157 Medicinal Chemist jobs in the United Kingdom
Lead Medicinal Chemist
Posted 1 day ago
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In this vital position, you will lead multi-disciplinary project teams, fostering collaboration between chemists, biologists, pharmacologists, and DMPK scientists. Your responsibilities will include setting strategic research directions, defining key chemical objectives, and overseeing the execution of synthesis plans to generate diverse and targeted compound libraries. You will play a key role in interpreting complex biological and chemical data, making critical decisions regarding compound progression, and identifying potential liabilities. The Lead Medicinal Chemist will be responsible for mentoring junior chemists, providing expert guidance on synthetic methodologies, analytical techniques, and SAR exploration. You will also contribute to the company's intellectual property strategy by identifying and documenting novel chemical entities. A significant portion of your time will involve staying abreast of the latest scientific literature, emerging technologies, and industry trends in drug discovery. This role offers a unique opportunity to make a significant impact on the development of life-saving medicines. The hybrid nature of this role allows for focused laboratory work and team collaboration on-site, complemented by the flexibility of remote work for data analysis, literature review, and strategic planning.
Qualifications:
- PhD in Organic Chemistry or Medicinal Chemistry from a reputable institution.
- Minimum of 10 years of relevant industry experience in medicinal chemistry within the pharmaceutical or biotech sector.
- Proven track record of successfully designing and synthesising novel small molecules with desirable pharmacological properties.
- Deep understanding of drug discovery processes, including target identification, hit-to-lead optimisation, and lead optimisation.
- Extensive experience with modern synthetic organic chemistry techniques and analytical methods (NMR, LC-MS, HPLC).
- Strong knowledge of SAR, ADMET properties, and computational chemistry tools.
- Demonstrated ability to lead and mentor scientific teams effectively.
- Excellent communication, presentation, and interpersonal skills.
- Experience in project management and managing external collaborations is a plus.
- Publication record in high-impact peer-reviewed journals.
Senior Medicinal Chemist
Posted 1 day ago
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Responsibilities:
- Design and synthesize novel small molecules for therapeutic targets.
- Optimize lead compounds to improve potency, selectivity, and pharmacokinetic properties.
- Characterize synthesized compounds using modern analytical techniques (NMR, MS, HPLC).
- Develop and implement efficient synthetic routes.
- Collaborate with biologists, pharmacologists, and other scientists to advance drug discovery projects.
- Interpret SAR data and guide future compound design.
- Contribute to patent filings and scientific publications.
- Maintain accurate laboratory notebooks and experimental records.
- Stay current with the latest advances in medicinal chemistry and drug discovery.
Qualifications:
- PhD in Organic Chemistry, Medicinal Chemistry, or a related field.
- Minimum of 5 years of post-doctoral or industrial experience in medicinal chemistry.
- Proven track record of successful compound design and synthesis.
- Extensive knowledge of organic synthesis and reaction mechanisms.
- Experience with analytical techniques such as NMR, MS, and HPLC.
- Familiarity with SAR analysis and drug discovery processes.
- Strong problem-solving skills and ability to work independently and as part of a team.
- Excellent written and oral communication skills.
Principal Medicinal Chemist
Posted 1 day ago
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Job Description
As a Principal Medicinal Chemist, you will play a crucial role in the design, synthesis, and optimization of novel drug candidates for various therapeutic indications. You will lead key medicinal chemistry projects, guiding synthetic strategies, interpreting structure-activity relationships (SAR), and driving the progression of compounds from lead identification through to preclinical development. This role requires a deep understanding of organic synthesis, computational chemistry, and drug metabolism, along with a proven track record of successful project leadership. You will collaborate closely with biologists, pharmacologists, and other scientists to achieve ambitious research goals.
Key responsibilities will include:
- Designing and synthesizing novel small molecules with desired pharmacological profiles.
- Developing and executing multi-step synthetic routes for complex organic molecules.
- Interpreting SAR data and using it to iteratively optimize lead compounds.
- Collaborating with computational chemists to guide structure-based drug design efforts.
- Working closely with biologists and pharmacologists to assess compound efficacy and safety profiles.
