5 Medicinal Chemist jobs in London
Principal Medicinal Chemist
W1U 6DL London, London
£70000 Annually
WhatJobs
Posted 18 days ago
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Job Description
Our client, a renowned pharmaceutical company dedicated to discovering life-saving therapeutics, is looking for a Principal Medicinal Chemist to join their innovative drug discovery team based in London, England, UK . This senior role is integral to designing, synthesising, and optimising novel drug candidates. You will leverage your deep expertise in organic chemistry and drug design principles to drive projects from hit identification through to lead optimisation. This hybrid role offers a balance of cutting-edge laboratory work and flexible remote engagement.
Responsibilities:
Responsibilities:
- Design and synthesise novel small molecules with desired pharmacological properties, targeting key disease pathways.
- Optimise lead compounds for potency, selectivity, ADME properties, and safety profiles.
- Develop and implement synthetic routes for complex organic molecules, troubleshooting synthetic challenges.
- Collaborate closely with biologists, pharmacologists, and DMPK scientists to define structure-activity relationships (SAR) and structure-property relationships (SPR).
- Utilise computational chemistry tools and databases to guide compound design and strategy.
- Manage external synthesis activities with Contract Research Organisations (CROs).
- Plan and execute multi-step synthesis projects, ensuring timely delivery of high-quality compounds.
- Interpret analytical data (NMR, LC-MS, HPLC) to confirm compound identity and purity.
- Stay current with advances in medicinal chemistry, synthetic methodology, and drug discovery technologies.
- Contribute to the strategic direction of drug discovery programmes and mentor junior chemists.
- Ph.D. in Organic or Medicinal Chemistry from a reputable institution.
- A minimum of 5-8 years of post-doctoral experience in medicinal chemistry within the pharmaceutical or biotechnology industry.
- Proven track record of successfully contributing to the discovery and optimisation of drug candidates.
- Extensive experience in modern synthetic organic chemistry techniques and instrumentation.
- Strong understanding of drug discovery principles, ADME/Tox properties, and bioassays.
- Proficiency in using chemical drawing and modelling software.
- Excellent analytical, problem-solving, and critical thinking skills.
- Strong communication and teamwork abilities, with experience working in multidisciplinary teams.
- Ability to manage multiple projects simultaneously and prioritise effectively.
- Familiarity with both in-lab and remote collaboration tools.
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Principal Medicinal Chemist - Drug Discovery
SW1A 0AA London, London
£75000 Annually
WhatJobs
Posted 14 days ago
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Job Description
Our client, a leading pharmaceutical research company based in London, England, UK , is seeking a highly accomplished Principal Medicinal Chemist to drive innovation in drug discovery. This critical, on-site role involves leading and executing cutting-edge medicinal chemistry programs aimed at identifying and optimizing novel therapeutic agents. The ideal candidate will possess a PhD in Organic Chemistry or Medicinal Chemistry, coupled with extensive hands-on experience in the design, synthesis, and characterization of small molecule drug candidates. You will be responsible for strategizing and guiding synthetic efforts, employing structure-activity relationship (SAR) analysis, and utilizing computational chemistry tools to accelerate lead optimization. This position demands exceptional scientific acumen, a deep understanding of drug discovery principles, and proven leadership skills. You will mentor junior chemists, contribute to project strategy, and collaborate effectively with biologists, pharmacologists, and other cross-functional teams. A strong publication record and experience in managing external collaborations are highly desirable. We are looking for an individual with a proven track record of delivering successful drug candidates into preclinical and clinical development, who is passionate about discovering life-changing medicines and eager to contribute to a world-class research environment. Your expertise in synthetic organic chemistry, heterocyclic chemistry, and a broad knowledge of therapeutic areas will be essential. This is an unparalleled opportunity to make a significant impact on the future of pharmaceutical innovation within a highly collaborative and dynamic research setting. The scope of this role includes setting scientific direction, managing research projects, and contributing to the intellectual property portfolio.
Responsibilities:
Responsibilities:
- Lead medicinal chemistry efforts for drug discovery programs.
- Design and synthesize novel small molecules with therapeutic potential.
- Conduct SAR studies and optimize lead compounds for potency, selectivity, and ADME properties.
- Utilize computational chemistry tools and databases for molecular design.
- Collaborate with biologists and pharmacologists to advance drug candidates.
- Mentor and supervise junior medicinal chemists.
- Develop and execute synthetic routes for complex molecules.
- Evaluate and implement new synthetic methodologies.
