46 Drug Discovery jobs in London

Principal Research Scientist, Drug Discovery

SW1A 0AA London, London £80000 Annually WhatJobs

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full-time
Our client, a pioneering biopharmaceutical company dedicated to developing breakthrough therapies, is seeking a highly accomplished Principal Research Scientist specializing in Drug Discovery to join their world-class, fully remote R&D team. This senior scientific role offers the exciting opportunity to lead cutting-edge research initiatives from the comfort of your own home, contributing significantly to the identification and validation of novel therapeutic targets. You will be instrumental in designing and executing complex experimental strategies, interpreting intricate biological data, and driving the early stages of drug development pipelines. Your expertise in medicinal chemistry, pharmacology, or a related biological science, coupled with a proven track record in target identification and validation, will be critical. You will lead collaborative research efforts, mentor junior scientists, and contribute to the strategic direction of our client's drug discovery programs. The ability to independently manage research projects, critically evaluate scientific literature, and effectively communicate complex scientific findings to diverse audiences in a virtual setting is paramount. This position requires a deep commitment to scientific rigor, innovation, and a passion for making a tangible impact on human health through innovative drug development. The job location context is London, England, but the role is fully remote.

Key responsibilities include:
  • Leading innovative research projects focused on identifying and validating novel drug targets.
  • Designing and executing complex experimental studies using state-of-the-art methodologies.
  • Interpreting and analyzing large datasets, drawing scientifically sound conclusions.
  • Developing and optimizing assays for target engagement and drug efficacy screening.
  • Collaborating with medicinal chemists and other R&D teams to advance drug candidates.
  • Mentoring and guiding junior scientists, fostering scientific growth and development.
  • Staying abreast of the latest advancements in relevant scientific fields and technologies.
  • Contributing to intellectual property generation through patents and publications.
  • Presenting research findings at internal meetings and external scientific conferences.
  • Playing a key role in shaping the strategic direction of the drug discovery portfolio.

The ideal candidate will possess a Ph.D. in Pharmacology, Biochemistry, Molecular Biology, Medicinal Chemistry, or a related discipline, with a strong publication record and a minimum of 8-10 years of post-doctoral research experience in drug discovery within the pharmaceutical or biotechnology industry. Proven expertise in a specific therapeutic area and a deep understanding of drug discovery processes, from target identification to lead optimization, are essential. Exceptional critical thinking, problem-solving skills, and proficiency in advanced experimental techniques are required. Excellent written and verbal communication skills are paramount for effective collaboration and knowledge sharing in a remote environment. The ability to lead, inspire, and manage research teams is crucial. Experience with bioinformatics and computational biology tools is highly desirable. This is a senior role for a driven scientist looking to make a significant impact remotely.
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Senior Medicinal Chemist - Drug Discovery

