42 High Throughput Screening jobs in London

Hello!

We're looking for an awesome Clinical Assay Development Scientist to join our team on our journey to revolutionize personalized medicine.

About your Role

• Lead the identification, validation, and application of novel blood biomarkers for disease prediction, prognosis, and treatment stratification  
• Direct large-scale clinical studies, ensuring compliance with regulatory and ethical standards (GCP/GLP, ISO 13485, IVDR, UKCA)
• Design, optimize, and validate blood-based clinical assays with high robustness, accuracy, and reproducibility.
• Oversee biological sample preparation and processing under biosafety standards, and safety compliance.
• Ensure data integrity through rigorous documentation (validation plans, reports, SOPs, lab notebooks), keeping outputs audit-ready.
• Provide scientific and strategic guidance on biomarker development, clinical study design, and AI/photonics-based diagnostics.
• Establish and manage collaborations with academic, clinical, and industry partners to accelerate biomarker discovery and validation.
• Provide scientific and strategic guidance to internal and external stakeholders on biomarker development, clinical study design, and regulatory requirements specific to photonics and AI-based diagnostics
• Communicate findings and technical insights clearly to both specialist and non-technical audiences; author validation protocols, technical summaries, and regulatory documentation.

Cultural Skills ️

• Builder’s mindset with high ownership, urgency, and empathy.
• Low‑ego, highly collaborative leader who elevates others.
• Mission‑driven and patient‑centered.

This role is based in London and collaborates with teams across the UK and Europe.

Technical / Professional Skills ️

• PhD in a relevant Life Sciences field - biology, medicine, biomedical engineering, molecular biology, others. 
• + 3 years relevant experience in the development/validation of blood biomarkers. Bonus: Spectral or AI Biomarkers
• Extensive knowledge and hands-on experience in blood biomarker discovery, validation, and clinical translation. Bonus: analytical assay development
• Familiarity with ISO 13485, IVDR, UKCA, and GCP/GLP expectations.
• Proficiency in applying statistical analysis and data interpretation methods to biomarker discovery and validation studies.
• Strong hands‑on experience with biosafety protocols, clinical sample handling, and assay preparation.
• Exceptional attention to detail and documentation discipline supporting data integrity.
• Excellent communicator; comfortable collaborating with cross‑functional teams and external partners.

Bonus Skills

• Industry experience is highly desirable, particularly in startup environments. Backgrounds in health tech or deep tech are especially valued.
• Exposure to immunoassays, molecular diagnostics, or multi‑omic platforms.
• Contributions to clinical studies or tech‑transfer in regulated settings.
• Understanding of Optics (spectroscopy, Raman, FTIR or similar techniques)
• Understanding of AI (machine learning, deep learning)
• Experience in IVD blood assay development 

iLoF in a nutshell

As personalized medicine becomes the norm, scientists, patients, and healthcare systems worldwide face massive barriers in providing the right treatment to the right patient.

Recognized by CB Insights and Financial Times as one of the most promising Digital Health companies in the world, iLoF is building an AI-powered platform capable of transforming precision medicine.

Our goal is to become the platform that democratizes access to personalized medicine for millions of people living with complex diseases around the globe.

Thanks to our proprietary optical fingerprint library of disease biomarkers and biological profiles we can offer personalized patient screening and stratification in a faster and more affordable way, saving up to 40% of the cost and 70% of the time while enabling a more human patient experience.

Supported by leading institutions like Microsoft Ventures, Mayfield, and the Oxford University, iLoF is currently focusing on validating its platform technology in one of the biggest challenges of our times: Alzheimer's, while maintaining ongoing verticals on Digestive Cancer, Stroke, and Infectious diseases.

Our Team

• Lead and design innovative drug discovery research projects.
• Develop and validate novel assays and experimental models.
• Interpret complex biological data and generate actionable insights.
• Mentor and guide junior scientific staff.
• Collaborate with cross-functional teams (chemistry, DMPK, clinical).
• Present research findings at internal meetings and external conferences.
• Stay current with scientific literature and emerging technologies.
• Contribute to intellectual property generation and patent filings.
• Manage project timelines, resources, and budgets.
• Ensure scientific rigor and adherence to company standards.