- Managing multiple medicinal chemistry projects concurrently, setting priorities and timelines.
- Mentoring junior chemists and contributing to a high-performance research culture.
- Troubleshooting synthetic challenges and developing innovative solutions.
- Keeping abreast of the latest advances in medicinal chemistry, organic synthesis, and drug discovery.
- Preparing scientific reports, presentations, and contributing to patent applications.
Principal Medicinal Chemist
Posted 1 day ago
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Job Description
Key Responsibilities:
- Lead and manage medicinal chemistry efforts within designated drug discovery projects, from hit identification through to lead optimisation.
- Design and synthesise novel chemical entities with desired pharmacological properties, utilising modern synthetic methodologies.
- Interpret and integrate complex biological, pharmacokinetic, and physicochemical data to guide the design of new molecules.
- Conduct thorough SAR studies and develop robust strategies for optimising potency, selectivity, metabolic stability, and other key drug-like properties.
- Collaborate extensively with biologists, pharmacologists, DMPK scientists, and other R&D teams to advance discovery projects.
- Supervise and mentor junior chemists, providing scientific guidance, training, and career development support.
- Maintain a comprehensive understanding of the relevant therapeutic area, competitive landscape, and emerging scientific trends.
- Prepare and present scientific findings at internal project meetings and external conferences.
- Author scientific publications and patent applications.
- Ensure all laboratory activities are conducted safely, efficiently, and in compliance with company policies and regulatory guidelines.
- Contribute to the strategic direction of the medicinal chemistry department and the wider R&D organisation.
- PhD in Organic Chemistry, Medicinal Chemistry, or a closely related field.
- A minimum of 8-10 years of hands-on experience in medicinal chemistry within the pharmaceutical or biotechnology industry.
- Demonstrated track record of successfully contributing to multiple drug discovery programmes that have progressed into clinical development.
- Extensive expertise in modern synthetic organic chemistry, including asymmetric synthesis and library design.
- Proven experience in SAR analysis, lead identification, and lead optimisation.
- Strong understanding of drug discovery principles, including pharmacokinetics, metabolism, and toxicology.
- Excellent problem-solving, analytical, and critical thinking skills.
- Exceptional written and verbal communication skills, with the ability to present complex scientific data clearly.
- Proven leadership capabilities and experience mentoring scientific staff.
- Experience with computational chemistry tools and techniques is a plus.
- Strong collaborative spirit and ability to work effectively in multidisciplinary teams.
Principal Medicinal Chemist
Posted 2 days ago
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Job Description
Key Responsibilities:
- Lead and execute complex synthetic chemistry projects focused on the discovery and development of novel drug candidates.
- Design and synthesize diverse libraries of small molecules targeting specific biological pathways.
- Utilize retrosynthetic analysis and advanced synthetic methodologies to efficiently prepare target compounds.
- Conduct structure-activity relationship (SAR) studies and iterative design-make-test-analyse cycles to optimize lead compounds.
- Interpret and troubleshoot experimental data, proposing scientifically sound solutions to synthetic challenges.
- Collaborate effectively with biologists, pharmacologists, and DMPK scientists to integrate medicinal chemistry efforts with broader drug discovery programs.
- Stay abreast of the latest advancements in medicinal chemistry, synthetic techniques, and relevant therapeutic areas.
- Mentor and guide junior chemists, fostering a collaborative and innovative research environment.
- Prepare high-quality scientific reports, presentations, and publications summarizing research findings.
- Contribute to intellectual property generation through patent filings.
- Ensure adherence to all laboratory safety protocols and ethical research standards.
- Manage external collaborations with CROs as needed.
- Ph.D. in Organic Chemistry, Medicinal Chemistry, or a related field.
- Minimum of 8 years of relevant postdoctoral and/or industry experience in medicinal chemistry, with a strong emphasis on small molecule drug discovery.
- Demonstrated expertise in modern synthetic organic chemistry, including complex multi-step synthesis.
- Proven experience in designing and optimizing drug-like molecules, including SAR exploration.
- Proficiency in data analysis, interpretation of spectroscopic data (NMR, MS), and chromatographic techniques.
