45 Astrazeneca jobs in London

Principal Scientist - Drug Discovery

SW1A 0AA London, London £75000 Annually WhatJobs

Posted 3 days ago

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full-time
Our client, a leading global pharmaceutical company, is seeking an exceptional Principal Scientist to join their cutting-edge Drug Discovery department based in London, England, UK . This is a critical role for an experienced scientist who will lead innovative research projects aimed at identifying and validating novel therapeutic targets. You will be instrumental in shaping the company's early-stage drug development pipeline, working at the forefront of scientific innovation to address unmet medical needs.

As a Principal Scientist, you will be responsible for designing and executing complex experimental strategies, interpreting data, and drawing robust conclusions. You will contribute to the development of new assays, technologies, and methodologies to advance drug discovery efforts. This role demands a deep understanding of molecular biology, cell biology, pharmacology, or a related discipline, coupled with extensive experience in hypothesis-driven research. You will mentor and guide junior scientists, fostering a collaborative and intellectually stimulating research environment. The ability to critically evaluate scientific literature, identify emerging trends, and translate them into viable research opportunities is essential.

The ideal candidate will possess a PhD in a relevant scientific field, such as molecular biology, biochemistry, immunology, or pharmacology, with a minimum of 8-10 years of post-doctoral and industry experience in drug discovery. A strong publication record in peer-reviewed journals is expected. You should have demonstrated success in leading research projects from conception to completion, with a proven ability to manage resources effectively and deliver results within defined timelines. Excellent communication, presentation, and interpersonal skills are required to effectively collaborate with internal teams, including medicinal chemists, DMPK scientists, and clinicians, as well as external partners and academic collaborators. Experience with specific therapeutic areas such as oncology, immunology, or neuroscience is a significant advantage. This is a challenging yet rewarding opportunity to make a profound impact on patient lives through the development of life-changing medicines. The laboratory facilities are state-of-the-art, providing an ideal environment for groundbreaking research.

Key Responsibilities:
  • Lead and design innovative drug discovery research projects.
  • Develop and validate novel assays and experimental models.
  • Interpret complex biological data and generate actionable insights.
  • Mentor and guide junior scientific staff.
  • Collaborate with cross-functional teams (chemistry, DMPK, clinical).
  • Present research findings at internal meetings and external conferences.
  • Stay current with scientific literature and emerging technologies.
  • Contribute to intellectual property generation and patent filings.
  • Manage project timelines, resources, and budgets.
  • Ensure scientific rigor and adherence to company standards.
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Principal Scientist - Drug Discovery

SW1A 0AA London, London £85000 Annually WhatJobs

Posted 18 days ago

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full-time
Our client, a prestigious biotechnology research institution renowned for its groundbreaking work, is seeking an exceptional Principal Scientist to join their leading Scientific Research & Development team. This role is based in a state-of-the-art facility in the heart of London and will involve pioneering research aimed at discovering novel therapeutics for unmet medical needs. As a Principal Scientist, you will be at the forefront of innovation, leading significant research projects, mentoring junior scientists, and contributing to the strategic direction of the R&D department.

Your core responsibilities will include designing and executing complex experimental studies, utilizing advanced techniques in molecular biology, cell biology, biochemistry, or related fields, relevant to drug discovery. You will critically analyze experimental data, interpret results, and develop innovative approaches to overcome research challenges. The Principal Scientist will be responsible for leading research teams, fostering a collaborative and intellectually stimulating environment, and ensuring the highest standards of scientific rigor and reproducibility. You will manage project timelines, resources, and budgets effectively, and prepare high-quality scientific publications and presentations for both internal and external audiences, including major scientific conferences. A key aspect of the role will involve contributing to the intellectual property strategy and identifying potential drug targets.