WC2B 5HN London, London £70000 Annually WhatJobs

Posted 2 days ago

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full-time
Our client, a leading pharmaceutical research company dedicated to the discovery of life-changing therapeutics, is seeking an accomplished Senior Medicinal Chemist to join their innovative, fully remote R&D team. This role is critical in designing and synthesizing novel small molecules with the potential to become new medicines. You will be at the forefront of hit-to-lead and lead optimization campaigns, contributing significantly to the drug discovery pipeline. Responsibilities include the design of target molecules using retrosynthetic analysis, planning and executing multi-step syntheses, purifying and characterizing synthesized compounds using modern analytical techniques (NMR, LC-MS), and evaluating the biological activity of synthesized compounds in collaboration with biologists. The ideal candidate will possess a PhD in Organic or Medicinal Chemistry, coupled with a strong track record of successfully contributing to drug discovery programs in an industry setting. Expertise in synthetic organic chemistry, including diverse reaction methodologies and stereoselective synthesis, is paramount. A deep understanding of structure-activity relationships (SAR) and structure-property relationships (SPR) is essential. You will be adept at utilizing computational chemistry tools for molecule design and analysis, and possess excellent problem-solving skills to overcome synthetic challenges. This is a remote-first position, allowing you to contribute your expertise from anywhere within the UK and collaborate virtually with a world-class team of scientists.
Key Responsibilities:
  • Design novel small molecule drug candidates based on biological targets and SAR data.
  • Plan and execute complex synthetic routes for the preparation of target compounds.
  • Optimize synthetic methodologies to improve yield, purity, and scalability.
  • Characterize synthesized compounds using advanced analytical techniques (e.g., NMR, LC-MS, HPLC).
  • Evaluate the biological activity and pharmacokinetic properties of synthesized molecules.
  • Collaborate effectively with biologists, pharmacologists, and computational chemists.
  • Analyze and interpret experimental data to guide iterative design cycles.
  • Troubleshoot synthetic challenges and develop innovative solutions.
  • Maintain detailed and accurate laboratory notebooks and research reports.
  • Stay current with the latest advancements in medicinal chemistry and drug discovery.
  • Present research findings at internal project meetings and scientific conferences.
  • Contribute to patent applications and scientific publications.
Qualifications:
  • PhD in Organic Chemistry or Medicinal Chemistry.
  • Minimum of 5 years of post-doctoral or industry experience in drug discovery.
  • Demonstrated expertise in synthetic organic chemistry and medicinal chemistry principles.
  • Proven ability to design and synthesize novel small molecules with desired biological activities.
  • Strong understanding of SAR and SPR for lead optimization.
  • Proficiency with spectroscopic and chromatographic analytical techniques.
  • Experience with computational chemistry software (e.g., Schrodinger, ChemDraw) is a plus.
  • Excellent problem-solving, critical thinking, and experimental design skills.
  • Strong written and verbal communication abilities, suitable for a remote scientific environment.
  • Ability to work independently and as part of a collaborative, distributed team.
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Senior Pharmaceutical Research Scientist - Drug Discovery

SW1A 0AA London, London £65000 Annually WhatJobs

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full-time
Our client, a leading global pharmaceutical company, is seeking a highly motivated and experienced Senior Pharmaceutical Research Scientist to join their dynamic drug discovery team. This role offers a hybrid working model, allowing for remote work combined with essential on-site laboratory presence at our facilities in London, England, UK . The successful candidate will play a critical role in identifying and validating novel drug targets, designing and synthesizing new chemical entities, and advancing lead compounds through the preclinical pipeline. You will be expected to contribute to innovative research strategies and lead scientific projects.

Key responsibilities include designing and executing complex biological assays, performing medicinal chemistry synthesis, and utilizing cutting-edge analytical techniques to characterize potential drug candidates. You will collaborate closely with cross-functional teams, including biologists, pharmacologists, and clinical development specialists, to ensure seamless progression of research programs. The ideal candidate will possess a Ph.D. in Organic Chemistry, Medicinal Chemistry, Pharmacology, or a related discipline, with a strong publication record and a proven track record in small molecule drug discovery. Excellent problem-solving skills, a meticulous approach to experimental design, and strong written and verbal communication abilities are essential. Experience with computational chemistry tools and structure-based drug design is highly desirable. This is an exceptional opportunity for a talented scientist to contribute to the development of life-changing medicines.

Responsibilities:
  • Lead research projects focused on the discovery and development of novel therapeutic agents.
  • Design, synthesize, and characterize small molecule drug candidates.
  • Develop and optimize biological assays for target validation and compound screening.
  • Perform in vitro and in vivo studies to evaluate drug efficacy and pharmacokinetics.
  • Collaborate with biologists, pharmacologists, and chemists to advance drug discovery programs.
  • Analyze and interpret experimental data, and present findings to internal stakeholders and at scientific conferences.
  • Contribute to the development of scientific strategy and identify new research opportunities.
  • Maintain detailed laboratory notebooks and prepare research reports.
  • Ensure compliance with all safety regulations and laboratory procedures.
  • Mentor junior scientists and contribute to team development.

Qualifications:
  • Ph.D. in Organic Chemistry, Medicinal Chemistry, Pharmacology, or a related field.
  • Minimum of 5 years of post-doctoral or industry experience in pharmaceutical drug discovery.
  • Proven track record in small molecule drug discovery, with a focus on medicinal chemistry.
  • Extensive experience with synthetic organic chemistry techniques and structure elucidation (NMR, Mass Spectrometry).
  • Proficiency in designing and performing a variety of biological assays.
  • Familiarity with DMPK, toxicology, and preclinical development processes.
  • Strong understanding of drug discovery principles and modern medicinal chemistry approaches.
  • Excellent analytical, problem-solving, and critical thinking skills.
  • Strong written and verbal communication skills, with a record of scientific publications.
  • Ability to work effectively in a hybrid remote and lab-based environment.
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Senior Pharmaceutical Research Scientist (Drug Discovery)