- Experience with computational chemistry tools is a plus.
- Excellent understanding of drug discovery processes, pharmacology, and ADMET properties.
- Strong leadership, project management, and communication skills.
- Ability to work independently and effectively in a remote research setting.
- Publication record in peer-reviewed journals and/or patent filings.
Principal Medicinal Chemist
Posted 4 days ago
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Job Description
As a Principal Medicinal Chemist, you will lead and execute complex medicinal chemistry programs aimed at identifying and optimizing novel drug candidates. You will employ state-of-the-art synthetic organic chemistry techniques, computational chemistry tools, and structure-based drug design principles to develop compounds with desirable pharmacological profiles. Your expertise will be vital in driving projects from early-stage hit identification through to lead optimization and preclinical candidate selection.
Responsibilities:
- Lead and manage medicinal chemistry projects focused on the discovery of novel therapeutics for (Specific therapeutic area, e.g., oncology, infectious diseases).
- Design, synthesize, and characterize novel small molecules with potential therapeutic value.
- Utilize advanced synthetic organic chemistry techniques and troubleshoot complex synthetic challenges.
- Collaborate closely with biologists, pharmacologists, and other scientists to define structure-activity relationships (SAR) and optimize compound properties.
- Employ computational chemistry tools, molecular modeling, and structure-based drug design strategies.
- Develop and implement robust analytical methods for compound characterization and purity assessment (NMR, LC-MS, HPLC).
- Interpret and present experimental data at project team meetings and scientific conferences.
- Manage external collaborations with CROs and academic institutions.
- Mentor and guide junior chemists, fostering their scientific development.
- Stay abreast of the latest scientific literature and technological advancements in medicinal chemistry and drug discovery.
- Contribute to intellectual property generation through patent filings.
- Ph.D. in Organic Chemistry, Medicinal Chemistry, or a closely related field.
- Minimum of 8-10 years of post-doctoral experience in the pharmaceutical or biotechnology industry, with a strong track record in drug discovery.
- Extensive experience in synthetic organic chemistry, including multi-step synthesis and purification techniques.
- Proven ability to design and synthesize novel compounds for lead optimization.
- Proficiency in medicinal chemistry principles, SAR analysis, and ADMET property optimization.
- Experience with computational chemistry software and structure-based drug design.
- Excellent analytical skills and experience with standard analytical instrumentation (NMR, LC-MS, HPLC).
- Strong understanding of biological assays and drug discovery processes.
- Exceptional problem-solving abilities and creativity in chemical synthesis.
- Outstanding written and verbal communication skills, suitable for a remote work environment.
- Demonstrated ability to work independently and lead research programs.
Lead Medicinal Chemist
Posted 5 days ago
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Job Description
Key Responsibilities:
- Lead and manage medicinal chemistry projects from hit identification through lead optimization to candidate selection.
- Design and synthesize novel small molecule compounds with desirable pharmacological and pharmacokinetic properties.
- Collaborate closely with in-house and external biology, pharmacology, and DMPK teams to define project goals and SAR strategies.
- Oversee compound design using computational chemistry tools and SAR data.
- Troubleshoot synthetic routes and purification challenges, ensuring efficient and reproducible chemistry.
- Mentor and guide junior medicinal chemists, fostering their scientific development and contributing to team productivity.
- Manage external chemistry collaborations and CRO activities.
- Maintain detailed and accurate laboratory notebooks and prepare scientific reports and presentations.
- Stay current with advances in medicinal chemistry, synthetic methodology, and drug discovery technologies.
- Contribute to the intellectual property portfolio through invention disclosures and patent applications.
Qualifications:
- PhD in Medicinal Chemistry, Organic Chemistry, or a related field.
- Minimum of 7 years of experience in the pharmaceutical industry, with a significant portion focused on medicinal chemistry drug discovery.
- Proven track record of successfully advancing drug candidates from discovery through preclinical development.
- Extensive experience in synthetic organic chemistry, including multi-step synthesis and purification techniques.
- Deep understanding of SAR, ADMET properties, and principles of drug design.
