What Senior Scientist Jobs are in the United Kingdom?

Immunocore (NASDAQ: IMCR) is a pioneering, commercial-stage T cell receptor biotechnology company whose purpose is to develop and commercialize a new generation of transformative medicines which address unmet patient needs in oncology, infectious diseases and autoimmune disease. Our leaders in R&D are internationally recognised as some of the biotech industry's most successful drug developers. We are creating not just an environment where great minds can interact but an innovation powerhouse answering the big questions.

Focused on delivering first-in-class biological therapies to patients, we have developed a highly innovative soluble TCR platform. Our ImmTAX molecules underpin a new generation of precision engineered drugs that harness the immune system to treat a broad spectrum of diseases with high unmet medical need, including oncology, infectious diseases and autoimmune diseases.

At Immunocore, we recognize that our employees are our greatest asset. We value the unique contributions each person brings to our team. By embracing Science, Trust, Respect, Integrity, Diversity, and Entrepreneurship (STRIDE), we create an environment where collaboration thrives, ideas flourish, and transformative changes happen. STRIDE represents more than just letters; it embodies our shared identity and drives our mission. We are dedicated to developing breakthrough therapies that transform patients' lives, advancing medicine, and supporting one another in these pursuits.

Immunocore is proud to be an equal opportunity employer. As such, we are committed to fostering an inclusive workplace where everyone feels valued, respected, and empowered. We encourage applications from individuals of all backgrounds, regardless of race, color, religion, sex, sexual orientation, gender identity or expression, pregnancy, age, national origin, disability status, or any other characteristic protected by law.

To characterise the companies biotherapeutic recombinant T-cell receptor based and related molecules using a wide variety of protein characterisation and mass spectrometry methods. To contribute to the development of characterisation methods for the company's biopharmaceutical products, including peptide mapping (LC-MS/MS) and intact mass spectrometry analysis.

KEY RESPONSIBILITIES

* Supporting drug substance and drug product impurity characterisation and identification
* Performing protein sequence and post translational modification identification, including glycosylation analysis.
* Supporting drug substance and drug product process development by performing characterisation of process intermediates
* Contribute to the Development of characterisation methods of ImmTAX and other products, including peptide mapping (LC-MS/MS) and intact mass analysis
* Designing and carrying out biochemical characterisation, chemical stability and comparability studies of biologics/drug products.
* Contribute to writing study protocols and reports.
* Independently testing and, increasingly, leading lines of investigation. Proposing new experiments based on emerging data and other related information. Providing support on technical aspects to others.
* Priorities: establishing priorities for own work and team-based projects; making decisions on prioritisation based on the overall goals of the team, department and project, using direct evidence and personal experience as guidance.
* Technical Knowledge: sharing knowledge with the wider team and, across departments representing the department. May also act as a mentor to other colleagues, sharing scientific knowledge. Providing analysis of new techniques and theories from outside the Company to advance the way the company works; sharing these with leaders across the department.
* Laboratory records: ensuring that all records and information are up to date, on time and recorded to the correct standard. Supporting and encouraging others to achieve this.
* Laboratory equipment: providing technical guidance to others within the team on how to use equipment most effectively.
* Reporting: communicating and presenting research findings at meetings with colleagues, senior management and partners.
* Adhere to safe working practices in laboratories according to Immunocore EHS policies.

PERSON SPECIFICATION

Experience & knowledge

Essential

* Experience in development of HPLC based peptide mapping methods and mass spectrometric characterisation of recombinant proteins or antibodies.
* Experience of glycosylation analysis of recombinant proteins or antibodies.
* Independently coordinated extensive testing of protein biomolecules.
* Experienced in the characterisation of proteins expressed in both microbial and mammalian systems.
* Understanding of expected post-translational modifications in biological systems.
* Worked in a bench-based biopharmaceutical laboratory environment.
* Established as an expert amongst peers in one or more of the following areas:
o electrophoretic
o chromatographic
o mass spectrometry
* Experienced in assay development
* Familiar with biopharmaceutical stability study principles and interpretation thereof
* Worked and contributed actively in a diverse team environment
* Proposed and driven changes in working practices that have improved efficiency, supported teams through adoption and change
* Presented detailed scientific findings and papers to internal and external audiences

