7,225 Principal Investigator jobs in the United Kingdom

Overview

The Principal Investigator is the physician responsible for the medical leadership, safety, and successful delivery of clinical trials at a research site. They ensure every study is conducted ethically, in line with regulatory standards, and with participant wellbeing at the Centre.

Key Responsibilities

• Provide overall medical oversight for trials and ensure studies follow GCP.
• Protect participant safety, rights, and confidentiality.
• Review protocols, evaluate medical history, and conduct trial-related assessments.
• Interpret clinical data, lab results, ECGs, and diagnostics.
• Report Serious Adverse Events (SAEs) on time.
• Oversee administration of investigational products.
• Keep accurate documentation and ensure compliance with ethics/regulatory boards.
• Support feasibility checks and answer sponsor queries.
• Participate in audits, monitoring visits, and inspections.

Skills & Competencies

• Strong knowledge of ICH GCP and clinical research ethics.
• Excellent clinical judgment and attention to detail.
• Clear communicator and effective collaborator.
• Analytical problem-solver with flexibility.

Qualifications

• MD or DO with an active medical license (valid where the research is conducted).
• Board certified/board eligible in a relevant specialty.
• GCP certified.
• Previous clinical research experience preferred.
• Willing to complete training and follow company SOPs.

Overview

The Principal Investigator is the physician responsible for the medical leadership, safety, and successful delivery of clinical trials at a research site. They ensure every study is conducted ethically, in line with regulatory standards, and with participant wellbeing at the Centre.

Key Responsibilities

• Provide overall medical oversight for trials and ensure studies follow GCP.
• Protect participant safety, rights, and confidentiality.
• Review protocols, evaluate medical history, and conduct trial-related assessments.
• Interpret clinical data, lab results, ECGs, and diagnostics.
• Report Serious Adverse Events (SAEs) on time.
• Oversee administration of investigational products.
• Keep accurate documentation and ensure compliance with ethics/regulatory boards.
• Support feasibility checks and answer sponsor queries.
• Participate in audits, monitoring visits, and inspections.

Skills & Competencies

• Strong knowledge of ICH GCP and clinical research ethics.
• Excellent clinical judgment and attention to detail.
• Clear communicator and effective collaborator.
• Analytical problem-solver with flexibility.

Qualifications

• MD or DO with an active medical license (valid where the research is conducted).
• Board certified/board eligible in a relevant specialty.
• GCP certified.
• Previous clinical research experience preferred.
• Willing to complete training and follow company SOPs.

Overview The Principal Investigator is the physician responsible for the medical leadership, safety, and successful delivery of clinical trials at a research site. They ensure every study is conducted ethically, in line with regulatory standards, and with participant wellbeing at the Centre. Key Responsibilities Provide overall medical oversight for trials and ensure studies follow GCP. Protect participant safety, rights, and confidentiality. Review protocols, evaluate medical history, and conduct trial-related assessments. Interpret clinical data, lab results, ECGs, and diagnostics. Report Serious Adverse Events (SAEs) on time. Oversee administration of investigational products. Keep accurate documentation and ensure compliance with ethics/regulatory boards. Support feasibility checks and answer sponsor queries. Participate in audits, monitoring visits, and inspections. Skills & Competencies Strong knowledge of ICH GCP and clinical research ethics. Excellent clinical judgment and attention to detail. Clear communicator and effective collaborator. Analytical problem-solver with flexibility. Qualifications MD or DO with an active medical license (valid where the research is conducted). Board certified/board eligible in a relevant specialty. GCP certified. Previous clinical research experience preferred. Willing to complete training and follow company SOPs.

