38 Astrazeneca jobs in Cambridgeshire
Principal Scientist - Drug Discovery
CB2 0AA Cambridge, Eastern
£80000 Annually
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Posted 1 day ago
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Job Description
Our client, a world-renowned biotechnology company at the forefront of pharmaceutical innovation, is seeking a highly experienced Principal Scientist to lead critical drug discovery initiatives. This is a fully remote role, allowing top-tier scientific talent to contribute to life-changing research from anywhere in the UK. While conceptually based in Cambridge, Cambridgeshire, UK , this position offers the flexibility and autonomy of a remote-first work environment, demanding exceptional self-discipline and communication skills. You will be instrumental in driving the early-stage discovery of novel therapeutics, working within a collaborative and intellectually stimulating virtual team.
As a Principal Scientist, you will be responsible for designing and executing complex research projects aimed at identifying and validating new drug targets and developing small molecule or biologic drug candidates. This involves leading a team of scientists, overseeing experimental design, data analysis, and interpretation. You will be expected to contribute to strategic planning, identify innovative research approaches, and stay abreast of the latest scientific advancements in your field. Close collaboration with cross-functional teams, including medicinal chemistry, pharmacology, and translational science, is essential. The role requires strong leadership capabilities, the ability to mentor junior researchers, and a proven track record of delivering high-impact research outcomes. Significant experience in contributing to IND-enabling studies is highly desirable.
We are seeking candidates with a PhD in a relevant life science discipline (e.g., Molecular Biology, Biochemistry, Pharmacology) and a minimum of 10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry. A deep understanding of disease biology, target validation, and drug development processes is essential. Demonstrated success in leading research projects and managing scientific teams, preferably in a remote or hybrid setting, is crucial. Exceptional analytical, problem-solving, and critical thinking skills are required. Excellent written and verbal communication skills, with a proven ability to present complex scientific data clearly and concisely, are a must. Experience with various assay technologies and biophysical techniques is also expected. This is an outstanding opportunity for a seasoned scientist to shape the future of medicine.
As a Principal Scientist, you will be responsible for designing and executing complex research projects aimed at identifying and validating new drug targets and developing small molecule or biologic drug candidates. This involves leading a team of scientists, overseeing experimental design, data analysis, and interpretation. You will be expected to contribute to strategic planning, identify innovative research approaches, and stay abreast of the latest scientific advancements in your field. Close collaboration with cross-functional teams, including medicinal chemistry, pharmacology, and translational science, is essential. The role requires strong leadership capabilities, the ability to mentor junior researchers, and a proven track record of delivering high-impact research outcomes. Significant experience in contributing to IND-enabling studies is highly desirable.
We are seeking candidates with a PhD in a relevant life science discipline (e.g., Molecular Biology, Biochemistry, Pharmacology) and a minimum of 10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry. A deep understanding of disease biology, target validation, and drug development processes is essential. Demonstrated success in leading research projects and managing scientific teams, preferably in a remote or hybrid setting, is crucial. Exceptional analytical, problem-solving, and critical thinking skills are required. Excellent written and verbal communication skills, with a proven ability to present complex scientific data clearly and concisely, are a must. Experience with various assay technologies and biophysical techniques is also expected. This is an outstanding opportunity for a seasoned scientist to shape the future of medicine.
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0
Principal Scientist - Drug Discovery
CB2 1AA Cambridge, Eastern
£75000 Annually
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Posted 21 days ago
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Job Description
Our client, a leading biopharmaceutical company at the forefront of scientific innovation, is seeking a highly accomplished Principal Scientist to join their fully remote drug discovery team. This senior role is critical for spearheading novel research initiatives, designing and executing complex experiments, and driving the development of groundbreaking therapeutics. You will leverage your extensive expertise in pharmacology, medicinal chemistry, or a related discipline to identify and validate new drug targets, optimise lead compounds, and contribute significantly to our pre-clinical pipeline. As a remote scientist, you will collaborate closely with a world-class team, utilising cutting-edge technologies and maintaining rigorous scientific standards.
