Principal Scientist - Drug Discovery

CB2 0AH Cambridge, Eastern £75000 Annually WhatJobs

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full-time
Our client is seeking a highly experienced Principal Scientist to join their prestigious pharmaceutical research team. This role is integral to driving early-stage drug discovery programs, focusing on identifying and validating novel therapeutic targets and lead compounds. You will leverage your deep scientific expertise to design and execute complex experiments, interpret critical data, and guide the direction of discovery projects. The ideal candidate will possess a strong background in medicinal chemistry, pharmacology, or a related field, with a proven ability to lead scientific initiatives and collaborate effectively within a hybrid work environment.

Key Responsibilities:
  • Lead the design and execution of innovative drug discovery projects from target identification to lead optimization.
  • Develop and implement strategies for hit identification, lead generation, and lead optimization using a variety of assay technologies.
  • Interpret complex biological and chemical data to make informed decisions regarding project direction.
  • Collaborate closely with cross-functional teams, including biologists, chemists, DMPK scientists, and toxicologists.
  • Mentor and guide junior scientists, fostering a culture of scientific excellence and innovation.
  • Prepare scientific reports, presentations, and contribute to regulatory filings.
  • Stay abreast of the latest advancements in therapeutic areas and drug discovery technologies.
  • Contribute to the development of intellectual property and patent filings.
  • Manage external collaborations with academic institutions and contract research organizations (CROs).

Qualifications:
  • PhD in Medicinal Chemistry, Pharmacology, Biochemistry, or a related life science discipline.
  • Minimum of 7 years of post-doctoral or industry experience in drug discovery.
  • Demonstrated track record of successfully contributing to drug discovery programs that have advanced into clinical development.
  • Expertise in assay development, high-throughput screening, and structure-activity relationship (SAR) analysis.
  • Strong understanding of molecular biology, cell biology, and relevant disease pathways.
  • Proficiency in data analysis and scientific documentation.
  • Excellent leadership, communication, and interpersonal skills.
  • Ability to work effectively in a collaborative, hybrid research environment.
  • Experience in project management and team leadership is highly desirable.

This hybrid role, based in the heart of the vibrant pharmaceutical hub near Cambridge, Cambridgeshire, UK , offers a challenging and rewarding opportunity for a dedicated scientist.
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Research Scientist - Drug Discovery

CB2 1GA Cambridge, Eastern £50000 Annually WhatJobs

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full-time
Our client, a leading pharmaceutical research organisation based in **Cambridge, Cambridgeshire, UK**, is seeking a dedicated and innovative Research Scientist to join their burgeoning drug discovery team. This hybrid role offers the exciting opportunity to contribute to the development of novel therapeutics that address unmet medical needs.

Key Responsibilities:
  • Design and execute in vitro and in vivo experiments to evaluate potential drug candidates.
  • Develop and optimize assays for target identification and validation.
  • Analyse experimental data, interpret results, and contribute to the scientific interpretation of findings.
  • Collaborate closely with cross-functional teams, including chemists, biologists, and pharmacologists, to advance projects from discovery to preclinical development.
  • Maintain detailed experimental records and contribute to the preparation of reports, publications, and presentations.
  • Stay current with the latest scientific literature and technological advancements in relevant therapeutic areas.
  • Contribute to the strategic direction of drug discovery programs.
  • Ensure compliance with all laboratory safety regulations and company policies.

Required Qualifications:
  • Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
  • Minimum of 2-3 years of post-doctoral or industry experience in drug discovery.
  • Proven expertise in designing and conducting biological assays (e.g., enzyme activity, cell-based assays, receptor binding).
  • Strong understanding of disease biology and relevant therapeutic areas.
  • Proficiency in data analysis software (e.g., GraphPad Prism) and statistical methods.
  • Excellent written and verbal communication skills, with the ability to present complex scientific information clearly.
  • Demonstrated ability to work effectively in a collaborative, team-oriented environment.
  • Experience with high-throughput screening (HTS) methodologies is a plus.
  • Familiarity with bioinformatics tools and techniques is desirable.