SW1A 0AA London, London £75000 Annually WhatJobs

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full-time
Our client, a leading force in innovative pharmaceutical development, is seeking a highly skilled and motivated Senior Pharmaceutical Research Scientist to join their cutting-edge drug discovery team. This is a fully remote, permanent position, offering unparalleled flexibility and the opportunity to contribute to life-changing therapies from the comfort of your home. The successful candidate will play a pivotal role in identifying and validating novel therapeutic targets, designing and executing complex biological assays, and analyzing experimental data to drive research projects forward. You will collaborate closely with cross-functional teams, including medicinal chemists, pharmacologists, and toxicologists, to advance drug candidates through the preclinical pipeline. Responsibilities include developing and optimizing in vitro and ex vivo models, performing high-throughput screening, troubleshooting experimental issues, and maintaining meticulous records of all research activities. We are looking for an individual with a deep understanding of disease biology, strong analytical and problem-solving skills, and a proven track record in pharmaceutical R&D. Exceptional written and verbal communication skills are essential for presenting findings to internal stakeholders and contributing to scientific publications and patent applications. This role requires a proactive approach, the ability to work independently, and a passion for scientific excellence in the pursuit of new medicines. Experience with molecular biology techniques, cell culture, primary cell isolation, and various analytical methods such as ELISA, Western blotting, and flow cytometry is highly desirable. A PhD in a relevant life science discipline (e.g., Pharmacology, Biochemistry, Molecular Biology, Immunology) or a Master's degree with equivalent substantial experience is required. Join a dynamic and collaborative environment where your contributions will directly impact the future of healthcare. This role offers a competitive salary, comprehensive benefits package, and the chance to work on exciting, high-impact projects. If you are a driven scientist looking to make a significant difference in drug discovery, we encourage you to apply.
Location: London, England, UK
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Principal Pharmaceutical Research Scientist (Drug Discovery)

WC1A 0AA London, London £70000 annum + bon WhatJobs

Posted 2 days ago

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Job Description

full-time
Our client, a leading global pharmaceutical company with a significant research and development presence in **London, England, UK**, is seeking a highly accomplished Principal Pharmaceutical Research Scientist to join their innovative Drug Discovery team. This hybrid role offers the chance to work on cutting-edge research projects, contributing to the development of novel therapeutics, with a blend of on-site laboratory work and remote data analysis and collaboration. You will lead and mentor research scientists, drive project strategy, and contribute to the advancement of the company's drug pipeline. Responsibilities include designing and executing complex experimental studies, interpreting data, and making critical decisions to move projects forward. You will stay abreast of the latest scientific advancements in relevant therapeutic areas and technologies, and represent the company at scientific conferences. Collaboration with internal and external partners, including academic institutions and contract research organizations, will be a key aspect of the role. The ideal candidate will hold a Ph.D. in a relevant scientific discipline (e.g., Pharmacology, Biochemistry, Molecular Biology) with a minimum of 8-10 years of post-doctoral research experience in the pharmaceutical industry, specifically focused on drug discovery. A strong publication record and a history of successful project leadership are essential. Expertise in specific therapeutic areas or modalities (e.g., oncology, neuroscience, small molecules, biologics) is highly desirable. Excellent analytical, problem-solving, and communication skills are required, along with the ability to lead multidisciplinary teams effectively. Experience with assay development, high-throughput screening, and preclinical development is also valued. This is a career-defining opportunity to make a substantial impact on human health by discovering and developing life-changing medicines.
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Remote Pharmaceutical Research Scientist

SW1A 0AA London, London £60000 Annually WhatJobs

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full-time
Our client, a leading pharmaceutical company, is seeking a talented and dedicated Pharmaceutical Research Scientist to join their innovative drug discovery team. This is a fully remote position, enabling you to contribute to cutting-edge research from the comfort of your home. You will be responsible for designing and conducting experiments, analysing data, and contributing to the development of novel therapeutics. The ideal candidate will possess a strong background in pharmaceutical sciences, excellent experimental skills, and a passion for scientific advancement.