The ideal candidate will possess a PhD in a relevant life science discipline (e.g., Molecular Biology, Pharmacology, Biochemistry, Immunology) with a minimum of 8-10 years of post-doctoral experience in the pharmaceutical or biotechnology industry, demonstrating a strong track record of successful drug discovery programs. Proven expertise in a specific therapeutic area (e.g., oncology, neuroscience, infectious diseases) and proficiency in a range of cutting-edge experimental techniques are essential. Exceptional leadership, team management, and strategic thinking skills are required. Outstanding written and verbal communication skills, with the ability to articulate complex scientific concepts clearly and persuasively, are critical. Experience in mentoring junior scientists and managing R&D projects is highly valued. The candidate must be adept at problem-solving and possess a deep understanding of the drug discovery and development process. This is a unique opportunity to join a world-class research team and make a significant contribution to advancing human health. The job location isLondon, England, UK .
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Principal Scientist, Drug Discovery

SW1A 0AA London, London £85000 Annually WhatJobs

Posted 18 days ago

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full-time
Our client is seeking a highly accomplished Principal Scientist to lead innovative research and development initiatives within drug discovery. This position offers a significant opportunity to contribute to groundbreaking scientific advancements in a dynamic, fully remote environment. You will be responsible for designing and executing complex research projects, mentoring a team of scientists, and driving the identification and validation of novel therapeutic targets and drug candidates.

Key Responsibilities:
  • Lead and manage research projects focused on identifying and validating new drug targets and therapeutic modalities.
  • Design and implement innovative experimental strategies and methodologies to support drug discovery programs.
  • Interpret complex experimental data, draw sound conclusions, and make strategic recommendations for project progression.
  • Develop and optimize assays for high-throughput screening (HTS) and lead optimization.
  • Collaborate effectively with cross-functional teams, including medicinal chemistry, pharmacology, toxicology, and clinical development.
  • Stay abreast of the latest scientific literature, technological advancements, and emerging trends in relevant therapeutic areas.
  • Author high-quality scientific publications, patent applications, and regulatory submissions.
  • Mentor and guide junior scientists, fostering a collaborative and intellectually stimulating research environment.
  • Manage project timelines, budgets, and resources effectively to ensure timely achievement of milestones.
  • Present research findings at internal meetings and external scientific conferences.
  • Contribute to the strategic direction of the research and development pipeline.
  • Ensure compliance with all laboratory safety regulations and best practices.
Qualifications and Skills:
  • Ph.D. in a relevant scientific discipline (e.g., Molecular Biology, Biochemistry, Pharmacology, Genetics).
  • Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong focus on drug discovery.
  • Proven track record of successfully identifying and advancing drug candidates through early development stages.
  • Extensive expertise in experimental design, data analysis, and interpretation using a variety of scientific techniques.
  • Deep understanding of molecular pathways, disease mechanisms, and therapeutic interventions in specific therapeutic areas (e.g., oncology, immunology, neuroscience).
  • Experience with various drug discovery platforms, including small molecules, biologics, or gene therapy.
  • Strong leadership, mentorship, and team management skills.
  • Excellent written and verbal communication skills, with the ability to present complex scientific information clearly and concisely.
  • Proficiency in relevant bioinformatics and computational biology tools is a plus.
  • Demonstrated ability to work independently and collaboratively in a remote research setting.
  • A passion for scientific innovation and a commitment to bringing life-changing medicines to patients.
This is an exciting opportunity to lead cutting-edge research and shape the future of medicine. The role is based in **London, England, UK**, and is fully remote.
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Principal Scientist, Drug Discovery

SW1A 0AA London, London £75000 Annually WhatJobs

Posted 19 days ago

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full-time
Our client, a leading innovator in the pharmaceutical sector, is seeking a highly experienced Principal Scientist to join their prestigious Research & Development team. This hybrid role, based in London, England, UK , offers the opportunity to contribute to groundbreaking drug discovery initiatives. The Principal Scientist will lead ambitious research projects, driving the identification and validation of novel therapeutic targets and small molecule leads.

Key responsibilities include designing and executing complex experiments, developing innovative assays, and interpreting scientific data to guide project strategy. You will mentor and supervise junior scientists, foster a collaborative research environment, and contribute to scientific publications and patent applications. The Principal Scientist will also play a key role in evaluating new technologies and methodologies to enhance drug discovery capabilities. A strong understanding of medicinal chemistry, pharmacology, and disease biology relevant to the client's therapeutic areas is essential. Experience with high-throughput screening (HTS) and compound library management is highly desirable.