This position offers a competitive salary, comprehensive benefits package, and the chance to work at the forefront of pharmaceutical innovation. Successful candidates will be required to spend a portion of their week on-site at our state-of-the-art facilities in **Cambridge**. If you are a passionate scientist driven by the pursuit of novel medicines, we encourage you to apply.
Location: Cambridge, Cambridgeshire, UK (Hybrid)
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Principal Scientist - Drug Discovery

CB2 1TN Cambridge, Eastern £75000 Annually WhatJobs

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full-time
Our client, a pioneering biotechnology firm at the forefront of therapeutic innovation, is seeking a highly accomplished Principal Scientist to join their esteemed Scientific Research & Development department in Cambridge, Cambridgeshire, UK . This senior role is crucial for driving groundbreaking research and development initiatives, particularly in early-stage drug discovery. You will be responsible for designing and executing complex experimental strategies, interpreting data, and translating scientific findings into actionable insights for novel drug candidates. The ideal candidate will possess extensive expertise in molecular biology, pharmacology, or a closely related field, with a proven history of success in the pharmaceutical or biotech industry. You will lead research projects, mentor junior scientists, and collaborate effectively with cross-functional teams, including chemistry, DMPK, and translational science. Key responsibilities include identifying and validating new drug targets, developing and optimizing assays, managing external collaborations, and contributing to regulatory submissions. A strong publication record and experience with intellectual property management are highly valued. The successful candidate must demonstrate exceptional scientific rigor, critical thinking, and leadership qualities. A PhD in a relevant life science discipline is a mandatory requirement. This is an exceptional opportunity to work in a state-of-the-art facility, contribute to cutting-edge research that has the potential to transform patient lives, and advance your career within a supportive and intellectually stimulating environment. Become a key player in shaping the future of medicine.
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Principal Scientist - Drug Discovery

CB2 0SW Cambridge, Eastern £65000 Annually WhatJobs

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full-time
Our client, a leading pharmaceutical research organisation, is seeking a talented Principal Scientist to spearhead critical drug discovery initiatives in Cambridge, Cambridgeshire, UK . This senior role will play a pivotal part in identifying and validating novel therapeutic targets, designing innovative small molecules, and progressing drug candidates through the early stages of development. You will be instrumental in shaping the company's pipeline and contributing to the advancement of transformative medicines.

Key Responsibilities:
  • Lead and manage multiple drug discovery projects from target identification through to preclinical candidate selection.
  • Design and execute complex biological assays to evaluate compound efficacy and mechanism of action.
  • Develop and implement innovative strategies for hit identification and lead optimization.
  • Collaborate closely with medicinal chemists, pharmacologists, and DMPK scientists to drive project progression.
  • Analyze and interpret complex biological data, ensuring scientific rigor and reproducibility.
  • Present research findings at internal project meetings and external scientific conferences.
  • Mentor and guide junior scientists, fostering a culture of scientific excellence and collaboration.
  • Contribute to the strategic direction of the drug discovery unit and identify new research opportunities.
  • Author scientific publications and patent applications.
  • Maintain a deep understanding of the scientific literature and competitive landscape within relevant therapeutic areas.