Responsibilities:
  • Design, optimise, and execute complex in vitro and in vivo experimental assays to evaluate drug candidates.
  • Analyse and interpret experimental data, applying statistical methods and drawing meaningful conclusions.
  • Contribute to the development of new drug discovery strategies and research programs.
  • Maintain detailed laboratory notebooks and records of experimental procedures and results.
  • Prepare scientific reports, presentations, and publications for internal and external dissemination.
  • Collaborate effectively with a multidisciplinary team of scientists, chemists, and biologists.
  • Stay up-to-date with the latest scientific literature and technological advancements in pharmaceutical research.
  • Troubleshoot experimental issues and develop alternative approaches when necessary.
  • Contribute to intellectual property generation through the identification of novel drug targets and lead compounds.
  • Ensure compliance with all relevant regulatory guidelines and safety protocols.
  • Present research findings at internal meetings and potentially at scientific conferences.
  • Assist in the management of research supplies and reagents.
Qualifications:
  • PhD or a Master's degree in Pharmacology, Pharmaceutical Sciences, Biology, Biochemistry, or a closely related field.
  • Minimum of 5 years of post-doctoral or industry research experience in drug discovery or a related area.
  • Proven expertise in a specific area of pharmaceutical research (e.g., oncology, immunology, neuroscience).
  • Extensive experience with a range of experimental techniques relevant to drug discovery.
  • Strong understanding of molecular and cellular biology, pharmacology, and pharmacokinetics.
  • Demonstrated ability to design, execute, and interpret complex experiments.
  • Excellent data analysis, statistical interpretation, and report-writing skills.
  • Strong written and verbal communication skills, essential for remote collaboration.
  • Ability to work independently with minimal supervision and as part of a collaborative research team.
  • Proficiency in relevant scientific software and databases.
  • A proactive and curious mindset with a genuine passion for scientific discovery and a commitment to producing high-quality research.
This is an exceptional opportunity for a skilled Pharmaceutical Research Scientist to contribute significantly to the development of life-changing medicines, working remotely to support our operations connected to London, England, UK . If you are driven by scientific excellence and innovation, we encourage you to apply.
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Remote Senior Pharmaceutical Research Scientist

SW1A 0AA London, London £75000 Annually WhatJobs

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full-time
Our client, a leading pharmaceutical innovator, is seeking an experienced and visionary Senior Pharmaceutical Research Scientist to join their fully remote research and development division. This position offers an exceptional opportunity to contribute to cutting-edge drug discovery and development from a remote setting, driving forward novel therapeutic solutions. The ideal candidate will possess a strong scientific background, extensive experience in pharmaceutical research, and the ability to lead complex projects with minimal supervision. This role demands scientific rigor, strategic thinking, and a passion for advancing healthcare. Key Responsibilities:
  • Lead and execute complex research projects focused on the discovery and development of novel pharmaceutical agents.
  • Design and conduct experiments, analyze data, and interpret results to advance drug candidate pipelines.
  • Develop and validate new assays and methodologies relevant to drug discovery and preclinical development.
  • Stay abreast of the latest scientific literature, technological advancements, and therapeutic trends in the pharmaceutical industry.
  • Collaborate effectively with internal cross-functional teams (e.g., chemistry, biology, toxicology) and external partners.
  • Mentor and guide junior scientists, fostering a collaborative and innovative research environment.
  • Prepare high-quality scientific reports, publications, and patent applications.
  • Contribute to the strategic planning and direction of the R&D department's research initiatives.
  • Ensure compliance with all relevant regulatory guidelines, laboratory safety standards, and ethical principles.
  • Manage research budgets and resources efficiently to achieve project milestones.
  • Present research findings at scientific conferences and internal meetings.
Qualifications:
  • Ph.D. in Pharmacology, Medicinal Chemistry, Biochemistry, Molecular Biology, or a closely related discipline.
  • Extensive postdoctoral experience and a strong track record of publications in peer-reviewed journals and/or patents in the pharmaceutical industry.
  • Proven experience in drug discovery and development, with a deep understanding of relevant therapeutic areas and mechanisms of action.
  • Expertise in designing, executing, and interpreting a range of experimental approaches relevant to pharmaceutical research.
  • Strong analytical and problem-solving skills, with the ability to think critically and creatively.
  • Excellent written and verbal communication skills, with the ability to clearly articulate complex scientific findings.
  • Experience with relevant scientific software and data analysis tools.
  • Demonstrated ability to lead research projects and work effectively within a collaborative team.
  • Self-motivated with the ability to work independently and manage time effectively in a fully remote environment.
This is a premier opportunity for a talented research scientist to significantly impact the future of medicine while enjoying the flexibility of remote work. If you are driven by scientific excellence and a desire to improve patient outcomes, we encourage you to apply and join our world-class team from your home office.
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Senior Pharmaceutical Research Scientist - Oncology

