What Jobs are available for Principal Investigator in the United Kingdom?
Showing 5000+ Principal Investigator jobs in the United Kingdom
Principal Investigator
Posted today
Job Viewed
Job Description
I am seeking an experienced and GMC-registered medical professional to serve as a Remote Principal Investigator for decentralised clinical trials across multiple therapeutic areas. This role is ideal for a physician passionate about advancing medical research through digital trial models, with oversight and compliance skills.
 
Requirements:
- Medical degree (MBBS or equivalent) and active GMC registration.
 - 2 years’ experience as a Principal Investigator or Sub-Investigator in clinical trials.
 - Strong understanding of Good Clinical Practice.
 - Ability to collaborate remotely.
 - Ability to commit part-time, depending on sponsor needs.
 
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                    Principal Investigator
Posted today
Job Viewed
Job Description
I am seeking an experienced and GMC-registered medical professional to serve as a Remote Principal Investigator for decentralised clinical trials across multiple therapeutic areas. This role is ideal for a physician passionate about advancing medical research through digital trial models, with oversight and compliance skills.
Requirements:
- Medical degree (MBBS or equivalent) and active GMC registration.
 - 2 years' experience as a Principal Investigator or Sub-Investigator in clinical trials.
 - Strong understanding of Good Clinical Practice.
 - Ability to collaborate remotely.
 - Ability to commit part-time, depending on sponsor needs.
 
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                    Principal Investigator
Posted 3 days ago
Job Viewed
Job Description
Principal Investigator – Clinical Research
 
Location- United Kingdom
Full-time | Competitive Compensation | Equity Potential
 
We are currently recruiting a Principal Investigator to join a growing and well-resourced clinical research site in the United Kingdom . This is a unique opportunity for an experienced or aspiring PI to join a high-performing team with strong sponsor relationships and a robust pipeline of upcoming trials.
This is a permanent position with competitive base compensation , bonus structure , potential equity , and flexibility in daily scheduling — ideal for someone looking to transition from private practice, hospital work, or academia into a more entrepreneurial clinical setting.
 
What You'll Do:
 
- Serve as Principal Investigator on a variety of Phase I–IV clinical trials
 - Ensure GCP and protocol compliance across study activities
 - Supervise and collaborate with research staff and sub-investigators
 - Conduct subject assessments and maintain regulatory documentation
 - Participate in sponsor meetings, SIVs, and audits as needed
 
 
Requirements:
 
- Prior experience as a PI or Sub-I in clinical trials is required
 - Strong interest in clinical research and patient care
 - Relocation may be required
 
 
Why This Role?
 
- Competitive base salary + performance-based bonuses
 - Flexible hours & supportive operational staff
 - Growing research pipeline across multiple therapeutic areas
 - Equity opportunity in a fast-scaling site organization
 - Relocation support for the right candidate
 
 
Interested in learning more?
 
Apply confidentially or reach out directly for a no-pressure discussion. We’re happy to walk you through the opportunity and see if it aligns with your career goals.
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                    Principal Investigator - Neurodegenerative Diseases
Posted 3 days ago
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Job Description
- Develop and implement a comprehensive research strategy for neurodegenerative disease research.
 - Lead a team of scientists, post-doctoral fellows, and technicians, fostering a collaborative and innovative environment.
 - Design and oversee experimental studies to investigate disease pathogenesis, identify biomarkers, and test therapeutic interventions.
 - Secure grant funding from national and international agencies to support research activities.
 - Disseminate research findings through publications in high-impact journals and presentations at international conferences.
 - Manage research budgets and resources effectively.
 - Provide mentorship and guidance to junior researchers.
 - Contribute to the strategic development of the R&D division.
 
- PhD or MD/PhD in Neuroscience, Molecular Biology, Genetics, or a related field.
 - Extensive post-doctoral and independent research experience with a strong publication record in top-tier scientific journals.
 - Demonstrated expertise in neurodegenerative disease research, including a deep understanding of relevant molecular and cellular mechanisms.
 - Proven experience in grant writing and successful funding acquisition.
 - Experience in managing research teams and laboratory operations.
 - Proficiency in a range of modern molecular and cellular biology techniques.
 - Excellent leadership, communication, and interpersonal skills.
 - Ability to thrive in a fast-paced, collaborative, and hybrid work setting.
 
