250 Principal Scientist jobs in London

We are currently looking for a Principal Scientist for a growing Biotechnology company in London.

As a Principal Scientist you will lead target validation to support multiple programs within the company’s drug discovery pipeline.

Responsibilities include

• Working with stakeholders you will provide expertise to discovery programs by developing and implementing validation strategies.
• Run experimental strategies to confirm and characterise therapeutic targets.
• Using your expertise in molecular biology, histology, and immunofluorescence techniques IHC, IF, confocal microscopy, qPCR, western blotting) you will evaluate target expression, localisation, and regulation in disease-relevant models and human tissues.
• Use and implement advanced technologies, such as multiplex IF, spatial transcriptomics, or digital pathology to expand the company’s validation capabilities.
• Design biomarker strategies that strengthen translational tools.

Ideal candidates will:

Have a PhD in Molecular Biology, Cell Biology, or Pathology or related subject along with significant experience in the Biotech or Pharmaceutical industry within target validation.

You will have experience working within drug discovery pipelines and have expertise in molecular biology, histology, and immunofluorescence techniques including IHC, IF, confocal microscopy, ISH, qPCR and western blotting.

The company offers a highly competitive salary and benefits package.

This is an opportunity to work with and influence the direction of some truly pioneering science that the company is leading on.

To apply for the Principal Scientist – Target validation role please send you CV to Peter at Rowland Talent.

Key word: Scientific, research, cancer, oncology, PCR, Assay, Molecular Biology, Cell Biology, or Pathology, principal scientist

• Lead and design innovative drug discovery research projects.
• Develop and validate novel assays and experimental models.
• Interpret complex biological data and generate actionable insights.
• Mentor and guide junior scientific staff.
• Collaborate with cross-functional teams (chemistry, DMPK, clinical).
• Present research findings at internal meetings and external conferences.
• Stay current with scientific literature and emerging technologies.
• Contribute to intellectual property generation and patent filings.
• Manage project timelines, resources, and budgets.
• Ensure scientific rigor and adherence to company standards.

• Leading and directing research programs in advanced materials science, encompassing areas such as nanomaterials, composites, polymers, or functional coatings.
• Defining strategic research objectives and developing multi-year project plans.
• Managing and mentoring a team of scientists, engineers, and technicians.
• Overseeing experimental design, execution, and data analysis for complex material science projects.
• Securing research funding through grant applications and industry partnerships.
• Publishing research findings in leading peer-reviewed journals and presenting at international conferences.
• Collaborating with internal and external stakeholders, including industry partners, academic institutions, and government agencies.
• Ensuring compliance with safety regulations and laboratory best practices.
• Driving the intellectual property strategy and patent development for new material innovations.
• Evaluating emerging technologies and identifying opportunities for future research directions.

• Lead and execute complex research projects in molecular biology, focusing on areas such as gene editing, genomics, and molecular diagnostics.
• Design and implement innovative experimental strategies to address key scientific questions.
• Develop and validate novel molecular assays and protocols.
• Interpret complex experimental data, draw scientifically sound conclusions, and present findings to internal and external stakeholders.
• Collaborate with cross-functional teams, including computational biologists, chemists, and clinicians, to achieve research objectives.
• Mentor and guide junior scientists and research associates, fostering scientific rigor and professional development.
• Stay abreast of the latest scientific literature, technological advancements, and industry trends in molecular biology.
• Contribute to patent applications and scientific publications.
• Manage research budgets and resources effectively.
• Ensure compliance with all laboratory safety and regulatory guidelines.
• Maintain effective communication and collaboration within a remote team environment.

• Ph.D. in Molecular Biology, Genetics, Biochemistry, or a related life sciences field.
• Minimum of 7 years of post-doctoral or industry research experience in molecular biology.
• Proven track record of independent research, evidenced by peer-reviewed publications and conference presentations.
• Extensive hands-on experience with a wide range of molecular biology techniques, including PCR, qPCR, next-generation sequencing (NGS), CRISPR/Cas9, cloning, and protein expression analysis.
• Strong understanding of experimental design, statistical analysis, and data interpretation.
• Excellent critical thinking, problem-solving, and analytical skills.
• Superb written and verbal communication skills, essential for remote collaboration and scientific writing.
• Demonstrated leadership and mentoring capabilities.
• Ability to work autonomously, manage multiple projects, and meet deadlines in a remote setting.
• Experience with bioinformatics tools and analysis is highly desirable.

