6,518 Senior Research Scientist jobs in the United Kingdom

• Designing and implementing advanced genomic research projects, including Next-Generation Sequencing (NGS) experiments.
• Developing and optimizing protocols for DNA/RNA extraction, library preparation, and sequencing.
• Analyzing large-scale genomic datasets using bioinformatics tools and statistical methods.
• Interpreting genomic data to identify disease markers, understand biological pathways, and drive therapeutic insights.
• Managing and maintaining genomic research infrastructure, including sequencing platforms and bioinformatics pipelines.
• Collaborating with internal and external research groups to foster new scientific partnerships.
• Preparing high-impact research publications for peer-reviewed journals and presenting findings at scientific conferences.
• Mentoring and providing technical guidance to junior scientists and research assistants.
• Ensuring strict adherence to all laboratory safety protocols and ethical guidelines.
• Contributing to the development of grant proposals and securing research funding.

• PhD in Genomics, Molecular Biology, Genetics, or a related life science discipline.
• Minimum of 5 years of post-doctoral research experience or equivalent industry experience.
• Extensive hands-on experience with Next-Generation Sequencing (NGS) technologies and associated workflows.
• Proficiency in bioinformatics tools and software for genomic data analysis (e.g., R, Python, Bioconductor).
• Strong understanding of molecular biology techniques and genetic principles.
• Proven ability to design, execute, and interpret complex scientific experiments.
• Excellent analytical and problem-solving skills.
• Strong publication record in reputable peer-reviewed journals.
• Excellent written and verbal communication skills for scientific reporting and presentations.
• Ability to work independently and as a collaborative member of a remote research team.

• Lead independent research projects focused on the discovery and development of biologic drugs (e.g., antibodies, proteins, vaccines).
• Design, optimize, and perform complex in vitro and in vivo experiments.
• Analyze and interpret large datasets, employing advanced statistical methods.
• Develop and implement novel assays and technologies for biological research.
• Author high-impact publications in peer-reviewed journals and present findings at international conferences.
• Mentor and guide junior research scientists and postdoctoral fellows.
• Collaborate effectively with cross-functional teams, including medicinal chemistry, pharmacology, and clinical development.
• Contribute to intellectual property generation and patent applications.
• Ensure adherence to all laboratory safety regulations and ethical guidelines.
• Manage research budgets and resources effectively.
• Stay abreast of the latest scientific advancements and competitive landscape in biologics research.

• PhD in Molecular Biology, Immunology, Biochemistry, or a related life science discipline.
• Minimum of 8 years of post-doctoral research experience in the biopharmaceutical industry or equivalent academic setting, with a strong focus on biologics.
• Demonstrated track record of successfully leading research projects and delivering impactful scientific outcomes.
• Extensive hands-on experience with a wide range of molecular and cellular biology techniques relevant to biologics development.
• Proven expertise in assay development, validation, and characterization of biologic molecules.
• Excellent scientific writing and presentation skills.
• Strong leadership, mentorship, and team collaboration abilities.
• Proficiency in data analysis software (e.g., GraphPad Prism, R).
• Experience with bioinformatics tools is a plus.
• Strong understanding of drug discovery and development processes.

• Lead and direct scientific research projects in biotechnology.
• Design and execute complex experiments and develop novel research methodologies.
• Analyze and interpret sophisticated scientific data to derive meaningful conclusions.
• Contribute to the development of new products, processes, or therapeutic solutions.
• Author scientific manuscripts, patents, and research reports.
• Collaborate with a global network of scientists and research partners.
• Mentor and guide junior researchers, fostering scientific excellence.
• Stay abreast of the latest scientific advancements and emerging technologies.

• PhD in a relevant life science discipline (e.g., Biology, Biochemistry, Molecular Biology, Biotechnology).
• Minimum of 8 years of post-doctoral and industry research experience in biotechnology.
• Proven track record of scientific innovation and achievement, including publications and/or patents.
• Expertise in a specialized area of biotechnology (e.g., molecular biology, genetics, cell biology).
• Strong experience in experimental design, data analysis, and scientific writing.
• Demonstrated leadership skills and experience in managing research projects.
• Excellent communication, collaboration, and problem-solving abilities.
• Ability to work effectively and autonomously in a remote research environment.