Qualifications:
  • A Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
  • A minimum of 8 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong focus on drug discovery.
  • Demonstrated success in leading cross-functional research teams and delivering on project milestones.
  • Extensive experience with a range of biochemical and cellular assay technologies.
  • In-depth knowledge of disease biology and target validation strategies in one or more therapeutic areas (e.g., oncology, immunology, neuroscience).
  • Proven ability to design and interpret in vivo efficacy studies.
  • Strong publication record in high-impact peer-reviewed journals.
  • Excellent leadership, communication, and presentation skills.
  • Experience with hit-to-lead and lead optimization campaigns.
  • Proficiency in data analysis software and bioinformatics tools.
This is a unique opportunity to make a significant impact on patient lives by contributing to the development of groundbreaking therapies. Our client offers a stimulating research environment and excellent career development prospects.
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Principal Scientist - Drug Discovery

CB2 1TN Cambridge, Eastern £80000 Annually WhatJobs

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full-time
Our client, a pioneering pharmaceutical company, is seeking an exceptional Principal Scientist to lead critical drug discovery initiatives within their fully remote research team. This senior position requires a visionary leader with a proven track record in identifying novel therapeutic targets and advancing preclinical candidates. You will be responsible for designing and executing complex research programs, interpreting experimental data, and making key strategic decisions to drive projects forward. The ideal candidate will possess extensive expertise in a relevant therapeutic area, coupled with strong leadership and communication skills to effectively guide multidisciplinary scientific teams. This role offers the unique opportunity to shape the future of medicine from a remote setting, collaborating with world-class researchers across the globe. You will be expected to contribute to the intellectual property portfolio through publications and patent filings, and to present findings at international conferences. The ability to work autonomously, manage resources efficiently, and inspire innovation is paramount for success in this role.

Responsibilities:
  • Lead and manage cutting-edge drug discovery projects from target identification through to preclinical development.
  • Design and oversee the execution of complex experimental strategies.
  • Analyze and interpret complex biological data, drawing robust conclusions.
  • Develop and implement innovative approaches to address challenging scientific problems.
  • Mentor and guide junior scientists, fostering a collaborative and high-performing team environment.
  • Contribute to the strategic direction of the company's research pipeline.
  • Prepare high-quality manuscripts for publication in peer-reviewed journals.
  • Present research findings at scientific conferences and to internal stakeholders.
  • Manage external collaborations with academic institutions and CROs.
  • Contribute to the development of intellectual property, including patent applications.

Qualifications:
  • Ph.D. in Molecular Biology, Pharmacology, Biochemistry, or a related life science discipline.
  • 10+ years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
  • Demonstrated success in leading drug discovery programs and advancing candidates into clinical development.
  • Deep scientific expertise in a specific therapeutic area (e.g., oncology, immunology, neuroscience).
  • Strong knowledge of various drug discovery technologies and methodologies.
  • Exceptional leadership, project management, and communication skills.
  • Proven ability to work independently and collaboratively in a remote, global setting.
  • Excellent track record of scientific publications and presentations.
This is a highly influential role based in Cambridge, Cambridgeshire, UK , offering the flexibility of full remote work, allowing you to contribute significantly to life-changing therapies from anywhere.
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Lead Computational Biologist - Drug Discovery

CB2 1TN Cambridge, Eastern £75000 Annually WhatJobs

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full-time
Our client is a pioneering biotechnology company looking for a talented and experienced Lead Computational Biologist to drive their drug discovery efforts. This is a fully remote position, offering the opportunity to work from anywhere while contributing to groundbreaking scientific advancements. You will lead a team of computational biologists and bioinformaticians, developing and implementing cutting-edge computational strategies to identify and validate novel drug targets. Your expertise will be crucial in analyzing large-scale biological datasets, including genomics, transcriptomics, proteomics, and metabolomics, to uncover biological insights and guide experimental design.

As the Lead Computational Biologist, you will design and manage complex bioinformatics pipelines for next-generation sequencing data analysis. You will develop predictive models for drug efficacy and toxicity, and employ machine learning algorithms to extract meaningful patterns from diverse biological data sources. This role requires a deep understanding of molecular biology, genetics, and disease pathways, coupled with strong programming skills in languages such as Python, R, and potentially C++. You will collaborate closely with experimental biologists, chemists, and pharmacologists to translate computational findings into tangible drug development progress. Strong communication and presentation skills are essential to effectively convey complex scientific concepts to both technical and non-technical audiences.