Desirable

* Experience of glycosylation analysis of recombinant proteins or antibodies
* Experience with late stage/commercial biopharmaceutical assay development and characterisation
* Familiar with the principles of Good Manufacturing Practise (GMP)
* Presented at external conferences
* Led a small project team, formally or informally, through a change in practice including project management
* Understanding of analytical requirements to support materials for use in clinical trials

Education & qualifications

* Essential: BSc. Or MSc. in biochemistry, biotechnology or related discipline
* Desirable: PhD in related discipline

Senior Scientist - Microbial Upstream Process Development
Darlington | Permanent | 34,500 - 46,500

About the Role

We are seeking a Senior Scientist with experience within Microbial Upstream process development to join a growing bioprocessing team, providing technical leadership across customer-facing biologics development projects.

This is a senior scientific role focused on technical project leadership rather than line management. You'll lead and coordinate microbial upstream process development activities, working closely with customers, project managers, commercial teams, and scientific colleagues to deliver innovative biologics programmes.

The ideal candidate will bring strong expertise in microbial fermentation, process development, and scale-up, alongside the ability to work across functions and confidently engage with external stakeholders.

What You'll Be Responsible For:

Microbial Upstream Process Development

• Lead the design, development, optimisation, and scale-up of microbial upstream processes for biologics production
• Support the development of processes for products such as:
  • Recombinant proteins
  • Antibodies and biologic products
  • Other microbial-expressed therapeutic molecules
• Apply expertise across microbial fermentation, strain development, and bioreactor operations

Technical Project Leadership

• Act as the technical lead for small to medium-sized development projects
• Coordinate activities across scientific, project management, and commercial functions
• Ensure technical work packages are delivered to scope, quality, and timeline requirements
• Provide scientific guidance and support to project teams and junior colleagues

Scale-Up & Technology Development

• Develop and scale bioprocesses from high-throughput systems through laboratory and pilot-scale bioreactors
• Support technology evaluation, optimisation, and implementation activities
• Apply experimental design and statistical approaches to process development and optimisation
• Evaluate data and translate findings into practical development solutions

Customer & Stakeholder Engagement

• Act as a primary technical contact for customers and collaborators
• Present scientific data and recommendations to internal and external stakeholders
• Build strong relationships with customers, partners, and multidisciplinary teams
• Support successful delivery of customer-funded and collaborative development programmes

Business Development & Innovation

• Contribute technical expertise to proposal development and work-winning activities
• Support customer discussions and identification of new opportunities
• Help shape future technical capabilities and scientific strategy within the team
• Maintain awareness of emerging technologies and industry developments

About You

You are an experienced bioprocess scientist with strong technical expertise and the ability to lead projects through influence rather than direct line management.

You'll bring:

• A PhD, postdoctoral experience, or equivalent industrial experience in biotechnology, microbiology, bioprocessing, or a related discipline
• Strong expertise in microbial fermentation for biologics production
• Experience working with microbial expression systems, ideally E. coli and/or Pichia pastoris
• Proven experience developing and scaling bioprocesses from high-throughput systems through laboratory and pilot-scale bioreactors
• Strong experimental design, data analysis, and process optimisation skills
• Experience leading technical projects and delivering complex scientific programmes
• Ability to work across scientific, project management, and commercial teams
• Strong communication and stakeholder management skills
• Commercial awareness and an interest in supporting customer engagement and proposal development

Desirable Experience

• Industrial R&D or technology development experience
• Experience within a CRO, CDMO, biotech, or innovation-led environment
• Knowledge of technology transfer and commercialisation activities
• Experience in collaborative R&D or grant-funded programmes
• Experience working with recombinant proteins, antibodies, or other biologics
• Familiarity with GMP environments and biopharmaceutical development

Why Join Us?