• Design, conduct, and interpret complex scientific experiments and research projects within your area of expertise.
• Develop and refine experimental methodologies, ensuring scientific rigor and reproducibility.
• Analyze large and complex datasets using advanced statistical and computational techniques.
• Collaborate with cross-functional teams, including chemists, biologists, physicists, and engineers, to achieve research objectives.
• Prepare and present research findings through written reports, scientific publications, and oral presentations to internal and external stakeholders.
• Contribute to the strategic planning and direction of research programs.
• Maintain detailed and accurate laboratory notebooks and research records.
• Stay abreast of the latest scientific literature, technological advancements, and emerging trends in relevant fields.
• Mentor junior researchers and provide technical guidance and support.
• Ensure compliance with all laboratory safety protocols and ethical guidelines.
• Contribute to patent applications and intellectual property development.
• Assist in the procurement and management of laboratory equipment and supplies.
• Participate in collaborative research initiatives with external partners and academic institutions.

• Ph.D. in Chemistry, Biology, Physics, Materials Science, or a related scientific discipline.
• A minimum of 5 years of post-doctoral or industry research experience, with a strong track record of independent research.
• Proven experience in experimental design, execution, and data analysis.
• Demonstrated expertise in relevant scientific techniques and instrumentation.
• Strong publication record in peer-reviewed scientific journals.
• Excellent analytical, critical thinking, and problem-solving skills.
• Proficiency in data analysis software and statistical packages (e.g., R, Python, SPSS).
• Exceptional written and verbal communication skills, with the ability to clearly articulate complex scientific concepts.
• Experience working in a hybrid or collaborative team environment, with effective remote communication skills.
• Ability to manage multiple research projects concurrently and meet deadlines.
• A proactive, curious, and self-motivated individual with a passion for scientific innovation.
• Familiarity with intellectual property processes and patent applications is a plus.
• Experience in (Specific Area relevant to R&D, e.g., gene editing, nanoparticle synthesis, quantum computing) is highly desirable.

• Designing, executing, and interpreting complex experiments to identify and validate novel therapeutic targets.
• Developing and optimizing assays for screening potential drug candidates.
• Utilizing advanced molecular and cellular biology techniques to investigate disease mechanisms.
• Analyzing large datasets using bioinformatics tools and statistical methods to derive meaningful insights.
• Collaborating closely with computational chemists, medicinal chemists, and pharmacologists to advance drug discovery programs.
• Keeping abreast of the latest scientific literature and emerging technologies in relevant therapeutic areas.
• Preparing detailed research reports, scientific presentations, and contributing to the writing of research publications and patent applications.
• Troubleshooting experimental challenges and developing innovative solutions.
• Maintaining meticulous laboratory records and ensuring compliance with all relevant safety and ethical guidelines.
• Contributing to the strategic direction of drug discovery projects and identifying new research opportunities.
• Participating actively in remote team meetings and contributing to a collaborative research environment.

Job Title : Research Scientist - Protein

Working Location : Bracknell

Rate : £18.41 per hour

Contract Length : 12 months

Start Date : 19th January 2026

We are looking for a hardworking, motivated individual who is quick to learn and apply themselves to join our dynamic, collaborative and industrious protein production team. This is a one-year contract to support the delivery of a critical protein production process. This role offers the opportunity for the successful candidate to gain hands on experience with an array of downstream processing techniques including protein chromatography and membrane filtration methods.