- Contribute to project strategy and intellectual property generation.
- Present research findings at internal meetings and external conferences.
- PhD in Organic Chemistry, Medicinal Chemistry, or a closely related field.
- Minimum of 8 years of post-doctoral experience in medicinal chemistry within the pharmaceutical industry or biotech.
- Demonstrated expertise in small molecule drug design and synthesis.
- Strong understanding of SAR, ADMET properties, and drug discovery processes.
- Proficiency in modern synthetic organic chemistry techniques.
- Experience with computational chemistry and molecular modelling tools.
- Excellent problem-solving and analytical skills.
- Proven leadership and team management abilities.
- Strong written and verbal communication skills.
- Eligibility to work in the UK.
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1
Principal Medicinal Chemist - Drug Discovery
SW1A 0AA London, London
£75000 annum + bon
WhatJobs
Posted 17 days ago
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Job Description
Our client, a pioneering pharmaceutical company based in London, England , is seeking an innovative and highly experienced Principal Medicinal Chemist to join their dynamic Drug Discovery team. This hybrid role requires a deep understanding of modern medicinal chemistry principles, synthetic organic chemistry, and drug design strategies to drive the discovery of novel therapeutics. You will lead complex synthesis projects, mentor junior chemists, and collaborate closely with biologists, pharmacologists, and other cross-functional teams. The ideal candidate will have a proven track record of contributing to successful drug discovery programs and a passion for translating scientific insights into potential medicines. This position offers a blend of laboratory-based work and strategic remote contributions.
Key Responsibilities:
Key Responsibilities:
- Design, synthesize, and optimize novel small molecules with desired biological activity and drug-like properties.
- Lead medicinal chemistry efforts within assigned drug discovery projects, setting strategic directions.
- Utilize structure-activity relationship (SAR) and structure-property relationship (SPR) analysis to guide compound design.
- Collaborate closely with computational chemists to leverage in silico design tools and strategies.
- Work with biologists and pharmacologists to design and interpret in vitro and in vivo assays.
- Manage synthetic chemistry efforts, including route scouting, optimization, and troubleshooting.
- Ensure the timely delivery of high-quality compounds for biological testing.
- Maintain accurate and detailed laboratory notebooks and contribute to scientific publications and patent applications.
- Mentor and guide junior medicinal chemists, fostering their scientific and professional development.
- Stay abreast of the latest advancements in medicinal chemistry, synthetic methodologies, and relevant therapeutic areas.
- Contribute to project strategy meetings and present research findings to senior management and scientific committees.
- Ensure compliance with laboratory safety protocols and ethical standards.
- Ph.D. in Medicinal Chemistry, Synthetic Organic Chemistry, or a closely related field.
- Extensive experience (typically 8+ years post-Ph.D.) in medicinal chemistry within the pharmaceutical or biotechnology industry.
- Demonstrated success in contributing to multiple drug discovery programs, with a strong understanding of the discovery process.
- Expertise in modern synthetic organic chemistry techniques and analytical methods (NMR, MS, HPLC).
- Proficiency in computational chemistry tools and SAR/SPR analysis.
- Excellent understanding of ADMET properties and their impact on drug development.
- Strong problem-solving, critical thinking, and communication skills.
- Ability to work effectively in a collaborative, multi-disciplinary team environment.
- Experience mentoring junior scientists is highly desirable.
- Willingness to travel to the London site for key meetings and laboratory work as required.
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2
Senior Medicinal Chemist - Drug Discovery
WC2B 5HN London, London
£70000 Annually
WhatJobs
Posted 22 days ago
Job Viewed
Job Description
Our client, a leading pharmaceutical research company dedicated to the discovery of life-changing therapeutics, is seeking an accomplished Senior Medicinal Chemist to join their innovative, fully remote R&D team. This role is critical in designing and synthesizing novel small molecules with the potential to become new medicines. You will be at the forefront of hit-to-lead and lead optimization campaigns, contributing significantly to the drug discovery pipeline. Responsibilities include the design of target molecules using retrosynthetic analysis, planning and executing multi-step syntheses, purifying and characterizing synthesized compounds using modern analytical techniques (NMR, LC-MS), and evaluating the biological activity of synthesized compounds in collaboration with biologists. The ideal candidate will possess a PhD in Organic or Medicinal Chemistry, coupled with a strong track record of successfully contributing to drug discovery programs in an industry setting. Expertise in synthetic organic chemistry, including diverse reaction methodologies and stereoselective synthesis, is paramount. A deep understanding of structure-activity relationships (SAR) and structure-property relationships (SPR) is essential. You will be adept at utilizing computational chemistry tools for molecule design and analysis, and possess excellent problem-solving skills to overcome synthetic challenges. This is a remote-first position, allowing you to contribute your expertise from anywhere within the UK and collaborate virtually with a world-class team of scientists.