EC1A 1BB London, London £75000 Annually WhatJobs

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full-time
Our client, a leading innovator in drug discovery, is seeking a highly motivated and experienced Senior Pharmaceutical Research Scientist to join their cutting-edge oncology research team. This role is fully remote, offering you the flexibility to contribute from anywhere within the UK.

As a Senior Pharmaceutical Research Scientist, you will be instrumental in driving forward novel therapeutic strategies for cancer treatment. Your primary responsibilities will include designing and executing complex experiments, analyzing vast datasets, and contributing to the development of pre-clinical and clinical candidates. You will work collaboratively with cross-functional teams, including medicinal chemists, biologists, pharmacologists, and clinical development professionals, to advance projects from early discovery through to IND filing.

Key Responsibilities:
  • Lead the design, execution, and interpretation of in vitro and in vivo experiments to assess the efficacy and safety of novel oncology drug candidates.
  • Develop and validate assays for target engagement, mechanism of action, and drug response.
  • Analyze and interpret complex biological and pharmacological data using statistical software and bioinformatics tools.
  • Stay abreast of the latest scientific literature and technological advancements in oncology drug discovery.
  • Contribute to the preparation of scientific publications, patents, and regulatory submissions.
  • Mentor junior scientists and contribute to a positive and collaborative research environment.
  • Effectively communicate research findings to internal stakeholders and at external scientific conferences.
  • Manage project timelines and resources effectively to meet research milestones.
  • Ensure all research activities are conducted in compliance with ethical standards and company policies.
Qualifications:
  • Ph.D. in Molecular Biology, Pharmacology, Immunology, or a related life science discipline.
  • Minimum of 5-7 years of post-doctoral or industry experience in oncology drug discovery.
  • Proven track record in designing and implementing complex biological assays.
  • Strong understanding of cancer biology, immunology, and relevant signaling pathways.
  • Proficiency in data analysis and statistical interpretation.
  • Excellent written and verbal communication skills, with experience in preparing scientific reports and presentations.
  • Demonstrated ability to work independently and as part of a collaborative team in a remote setting.
  • Experience with preclinical models of cancer is highly desirable.
This is an exceptional opportunity to make a significant impact in the fight against cancer within a dynamic and supportive remote work environment. Our client is committed to fostering scientific excellence and professional growth. The position is based in London, England, UK .
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Principal Pharmaceutical Research Scientist (Remote)

SW1A 0AA London, London £80000 Annually WhatJobs

Posted 1 day ago

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full-time
Our client, a leading pharmaceutical innovator, is seeking a distinguished Principal Pharmaceutical Research Scientist to spearhead groundbreaking research and development initiatives. This is a fully remote position, offering the unique opportunity to contribute significantly to drug discovery and development from your home-based laboratory or study. You will be at the forefront of identifying and validating novel therapeutic targets, designing and synthesizing potential drug candidates, and advancing preclinical development programs. The ideal candidate will possess a Ph.D. in Pharmacology, Medicinal Chemistry, Biochemistry, or a closely related field, with a minimum of 10 years of progressive experience in the pharmaceutical industry. Your expertise should encompass a deep understanding of disease mechanisms, drug discovery pipelines, and various therapeutic modalities. Responsibilities include designing and executing complex research projects, interpreting experimental data, and leading cross-functional research teams. You will be responsible for contributing to intellectual property generation, preparing scientific publications, and presenting research findings at international conferences. Experience with modern drug discovery technologies, such as high-throughput screening, fragment-based drug discovery, or structure-based drug design, is highly advantageous. You must possess exceptional analytical, problem-solving, and critical thinking skills, coupled with a strong publication record. Excellent communication, leadership, and interpersonal skills are essential for collaborating effectively with internal teams, external academic collaborators, and contract research organizations (CROs) in a virtual setting. This role requires a visionary scientist with a passion for translating scientific discoveries into life-changing medicines. If you are a seasoned researcher looking to make a profound impact on global health through innovative drug development, we invite you to apply.