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                    Principal Forensic Investigator (Mechanical)
                        Posted today
Job Viewed
Job Description
Newsweek Recognizes Sedgwick as America's Greatest Workplaces National Top Companies
Certified as a Great Place to Work®
Fortune Best Workplaces in Financial Services & Insurance
Principal Forensic Investigator (Mechanical)
**Job Location:** **UK wide**
**Job Type:** **Permanent**
**Remuneration** **: Competitive salary taking into account skills, experience and qualifications**
**Join EFI Global UK as a Principal Forensic Investigator and play a pivotal role in uncovering the causes behind complex incidents while shaping best practices in safety and forensic investigation.**
EFI Global UK, part of the internationally respected EFI Global Inc and Sedgwick Group, delivers impartial expert opinion in environmental consultancy and forensic investigations. With a client base that includes insurance companies, brokers, loss adjusters, government bodies, and private individuals, EFI Global UK is known for its technical excellence and commitment to service.
An exciting opportunity has arisen for a skilled Principal Forensic Investigator (Mechanical) to join the team. This is a dynamic and multifaceted role that combines technical investigation with strategic support for health and safety processes across the department and wider Sedgwick organisation. The successful candidate will be involved in examining a broad spectrum of incidents in both domestic and commercial environments-from routine insurance claims to complex, high-value cases such as large marine losses.
The role offers a hands-on investigative element, requiring visits to incident sites and laboratories to collect evidence, interview witnesses, and occasionally dismantle machinery or equipment to determine the root cause of incidents. You may also be called upon to design and conduct tests in collaboration with external agencies, adding a practical and experimental dimension to your work.
Beyond investigations, you'll play a key role in promoting health and safety best practices, supporting internal procedures, and contributing to the team's reputation for technical expertise. This position demands a blend of engineering knowledge, analytical thinking, and interpersonal skills, making it ideal for someone who thrives in a varied and intellectually stimulating environment.
**The skills you will have when you apply:**
+ **Educational background** : Degree-level qualification or equivalent experience - chartered status preferred, ideally supported by IOSH or NEBOSH certifications.
+ **Engineering expertise** : Strong understanding and practical application of engineering principles.
+ **Health and safety knowledge** : Proven experience in preparing and delivering health and safety processes and procedures.
+ **Expert witness experience** : Ideally has experience providing expert opinion in legal or insurance contexts.
+ **Regulatory familiarity** : Comfortable working with approved documents, codes, and standards relevant to the role.
+ **Interpersonal skills** : Able to motivate, inspire confidence, and communicate effectively with a range of stakeholders.
+ **Flexibility and resilience** : Willingness to work occasional long hours and maintain motivation in challenging situations.
+ **Organisational ability** : Strong planning and time management skills.
+ **Technical proficiency** : IT skills appropriate to the role, including report writing and data handling.
+ **Driving licence** : Full UK driving license is essential for travel to incident sites and laboratories.
+ **Insurance industry exposure** : Experience in the insurance sector is beneficial but not essential, as training will be provided.
**What we'll give you for this role:**
**Remuneration & more**
+ Competitive salary taking into account skills, experience and qualifications
+ Fully funded company vehicle or cash in lieu allowance
+ A Self Invested Personal Pension Scheme (SIPP)
+ Holiday allowance of 25 days plus bank holidays
+ Flexible working from our office or your home
**Health & support**
+ Private healthcare plan (including pre-existing conditions)
+ Life assurance
+ Group Income Protection
**Other benefits**
+ Voluntary benefits - dental cover, cycle to work scheme, season ticket loan, wellbeing and digital GP applications
+ Employee assistance programme for employee wellbeing
+ Discounts on various products and services
**This isn't just a position, it's a pivotal role in shaping our industry**
At Sedgwick, not only will you be working behind the scenes for some of the UK's most trusted insurance brands helping to resolve millions of claims every year, you'll also be an architect of tomorrow's insurance landscape with Sedgwick University. Our proprietary offering is the most comprehensive training and development program in the industry with more than 15,000 courses on demand, training specific to roles, and opportunities to continue your formal education - all available to you starting from your very first day.
You'll join a community passionate about making a difference, where every role contributes to a larger mission; protecting people and businesses. This isn't just a job; it's an opportunity to shape the future of insurance.
**Next steps for you:**
**Think we'd be a great match? Apply now - we want to hear from you.**
If you're unsure whether you have all the skills needed then do apply - we are looking for all backgrounds from seasoned professionals to those returning to the workforce, and everyone in-between.
Not only that, we are proud to have a zero tolerance policy towards discrimination of any kind regardless of age, disability, gender identity, marital/ family status, race, religion, sex or sexual orientation.
After the closing date we will review all applications and may select some applicants for an interview (which may be virtual, or in-person).
#LI-HYBRID
Sedgwick is an Equal Opportunity Employer.
The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Sedgwick retains the discretion to add or to change the duties of the position at any time.
**Sedgwick is the world's leading risk and claims administration partner, which helps clients thrive by navigating the unexpected. The company's expertise, combined with the most advanced AI-enabled technology available, sets the standard for solutions in claims administration, loss adjusting, benefits administration, and product recall. With over 33,000 colleagues and 10,000 clients across 80 countries, Sedgwick provides unmatched perspective, caring that counts, and solutions for the rapidly changing and complex risk landscape. For more, see** **sedgwick.com**
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                    Principal Forensic Investigator (Mechanical)
                        Posted today
Job Viewed
Job Description
IF YOU CARE, THERE'S A PLACE FOR YOU HERE
EFI Global is a full-service engineering, fire investigation, environmental, health and safety, and specialty consulting services firm serving a variety of industries in both the public and private sectors. Over the last four decades, we have grown from a boutique firm specializing in handling insurance fraud and arson cases and providing expert witness testimony, into a recognized global leader in engineering failure analysis, origin-and-cause investigations, environmental consulting, laboratory testing and specialty consulting. Our forensic investigation, engineering and environmental services teams around the world share a dedication to expertise, quality and demonstrating to customers that caring counts®. Each of our more than 700 professional engineers, fire investigators, architects and scientists was selected for their technical proficiency, in-depth industry knowledge and commitment to professional integrity. Together, our diverse backgrounds and collective insights empower clients to make better-informed business decisions. EFI's combination of global solutions and local expertise has earned the firm a reputation for delivering timely responses that consistently meet our clients' expectations-anytime, anywhere. Click here to learn more about EFI Global.