Responsibilities:
Responsibilities:
- Lead the design, execution, and interpretation of complex in vitro and/or in vivo studies to identify and validate new therapeutic targets and drug candidates.
- Develop and implement innovative experimental strategies and methodologies to advance drug discovery programs.
- Critically evaluate scientific data, propose hypotheses, and guide research directions.
- Optimise lead compounds for potency, selectivity, pharmacokinetics, and safety.
- Collaborate effectively with cross-functional teams, including medicinal chemists, biologists, toxicologists, and clinical development experts.
- Stay abreast of the latest scientific advancements, literature, and technologies in relevant therapeutic areas and drug discovery.
- Author high-quality scientific reports, publications, and regulatory submissions.
- Present research findings at internal meetings and external scientific conferences.
- Contribute to the strategic planning and pipeline development of the drug discovery portfolio.
- Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
- Ensure all research activities comply with relevant ethical guidelines, regulatory requirements, and company policies.
- Manage external collaborations with academic institutions and CROs.
- Contribute to intellectual property generation and patent filings.
- PhD in Pharmacology, Biochemistry, Molecular Biology, Medicinal Chemistry, or a closely related life science discipline.
- Minimum of 7-10 years of progressive drug discovery experience in the pharmaceutical or biotechnology industry.
- Demonstrated track record of success in identifying and advancing novel drug candidates through the pre-clinical stages.
- Deep expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience) is highly desirable.
- Proven ability to design and interpret complex biological assays and PK/PD studies.
- Strong understanding of drug development processes and regulatory requirements.
- Excellent analytical, problem-solving, and critical thinking skills.
- Outstanding written and verbal communication skills, with a proven ability to publish and present scientific work.
- Experience with remote collaboration tools and working effectively in a distributed research setting.
- A proactive, self-motivated individual with a strong commitment to scientific excellence and teamwork.
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1
Principal Formulation Scientist - Drug Discovery
CB2 0AA Cambridge, Eastern
£85000 Annually
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Posted 1 day ago
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Job Description
Our client, a pioneering pharmaceutical research company, is seeking a highly accomplished Principal Formulation Scientist to join their world-class, fully remote R&D division. This senior role is critical to the advancement of innovative drug delivery systems and the successful transition of novel therapeutics from discovery to clinical trials. You will lead research initiatives focused on developing robust and effective drug formulations, employing cutting-edge technologies and methodologies. Working remotely, you will collaborate closely with interdisciplinary teams, including medicinal chemists, biologists, and analytical scientists, to overcome complex formulation challenges. Your responsibilities will encompass designing experimental strategies, executing formulation development studies, characterizing drug product performance, and providing expert scientific guidance. The ideal candidate will possess extensive experience in pharmaceutical formulation development, with a deep understanding of various dosage forms (e.g., oral, parenteral, topical) and associated manufacturing processes. A strong background in physicochemical characterization, stability testing, and drug delivery technologies is essential. You will be expected to publish research findings, present at scientific conferences, and contribute to intellectual property generation. This role demands exceptional scientific leadership, strategic thinking, and the ability to mentor junior scientists. Excellent communication and collaboration skills are vital for success in this remote setting. If you are driven by scientific excellence and passionate about developing life-changing medicines, we encourage you to apply.
Responsibilities:
Qualifications:
This is a fully remote position, with the successful candidate ideally situated within reach of our research facilities near Cambridge, Cambridgeshire, UK for occasional key meetings.
Responsibilities:
- Lead the design, development, and optimization of pharmaceutical formulations for various therapeutic modalities.
- Conduct comprehensive physicochemical characterization of drug substances and drug products.
- Develop and execute experimental plans for formulation and drug delivery studies.
- Evaluate drug product stability under various conditions according to ICH guidelines.
- Investigate and resolve complex formulation-related challenges.
- Collaborate with analytical development teams to establish appropriate testing methods.
- Provide scientific leadership and mentorship to formulation scientists and technicians.
- Prepare and review scientific reports, protocols, and regulatory documents.
- Present research findings and strategic recommendations to senior management and cross-functional teams.