Role profile and expectations:

• Work as part of a protein production team to deliver gram quantities of purified recombinant protein to support one of Syngenta’s critical commercial projects
• Provide hands-on support during this large-scale protein production campaign
• Learn and conduct the necessary analytical methods to validate final outputs meet defined specifications
• Accurately record results to agreed company standards
• Prepare technical reports, present findings within project groups and be an active communicator within the wider Syngenta scientific community
• Work safely and with due care to others ensuring compliance with company HSE policies

Essential education & experience:

• Bachelor’s degree in relevant science e.g. Biology, Biochemistry, Biomedical or other similar disciplines
• Good theoretical understanding of recombinant protein expression
• Good theoretical understanding of chromatography techniques including affinity, ion exchange (IEX), hydrophobic interaction (HIC) and size exclusion (SEC) chromatography
• Strong evidence of troubleshooting and innovative problem solving
• Ability to work independently and as part of a team
• Good communication and planning skills

Desirable experience:

• Master’s degree or 1-2 years’ experience working in a laboratory environment
• 1-2 years lab experience working in any of the core areas highlighted in the above job description
• Experience with data management tools (e.g. Benchling) and data analysis software (e.g. JMP)
• Experience of working with scalable bioprocess technologies e.g. TFF, Hollow fibre

Research Scientist

Oxford

About Exogene

At Exogene, we’re reimagining what’s possible in cancer immunotherapy. Our mission is to engineer T-cell receptor therapies that can precisely and powerfully target advanced solid tumours.

To do this, we’ve built a proprietary lab-in-the-loop platform that merges generative AI, biophysical modelling, and high-throughput TCR screening to rapidly design, test, and optimise TCRs with exceptional affinity and specificity. This convergence of computation and wet-lab experimentation allows us to go from concept to candidate molecules in record time.

We’re developing TCR-based trispecific T cell engagers (TCR-TriTCEs)—a new therapeutic modality designed to overcome the unique challenges of the solid tumour microenvironment. This work spans multiple disciplines, from protein engineering and AI-driven design to in vivo validation and translational development.

We are looking for a dynamic research scientist who will help drive the TCR engineering processes and development. The successful candidate will contribute to in vivo and in vitro validation of TCEs. You’ll get involved in purifying recombinant TCRs to perform high-throughput TCR display methods and deep sequencing.

Responsibilities

• Contribute to in vivo and in vitro validation of TCEs.
• Collaboratively design and characterise TCRs for proprietary and partnered disease targets.
• Conduct a suite of protein science operations, including expression, purification, and biophysical analysis.
• Tackle molecular biology duties: cloning, mutagenesis, DNA isolation, and preparing libraries for deep sequencing.
• Manage tissue culture assignments, spanning from media prep and cell line care to cryopreservation.
• Join forces with founders, R&D, academia, and industrial stakeholders to fulfil ambitious R&D objectives.
• Draft, revise, and oversee repertoire of lab protocols.
• Offer essential lab support and uphold facility upkeep.

Skills and Qualifications

• PhD in Immunology, Cell Biology, Biochemistry, or an alike field, paired with at least 1-2 years of relevant lab experience is required.
• Knowledge of molecular biology protocols, with an emphasis on cloning and PCR is preferred.
• A background in molecular biology, protein expression, purification and biophysical characterisation is preferred.
• Experience in cell and immunological assays (flow cytometry, ELISA etc.) is desired.
• Experience with in vivo and in vitro validation of TCEs (T-cell engagers) in some or all aspects of investigational new drug (IND) approval is desired.
• Experience TCR engineering is desired.
• SOP documentation experience is desired.
• The highest standards in lab precision, record maintenance, and documentation.
• Excellent written and oral communication skills.

Attributes

• Self-starter with sound analytical skills, who values scientific integrity and novelty.
• Collaborative spirit within the lab, open to both giving and receiving actionable feedback.
• Exceptional at diagnosing and overcoming unforeseen technical challenges.
• Adept at juggling and prioritising multiple projects to meet deadlines.
• Versatile and efficient within an interdisciplinary, fast-paced team setup.

What We Offer

• Market-competitive salary and stock option package.
• A generous leave policy: 25 days holiday, public holidays, plus a day off for your birthday!
• Access to fully equipped private lab.
• Flexibility to work from home as project demands allow.
• A supportive, cross-disciplinary team fostering a highly collaborative work environment.

How to apply

Launch your journey with Exogene by submitting your CV and a brief cover letter (maximum 400 words) to m.hasan at exogene.co.uk