• Lead innovative microbial bioprocess development projects
• Work directly with customers developing next-generation biologics
• Gain exposure to a broad range of technologies, partners, and development programmes
• Be part of a highly collaborative team of upstream specialists
• Competitive salary (34,500 - 46,500)

Location & Working Pattern

• Based in Darlington
• Permanent position, based onsite
• Collaborative, customer-facing environment

The Opportunity
This is an excellent opportunity for an experienced upstream scientist looking to step into a role with greater technical leadership, customer interaction, and project responsibility. You'll play a key role in developing innovative biologics manufacturing processes while helping shape the future capabilities of a growing scientific team.

Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy.

Are you an experienced protein scientist looking to translate your experience into real-world impact whilst working with some of the UK's leading scientists? Well this role could be for you.

The Company

SRG are delighted to be working with one of the UK's most recognisable scientific brands who are growing out their CRO and drug discovery capability in Glasgow. This organisation are at the forefront of drug discovery in the cancer therapy field and are looking to grow out their therapeutic innovation team by adding an experienced protein scientist to assist on a number of drug discovery programmes.

The Role

As Senior Protein scientist you will be responsible for the expression and purification of a wide range of recombinant proteins using both bacterial and insect systems. You will ensure all protein production is appropriately quality checked using biochemical and biophysical techniques.

You will also collaborate and communicate with key stakeholders to provide technical support on a variety of drug discovery programmes, assisting in process development and establishment - working alongside the wider protein production team.

The Right Person

• PhD (or similar experience) in a relevant topic (protein science, chemistry, biochemistry, etc)
• Relevant experience in a drug discovery environment is highly desirable
• Demonstrable experience producing, purifying and analysing proteins using tools and techniques such as PCR, AKTA, SDS-PAGE, Western Blotting, etc.
• Experience of tissue culture and transgenic cell line generation
• Project management experience
• Prior experience in a drug discovery environment is highly desirable
• Experience expressing proteins using insect systems is highly desirable

If this sounds like you, or anyone you know, hit apply!

Guidant, Carbon60, Lorien & SRG - The Impellam Group Portfolio are acting as an Employment Business in relation to this vacancy.

Senior Protein Scientist

Permanent, full-time, onsite.

Location: Macclesfield

Up to c40,000 depending on experience.

Our client are a multi-national drug discovery organisation providing a range of research services and internal drug discovery programmes across a variety of disease areas and drug modalities. They are currently seeking to expand their protein science team with the addition of a full-time and permanent Senior Scientist.

As a Senior Scientist within the Protein Sciences team, you will be responsible for:

• Supporting and leading client drug discovery projects across biologics and antibody portfolios.
• Designing and running a range of protein biochemistry experiments including protein design (using a range of molecular biology techniques including cloning), protein expression (using AKTA systems for IEX, SEC etc), protein characterisation (using DLS, HPLC, capillary electrophoresis and plate assays).
• Supporting the growth of more junior team members, some of whom will report directly into you. This will include creating personal development plans and other management responsibilities.
• Liaising with clients throughout the projects including data updates, presentations and scope of works.
• Working on multiple projects simultaneously.

To be successful in this position, our client are accepting applications from candidates with the following experience:

• PhD in a biological or biochemical discipline, with additional post-doctoral experience (essential, ideally with industry experience of 1+ year), or a MSc / BSc with 5+ years of industry experience in biochemistry / protein research.
• Prior experience in supervising or managing scientists / technicians (essential)
• Must have strong protein biochemistry knowledge (essential, structural biology and/or biophysical characterisation is a bonus).
• Must have experience in designing proteins using molecular biology (cloning, CRISPR etc) (essential)
• Must have protein expression experience across a range of systems including mammalian and bacterial (essential)
• Must have protein purification and characterisation experience using ion-exclusion chromatography, size-exclusion chromatography, affinity, AKTA / FPLC, plate-based assays, capillary electrophoresis (essential)
• Protein characterisation experience using biophysical (DLS, SPR etc) (desired)
• Experience of liaising with external partners / clients for project updates (desired)

The Package

As an established global organisation, our client is able to offer a competitive salary, progression options and benefits package including private pension.

Exciting new opportunity for an experienced, personable and analytically minded Scientist seeking career progression with an internationally renowned and expanding Biopharmaceutical Laboratory!