- Stay abreast of emerging trends and technologies in pharmaceutical formulation and drug delivery.
- Contribute to the intellectual property portfolio through invention disclosures and patent applications.
- Ensure compliance with all relevant GxP regulations and company policies.
Qualifications:
- Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemistry, Chemical Engineering, or a related field.
- 10+ years of progressive experience in pharmaceutical formulation development.
- Proven track record in developing diverse dosage forms (e.g., tablets, capsules, injectables, extended-release formulations).
- In-depth knowledge of drug delivery technologies, excipients, and manufacturing processes.
- Expertise in physicochemical characterization techniques (e.g., DSC, TGA, XRD, particle size analysis).
- Strong understanding of GMP, ICH guidelines, and regulatory requirements.
- Demonstrated scientific leadership, project management, and problem-solving skills.
- Excellent written and verbal communication skills, with experience presenting scientific data.
- Ability to work independently and effectively in a remote, collaborative research environment.
- Experience with biologics formulation is a significant asset.
This is a fully remote position, with the successful candidate ideally situated within reach of our research facilities near Cambridge, Cambridgeshire, UK for occasional key meetings.
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2
Senior Research Scientist - Drug Discovery
CB2 0AA Cambridge, Eastern
£70000 Annually
WhatJobs
Posted 1 day ago
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Job Description
Our client, a leading biopharmaceutical innovator, is seeking a talented and experienced Senior Research Scientist to join their cutting-edge drug discovery team. This is a fully remote position, allowing you to contribute to groundbreaking research from the comfort of your home office. The ideal candidate will possess a deep understanding of molecular biology, assay development, and preclinical research within a pharmaceutical or biotechnology setting.
You will play a pivotal role in the early stages of drug discovery, identifying and validating novel therapeutic targets, designing and implementing complex biological assays, and analyzing experimental data to drive project progression. This role requires a highly analytical and scientifically rigorous individual who can work independently and collaboratively within a virtual team environment. Experience in specific therapeutic areas such as oncology, immunology, or neuroscience is a significant advantage.
Key Responsibilities:
You will play a pivotal role in the early stages of drug discovery, identifying and validating novel therapeutic targets, designing and implementing complex biological assays, and analyzing experimental data to drive project progression. This role requires a highly analytical and scientifically rigorous individual who can work independently and collaboratively within a virtual team environment. Experience in specific therapeutic areas such as oncology, immunology, or neuroscience is a significant advantage.
Key Responsibilities:
- Design, develop, and optimize robust biological assays to support target validation and compound screening.
- Conduct in vitro and ex vivo experiments to assess drug efficacy and mechanism of action.
- Analyze and interpret complex experimental data, generating clear and concise reports for project teams.
- Collaborate with medicinal chemists, pharmacologists, and other scientists to advance drug candidates through the discovery pipeline.
- Stay current with the latest scientific literature and technological advancements in drug discovery.
- Contribute to the strategic planning and execution of research projects.
- Present findings at internal team meetings and potentially at scientific conferences.
- Mentor and guide junior research associates.
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
- Minimum of 5 years of post-doctoral or industry experience in drug discovery.
- Proven expertise in assay development (e.g., HTS, ELISA, Western Blot, flow cytometry).
- Hands-on experience with relevant biological models and techniques.
- Strong analytical and problem-solving skills with meticulous attention to detail.
- Excellent written and verbal communication skills, with the ability to effectively communicate complex scientific information.
- Demonstrated ability to work independently and manage multiple projects in a remote setting.
- Experience with data analysis software (e.g., GraphPad Prism, R) is preferred.
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3
Principal Research Scientist - Drug Discovery
CB2 0SW Cambridge, Eastern
£75000 Annually
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Posted 1 day ago
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Job Description
Our client, a pioneering pharmaceutical company at the forefront of medical innovation, is seeking a highly accomplished Principal Research Scientist to join their esteemed, fully remote research and development team. This pivotal role will focus on spearheading cutting-edge drug discovery initiatives, from target identification and validation through to lead optimisation. You will be instrumental in designing and executing complex research projects, analysing experimental data, and contributing to the strategic direction of the company's drug pipeline. The ideal candidate will possess a PhD in a relevant scientific discipline, a strong publication record, and extensive experience in preclinical drug discovery, all within a remote-first research environment.