Key responsibilities include staying at the forefront of scientific literature, evaluating new technologies and methodologies, and championing innovation within the computational biology team. You will oversee the development of internal tools and databases to support research efforts and ensure data integrity and reproducibility. Mentoring junior team members, fostering a collaborative and intellectually stimulating environment, and contributing to the strategic direction of the company's R&D programs are also vital aspects of this role. A PhD in Computational Biology, Bioinformatics, Computer Science, or a closely related quantitative field is required, along with a substantial track record of research and publication in relevant areas. Experience in leading scientific teams and managing projects in a research and development setting is highly desirable. This is an exceptional opportunity for a visionary scientist to make a significant impact on the future of medicine from a remote-first perspective.

Qualifications:
  • PhD in Computational Biology, Bioinformatics, Genetics, or a related quantitative field.
  • Minimum of 7 years of post-doctoral or industry experience in computational biology/bioinformatics, with demonstrable leadership experience.
  • Proven expertise in analyzing large-scale omics data (genomics, transcriptomics, proteomics) and applying statistical and machine learning methods.
  • Strong programming skills in Python and/or R, and experience with relevant bioinformatics tools and databases.
  • Deep understanding of molecular biology, genetics, and drug discovery processes.
  • Excellent problem-solving, analytical, and critical thinking skills.
  • Exceptional communication, presentation, and interpersonal skills, with the ability to mentor and lead a team effectively.
  • Experience with cloud computing platforms (e.g., AWS, GCP) is a plus.
This is a unique opportunity to lead cutting-edge research in drug discovery within a dynamic and fully remote scientific environment.
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Principal Research Scientist - Drug Discovery

CB2 1TN Cambridge, Eastern £80000 Annually WhatJobs

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full-time
Our client, a leading innovator in pharmaceutical research, is seeking an exceptional Principal Research Scientist to join their cutting-edge drug discovery team. This role is based in Cambridge, Cambridgeshire, UK and offers a fully remote working arrangement, allowing you to contribute from anywhere. You will be at the forefront of identifying and validating novel therapeutic targets, designing and synthesising small molecules, and advancing drug candidates through early-stage development. This position requires a deep understanding of medicinal chemistry, molecular biology, and pharmacology, coupled with a proven track record of leading successful research projects. You will collaborate with a multidisciplinary team of scientists, chemists, and biologists, driving scientific innovation and contributing to the development of life-changing medicines.

Key Responsibilities:
  • Lead and execute research projects focused on novel drug discovery and development.
  • Design and synthesise diverse compound libraries for high-throughput screening.
  • Optimise lead compounds for potency, selectivity, and pharmacokinetic properties.
  • Develop and validate biochemical and cellular assays to support drug discovery efforts.
  • Interpret complex experimental data, propose next steps, and present findings at internal and external forums.
  • Collaborate closely with biologists, pharmacologists, and computational chemists.
  • Mentor and guide junior research scientists, fostering a collaborative and innovative research environment.
  • Stay abreast of the latest scientific literature and emerging technologies in drug discovery.
  • Contribute to intellectual property generation and patent applications.

The ideal candidate will hold a PhD in Chemistry, Pharmacology, Molecular Biology, or a related discipline, with extensive postdoctoral and industry experience in drug discovery. Demonstrable expertise in medicinal chemistry, structure-activity relationship (SAR) analysis, and assay development is essential. A strong publication record and experience in leading research teams are highly valued. This is a remote-first role, demanding exceptional self-management, communication, and collaborative skills. You will have the autonomy to shape research directions and make significant contributions to the company's pipeline. Our client is committed to scientific excellence and offers a stimulating work environment where innovation thrives. Embrace the opportunity to shape the future of medicine from a remote setting, working with a passionate and dedicated team.
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Principal Research Scientist - Drug Discovery