In this diverse, multifaceted position you will call upon your expertise in a range of ligand binding assay techniques to undertake a broad range of challenging projects for several world leading organisations. Acting as a scientific point of contact for both internal teams and external clients, your work will focus on the development, validation, and troubleshooting of immunoassays used to support PK, immunogenicity, and biomarker studies, ensuring delivery to the highest scientific and regulatory standards.

The ideal candidate will have:

• A relevant degree (BSc/ MSc in Biology or related)
• Specialist knowledge & experience in immunoassay
• Excellent method development, validation & troubleshooting skills
• Expert understanding of Pharmacokinetic (PK), Pharmacodynamic (PD), Anti-drug Antibody (ADA) & Biomarker studies
• Proven experience working to GMP/GLP/GCP regulations
• Expertise in the development and validation of immunogenicity assays on a variety of platforms, principally MSD but also Gyrolab.
• Excellent written and verbal communication skills
• Strong work ethic and drive to learn

This is an excellent opportunity to join a respected organisation, where scientific quality, collaboration, and professional development are genuinely valued.

Please apply now to VRS recruitment to find out more!

Keywords: biology, Biopharmaceuticals, biotherapeutics, immunoassay, ELISA, bioanalysis, analysis, analytical, anti-drug, immunoaffinity, GLP, GCP, protein, peptide, antibodies, enzyme immunoassay, ELISA, Gyrolab, MSD, Mesoscale Discovery, Singulex Erenna, radioimmunoassay, AlphaLISA, DELFIA, pharmacokinetic analysis, flow cytometry, mass spectrometry, immunogenicity testing, cytokines, biomarker quantification, assay automation, cell-based assays, molecular biology, qPCR, western blotting, electrophoresis, DNA sequencing, GLP, Good Laboratory Practice, GCP, Good Clinical Practice, LIMS, industrial lab, graduate, clinical studies, therapeutics, biomarkers, Cambridgeshire, Cambridge, Suffolk, East Anglia, Cambridge, Cambridgeshire, VRS9332PC

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Location: Cambridge (UK) Job Type: Full time

Revvity is a developer and provider of end-to-end solutions designed to help scientists, researchers, and clinicians solve the world’s greatest health challenges. We pair the enthusiasm of an industry disruptor with the experience of a longtime leader. Our team of 11,000+ colleagues from around the globe are vital to our success and the reason we’re able to push boundaries in pursuit of better human health.

Revvity's Bioprocessing group pioneer advanced expression platforms that power the manufacturing of next generation biotherapeutics. Our portfolio includes specialized mammalian host cell lines and expression systems, designed to produce viral vector therapeutics of choice. Through our gene editing expertise, we deliver custom cell line engineering services that precisely tailor bioproduction cell lines to meet our clients' specific manufacturing requirements for viral vector therapeutics.

As a Senior Scientist in our R&D team, you will serve as our lentiviral vectors subject matter expert, spearheading the development of Revvity's lentiviral vector offering including supporting further development of our transduction enhancer LentiBOOST. You will develop cutting-edge vector systems specifically engineered to improve lentiviral vector tropism and transduction efficiency. This role requires close collaboration with the Revvity Gene Delivery group to ensure seamless integration of vector technologies and optimize delivery strategies across therapeutic applications. This lab-based role requires hands-on expertise and deep knowledge of lentiviral vector biology, production and purification, with previous experience in engineering lentiviral vectors for delivery of large and complex cargo, as well as transduction assays and potency assay development and validation.

• Lead independent research projects from design through execution, analysis, and troubleshooting with meticulous attention to detail
• Drive innovation to enhance Revvity's lentiviral vector offering
• Support further development of the LentiBOOST portfolio
• Foster collaborative relationships across Revvity departments (Vectorology and Process Development teams amongst others)
• Maintain comprehensive laboratory documentation and develop standard operating procedures
• Present clear, concise data at both internal and external meetings