• Lead and manage research projects focused on identifying and validating new drug targets and therapeutic modalities.
• Design and implement innovative experimental strategies and methodologies to support drug discovery programs.
• Interpret complex experimental data, draw sound conclusions, and make strategic recommendations for project progression.
• Develop and optimize assays for high-throughput screening (HTS) and lead optimization.
• Collaborate effectively with cross-functional teams, including medicinal chemistry, pharmacology, toxicology, and clinical development.
• Stay abreast of the latest scientific literature, technological advancements, and emerging trends in relevant therapeutic areas.
• Author high-quality scientific publications, patent applications, and regulatory submissions.
• Mentor and guide junior scientists, fostering a collaborative and intellectually stimulating research environment.
• Manage project timelines, budgets, and resources effectively to ensure timely achievement of milestones.
• Present research findings at internal meetings and external scientific conferences.
• Contribute to the strategic direction of the research and development pipeline.
• Ensure compliance with all laboratory safety regulations and best practices.

• Ph.D. in a relevant scientific discipline (e.g., Molecular Biology, Biochemistry, Pharmacology, Genetics).
• Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong focus on drug discovery.
• Proven track record of successfully identifying and advancing drug candidates through early development stages.
• Extensive expertise in experimental design, data analysis, and interpretation using a variety of scientific techniques.
• Deep understanding of molecular pathways, disease mechanisms, and therapeutic interventions in specific therapeutic areas (e.g., oncology, immunology, neuroscience).
• Experience with various drug discovery platforms, including small molecules, biologics, or gene therapy.
• Strong leadership, mentorship, and team management skills.
• Excellent written and verbal communication skills, with the ability to present complex scientific information clearly and concisely.
• Proficiency in relevant bioinformatics and computational biology tools is a plus.
• Demonstrated ability to work independently and collaboratively in a remote research setting.
• A passion for scientific innovation and a commitment to bringing life-changing medicines to patients.

• Design and implement cutting-edge research projects focused on the identification and validation of novel therapeutic targets.
• Develop and optimize in vitro and ex vivo assays to assess compound efficacy and mechanism of action.
• Conduct rigorous data analysis, interpret experimental results, and generate comprehensive reports.
• Stay abreast of the latest scientific literature, emerging technologies, and competitive landscape in relevant therapeutic areas.
• Collaborate effectively with medicinal chemists, pharmacologists, and other research scientists to advance drug candidates through the discovery pipeline.
• Contribute to the preparation of scientific publications, patents, and regulatory submissions.
• Present research findings at internal meetings and external scientific conferences.
• Troubleshoot experimental challenges and propose innovative solutions.
• Maintain accurate and detailed laboratory notebooks and research records.
• Contribute to the strategic direction of the drug discovery program.

• PhD in Molecular Biology, Cell Biology, Biochemistry, Pharmacology, or a related field.
• Minimum of 5 years of post-doctoral or industry research experience in drug discovery.
• Proven expertise in a range of biological techniques, including but not limited to cell culture, western blotting, ELISA, qPCR, and high-throughput screening.
• Experience with target validation and assay development.
• Strong understanding of disease biology and target engagement.
• Excellent data analysis and interpretation skills.
• Proficiency in scientific writing and presentation.
• Demonstrated ability to work independently and as a productive member of a remote team.
• Strong problem-solving abilities and a creative scientific approach.
• Familiarity with bioinformatics tools is a plus.

• Lead and manage independent research projects within drug discovery, from target identification to preclinical candidate selection.
• Design, synthesise, and characterise novel small molecules with therapeutic potential.
• Develop and implement robust experimental assays to evaluate compound efficacy, selectivity, and mechanism of action.
• Conduct detailed data analysis, interpretation, and reporting, presenting findings at internal and external scientific forums.
• Collaborate closely with medicinal chemists, biologists, pharmacologists, and toxicologists to advance drug candidates.
• Provide scientific leadership and mentorship to junior researchers and technicians.
• Stay abreast of the latest scientific literature, technological advancements, and industry trends in pharmaceutical research.
• Contribute to the strategic planning and prioritisation of drug discovery programmes.
• Maintain excellent laboratory practices and ensure compliance with all relevant regulations and safety protocols.

• PhD in Medicinal Chemistry, Organic Chemistry, Pharmacology, or a related life sciences discipline.
• Minimum of 8 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
• Proven track record of successfully advancing drug candidates from discovery to preclinical development.
• Extensive experience in synthetic organic chemistry, medicinal chemistry, and assay development.
• Deep understanding of drug discovery processes and a broad knowledge of therapeutic areas.
• Excellent analytical, problem-solving, and critical thinking skills.
• Strong publication record and presentation skills.
• Demonstrated ability to lead research teams and collaborate effectively in a multidisciplinary environment.
• Familiarity with hybrid work models and effective remote collaboration tools.