CB2 1AG Cambridge, Eastern £75000 Annually WhatJobs

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Job Description

full-time
A world-renowned research institution at the forefront of scientific innovation is seeking a highly accomplished Principal Research Scientist to lead critical drug discovery projects. This influential role is based at their state-of-the-art facility in Cambridge, Cambridgeshire, UK . You will be responsible for driving research strategy, designing and executing complex experiments, and contributing to the development of novel therapeutic agents. The ideal candidate will possess a deep expertise in a relevant scientific discipline such as molecular biology, pharmacology, biochemistry, or medicinal chemistry, backed by a significant publication record and a proven history of successful drug discovery or development. You will lead a team of talented researchers, mentor junior scientists, and foster a collaborative and innovative research environment. Responsibilities include:
  • Designing and leading cutting-edge research programs in early-stage drug discovery.
  • Developing and validating novel assays and experimental approaches.
  • Interpreting complex experimental data and drawing meaningful conclusions.
  • Guiding and mentoring a team of postdoctoral researchers and scientific staff.
  • Collaborating with internal and external partners to advance projects.
  • Contributing to the strategic direction of the research department.
  • Authoring high-impact scientific publications and presenting research findings at international conferences.
  • Managing project timelines, budgets, and resources effectively.
  • Ensuring compliance with all relevant ethical and safety regulations.
  • Identifying and evaluating new technologies and platforms relevant to drug discovery.

Qualifications:
  • PhD in Molecular Biology, Pharmacology, Biochemistry, Medicinal Chemistry, or a related field.
  • Minimum of 8 years of post-doctoral research experience, with a substantial focus on drug discovery.
  • Demonstrated track record of independent research, evidenced by peer-reviewed publications and external grant funding.
  • Extensive experience in designing and executing complex biological or chemical experiments.
  • Proven leadership and team management skills.
  • Strong understanding of disease biology and target identification/validation.
  • Excellent analytical, problem-solving, and critical thinking abilities.
  • Superb communication and presentation skills, capable of conveying complex scientific concepts.
  • Experience with in vitro and in vivo models relevant to therapeutic areas.
  • A collaborative spirit and ability to work effectively in a multidisciplinary team.

This is an unparalleled opportunity to make a significant contribution to the development of life-changing medicines. The position offers a highly competitive salary, comprehensive benefits, and access to world-class facilities and resources.
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Principal Research Scientist - Drug Discovery

CB2 0AA Cambridge, Eastern £90000 Annually WhatJobs

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full-time
Our client, a prestigious pharmaceutical research organization, is seeking a highly accomplished Principal Research Scientist to lead groundbreaking initiatives in drug discovery. This fully remote position is ideal for a seasoned scientist with a deep understanding of molecular biology, pharmacology, and medicinal chemistry. You will be instrumental in identifying and advancing novel therapeutic targets, designing and synthesizing drug candidates, and driving research programs from inception to preclinical development.

Key Responsibilities:
  • Lead and manage complex drug discovery projects, setting strategic research directions and milestones.
  • Design and execute innovative experiments to identify and validate novel therapeutic targets in key disease areas.
  • Develop and optimize hit-to-lead and lead optimization strategies, employing a range of medicinal chemistry and biological assays.
  • Oversee the synthesis and characterization of small molecule drug candidates, ensuring high quality and appropriate documentation.
  • Collaborate closely with internal teams (e.g., DMPK, toxicology, CMC) and external partners to advance projects through the drug development pipeline.
  • Interpret complex biological and chemical data, making critical decisions to guide research efforts.
  • Stay at the forefront of scientific literature and technological advancements in drug discovery relevant to our therapeutic focus.
  • Mentor and guide junior scientists, fostering a culture of scientific excellence and collaboration.
  • Prepare high-quality research reports, manuscripts for publication, and presentations for scientific conferences and internal reviews.
  • Contribute to the intellectual property strategy, including patent filings.
  • Manage external research collaborations and contract research organizations (CROs) effectively.
  • Ensure compliance with all relevant ethical, safety, and regulatory guidelines.