By joining Sedgwick, you'll be part of something truly meaningful. It's what our 33,000 colleagues do every day for people around the world who are facing the unexpected. We invite you to grow your career with us, experience our caring culture, and enjoy work-life balance. Here, there's no limit to what you can achieve.
Newsweek Recognizes Sedgwick as America's Greatest Workplaces National Top Companies
Certified as a Great Place to Work®
Fortune Best Workplaces in Financial Services & Insurance
Principal Forensic Investigator (Mechanical)
**Job Location:** **UK wide**
**Job Type:** **Permanent**
**Remuneration** **: Competitive salary taking into account skills, experience and qualifications**
**Join EFI Global UK as a Principal Forensic Investigator and play a pivotal role in uncovering the causes behind complex incidents while shaping best practices in safety and forensic investigation.**
EFI Global UK, part of the internationally respected EFI Global Inc and Sedgwick Group, delivers impartial expert opinion in environmental consultancy and forensic investigations. With a client base that includes insurance companies, brokers, loss adjusters, government bodies, and private individuals, EFI Global UK is known for its technical excellence and commitment to service.
An exciting opportunity has arisen for a skilled Principal Forensic Investigator (Mechanical) to join the team. This is a dynamic and multifaceted role that combines technical investigation with strategic support for health and safety processes across the department and wider Sedgwick organisation. The successful candidate will be involved in examining a broad spectrum of incidents in both domestic and commercial environments-from routine insurance claims to complex, high-value cases such as large marine losses.
The role offers a hands-on investigative element, requiring visits to incident sites and laboratories to collect evidence, interview witnesses, and occasionally dismantle machinery or equipment to determine the root cause of incidents. You may also be called upon to design and conduct tests in collaboration with external agencies, adding a practical and experimental dimension to your work.
Beyond investigations, you'll play a key role in promoting health and safety best practices, supporting internal procedures, and contributing to the team's reputation for technical expertise. This position demands a blend of engineering knowledge, analytical thinking, and interpersonal skills, making it ideal for someone who thrives in a varied and intellectually stimulating environment.
**The skills you will have when you apply:**
+ **Educational background** : Degree-level qualification or equivalent experience - chartered status preferred, ideally supported by IOSH or NEBOSH certifications.
+ **Engineering expertise** : Strong understanding and practical application of engineering principles.
+ **Health and safety knowledge** : Proven experience in preparing and delivering health and safety processes and procedures.
+ **Expert witness experience** : Ideally has experience providing expert opinion in legal or insurance contexts.
+ **Regulatory familiarity** : Comfortable working with approved documents, codes, and standards relevant to the role.
+ **Interpersonal skills** : Able to motivate, inspire confidence, and communicate effectively with a range of stakeholders.
+ **Flexibility and resilience** : Willingness to work occasional long hours and maintain motivation in challenging situations.
+ **Organisational ability** : Strong planning and time management skills.
+ **Technical proficiency** : IT skills appropriate to the role, including report writing and data handling.
+ **Driving licence** : Full UK driving license is essential for travel to incident sites and laboratories.
+ **Insurance industry exposure** : Experience in the insurance sector is beneficial but not essential, as training will be provided.
**What we'll give you for this role:**
**Remuneration & more**
+ Competitive salary taking into account skills, experience and qualifications
+ Fully funded company vehicle or cash in lieu allowance
+ A Self Invested Personal Pension Scheme (SIPP)
+ Holiday allowance of 25 days plus bank holidays
+ Flexible working from our office or your home
**Health & support**
+ Private healthcare plan (including pre-existing conditions)
+ Life assurance
+ Group Income Protection
**Other benefits**
+ Voluntary benefits - dental cover, cycle to work scheme, season ticket loan, wellbeing and digital GP applications
+ Employee assistance programme for employee wellbeing
+ Discounts on various products and services
**This isn't just a position, it's a pivotal role in shaping our industry**
At Sedgwick, not only will you be working behind the scenes for some of the UK's most trusted insurance brands helping to resolve millions of claims every year, you'll also be an architect of tomorrow's insurance landscape with Sedgwick University. Our proprietary offering is the most comprehensive training and development program in the industry with more than 15,000 courses on demand, training specific to roles, and opportunities to continue your formal education - all available to you starting from your very first day.
You'll join a community passionate about making a difference, where every role contributes to a larger mission; protecting people and businesses. This isn't just a job; it's an opportunity to shape the future of insurance.
**Next steps for you:**
**Think we'd be a great match? Apply now - we want to hear from you.**
If you're unsure whether you have all the skills needed then do apply - we are looking for all backgrounds from seasoned professionals to those returning to the workforce, and everyone in-between.
Not only that, we are proud to have a zero tolerance policy towards discrimination of any kind regardless of age, disability, gender identity, marital/ family status, race, religion, sex or sexual orientation.
After the closing date we will review all applications and may select some applicants for an interview (which may be virtual, or in-person).
#LI-HYBRID
Sedgwick is an Equal Opportunity Employer.
The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Sedgwick retains the discretion to add or to change the duties of the position at any time.
**Sedgwick is the world's leading risk and claims administration partner, which helps clients thrive by navigating the unexpected. The company's expertise, combined with the most advanced AI-enabled technology available, sets the standard for solutions in claims administration, loss adjusting, benefits administration, and product recall. With over 33,000 colleagues and 10,000 clients across 80 countries, Sedgwick provides unmatched perspective, caring that counts, and solutions for the rapidly changing and complex risk landscape. For more, see** **sedgwick.com**