Key Responsibilities:
  • Lead the design and execution of pharmaceutical research projects.
  • Identify and validate novel therapeutic targets.
  • Design and synthesize potential drug candidates.
  • Oversee preclinical development and characterization of lead compounds.
  • Analyze and interpret complex biological and chemical data.
  • Contribute to patent filings and scientific publications.
  • Present research findings to internal and external stakeholders.
  • Collaborate with cross-functional teams and external partners.
  • Mentor junior scientists and foster scientific excellence.
  • Stay abreast of cutting-edge research and technologies in drug discovery.

Qualifications:
  • Ph.D. in Pharmacology, Medicinal Chemistry, Biochemistry, or a related life science discipline.
  • 10+ years of relevant experience in pharmaceutical R&D.
  • Proven track record in drug discovery and development.
  • Expertise in one or more therapeutic areas or modalities.
  • Strong understanding of molecular biology, biochemistry, and pharmacology.
  • Experience with modern drug discovery techniques.
  • Excellent analytical, problem-solving, and critical thinking skills.
  • Exceptional communication, leadership, and presentation skills.
  • Demonstrated ability to publish in high-impact journals.
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Principal Pharmaceutical Research Scientist (Remote)

SW1A 0AA London, London £80000 Annually WhatJobs

Posted 1 day ago

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full-time
Our client, a leading innovator in the pharmaceutical industry, is seeking a highly accomplished Principal Pharmaceutical Research Scientist to spearhead groundbreaking research initiatives. This is a fully remote position, offering the flexibility to contribute significantly from your home base anywhere within the UK. You will be at the forefront of drug discovery and development, focusing on novel therapeutic agents and innovative treatment modalities. The ideal candidate will possess a deep and expansive knowledge of pharmaceutical sciences, including medicinal chemistry, pharmacology, drug metabolism, and pharmacokinetics (DMPK), and pre-clinical development. You will have a distinguished track record of scientific achievement, evidenced by publications, patents, and successful contributions to drug candidates advancing into clinical trials. Responsibilities include designing and executing complex research projects, developing and validating new assays, leading scientific teams, mentoring junior scientists, critically evaluating experimental data, and preparing comprehensive research reports and regulatory submissions. This role demands exceptional problem-solving abilities, a rigorous scientific approach, and the capacity to think creatively and strategically about therapeutic challenges. You will collaborate closely with internal cross-functional teams (e.g., toxicology, clinical development, regulatory affairs) and external partners, including academic institutions and contract research organizations (CROs). Proficiency in state-of-the-art research technologies and methodologies, along with a strong understanding of regulatory requirements (e.g., FDA, EMA), is essential. This is an unparalleled opportunity for a senior scientist to make a profound impact on patient lives by driving the development of next-generation medicines.

Key Responsibilities:
  • Lead and conduct cutting-edge research in drug discovery and development.
  • Design, execute, and interpret complex experiments to identify and validate novel drug targets and candidates.
  • Develop and implement innovative scientific methodologies and assays.
  • Provide scientific leadership and mentorship to research teams.
  • Critically analyze data, draw sound conclusions, and make informed recommendations.
  • Author high-quality scientific publications, patents, and regulatory documents.
  • Collaborate effectively with internal and external stakeholders, including CROs and academic collaborators.
  • Stay abreast of the latest scientific advancements and therapeutic trends in relevant disease areas.
  • Contribute to the strategic planning and direction of the R&D pipeline.

Qualifications:
  • PhD in Pharmacology, Medicinal Chemistry, Biochemistry, or a related life science discipline.
  • Minimum of 8-10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry.
  • Proven track record of scientific innovation and leadership, with significant contributions to drug discovery programs.
  • Extensive experience in experimental design, data analysis, and interpretation.
  • Strong publication record and/or patent portfolio.
  • Excellent understanding of DMPK, toxicology, and early clinical development principles.
  • Proficiency with relevant scientific software and instrumentation.
  • Exceptional communication, presentation, and interpersonal skills.
  • Ability to work independently and drive projects forward in a remote setting.
This is a premier opportunity to join a world-class research organization and influence the future of medicine.
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