Qualifications and Skills:
  • Ph.D. in Medicinal Chemistry, Pharmacology, Molecular Biology, Biochemistry, or a closely related field.
  • Minimum of 8-10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry.
  • Demonstrated success in leading discovery projects that have advanced to preclinical or clinical development.
  • Extensive expertise in small molecule drug design, synthesis, and structure-activity relationship (SAR) analysis.
  • Strong understanding of disease biology, target validation, and assay development.
  • Proficiency in modern drug discovery techniques and technologies.
  • Excellent analytical, problem-solving, and critical thinking skills.
  • Proven ability to manage complex projects, timelines, and budgets.
  • Exceptional written and verbal communication skills, with a track record of impactful scientific presentations and publications.
  • Experience in mentoring and leading scientific teams.
  • Ability to thrive in a fast-paced, collaborative, and remote research environment.

This is a unique opportunity to make a significant impact on patient lives by contributing to the development of novel medicines. We are looking for passionate and experienced scientists to drive our innovative drug discovery efforts from afar.
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Principal Pharmaceutical Scientist - Drug Discovery

CB2 0AA Cambridge, Eastern £80000 Annually WhatJobs

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full-time
Our client, a globally recognized pharmaceutical company at the forefront of medical innovation, is seeking an exceptional Principal Pharmaceutical Scientist to join their state-of-the-art research and development facility. This on-site role, located in the vibrant scientific hub of **Cambridge, Cambridgeshire, UK**, is crucial for advancing our drug discovery pipeline. The successful candidate will lead cutting-edge research, contribute to the design and synthesis of novel therapeutic agents, and mentor a team of talented scientists. We are looking for an individual with a profound expertise in medicinal chemistry, a proven track record of innovation, and a strong drive to impact patient lives.

Key Responsibilities:
  • Lead and execute complex research projects focused on the discovery and development of novel small molecule therapeutics.
  • Design, synthesize, and characterize novel chemical entities with potential therapeutic applications.
  • Develop and optimize synthetic routes for target molecules, ensuring efficiency and scalability.
  • Utilize advanced analytical techniques (NMR, Mass Spectrometry, HPLC, etc.) for structural elucidation and purity assessment.
  • Collaborate closely with biologists, pharmacologists, and DMPK scientists to assess the efficacy, safety, and pharmacokinetic properties of drug candidates.
  • Manage project timelines, resources, and budgets effectively.
  • Stay abreast of the latest advancements in medicinal chemistry, drug discovery technologies, and relevant therapeutic areas.
  • Mentor and guide junior scientists, fostering their professional development and research skills.
  • Contribute to the strategic direction of the drug discovery programs.
  • Prepare and present research findings at internal meetings and external scientific conferences.
  • Author and contribute to patent applications and scientific publications.
Qualifications and Experience:
  • PhD in Organic Chemistry, Medicinal Chemistry, or a closely related field.
  • A minimum of 8-10 years of progressive experience in pharmaceutical drug discovery, with a strong emphasis on small molecule design and synthesis.
  • Demonstrated expertise in synthetic organic chemistry, including modern synthetic methodologies and reaction optimization.
  • Proven experience in leading research projects and achieving key milestones in drug discovery.
  • Strong understanding of structure-activity relationships (SAR) and structure-property relationships (SPR).
  • Proficiency in state-of-the-art analytical techniques for chemical characterization.
  • Excellent problem-solving, critical thinking, and experimental design skills.
  • Superb communication, presentation, and interpersonal skills, with the ability to collaborate effectively in a multidisciplinary team.
  • Experience with computational chemistry tools is desirable.
  • A strong publication record and/or patent filings are highly valued.
  • This role is laboratory-based and requires the candidate to work on-site in **Cambridge, Cambridgeshire, UK**.
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