- Experience with computational chemistry tools and databases.
- Demonstrated leadership ability, with experience mentoring junior scientists and managing projects.
- Excellent problem-solving, analytical, and critical thinking skills.
- Strong written and verbal communication skills, with the ability to present complex scientific information effectively.
- Familiarity with relevant therapeutic areas is a plus.
- This role requires a hybrid working model, combining lab-based work in Oxford, Oxfordshire, UK with potential remote contribution.
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Principal Medicinal Chemist
Posted 6 days ago
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Responsibilities:
- Lead the design and synthesis of novel small molecules with therapeutic potential, targeting a range of diseases.
- Develop and optimize synthetic routes for complex target compounds.
- Utilize structure-activity relationship (SAR) studies and computational chemistry tools to guide compound design.
- Collaborate closely with biologists, pharmacologists, and ADME scientists to advance drug candidates through the discovery pipeline.
- Oversee the synthesis of compounds for in vitro and in vivo testing, ensuring high quality and timely delivery.
- Troubleshoot challenging synthetic problems and develop innovative solutions.
- Mentor and guide junior chemists, fostering their professional development.
- Stay abreast of the latest advancements in medicinal chemistry, synthetic methodology, and drug discovery technologies.
- Contribute to intellectual property generation and patent filings.
- Prepare and present research findings at internal meetings and external scientific conferences.
- Ensure adherence to all safety protocols and good laboratory practices (GLP).
- PhD in Organic Chemistry or Medicinal Chemistry from a reputable institution.
- A minimum of 7-10 years of experience in drug discovery within the pharmaceutical or biotechnology industry.
- Demonstrated expertise in synthetic organic chemistry, including multi-step synthesis and purification techniques.
- Proven track record of contributing to the discovery and progression of drug candidates.
- Strong understanding of medicinal chemistry principles, SAR development, and physicochemical properties of drug molecules.
- Experience with modern drug discovery technologies and methodologies.
- Excellent problem-solving skills and creativity in synthetic design.
- Proficiency in using chemical literature databases (e.g., SciFinder, Reaxys) and data analysis software.
- Strong written and verbal communication skills, with the ability to present complex scientific data effectively.
- Leadership qualities and experience mentoring junior scientists.
Principal Medicinal Chemist
Posted 11 days ago
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Job Description
Principal Medicinal Chemist
Posted 12 days ago
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Job Description
Responsibilities:
- Design and synthesize novel small molecules with therapeutic potential, optimizing for potency, selectivity, and pharmacokinetic properties.
- Lead medicinal chemistry efforts within assigned drug discovery projects, setting strategic direction and prioritizing activities.
- Collaborate closely with biologists, pharmacologists, and DMPK scientists to integrate data and guide project progression.
- Develop and implement innovative synthetic routes and chemical strategies.
- Perform literature searches and patent analysis to identify new targets and intellectual property opportunities.
- Critically analyze experimental data and guide the synthesis of analog series to explore structure-activity relationships (SAR).
- Contribute to the selection of development candidates for further preclinical and clinical evaluation.
- Mentor and train junior medicinal chemists and research associates.
- Present research findings at internal meetings and external scientific conferences.
- Ensure compliance with all laboratory safety protocols and regulatory guidelines.
- Manage external collaborations with CROs and academic institutions as needed.
Qualifications:
- Ph.D. in Organic Chemistry, Medicinal Chemistry, or a closely related field.
- Minimum of 8 years of post-doctoral experience in the pharmaceutical industry or biotechnology sector, with a focus on drug discovery.
- Demonstrated expertise in synthetic organic chemistry and medicinal chemistry principles.
- Proven track record of successfully designing and synthesizing novel drug candidates.
- Strong understanding of structure-activity relationships (SAR), ADMET properties, and pharmacokinetic principles.
- Experience with various assay formats and in vitro/in vivo pharmacology is highly desirable.
- Excellent problem-solving skills and the ability to think creatively.
- Strong written and verbal communication skills, with a publication record.
- Ability to lead projects, mentor junior scientists, and work effectively in a collaborative, remote team environment.
- Proficiency in chemical drawing software and databases.