Key Responsibilities:
Qualifications and Experience:
This is a unique opportunity to lead groundbreaking research and shape the future of medicine within a globally recognised organisation that embraces cutting-edge remote work practices. Join a team of world-class scientists and contribute to developing life-changing therapies from your home.
Key Responsibilities:
- Lead and manage innovative drug discovery projects from conception to preclinical development.
- Design, optimise, and execute complex experimental protocols in areas such as molecular biology, biochemistry, and cell biology.
- Analyse and interpret large datasets, drawing robust conclusions and making data-driven recommendations.
- Identify and validate novel drug targets and therapeutic strategies.
- Oversee the development of assays for screening and evaluating potential drug candidates.
- Collaborate with cross-functional teams, including medicinal chemists, pharmacologists, and toxicologists.
- Stay abreast of the latest scientific literature, technological advancements, and industry trends in drug discovery.
- Mentor and guide junior scientists, fostering a collaborative and high-performance research environment.
- Prepare scientific manuscripts for publication in peer-reviewed journals and present findings at international conferences.
- Contribute to the strategic planning and direction of the company's R&D pipeline.
- Ensure all research activities are conducted in compliance with ethical standards and regulatory requirements.
Qualifications and Experience:
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a closely related field.
- Minimum of 10 years of post-doctoral research experience in drug discovery within the pharmaceutical or biotechnology industry.
- Proven track record of success in leading R&D projects and delivering preclinical candidates.
- Extensive experience in target validation, assay development, and high-throughput screening.
- Deep understanding of disease mechanisms and therapeutic intervention strategies.
- Proficiency in relevant scientific techniques and instrumentation.
- Excellent analytical, problem-solving, and critical thinking skills.
- Exceptional written and verbal communication skills, with the ability to present complex scientific information clearly.
- Demonstrated ability to work independently and collaboratively in a virtual team setting.
- Strong publication record in reputable scientific journals.
- Experience with data analysis software and bioinformatics tools is advantageous.
This is a unique opportunity to lead groundbreaking research and shape the future of medicine within a globally recognised organisation that embraces cutting-edge remote work practices. Join a team of world-class scientists and contribute to developing life-changing therapies from your home.
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4
Principal Research Scientist - Drug Discovery
CB2 0AA Cambridge, Eastern
£80000 Annually
WhatJobs
Posted 3 days ago
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Job Description
Our client, a leading pharmaceutical innovator, is seeking an exceptional Principal Research Scientist to lead cutting-edge drug discovery initiatives. This key role, based in our Cambridge facility, is crucial for identifying and advancing novel therapeutic candidates. You will be responsible for designing and executing complex research projects, employing state-of-the-art methodologies to discover and characterise potential new medicines. This position requires a highly skilled scientist with a deep understanding of drug discovery principles, a strong publication record, and a proven ability to lead research teams and drive projects from early concept through to preclinical development.
Key responsibilities include:
The ideal candidate will hold a PhD in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline, with a minimum of 8-10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry. A strong track record of success in drug discovery, demonstrated by key contributions to preclinical candidates, is essential. Expertise in (mention specific therapeutic area, e.g., oncology, immunology, neuroscience) is highly desirable. Exceptional analytical, problem-solving, and leadership skills are required. Excellent written and verbal communication skills, along with the ability to foster collaboration and drive innovation, are paramount. This is a career-defining opportunity to make a significant impact on patient health through pioneering pharmaceutical research.
Key responsibilities include:
- Leading the design and implementation of innovative drug discovery research programs.
- Developing and optimising assays and experimental protocols for target validation and compound screening.
- Identifying and evaluating novel drug targets and therapeutic modalities.
- Supervising and mentoring a team of research scientists and technicians.
- Collaborating closely with chemists, biologists, pharmacologists, and toxicologists.