**The 'Apply with SEEK option' will be utilized for International applicants, mainly Australia. If this does not apply to you please use the 'Apply' option.**
IF YOU CARE, THERE'S A PLACE FOR YOU HERE
EFI Global is a full-service engineering, fire investigation, environmental, health and safety, and specialty consulting services firm serving a variety of industries in both the public and private sectors. Over the last four decades, we have grown from a boutique firm specializing in handling insurance fraud and arson cases and providing expert witness testimony, into a recognized global leader in engineering failure analysis, origin-and-cause investigations, environmental consulting, laboratory testing and specialty consulting. Our forensic investigation, engineering and environmental services teams around the world share a dedication to expertise, quality and demonstrating to customers that caring counts®. Each of our more than 700 professional engineers, fire investigators, architects and scientists was selected for their technical proficiency, in-depth industry knowledge and commitment to professional integrity. Together, our diverse backgrounds and collective insights empower clients to make better-informed business decisions. EFI's combination of global solutions and local expertise has earned the firm a reputation for delivering timely responses that consistently meet our clients' expectations-anytime, anywhere. Click here to learn more about EFI Global.
**Job Location:** **UK wide**
**Job Type:** **Permanent**
**Remuneration** **: Competitive salary taking into account skills, experience and qualifications**
**Join EFI Global UK as a Principal Forensic Investigator and play a pivotal role in uncovering the causes behind complex incidents while shaping best practices in safety and forensic investigation.**
EFI Global UK, part of the internationally respected EFI Global Inc and Sedgwick Group, delivers impartial expert opinion in environmental consultancy and forensic investigations. With a client base that includes insurance companies, brokers, loss adjusters, government bodies, and private individuals, EFI Global UK is known for its technical excellence and commitment to service.
An exciting opportunity has arisen for a skilled Principal Forensic Investigator (Mechanical) to join the team. This is a dynamic and multifaceted role that combines technical investigation with strategic support for health and safety processes across the department and wider Sedgwick organisation. The successful candidate will be involved in examining a broad spectrum of incidents in both domestic and commercial environments-from routine insurance claims to complex, high-value cases such as large marine losses.
The role offers a hands-on investigative element, requiring visits to incident sites and laboratories to collect evidence, interview witnesses, and occasionally dismantle machinery or equipment to determine the root cause of incidents. You may also be called upon to design and conduct tests in collaboration with external agencies, adding a practical and experimental dimension to your work.
Beyond investigations, you'll play a key role in promoting health and safety best practices, supporting internal procedures, and contributing to the team's reputation for technical expertise. This position demands a blend of engineering knowledge, analytical thinking, and interpersonal skills, making it ideal for someone who thrives in a varied and intellectually stimulating environment.
**The skills you will have when you apply:**
+ **Educational background** : Degree-level qualification or equivalent experience - chartered status preferred, ideally supported by IOSH or NEBOSH certifications.
+ **Engineering expertise** : Strong understanding and practical application of engineering principles.
+ **Health and safety knowledge** : Proven experience in preparing and delivering health and safety processes and procedures.
+ **Expert witness experience** : Ideally has experience providing expert opinion in legal or insurance contexts.
+ **Regulatory familiarity** : Comfortable working with approved documents, codes, and standards relevant to the role.
+ **Interpersonal skills** : Able to motivate, inspire confidence, and communicate effectively with a range of stakeholders.
+ **Flexibility and resilience** : Willingness to work occasional long hours and maintain motivation in challenging situations.
+ **Organisational ability** : Strong planning and time management skills.
+ **Technical proficiency** : IT skills appropriate to the role, including report writing and data handling.
+ **Driving licence** : Full UK driving license is essential for travel to incident sites and laboratories.
+ **Insurance industry exposure** : Experience in the insurance sector is beneficial but not essential, as training will be provided.
**What we'll give you for this role:**
**Remuneration & more**
+ Competitive salary taking into account skills, experience and qualifications
+ Fully funded company vehicle or cash in lieu allowance
+ A Self Invested Personal Pension Scheme (SIPP)
+ Holiday allowance of 25 days plus bank holidays
+ Flexible working from our office or your home
**Health & support**
+ Private healthcare plan (including pre-existing conditions)
+ Life assurance
+ Group Income Protection
**Other benefits**
+ Voluntary benefits - dental cover, cycle to work scheme, season ticket loan, wellbeing and digital GP applications
+ Employee assistance programme for employee wellbeing
+ Discounts on various products and services
**This isn't just a position, it's a pivotal role in shaping our industry**
At Sedgwick, not only will you be working behind the scenes for some of the UK's most trusted insurance brands helping to resolve millions of claims every year, you'll also be an architect of tomorrow's insurance landscape with Sedgwick University. Our proprietary offering is the most comprehensive training and development program in the industry with more than 15,000 courses on demand, training specific to roles, and opportunities to continue your formal education - all available to you starting from your very first day.
You'll join a community passionate about making a difference, where every role contributes to a larger mission; protecting people and businesses. This isn't just a job; it's an opportunity to shape the future of insurance.
**Next steps for you:**
**Think we'd be a great match? Apply now - we want to hear from you.**
If you're unsure whether you have all the skills needed then do apply - we are looking for all backgrounds from seasoned professionals to those returning to the workforce, and everyone in-between.
Not only that, we are proud to have a zero tolerance policy towards discrimination of any kind regardless of age, disability, gender identity, marital/ family status, race, religion, sex or sexual orientation.
After the closing date we will review all applications and may select some applicants for an interview (which may be virtual, or in-person).
#LI-HYBRID
The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or to change the duties of the position at any time.
Sedgwick is an Equal Opportunity Employer and a Drug-Free Workplace
Our business is founded on people with the best technical skills and outstanding industry knowledge and we strive to employ and retain exceptional talent. EFI Global is an equal opportunity employer welcoming applications from all qualified persons.
If you are interested in working for us, please visit our job board.

