload. They will be a confident communicator, both written and verbal, and offer high levels of customer service. You will be an organised individual who can organise meetings and can take accurate minutes.
We are looking for a proactive individual who has experience in handling confidential information with discretion. This particular individual will have excellent time management skills and can meet tight deadlines.
If this sounds like you, apply today!
About the Role
This role supports the efficient delivery of national healthcare research projects and other ongoing workstreams within the Research Team. This includes general administration, meeting preparation and note taking, and answering queries.
Key tasks and responsibilities include (but are not limited to):
- Act as secretary, or deputy to all committees, sub-groups or meetings relating to assigned projects, including drafting agendas and minutes, and document management. li>Provide administrative support to all assigned research projects.
- Respond to general enquiries and act as a first point of contact for all assigned projects and other research-related matters.
- Provide high quality, day-to-day helpdesk and inbox service to research projects as required.
- Provide first line support to research project data entry web-tool users, including, capturing and logging user problems and proactively dealing with user issues.
We are ideally looking for someone with the following experience, knowledge, and skills:
- Experience of handling administrative work of a considerable variety and prioritising successfully.
- Experience of supporting designated projects or programme of work.
- Experience of organising meetings and note taking.
- Experience in a public facing role and/or customer service.
- Experience of dealing with confidential and/or sensitive data.
- Proven, self-starter and team player who sets and delivers high standards.
- Good communication and interpersonal skills.
- Excellent time management, including ability to work under pressure and to deadlines.
The Package
This is a part-time, permanent position with a competitive employee benefits package, which includes (but is not limited to):
- 16 days of annual leave, plus bank holiday
- Healthcare support through Benenden Health
- Up to 12% pension contribution
- Hybrid and flexible working
- Wellbeing hour once a week
- Cycle to work and employee discounts schemes
- Training and development opportunities
- Access to Mental Health First Aiders and Employee Assistance Programmes
About the College
The Royal College of Anaesthetists is the professional body responsible for the specialty throughout the UK. We are the third largest medical royal college in the UK by membership. With a combined membership of more than 24,000 Fellows and Members, we ensure the quality of patient care by safeguarding standards in the three specialties of anaesthesia, intensive care and pain medicine.
At RCoA diversity, equality and inclusion is an integral part of our culture so it is important to us that this is reflected in everything that we do. We welcome applications from all individuals irrespective of age, race, gender, sexual orientation, ethnicity, religion or belief, disability, marital status, or parental responsibilities to ensure we actively embrace an inclusive and representative culture that encourages, supports, and celebrates our differences.
Unfortunately, due to the volume of applications, we are unable to provide detailed feedback to candidates on their application. Only short-listed applicants will be contacted after the closing date. Please note that the closing date is subject to change.
Applicants must reside and have the right to work in the UK. No agencies please.
Unfortunately, due to the volume of applications, we are unable to provide detailed feedback to candidates on their application. Only short-listed applicants will be contacted after the closing date.
Remote Scientific Research Lead - Bioinformatics
Posted 13 days ago
Job Viewed
Job Description
Key responsibilities include overseeing data analysis workflows, interpreting results, and translating complex biological findings into clear, actionable insights. The Research Lead will manage computational resources, ensure data integrity, and implement rigorous quality control measures. A significant part of the role involves collaborating with a geographically dispersed team of biologists, clinicians, and data scientists through virtual communication channels. You will also be responsible for staying abreast of the latest advancements in bioinformatics, computational biology, and relevant 'omics' technologies, and actively contributing to scientific publications and conference presentations. The ability to mentor junior researchers and provide technical guidance in a remote setting is essential. This role offers the unique advantage of a fully remote work environment, empowering you to work from anywhere while contributing to world-class scientific endeavors. The position requires a self-disciplined individual with exceptional project management skills and a proven ability to deliver high-impact research outcomes independently.
Key Responsibilities:
- Lead the design and execution of complex bioinformatics research projects.
- Develop and implement advanced computational methods and pipelines for 'omics' data analysis.
- Analyze large-scale genomic, transcriptomic, and proteomic datasets.
- Interpret biological findings and translate them into research insights.
- Ensure data quality, integrity, and robust statistical analysis.
- Collaborate effectively with remote scientific teams and stakeholders.
- Manage computational resources and optimize analysis workflows.
- Contribute to scientific publications, grant proposals, and presentations.
- Mentor and guide junior bioinformatics researchers.
- Stay current with cutting-edge bioinformatics tools and techniques.
- Ph.D. in Bioinformatics, Computational Biology, Computer Science, Statistics, or a related field.
- Minimum of 8 years of post-doctoral research experience in bioinformatics.
- Extensive experience with various 'omics' data types and analysis pipelines.
- Proficiency in programming languages such as Python and R, and strong command-line skills.
- Expertise in statistical analysis and machine learning methods relevant to biological data.
- Demonstrated track record of high-impact scientific publications.
- Proven ability to lead research projects and work independently in a remote setting.
- Excellent communication, collaboration, and problem-solving skills.