• Lead and manage research projects focused on identifying and validating new drug targets and therapeutic modalities.
• Design and implement innovative experimental strategies and methodologies to support drug discovery programs.
• Interpret complex experimental data, draw sound conclusions, and make strategic recommendations for project progression.
• Develop and optimize assays for high-throughput screening (HTS) and lead optimization.
• Collaborate effectively with cross-functional teams, including medicinal chemistry, pharmacology, toxicology, and clinical development.
• Stay abreast of the latest scientific literature, technological advancements, and emerging trends in relevant therapeutic areas.
• Author high-quality scientific publications, patent applications, and regulatory submissions.
• Mentor and guide junior scientists, fostering a collaborative and intellectually stimulating research environment.
• Manage project timelines, budgets, and resources effectively to ensure timely achievement of milestones.
• Present research findings at internal meetings and external scientific conferences.
• Contribute to the strategic direction of the research and development pipeline.
• Ensure compliance with all laboratory safety regulations and best practices.

• Ph.D. in a relevant scientific discipline (e.g., Molecular Biology, Biochemistry, Pharmacology, Genetics).
• Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong focus on drug discovery.
• Proven track record of successfully identifying and advancing drug candidates through early development stages.
• Extensive expertise in experimental design, data analysis, and interpretation using a variety of scientific techniques.
• Deep understanding of molecular pathways, disease mechanisms, and therapeutic interventions in specific therapeutic areas (e.g., oncology, immunology, neuroscience).
• Experience with various drug discovery platforms, including small molecules, biologics, or gene therapy.
• Strong leadership, mentorship, and team management skills.
• Excellent written and verbal communication skills, with the ability to present complex scientific information clearly and concisely.
• Proficiency in relevant bioinformatics and computational biology tools is a plus.
• Demonstrated ability to work independently and collaboratively in a remote research setting.
• A passion for scientific innovation and a commitment to bringing life-changing medicines to patients.

• Lead the design and execution of computational biology projects, from conception to the delivery of actionable biological insights.
• Develop, implement, and validate novel algorithms and computational pipelines for the analysis of diverse biological data, including genomics, transcriptomics, proteomics, and metabolomics.
• Integrate multi-omics datasets to uncover complex biological relationships and disease drivers.
• Collaborate closely with experimental biologists, clinicians, and data scientists to interpret results and guide experimental design.
• Identify and validate novel drug targets and biomarkers for therapeutic intervention.
• Stay at the forefront of computational biology and bioinformatics, evaluating and adopting new technologies and methodologies.
• Mentor and guide junior computational biologists and data scientists, fostering scientific growth and technical excellence.
• Communicate complex scientific findings effectively to both technical and non-technical audiences through presentations, publications, and reports.
• Contribute to the strategic scientific vision of the company, identifying new research opportunities and collaborations.
• Ensure the quality, reproducibility, and documentation of all computational analyses.
• Manage external collaborations with academic institutions and research partners.
• Contribute to patent applications and scientific publications.

• PhD in Computational Biology, Bioinformatics, Computer Science, Statistics, or a related quantitative field.
• A minimum of 8 years of relevant post-doctoral and/or industry experience in computational biology and data analysis.
• Proven track record of leading complex research projects and delivering significant scientific contributions.
• Expertise in programming languages commonly used in bioinformatics (e.g., Python, R) and experience with high-performance computing environments.
• Deep understanding of statistical methods and machine learning techniques applied to biological data.
• Experience with common bioinformatics tools and databases for genomics, transcriptomics, and proteomics analysis.
• Strong knowledge of molecular biology, genetics, and disease biology.
• Excellent problem-solving, critical thinking, and analytical skills.
• Superb communication and interpersonal skills, with the ability to present complex data clearly and persuasively.
• Experience mentoring junior scientists and leading scientific teams is essential.
• Familiarity with cloud computing platforms (e.g., AWS, GCP) is a plus.
• Candidates must be based within commuting distance of London, England, UK and able to work in the office on a hybrid schedule.

• Developing and analyzing novel quantum algorithms for complex computational problems.
• Designing and exploring advanced quantum computing architectures and hardware concepts.
• Conducting theoretical and simulation-based research to assess the feasibility and performance of quantum solutions.
• Collaborating with external academic institutions and industry partners to foster innovation.
• Publishing research findings in leading scientific journals and presenting at international conferences.
• Mentoring and guiding junior scientists and research engineers.
• Staying at the cutting edge of quantum information science and related fields.
• Contributing to the strategic direction of the quantum research program.
• Developing and maintaining high-quality research code and simulation frameworks.
• Identifying and pursuing funding opportunities through grants and research proposals.