**Job Location:** **UK wide**
**Job Type:** **Permanent**
**Remuneration** **: Competitive salary taking into account skills, experience and qualifications**
**Join EFI Global UK as a Principal Forensic Investigator and play a pivotal role in uncovering the causes behind complex incidents while shaping best practices in safety and forensic investigation.**
EFI Global UK, part of the internationally respected EFI Global Inc and Sedgwick Group, delivers impartial expert opinion in environmental consultancy and forensic investigations. With a client base that includes insurance companies, brokers, loss adjusters, government bodies, and private individuals, EFI Global UK is known for its technical excellence and commitment to service.
An exciting opportunity has arisen for a skilled Principal Forensic Investigator (Mechanical) to join the team. This is a dynamic and multifaceted role that combines technical investigation with strategic support for health and safety processes across the department and wider Sedgwick organisation. The successful candidate will be involved in examining a broad spectrum of incidents in both domestic and commercial environments-from routine insurance claims to complex, high-value cases such as large marine losses.
The role offers a hands-on investigative element, requiring visits to incident sites and laboratories to collect evidence, interview witnesses, and occasionally dismantle machinery or equipment to determine the root cause of incidents. You may also be called upon to design and conduct tests in collaboration with external agencies, adding a practical and experimental dimension to your work.
Beyond investigations, you'll play a key role in promoting health and safety best practices, supporting internal procedures, and contributing to the team's reputation for technical expertise. This position demands a blend of engineering knowledge, analytical thinking, and interpersonal skills, making it ideal for someone who thrives in a varied and intellectually stimulating environment.
**The skills you will have when you apply:**
+ **Educational background** : Degree-level qualification or equivalent experience - chartered status preferred, ideally supported by IOSH or NEBOSH certifications.
+ **Engineering expertise** : Strong understanding and practical application of engineering principles.
+ **Health and safety knowledge** : Proven experience in preparing and delivering health and safety processes and procedures.
+ **Expert witness experience** : Ideally has experience providing expert opinion in legal or insurance contexts.
+ **Regulatory familiarity** : Comfortable working with approved documents, codes, and standards relevant to the role.
+ **Interpersonal skills** : Able to motivate, inspire confidence, and communicate effectively with a range of stakeholders.
+ **Flexibility and resilience** : Willingness to work occasional long hours and maintain motivation in challenging situations.
+ **Organisational ability** : Strong planning and time management skills.
+ **Technical proficiency** : IT skills appropriate to the role, including report writing and data handling.
+ **Driving licence** : Full UK driving license is essential for travel to incident sites and laboratories.
+ **Insurance industry exposure** : Experience in the insurance sector is beneficial but not essential, as training will be provided.
**What we'll give you for this role:**
**Remuneration & more**
+ Competitive salary taking into account skills, experience and qualifications
+ Fully funded company vehicle or cash in lieu allowance
+ A Self Invested Personal Pension Scheme (SIPP)
+ Holiday allowance of 25 days plus bank holidays
+ Flexible working from our office or your home
**Health & support**
+ Private healthcare plan (including pre-existing conditions)
+ Life assurance
+ Group Income Protection
**Other benefits**
+ Voluntary benefits - dental cover, cycle to work scheme, season ticket loan, wellbeing and digital GP applications
+ Employee assistance programme for employee wellbeing
+ Discounts on various products and services
**This isn't just a position, it's a pivotal role in shaping our industry**
At Sedgwick, not only will you be working behind the scenes for some of the UK's most trusted insurance brands helping to resolve millions of claims every year, you'll also be an architect of tomorrow's insurance landscape with Sedgwick University. Our proprietary offering is the most comprehensive training and development program in the industry with more than 15,000 courses on demand, training specific to roles, and opportunities to continue your formal education - all available to you starting from your very first day.
You'll join a community passionate about making a difference, where every role contributes to a larger mission; protecting people and businesses. This isn't just a job; it's an opportunity to shape the future of insurance.
**Next steps for you:**
**Think we'd be a great match? Apply now - we want to hear from you.**
If you're unsure whether you have all the skills needed then do apply - we are looking for all backgrounds from seasoned professionals to those returning to the workforce, and everyone in-between.
Not only that, we are proud to have a zero tolerance policy towards discrimination of any kind regardless of age, disability, gender identity, marital/ family status, race, religion, sex or sexual orientation.
After the closing date we will review all applications and may select some applicants for an interview (which may be virtual, or in-person).
#LI-HYBRID
The statements contained in this document are intended to describe the general nature and level of work being performed by a colleague assigned to this description. They are not intended to constitute a comprehensive list of functions, duties, or local variances. Management retains the discretion to add or to change the duties of the position at any time.
Sedgwick is an Equal Opportunity Employer and a Drug-Free Workplace
Our business is founded on people with the best technical skills and outstanding industry knowledge and we strive to employ and retain exceptional talent. EFI Global is an equal opportunity employer welcoming applications from all qualified persons.
If you are interested in working for us, please visit our job board.
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                    Senior Scientific Research Scientist (Bioinformatics)
Posted 3 days ago
Job Viewed
Job Description
Key Responsibilities:
- Design and execute bioinformatics analyses for large-scale genomics, transcriptomics, proteomics, and metabolomics datasets.
 - Develop and implement novel computational tools and algorithms to support research objectives.
 - Collaborate with experimental biologists, clinicians, and other researchers to interpret biological data and generate actionable insights.
 - Contribute to the conceptualization and design of new research projects and grant proposals.
 - Manage bioinformatics workflows and pipelines, ensuring data integrity and reproducibility.
 - Stay abreast of the latest advancements in bioinformatics, computational biology, and relevant scientific fields.
 - Present research findings at internal meetings and external scientific conferences.
 - Mentor junior scientists and contribute to the growth of the research team's computational capabilities.
 - Author scientific publications in peer-reviewed journals.
 - Ensure compliance with data management best practices and ethical guidelines.
 