The ideal candidate will possess a PhD in a relevant scientific discipline (e.g., Pharmacology, Biochemistry, Molecular Biology) with a minimum of 7 years of post-doctoral research experience in the pharmaceutical or biotechnology industry. Demonstrated leadership in project management and a strong publication record are required. Excellent communication, presentation, and critical thinking skills are paramount. This is an exceptional opportunity for a talented scientist to make a significant impact on the future of medicine within a world-class research organisation.
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Senior Research Scientist - Drug Discovery

WC2N 5DU London, London £75000 Annually WhatJobs

Posted 2 days ago

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full-time
Our client, a groundbreaking biopharmaceutical company at the forefront of innovative therapeutics, is seeking a highly motivated and experienced Senior Research Scientist to join their expanding Drug Discovery team. This is a fully remote position, offering the flexibility to work from anywhere within the UK, fostering a seamless integration of work and life. You will play a crucial role in identifying and validating novel drug targets, designing and executing experiments, and contributing to the preclinical development of next-generation medicines. The ideal candidate will possess a PhD in a relevant scientific discipline, extensive hands-on experience in molecular biology, cell biology, or biochemistry, and a strong publication record. You will be a self-starter, capable of independently driving research projects, troubleshooting complex problems, and effectively communicating scientific findings to a multidisciplinary team.

Key Responsibilities:
  • Design and implement cutting-edge research projects focused on the identification and validation of novel therapeutic targets.
  • Develop and optimize in vitro and ex vivo assays to assess compound efficacy and mechanism of action.
  • Conduct rigorous data analysis, interpret experimental results, and generate comprehensive reports.
  • Stay abreast of the latest scientific literature, emerging technologies, and competitive landscape in relevant therapeutic areas.
  • Collaborate effectively with medicinal chemists, pharmacologists, and other research scientists to advance drug candidates through the discovery pipeline.
  • Contribute to the preparation of scientific publications, patents, and regulatory submissions.
  • Present research findings at internal meetings and external scientific conferences.
  • Troubleshoot experimental challenges and propose innovative solutions.
  • Maintain accurate and detailed laboratory notebooks and research records.
  • Contribute to the strategic direction of the drug discovery program.
Qualifications:
  • PhD in Molecular Biology, Cell Biology, Biochemistry, Pharmacology, or a related field.
  • Minimum of 5 years of post-doctoral or industry research experience in drug discovery.
  • Proven expertise in a range of biological techniques, including but not limited to cell culture, western blotting, ELISA, qPCR, and high-throughput screening.
  • Experience with target validation and assay development.
  • Strong understanding of disease biology and target engagement.
  • Excellent data analysis and interpretation skills.
  • Proficiency in scientific writing and presentation.
  • Demonstrated ability to work independently and as a productive member of a remote team.
  • Strong problem-solving abilities and a creative scientific approach.
  • Familiarity with bioinformatics tools is a plus.
This remote opportunity is ideal for a passionate scientist looking to make a significant impact in the pharmaceutical industry. Our client offers a competitive remuneration package, excellent benefits, and the chance to work on transformative medicines.
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Principal Pharmaceutical Scientist (Drug Discovery)

SW1A 0AA London, London £80000 Annually WhatJobs

Posted 5 days ago

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full-time
Our client, a leading global pharmaceutical company renowned for its commitment to innovation and patient well-being, is seeking a highly accomplished Principal Pharmaceutical Scientist to drive cutting-edge drug discovery initiatives. This is a crucial role based at their state-of-the-art facility in London, England, UK . The successful candidate will lead and execute complex research projects aimed at identifying and validating novel therapeutic targets and developing innovative drug candidates. You will be instrumental in designing and implementing experimental strategies, utilizing a wide range of biochemical, molecular biology, and cellular assay techniques. Responsibilities include critically analyzing experimental data, interpreting results in the context of disease biology, and making informed recommendations for project progression. This role requires a strong understanding of medicinal chemistry principles, pharmacology, and disease pathophysiology. You will be expected to manage multiple projects concurrently, mentor and guide junior scientists, and foster collaborative relationships with internal and external partners, including academic institutions and contract research organizations. Excellent written and oral communication skills are essential for presenting findings to diverse audiences, including senior management and regulatory bodies. The ideal candidate will have a PhD in a relevant scientific discipline (e.g., Pharmacology, Biochemistry, Molecular Biology, Chemistry) with a minimum of 8-10 years of post-doctoral experience in the pharmaceutical or biotechnology industry, with a proven track record of successfully contributing to drug discovery programs. Experience in leading research teams and a deep understanding of the drug development process from discovery through to early clinical development are vital. This is an exceptional opportunity to join a world-class organization, contribute to the development of life-changing medicines, and advance your career in a challenging and rewarding environment. We offer a competitive compensation package, comprehensive benefits, and unparalleled opportunities for professional growth.
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Principal Research Scientist - Drug Discovery

SW1A 0AA London, London £75000 Annually WhatJobs

Posted 8 days ago

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full-time
A world-renowned pharmaceutical company is seeking a highly experienced and innovative Principal Research Scientist to join their cutting-edge drug discovery team based in London, England, UK . This hybrid role offers an exciting opportunity to contribute to the development of novel therapeutics in a collaborative and dynamic research environment.