- Analysing complex biological and chemical data, and interpreting results to guide research direction.
- Authoring scientific publications, patents, and regulatory submissions.
- Presenting research findings at internal meetings and external scientific conferences.
- Staying abreast of the latest scientific advancements and emerging technologies in the field.
- Managing research budgets and ensuring efficient resource allocation.
The ideal candidate will hold a PhD in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline, with a minimum of 8-10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry. A strong track record of success in drug discovery, demonstrated by key contributions to preclinical candidates, is essential. Expertise in (mention specific therapeutic area, e.g., oncology, immunology, neuroscience) is highly desirable. Exceptional analytical, problem-solving, and leadership skills are required. Excellent written and verbal communication skills, along with the ability to foster collaboration and drive innovation, are paramount. This is a career-defining opportunity to make a significant impact on patient health through pioneering pharmaceutical research.
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5
Senior Research Scientist - Drug Discovery
CB2 0QA Cambridge, Eastern
£75000 Annually
WhatJobs
Posted 4 days ago
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Job Description
Our client, a prominent pharmaceutical company at the forefront of medical innovation, is seeking a highly skilled Senior Research Scientist to join their dynamic Drug Discovery team in **Cambridge, Cambridgeshire, UK**. This is a laboratory-based role critical to advancing novel therapeutic agents.
As a Senior Research Scientist, you will spearhead cutting-edge research projects focused on identifying and validating new drug targets, developing and optimizing lead compounds, and contributing to the preclinical development of innovative medicines. You will apply your extensive expertise in molecular biology, pharmacology, medicinal chemistry, or a related field to design and execute experiments, interpret complex data, and contribute to scientific publications and patent filings. This role demands a rigorous scientific approach, strong problem-solving abilities, and a collaborative spirit.
Key Responsibilities:
As a Senior Research Scientist, you will spearhead cutting-edge research projects focused on identifying and validating new drug targets, developing and optimizing lead compounds, and contributing to the preclinical development of innovative medicines. You will apply your extensive expertise in molecular biology, pharmacology, medicinal chemistry, or a related field to design and execute experiments, interpret complex data, and contribute to scientific publications and patent filings. This role demands a rigorous scientific approach, strong problem-solving abilities, and a collaborative spirit.
Key Responsibilities:
- Design, execute, and critically analyze complex experiments to identify and validate novel drug targets and therapeutic modalities.
- Develop and optimize assays for target engagement, mechanism of action, and compound efficacy screening.
- Synthesize, characterize, and evaluate small molecules or biologics for potential therapeutic use.
- Contribute to lead optimization efforts by designing and synthesizing new analogues and assessing their pharmacological properties.
- Conduct preclinical studies to assess the safety and efficacy of drug candidates.
- Analyze and interpret large datasets, employing statistical methods and bioinformatics tools where appropriate.
- Prepare high-quality scientific reports, presentations, and manuscripts for internal review and external publication.
- Contribute to the filing of intellectual property (e.g., patents) based on research findings.
- Collaborate effectively with multidisciplinary teams, including chemists, biologists, pharmacologists, and toxicologists.
- Mentor and guide junior scientists and research associates, fostering a culture of scientific excellence and continuous learning.
- Stay abreast of the latest scientific advancements, methodologies, and technologies in drug discovery and relevant therapeutic areas.
- Ensure all research activities are conducted in compliance with regulatory guidelines and safety protocols.
- PhD in Molecular Biology, Pharmacology, Medicinal Chemistry, Biochemistry, or a closely related field.
- Minimum of 5-7 years of post-doctoral or industry research experience in drug discovery.
- Demonstrated expertise in at least one key area of drug discovery, such as target validation, hit-to-lead optimization, or preclinical development.
- Proven experience in designing and executing complex biological assays and/or synthesis of small molecules.
- Strong understanding of disease biology and therapeutic intervention strategies.
- Proficiency in relevant analytical techniques (e.g., HPLC, Mass Spectrometry, ELISA, Western Blotting, Flow Cytometry).
- Experience with computational tools for data analysis and molecular modelling is a plus.