We are seeking an exceptional Principal Aviation Safety Investigator to lead critical safety analysis and incident investigation efforts for our client's global operations. This is a fully remote position, allowing you to leverage your expertise from anywhere, with the conceptual base being near Leicester, Leicestershire, UK . You will be responsible for conducting in-depth investigations into aviation incidents and accidents, meticulously gathering and analyzing evidence, and developing comprehensive safety recommendations to prevent recurrence. This role demands an analytical mindset, exceptional attention to detail, and a profound understanding of aviation safety protocols and regulatory frameworks. Your responsibilities will include leading multidisciplinary investigation teams, interviewing witnesses, reconstructing accident scenarios, and preparing detailed reports for regulatory bodies and internal stakeholders. You will also play a key role in developing and implementing proactive safety management systems, risk assessments, and safety training programs across the organization. A crucial part of your mandate will be to stay abreast of emerging safety trends and technologies in the aviation industry and translate this knowledge into actionable safety improvements. This position requires the ability to work autonomously, manage complex projects with tight deadlines, and communicate highly technical information clearly and concisely to diverse audiences, including senior leadership and aviation authorities. The ideal candidate will possess extensive experience in aviation safety, accident investigation, and risk management, ideally with a background as a pilot, air traffic controller, engineer, or maintenance specialist with significant investigative experience. Relevant certifications in accident investigation and a deep knowledge of international aviation safety standards (e.g., ICAO, EASA, FAA) are essential. If you are a driven professional committed to enhancing aviation safety and seeking a challenging and impactful remote role, we encourage you to submit your application.