• Ph.D. plus minimum 5 years of demonstrated experience in a relevant scientific discipline (virology, molecular biology, biochemistry, or genetics)
• Proven track record designing and optimizing lentiviral vectors and purification processes, with direct experience in transduction workflows, including assay development and optimization
• Advanced technical skills in molecular biology, cell biology, cell culture, and flow cytometry
• Strong leadership capabilities with ability to drive innovation and scientific excellence
• Exceptional team collaboration skills with strong communication abilities and meticulous attention to detail
• Previous experience in envelope protein engineering and pseudo-typing strategies would be a plus.
• Previous experience working in Global and commercial environments would be preferred
• Demonstrated scientific curiosity with a proactive approach to knowledge development

Package: Competitive Salary + Benefits

Role ID: SF19360

Are you ready to be part of the future? At QinetiQ, we’re not just imagining tomorrow we are creating it. From cutting‑edge defence technology to ground‑breaking innovations our mission is to empower and protect lives. Join us as a Senior Scientist at our Portsmouth Technology Park (PTP) site, where you will have the opportunity to work with cutting‑edge technology in partnership with some of the most brilliant minds.

As a Senior Scientist, you will lead and deliver advanced radar and signal processing activities, providing technical authority and direction across complex projects that directly support our customers and operational capability.

Day‑to‑day, you’ll be shaping technical solutions, leading modelling and simulation work, developing and validating algorithms, and working closely with multidisciplinary teams to deliver high‑impact outcomes. You’ll also act as a subject matter expert, supporting bids, guiding technical strategy and mentoring junior scientists and engineers.

• Leading the development and optimisation of models, simulations and analytical tools
• Providing technical leadership across radar and signal processing projects
• Designing and assessing advanced signal processing chains and algorithms
• Interpreting complex datasets and presenting clear recommendations to customers
• Supporting bid activities and technical governance
• Mentoring and developing junior scientists and engineers

• Significant experience in radar, signal processing, algorithm development or modelling and simulation
• Proven ability to lead complex technical work packages or projects
• Strong background in applied mathematics and physics
• Coding experience in MATLAB or other languages such as Python or C++
• Experience working with customers and stakeholders, influencing technical decisions
• Demonstrable mentoring or technical leadership experience

• Degree in Science or Engineering (Physics, Mathematics or similar)
• Substantial relevant industry or research experience

We value difference and we don’t have a fixed idea when it comes to background or education, provided you can show the required level of experience and willingness to learn then we would like to hear from you.

This role is 37 hours per week based at Portsmouth Technology Park (PTP). Hybrid working patterns are available. Travel to other QinetiQ and customer sites will be expected.

Portsmouth Technology Park (PTP) is one of QinetiQ’s key facilities, focusing on advanced technology development and engineering services. It is dedicated to research and development, ensuring that complex systems are designed, integrated, and tested effectively to meet operational requirements. The facility utilises sophisticated modelling and simulation techniques to analyse and predict performance.

• Matched contribution pension scheme, with life assurance
• Generous holiday allowance, with the option to purchase additional days
• Options to join Health Cash Plan, Private Medical Insurance and Dental Insurance
• Employee discount portal: Personal Accident Insurance, Travel Insurance, Restaurants, Cinema Tickets and much more
• We are proud to support the Armed Forces community by honouring the Armed Forces Covenant and maintaining our Gold Award standard in the Defence Employer Recognition Scheme
• Volunteering Opportunities – helping charities and local community

Please note that all applicants for this role must be eligible for SC clearance, as a minimum.

We are seeking a Senior Scientist to join our Oncology R&D team, supporting our ex vivo platform through hands‑on laboratory work and advanced data analysis, with a particular focus on transcriptomics.

The successful candidate will be fully competent in their research area within the Bioscience discipline , capable of initiating, directing, and performing research experiments while implementing strategic approaches. This role requires the ability to work independently with minimal supervision and provide guidance and training to less experienced scientists.