Qualifications:
- PhD in Bioinformatics, Computational Biology, Computer Science, Statistics, or a related quantitative field.
 - Minimum of 6 years of post-doctoral research experience in bioinformatics or computational biology.
 - Proven track record of leading successful research projects and contributing to high-impact publications.
 - Expertise in analysing diverse biological datasets using statistical and machine learning methods.
 - Proficiency in programming languages commonly used in bioinformatics (e.g., Python, R, Perl) and experience with bioinformatics software packages and databases.
 - Strong understanding of molecular biology principles and experimental techniques.
 - Excellent problem-solving, analytical, and critical-thinking skills.
 - Outstanding communication and presentation skills, with the ability to articulate complex scientific concepts effectively.
 - Experience with high-performance computing environments is a plus.
 - Ability to work independently, manage priorities, and collaborate effectively in a remote research setting.
 
This is an exceptional opportunity for a dedicated scientist to drive innovation in a dynamic and collaborative remote research environment. Our client offers a highly competitive salary, comprehensive benefits, and the chance to contribute to significant scientific breakthroughs.
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Principal Scientific Research Scientist (Biotechnology)
Posted 3 days ago
Job Viewed
Job Description
Key Responsibilities:
- Lead the design and execution of ambitious research projects in biotechnology, with a focus on developing novel therapeutics for unmet medical needs.
 - Direct and mentor a team of research scientists and technicians, fostering a collaborative and high-performance research environment.
 - Develop and implement innovative experimental strategies using advanced molecular biology, genomics, and proteomics techniques.
 - Critically analyse complex biological data, interpret results, and draw robust conclusions to guide research direction.
 - Contribute to the preparation of grant proposals and secure external funding for research initiatives.
 - Publish findings in high-impact peer-reviewed journals and present research at international conferences.
 - Collaborate effectively with cross-functional teams, including chemistry, pharmacology, and clinical development departments.
 - Ensure compliance with all relevant ethical guidelines, regulatory requirements, and safety protocols within the laboratory.
 - Identify emerging scientific trends and technologies relevant to the company's strategic goals.
 - Contribute to the intellectual property strategy through patent filings and disclosures.
 