Our client, a globally recognized leader in scientific research and development, is seeking an exceptional Principal Scientific Research Scientist to join their state-of-the-art facility in Newcastle upon Tyne, Tyne and Wear, UK . This senior role is critical for driving innovation and leading research initiatives in the field of biotechnology, specifically focusing on novel therapeutic development. The successful candidate will possess a deep understanding of molecular biology, genetics, and advanced drug discovery techniques, coupled with a proven ability to lead research teams and secure funding. You will be responsible for conceptualizing, designing, and executing complex research projects from inception to potential clinical application.

Key Responsibilities:

• Lead the design and execution of ambitious research projects in biotechnology, with a focus on developing novel therapeutics for unmet medical needs.
• Direct and mentor a team of research scientists and technicians, fostering a collaborative and high-performance research environment.
• Develop and implement innovative experimental strategies using advanced molecular biology, genomics, and proteomics techniques.
• Critically analyse complex biological data, interpret results, and draw robust conclusions to guide research direction.
• Contribute to the preparation of grant proposals and secure external funding for research initiatives.
• Publish findings in high-impact peer-reviewed journals and present research at international conferences.
• Collaborate effectively with cross-functional teams, including chemistry, pharmacology, and clinical development departments.
• Ensure compliance with all relevant ethical guidelines, regulatory requirements, and safety protocols within the laboratory.
• Identify emerging scientific trends and technologies relevant to the company's strategic goals.
• Contribute to the intellectual property strategy through patent filings and disclosures.

Qualifications and Skills:

• A Ph.D. in Molecular Biology, Biochemistry, Genetics, Biotechnology, or a closely related life science discipline.
• A minimum of 10 years of post-doctoral research experience in an academic or industrial R&D setting.
• A distinguished track record of publications in leading scientific journals and successful grant acquisition.
• Extensive hands-on experience with advanced techniques such as CRISPR-Cas9, next-generation sequencing (NGS), mammalian cell culture, protein expression and purification, and various assay development platforms.
• Proven experience in leading and managing research projects and scientific teams.
• Strong understanding of drug discovery and development processes.
• Exceptional analytical, critical thinking, and problem-solving skills.
• Excellent written and verbal communication skills, with the ability to present complex scientific information effectively.
• A strategic mindset with the ability to identify and pursue novel research opportunities.
• Experience in bioinformatics and computational biology is advantageous.

This is a fantastic opportunity to make a significant impact on the future of medicine within a leading research organization. If you are a visionary scientist ready to lead groundbreaking discoveries, we want to hear from you.

Join a world-class scientific research and development institution in **Leicester, Leicestershire, UK**, as a Senior Scientific Research Scientist specializing in Genomics. This exciting opportunity sits within a collaborative and innovative environment focused on pushing the boundaries of biological understanding and its applications. You will lead significant research projects, contribute to groundbreaking discoveries, and mentor a team of talented researchers.