• Ex vivo tissue processing and sample preparation
• Single‑cell analysis techniques (flow cytometry, RNA sequencing)
• Strong aseptic technique and cell culture proficiency
• Cell‑based assay development and execution

• Proficiency in coding and IDE usage for bioinformatics analysis
• Transcriptomics data analysis and interpretation

• Strong laboratory skills with excellent aseptic technique
• Background in cell culture and cell‑based assays
• Collaborative team player with a growth‑oriented learning mindset
• Hands‑on laboratory experience through full‑time internships, co‑op programs, or significant research work (beyond undergraduate coursework)
• Experience with in vitro immune assays (ELISAs, flow cytometry, transcriptomics, imaging)

• Immunology background with practical experience in immunology research
• PhD desirable; or MSc with industry experience
• Experience with tissue and cell processing for flow cytometry and single‑cell RNA sequencing

Gain exposure to patient‑centric human model systems that directly inform drug development decisions and accelerate therapeutic innovation.

Collaborate across functions on high‑impact projects that drive meaningful change in Early Oncology research and development.

Senior Scientist – Microbial Upstream Process Development About the Role

We are seeking a Senior Scientist with experience within Microbial Upstream process development to join a growing bioprocessing team, providing technical leadership across customer‑facing biologics development projects.

This is a senior scientific role focused on technical project leadership rather than line management. You'll lead and coordinate microbial upstream process development activities, working closely with customers, project managers, commercial teams, and scientific colleagues to deliver innovative biologics programmes.

The ideal candidate will bring strong expertise in microbial fermentation, process development, and scale‑up, alongside the ability to work across functions and confidently engage with external stakeholders.

• Lead the design, development, optimisation, and scale‑up of microbial upstream processes for biologics production
• Support the development of processes for products such as:
• Antibodies and biologic products
• Other microbial‑expressed therapeutic molecules
• Apply expertise across microbial fermentation, strain development, and bioreactor operations

• Act as the technical lead for small to medium‑size development projects
• Coordinate activities across scientific, project management, and commercial functions
• Ensure technical work packages are delivered to scope, quality, and timeline requirements
• Provide scientific guidance and support to project teams and junior colleagues
• Develop and scale bioprocesses from high‑throughput systems through laboratory and pilot‑scale bioreactors
• Support technology evaluation, optimisation, and implementation activities
• Apply experimental design and statistical approaches to process development and optimisation
• Evaluate data and translate findings into practical development solutions
• Act as a primary technical contact for customers and collaborators
• Present scientific data and recommendations to internal and external stakeholders
• Build strong relationships with customers, partners, and multidisciplinary teams
• Support successful delivery of customer‑funded and collaborative development programmes

• Contribute technical expertise to proposal development and work‑winning activities
• Support customer discussions and identification of new opportunities
• Help shape future technical capabilities and scientific strategy within the team
• Maintain awareness of emerging technologies and industry developments

You are an experienced bioprocess scientist with strong technical expertise and the ability to lead projects through influence rather than direct line management.

You’ll bring:

• A PhD, postdoctoral experience, or equivalent industrial experience in biotechnology, microbiology, bioprocessing, or a related discipline
• Strong expertise in microbial fermentation for biologics production
• Experience working with microbial expression systems, ideally E. coli and/or Pichia pastoris
• Proven experience developing and scaling bioprocesses from high‑throughput systems through laboratory and pilot‑scale bioreactors
• Strong experimental design, data analysis, and process optimisation skills
• Experience leading technical projects and delivering complex scientific programmesli>
• Ability to work across scientific, project management, and commercial teams
• Strong communication and stakeholder management skills
• Commercial awareness and an interest in supporting customer engagement and proposal development
• Industrial R&D or technology development experience
• Experience within a CRO, CDMO, biotech, or innovation‑led environment
• Knowledge of technology transfer and commercialisation activities
• Experience in collaborative R&D or grant‑funded programmes
• Experience working with recombinant proteins, antibodies, or other biologics
• Familiarity with GMP environments and biopharmaceutical development

• Lead innovative microbial bioprocess development projects
• Work directly with customers developing next‑generation biologics
• Gain exposure to a broad range of technologies, partners, and development programmes
• Be part of a highly collaborative team of upstream specialists

• Based in Darlington
• Permanent position, based onsite
• Collaborative, customer‑facing environment

This is an excellent opportunity for an experienced upstream scientist looking to step into a role with greater technical leadership, customer interaction, and project responsibility. You’ll play a key role in developing innovative biologics manufacturing processes while helping shape the future capabilities of a growing scientific team.