- Excellent track record of scientific achievement, evidenced by publications in peer-reviewed journals and/or patent filings.
- Strong problem-solving, critical thinking, and data interpretation skills.
- Excellent written and verbal communication skills, with the ability to present complex scientific information clearly.
- Proven ability to work effectively in a collaborative, fast-paced research environment.
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6
Lead Medicinal Chemist - Drug Discovery
CB2 0AW Cambridge, Eastern
£65000 Annually
WhatJobs
Posted 4 days ago
Job Viewed
Job Description
Our client is a pioneering pharmaceutical company at the forefront of developing novel therapeutics to address unmet medical needs. We are seeking an exceptional Lead Medicinal Chemist to join our dynamic drug discovery team. This is a critical, fully remote role where you will spearhead innovative chemistry initiatives from conception through to preclinical development. You will be instrumental in designing and synthesizing novel chemical entities with the potential to become life-changing medicines.
Responsibilities:
Responsibilities:
- Lead the design and synthesis of small molecule drug candidates, applying expertise in medicinal chemistry principles and modern synthetic methodologies.
- Oversee multiple drug discovery projects, guiding synthetic strategies and troubleshooting synthetic challenges.
- Collaborate closely with biologists, pharmacologists, and DMPK scientists to integrate biological and ADME data into the design cycle.
- Manage external collaborations with Contract Research Organizations (CROs) for synthesis and process development.
- Maintain a deep understanding of therapeutic areas and competitive landscapes to inform project strategy.
- Develop and optimize synthetic routes for key intermediates and final compounds, considering scalability and cost-effectiveness.
- Analyze and interpret complex experimental data, including spectroscopic and chromatographic analyses.
- Prepare technical reports, patent applications, and presentations for internal and external audiences.
- Mentor and guide junior chemists, fostering a collaborative and scientifically rigorous environment.
- Stay abreast of the latest advancements in medicinal chemistry, synthetic organic chemistry, and drug discovery technologies.
- Contribute to the strategic direction of the medicinal chemistry department and the company's pipeline.
- Ensure safe laboratory practices and compliance with all relevant regulations.
- Evaluate new chemical technologies and methodologies for potential adoption.
- Ph.D. in Organic or Medicinal Chemistry with a minimum of 5-7 years of relevant industry experience in drug discovery.
- Demonstrated success in designing and synthesizing novel bioactive molecules, leading to preclinical candidates.
- Expertise in modern synthetic organic chemistry, including asymmetric synthesis, catalysis, and heterocyclic chemistry.
- Strong understanding of structure-activity relationships (SAR), structure-property relationships (SPR), and drug metabolism and pharmacokinetics (DMPK).
- Proficiency in literature searching, reaction planning, and data analysis tools.
- Experience managing projects and external CROs is highly desirable.
- Excellent problem-solving, analytical, and critical thinking skills.
- Exceptional communication and presentation skills, with the ability to effectively convey complex scientific information.
- Proven ability to work independently, manage multiple priorities, and deliver results in a fast-paced, remote environment.
- A passion for drug discovery and a commitment to scientific excellence.
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7
Senior Research Scientist - Drug Discovery
CB2 0AH Cambridge, Eastern
£65000 Annually
WhatJobs
Posted 5 days ago
Job Viewed
Job Description
Our client, a world-leading biopharmaceutical company dedicated to pioneering new therapies, is seeking an exceptional Senior Research Scientist to join their fully remote drug discovery team. This role is pivotal in advancing our client's pipeline, focusing on the design and execution of innovative research programs to identify novel therapeutic targets and lead compounds. You will leverage your deep expertise in molecular biology, biochemistry, or pharmacology to drive early-stage drug discovery projects forward. As a remote-first scientist, you will collaborate closely with cross-functional teams, including medicinal chemists, biologists, and computational scientists, utilizing state-of-the-art technologies and methodologies.
Key Responsibilities:
Key Responsibilities:
- Design and lead experimental strategies for target identification and validation in specific therapeutic areas.