Your key responsibilities will include:

• Designing and implementing advanced genomic research projects, including Next-Generation Sequencing (NGS) experiments.
• Developing and optimizing protocols for DNA/RNA extraction, library preparation, and sequencing.
• Analyzing large-scale genomic datasets using bioinformatics tools and statistical methods.
• Interpreting genomic data to identify disease markers, understand biological pathways, and drive therapeutic insights.
• Managing and maintaining genomic research infrastructure, including sequencing platforms and bioinformatics pipelines.
• Collaborating with internal and external research groups to foster new scientific partnerships.
• Preparing high-impact research publications for peer-reviewed journals and presenting findings at scientific conferences.
• Mentoring and providing technical guidance to junior scientists and research assistants.
• Ensuring strict adherence to all laboratory safety protocols and ethical guidelines.
• Contributing to the development of grant proposals and securing research funding.

We are seeking individuals with a Ph.D. in Genomics, Molecular Biology, Bioinformatics, or a closely related field. A minimum of 5 years of post-doctoral or industry research experience focused on genomics is essential, supported by a strong publication record. Expertise in NGS technologies (e.g., Illumina, PacBio), library preparation techniques, and a variety of sequencing applications (e.g., WGS, WES, RNA-Seq, ChIP-Seq) is required. Proficiency in bioinformatics analysis tools, programming languages (e.g., Python, R), and statistical software is crucial. Experience with data visualization and interpretation of complex genomic datasets is highly desirable. Excellent analytical, problem-solving, and critical thinking skills are a must. Outstanding written and verbal communication abilities, with experience in presenting scientific findings, are essential. The ability to lead research projects, manage multiple priorities, and foster a collaborative team environment is vital. If you are a passionate and experienced genomics researcher looking for a challenging and impactful role, we encourage you to apply.

Our client is seeking a highly motivated and experienced Senior Scientific Research Scientist specializing in Genomics for a fully remote, permanent position. This role offers an exceptional opportunity to contribute to groundbreaking research from the convenience of your home office, with a focus on advancing our understanding of complex biological systems. You will be integral to the research and development efforts of our client, contributing to projects that push the boundaries of scientific discovery. While working remotely, your insights and expertise will be critical to the success of research based in the Milton Keynes, Buckinghamshire, UK area and extending globally.

Your responsibilities will include designing and conducting complex experiments, analyzing large-scale genomic datasets, and developing innovative research methodologies. You will play a key role in interpreting experimental results, contributing to scientific publications, and presenting findings at conferences. Collaboration is key, and you will work closely with a multidisciplinary team of scientists, bioinformaticians, and clinicians, sharing knowledge and expertise effectively. Staying abreast of the latest advancements in genomics, molecular biology, and bioinformatics is essential.

The ideal candidate will possess a PhD in Genomics, Molecular Biology, Genetics, or a related field, with a strong publication record and extensive experience in experimental design and data analysis. Proven expertise in various genomic technologies (e.g., NGS, qPCR, microarrays) and bioinformatics tools is required. Excellent critical thinking, problem-solving skills, and the ability to manage multiple research projects simultaneously are paramount. Exceptional communication and collaboration skills are necessary to thrive in this remote research environment.

Qualifications:

• PhD in Genomics, Molecular Biology, Genetics, or a related life science discipline.
• Minimum of 5 years of post-doctoral research experience or equivalent industry experience.
• Extensive hands-on experience with Next-Generation Sequencing (NGS) technologies and associated workflows.
• Proficiency in bioinformatics tools and software for genomic data analysis (e.g., R, Python, Bioconductor).
• Strong understanding of molecular biology techniques and genetic principles.
• Proven ability to design, execute, and interpret complex scientific experiments.
• Excellent analytical and problem-solving skills.
• Strong publication record in reputable peer-reviewed journals.
• Excellent written and verbal communication skills for scientific reporting and presentations.
• Ability to work independently and as a collaborative member of a remote research team.

This is a prime opportunity for a driven scientist to make a significant impact on the field of genomics in a flexible, remote-first setting.