Key Responsibilities:
Key Responsibilities:
- Design novel small molecule drug candidates based on biological targets and SAR data.
- Plan and execute complex synthetic routes for the preparation of target compounds.
- Optimize synthetic methodologies to improve yield, purity, and scalability.
- Characterize synthesized compounds using advanced analytical techniques (e.g., NMR, LC-MS, HPLC).
- Evaluate the biological activity and pharmacokinetic properties of synthesized molecules.
- Collaborate effectively with biologists, pharmacologists, and computational chemists.
- Analyze and interpret experimental data to guide iterative design cycles.
- Troubleshoot synthetic challenges and develop innovative solutions.
- Maintain detailed and accurate laboratory notebooks and research reports.
- Stay current with the latest advancements in medicinal chemistry and drug discovery.
- Present research findings at internal project meetings and scientific conferences.
- Contribute to patent applications and scientific publications.
- PhD in Organic Chemistry or Medicinal Chemistry.
- Minimum of 5 years of post-doctoral or industry experience in drug discovery.
- Demonstrated expertise in synthetic organic chemistry and medicinal chemistry principles.
- Proven ability to design and synthesize novel small molecules with desired biological activities.
- Strong understanding of SAR and SPR for lead optimization.
- Proficiency with spectroscopic and chromatographic analytical techniques.
- Experience with computational chemistry software (e.g., Schrodinger, ChemDraw) is a plus.
- Excellent problem-solving, critical thinking, and experimental design skills.
- Strong written and verbal communication abilities, suitable for a remote scientific environment.
- Ability to work independently and as part of a collaborative, distributed team.
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3
Lead Process Chemist - Pharmaceutical Manufacturing
SW1A 0AA London, London
£70000 Annually
WhatJobs
Posted 1 day ago
Job Viewed
Job Description
Our client, a globally recognized pharmaceutical company, is seeking an experienced Lead Process Chemist to join their innovative research and development division in London, England, UK . This role operates on a hybrid model, offering a flexible work arrangement. The Lead Process Chemist will be responsible for the development, optimization, and scale-up of chemical processes for novel drug substances. You will play a crucial role in translating laboratory-scale synthesis into robust, efficient, and safe manufacturing processes. Key duties include designing and executing experiments, performing process hazard analyses, troubleshooting manufacturing issues, and ensuring compliance with GMP regulations. The ideal candidate will possess a strong background in organic chemistry, process chemistry, and chemical engineering principles. Experience with analytical techniques (HPLC, GC, MS) and process analytical technology (PAT) is essential. You should have a proven ability to lead projects, mentor junior chemists, and collaborate effectively with cross-functional teams including manufacturing, quality assurance, and regulatory affairs. Strong problem-solving skills, attention to detail, and excellent documentation practices are required. This position offers an exciting opportunity to contribute to the development of life-saving medicines and advance your career within a leading pharmaceutical organization. We are looking for a strategic thinker with a passion for chemical process innovation and a commitment to scientific excellence.
Key Responsibilities:
Key Responsibilities:
- Lead the development and optimization of chemical synthesis processes.
- Scale-up processes from laboratory to pilot plant and commercial manufacturing.
- Perform process hazard assessments (PHA) and safety reviews.
- Troubleshoot and resolve process-related issues during manufacturing campaigns.
- Ensure all processes comply with Good Manufacturing Practices (GMP) and regulatory guidelines.
- Develop and validate analytical methods for process monitoring.
- Write comprehensive process development reports and documentation.
- Mentor and provide technical guidance to junior chemists and technicians.
- Collaborate with manufacturing, QA, and regulatory affairs teams.
- Ph.D. or Master's degree in Organic Chemistry, Process Chemistry, Chemical Engineering, or a related field.
- 5-7 years of experience in pharmaceutical process development.
- Strong knowledge of synthetic organic chemistry and reaction mechanisms.
- Expertise in process optimization, scale-up, and technology transfer.
- Experience with GMP, ICH guidelines, and regulatory submissions.
- Proficiency in analytical techniques (HPLC, GC, MS, NMR).
- Excellent leadership, communication, and interpersonal skills.
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