- Develop and optimize assays (e.g., biochemical, cellular, phenotypic) to assess compound efficacy and mechanism of action.
- Interpret complex experimental data, draw insightful conclusions, and present findings to project teams and senior management.
- Collaborate effectively with medicinal chemists to guide lead optimization efforts.
- Stay abreast of the latest scientific literature, technologies, and trends in drug discovery and relevant therapeutic fields.
- Contribute to the intellectual property portfolio through patent filings and publications.
- Mentor and guide junior scientists and research associates.
- Manage external collaborations with academic institutions and contract research organizations.
- Contribute to the strategic planning and direction of drug discovery programs.
- Ensure adherence to laboratory safety standards and good research practices.
- Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a closely related life science discipline.
- Minimum of 5 years of post-doctoral and/or industry experience in drug discovery research.
- Demonstrated expertise in one or more therapeutic areas (e.g., oncology, immunology, neuroscience).
- Proven track record of designing and executing complex biological assays and experiments.
- Hands-on experience with various molecular and cellular biology techniques.
- Strong analytical and problem-solving skills with the ability to interpret complex datasets.
- Excellent written and verbal communication skills, with a track record of scientific publications or presentations.
- Ability to work independently and collaboratively in a remote, fast-paced research environment.
- Experience with data analysis software and a passion for scientific innovation.
- Ability to manage multiple projects and priorities effectively.
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8
Principal Research Scientist - Drug Discovery
CB2 0AX Cambridge, Eastern
£70000 Annually
WhatJobs
Posted 6 days ago
Job Viewed
Job Description
Our client, a cutting-edge biotechnology firm at the forefront of innovative pharmaceutical research, is seeking an exceptional Principal Research Scientist specializing in Drug Discovery to join their distinguished, fully remote scientific team. This pivotal role offers the unique chance to lead groundbreaking research initiatives aimed at identifying and developing novel therapeutic agents. You will be instrumental in driving the early-stage drug discovery pipeline, from target validation and hit identification through to lead optimization. This position requires a deep scientific understanding, a passion for innovation, and the ability to excel in a collaborative, geographically dispersed research environment. The role is entirely remote, offering unparalleled flexibility and the opportunity to contribute to life-changing discoveries from anywhere. Key Responsibilities:
- Lead and manage drug discovery projects, defining project goals, timelines, and strategic direction.
- Design and execute complex experiments in medicinal chemistry, biology, or pharmacology to identify and validate novel drug targets and hit compounds.
- Develop and optimize assays for high-throughput screening (HTS) and lead compound profiling.
- Utilize cutting-edge technologies and methodologies in drug discovery, such as fragment-based drug design, structure-based drug design, and AI/ML in drug discovery.
- Analyze and interpret experimental data, drawing robust conclusions and making data-driven decisions.
- Supervise and mentor junior scientists and research associates, fostering a culture of scientific rigor and innovation.
- Collaborate extensively with internal teams (e.g., chemistry, biology, DMPK, toxicology) and external partners in a fully remote setting, ensuring seamless project progression.
- Prepare and present research findings at scientific conferences and in peer-reviewed publications.
- Contribute to the writing of grant proposals and intellectual property filings.
- Maintain comprehensive and accurate laboratory notebooks and research records.
- Stay abreast of the latest scientific literature and advancements in relevant therapeutic areas and drug discovery technologies.
- Ph.D. in Medicinal Chemistry, Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
- A minimum of 8-10 years of progressive experience in the pharmaceutical or biotechnology industry, with a strong focus on small molecule drug discovery.
- Demonstrated success in leading drug discovery projects from conception to early development candidates.
- Extensive experience with a variety of drug discovery techniques and platforms.
- Strong understanding of disease biology, target validation, and mechanism of action.
- Proven ability to design and interpret complex biological or chemical assays.
- Excellent analytical, problem-solving, and critical thinking skills.
- Exceptional leadership, communication, and interpersonal skills, with the ability to inspire and guide research teams remotely.
- Proficiency in scientific literature databases and data analysis software.
- A track record of high-impact scientific contributions (publications, patents).
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