As a Principal Research Scientist, you will lead research projects focused on identifying and validating new drug targets, designing and synthesising novel chemical entities, and advancing lead compounds through preclinical development. Your expertise will be critical in designing and executing complex experiments, interpreting data, and contributing to the strategic direction of drug discovery programmes.

Key Responsibilities:
  • Lead and manage independent research projects within drug discovery, from target identification to preclinical candidate selection.
  • Design, synthesise, and characterise novel small molecules with therapeutic potential.
  • Develop and implement robust experimental assays to evaluate compound efficacy, selectivity, and mechanism of action.
  • Conduct detailed data analysis, interpretation, and reporting, presenting findings at internal and external scientific forums.
  • Collaborate closely with medicinal chemists, biologists, pharmacologists, and toxicologists to advance drug candidates.
  • Provide scientific leadership and mentorship to junior researchers and technicians.
  • Stay abreast of the latest scientific literature, technological advancements, and industry trends in pharmaceutical research.
  • Contribute to the strategic planning and prioritisation of drug discovery programmes.
  • Maintain excellent laboratory practices and ensure compliance with all relevant regulations and safety protocols.

Essential Qualifications:
  • PhD in Medicinal Chemistry, Organic Chemistry, Pharmacology, or a related life sciences discipline.
  • Minimum of 8 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
  • Proven track record of successfully advancing drug candidates from discovery to preclinical development.
  • Extensive experience in synthetic organic chemistry, medicinal chemistry, and assay development.
  • Deep understanding of drug discovery processes and a broad knowledge of therapeutic areas.
  • Excellent analytical, problem-solving, and critical thinking skills.
  • Strong publication record and presentation skills.
  • Demonstrated ability to lead research teams and collaborate effectively in a multidisciplinary environment.
  • Familiarity with hybrid work models and effective remote collaboration tools.

This is a prestigious opportunity for a seasoned scientist to make a significant impact on patient lives by contributing to the development of next-generation medicines. You will be part of a world-class research organisation, pushing the boundaries of scientific innovation.
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Principal Research Scientist, Drug Discovery

SW1A 0AA London, London £90000 Annually WhatJobs

Posted 8 days ago

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full-time
Our client, a leading pharmaceutical innovator, is seeking a highly accomplished Principal Research Scientist to spearhead critical drug discovery initiatives within their state-of-the-art, fully remote research division. This is a unique opportunity to drive cutting-edge scientific research and contribute to the development of novel therapeutics. The ideal candidate will possess a deep expertise in medicinal chemistry, molecular biology, or a related field, with a proven track record of successfully translating scientific concepts into preclinical drug candidates. You will lead a virtual team of scientists, mentor junior researchers, and collaborate extensively with cross-functional teams, including clinical development, regulatory affairs, and business development. Your responsibilities will encompass designing and executing complex experiments, interpreting data, and identifying novel therapeutic targets. A strong understanding of disease biology and the drug discovery process is essential, along with extensive experience in target validation, hit identification, and lead optimization. This role demands exceptional analytical and problem-solving skills, as well as the ability to think creatively and strategically to overcome scientific challenges. As a remote-first position, you will need to demonstrate excellent communication, leadership, and project management capabilities to effectively guide research efforts from a distance. The ability to foster a collaborative and innovative research environment, even remotely, is paramount. You will be expected to publish research findings in high-impact journals and present at international conferences. The successful candidate will have access to advanced computational tools and resources to facilitate their research. This role offers the chance to make a significant impact on patient lives by advancing innovative medicines through the drug discovery pipeline, all while enjoying the flexibility of a remote work arrangement. Join a company committed to scientific excellence and patient well-being, working from your home base near London, England, UK .
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Principal Pharmaceutical Scientist - Drug Discovery