Qualifications and Skills:
- A Ph.D. in Molecular Biology, Biochemistry, Genetics, Biotechnology, or a closely related life science discipline.
 - A minimum of 10 years of post-doctoral research experience in an academic or industrial R&D setting.
 - A distinguished track record of publications in leading scientific journals and successful grant acquisition.
 - Extensive hands-on experience with advanced techniques such as CRISPR-Cas9, next-generation sequencing (NGS), mammalian cell culture, protein expression and purification, and various assay development platforms.
 - Proven experience in leading and managing research projects and scientific teams.
 - Strong understanding of drug discovery and development processes.
 - Exceptional analytical, critical thinking, and problem-solving skills.
 - Excellent written and verbal communication skills, with the ability to present complex scientific information effectively.
 - A strategic mindset with the ability to identify and pursue novel research opportunities.
 - Experience in bioinformatics and computational biology is advantageous.
 
This is a fantastic opportunity to make a significant impact on the future of medicine within a leading research organization. If you are a visionary scientist ready to lead groundbreaking discoveries, we want to hear from you.
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                    Senior Scientific Research Scientist - Genomics
Posted 3 days ago
Job Viewed
Job Description
Your key responsibilities will include:
- Designing and implementing advanced genomic research projects, including Next-Generation Sequencing (NGS) experiments.
 - Developing and optimizing protocols for DNA/RNA extraction, library preparation, and sequencing.
 - Analyzing large-scale genomic datasets using bioinformatics tools and statistical methods.
 - Interpreting genomic data to identify disease markers, understand biological pathways, and drive therapeutic insights.
 - Managing and maintaining genomic research infrastructure, including sequencing platforms and bioinformatics pipelines.
 - Collaborating with internal and external research groups to foster new scientific partnerships.
 - Preparing high-impact research publications for peer-reviewed journals and presenting findings at scientific conferences.
 - Mentoring and providing technical guidance to junior scientists and research assistants.
 - Ensuring strict adherence to all laboratory safety protocols and ethical guidelines.
 - Contributing to the development of grant proposals and securing research funding.
 
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                    Principal Aviation Safety Investigator
Posted 3 days ago
Job Viewed
Job Description
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