SW1A 0AA London, London £80000 Annually WhatJobs

Posted 9 days ago

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full-time
Our client is a leading pharmaceutical company seeking an exceptional Principal Pharmaceutical Scientist to join their pioneering drug discovery team. This is a fully remote role, allowing top scientific talent to contribute to vital research from anywhere. You will lead critical research initiatives aimed at identifying and validating novel drug targets and developing innovative therapeutic strategies. Your responsibilities will encompass designing and executing complex in vitro and in vivo studies, meticulously analyzing experimental data, and contributing to the strategic direction of drug discovery programs. A profound understanding of pharmacology, medicinal chemistry, and disease biology is essential. You will collaborate closely with multidisciplinary teams, including biologists, chemists, and toxicologists, to advance candidate molecules through the preclinical pipeline. This role requires a proven track record of scientific leadership, a passion for innovation, and the ability to translate complex scientific concepts into actionable research plans. Publishing in high-impact journals and presenting at key industry conferences will be integral to this position. The ideal candidate is a strategic thinker with a deep commitment to discovering life-changing medicines. Responsibilities will include:
  • Leading the design and execution of innovative drug discovery research projects.
  • Identifying and validating novel therapeutic targets for various diseases.
  • Developing and optimizing in vitro and in vivo experimental models.
  • Analyzing and interpreting complex pharmacological and biological data.
  • Providing strategic scientific leadership and mentorship to research teams.
  • Collaborating effectively with cross-functional R&D departments.
  • Authoring and contributing to scientific publications and patent applications.
  • Presenting research findings to internal and external stakeholders.
  • Staying abreast of cutting-edge research and technologies in pharmaceutical sciences.
  • Contributing to the overall research strategy and pipeline development.
Qualifications:
  • PhD in Pharmacology, Pharmaceutical Sciences, Biochemistry, or a related field.
  • 10+ years of relevant experience in drug discovery within the pharmaceutical industry.
  • Demonstrated success in leading research programs and delivering preclinical candidates.
  • Strong expertise in target identification, validation, and assay development.
  • In-depth knowledge of disease mechanisms and therapeutic interventions.
  • Excellent scientific communication, presentation, and writing skills.
  • Proven ability to mentor junior scientists and foster a collaborative research environment, essential for remote leadership.
  • Experience with data analysis software and bioinformatics tools.
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Lead Research Scientist - Drug Discovery

SW1A 0AA London, London £75000 Annually WhatJobs

Posted 10 days ago

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full-time
Our client, a pioneering pharmaceutical company, is seeking a highly accomplished Lead Research Scientist to spearhead drug discovery initiatives. This hybrid role, based in the heart of London, England, UK , offers a unique opportunity to blend cutting-edge laboratory work with strategic research planning. You will lead a team of talented scientists, driving the identification and validation of novel therapeutic targets and the development of innovative drug candidates. A strong background in a relevant scientific discipline, exceptional leadership capabilities, and a passion for translating scientific breakthroughs into life-changing medicines are essential.

Key Responsibilities:
  • Lead and manage a team of research scientists involved in early-stage drug discovery projects.
  • Design, execute, and interpret complex experiments to identify and validate novel drug targets.
  • Develop and implement innovative research strategies and methodologies.
  • Oversee the design and synthesis of potential drug molecules, and their preclinical evaluation.
  • Collaborate with internal cross-functional teams (e.g., chemistry, biology, DMPK) and external partners to advance projects.
  • Analyze and interpret experimental data, present findings at scientific conferences, and contribute to publications.
  • Manage research budgets, resources, and timelines effectively.
  • Stay abreast of the latest scientific advancements and emerging technologies in pharmaceutical research.
  • Mentor and guide junior scientists, fostering a culture of scientific excellence and innovation.
  • Ensure all research activities are conducted in compliance with ethical standards and regulatory guidelines.
Qualifications:
  • Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
  • Significant postdoctoral and industry experience in drug discovery.
  • Proven track record of leading research projects from concept to preclinical development.
  • Extensive experience in a specific therapeutic area (e.g., oncology, immunology, neuroscience).
  • Expertise in relevant experimental techniques and assays.
  • Strong understanding of medicinal chemistry principles and drug development processes.
  • Excellent leadership, team management, and communication skills.
  • Demonstrated ability to think critically and solve complex scientific problems.
  • Experience with grant writing and publications in high-impact journals.
  • Proficiency in data analysis software and laboratory information management systems.
This is an unparalleled opportunity to make a significant contribution to the future of medicine. If you are a visionary scientist with a passion for innovation and a commitment to patient well-being, we invite you to apply.
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