213 Drug Discovery jobs in the United Kingdom
Principal Scientist - Drug Discovery
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Responsibilities:
- Lead and design innovative drug discovery projects, from target identification through to lead optimization.
- Develop and implement cutting-edge scientific strategies and experimental approaches to address key research questions.
- Manage and mentor a team of research scientists, fostering a collaborative and high-performing research environment.
- Analyze complex biological data, interpret results, and make informed recommendations for project progression.
- Author high-quality scientific publications, patents, and regulatory submission documents.
- Collaborate effectively with internal cross-functional teams (e.g., DMPK, toxicology, clinical development) and external partners.
- Stay abreast of the latest advancements in pharmaceutical research, disease biology, and relevant therapeutic areas.
- Present research findings at internal and external scientific conferences.
- Manage external research collaborations and CROs to achieve project milestones.
- Contribute to the strategic planning and intellectual property portfolio of the R&D division.
- Ensure adherence to all laboratory safety standards and ethical guidelines.
- Evaluate and implement new technologies to enhance drug discovery capabilities.
- PhD in Pharmacology, Molecular Biology, Biochemistry, or a related life sciences discipline.
- Minimum of 8-10 years of relevant experience in the pharmaceutical or biotechnology industry, with a strong track record in drug discovery and development.
- Demonstrated expertise in target validation, assay development, hit identification, and lead optimization.
- Proven experience in managing research projects and leading scientific teams.
- In-depth knowledge of one or more therapeutic areas (e.g., oncology, immunology, CNS disorders).
- Excellent understanding of modern drug discovery methodologies and technologies.
- Strong publication record and presentation experience.
- Exceptional analytical, critical thinking, and problem-solving skills.
- Outstanding written and verbal communication skills, with the ability to articulate complex scientific concepts.
- Ability to work independently and drive projects forward in a remote, fast-paced environment.
- Experience with small molecule or biologic drug discovery is required.
Principal Scientist, Drug Discovery
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The ideal candidate will hold a PhD in a relevant scientific discipline (e.g., Biology, Chemistry, Biochemistry, Pharmacology) and possess a minimum of 7-10 years of post-doctoral experience in the pharmaceutical or biotechnology industry. A strong track record of successfully managing complex research projects, a history of high-impact publications, and experience with various assay development techniques are essential. You should be proficient in modern drug discovery methodologies and possess a comprehensive understanding of disease biology and target validation strategies. Experience with small molecule drug discovery and/or biologics is highly desirable.
Key responsibilities include designing and executing complex experiments, interpreting data, and making strategic recommendations for project progression. You will mentor junior scientists, foster a collaborative research environment, and effectively communicate research findings to internal stakeholders and external partners. A strong understanding of intellectual property and regulatory landscapes within drug development is also beneficial. This is a unique opportunity to make a significant contribution to the development of life-saving medicines within a dynamic and innovative research setting. Join a world-class team dedicated to advancing human health through scientific excellence.
Location: On-site role in Aberdeen, Scotland, UK .
Lead Biophysicist - Drug Discovery
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As the Lead Biophysicist, you will be instrumental in designing, executing, and interpreting a wide range of biophysical assays to characterize drug candidates, their interactions with biological targets, and their overall pharmacological profiles. Your responsibilities will include developing and validating novel biophysical techniques and methodologies to address complex scientific questions in drug discovery. You will lead a team of highly skilled biophysicists and technicians, providing scientific direction, mentorship, and performance management. Collaboration with medicinal chemists, pharmacologists, structural biologists, and other R&D teams will be essential to integrate biophysical data into the broader drug discovery strategy. You will be expected to stay abreast of the latest advancements in biophysics and drug discovery, applying this knowledge to optimize research strategies and troubleshoot challenging projects. Presenting scientific findings at internal meetings and external conferences, as well as authoring scientific publications, will be key aspects of the role.
The ideal candidate will hold a Ph.D. in Biophysics, Biochemistry, Chemistry, or a related discipline, with a minimum of 7-10 years of post-doctoral and industry experience in biophysical characterization relevant to drug discovery. A deep understanding of various biophysical techniques, such as Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), Microscale Thermophoresis (MST), and various spectroscopic methods, is essential. Proven experience in leading research projects and managing scientific teams is required. You should possess excellent analytical and problem-solving skills, with a strong publication record demonstrating scientific rigor and innovation. Exceptional communication, presentation, and interpersonal skills are crucial for effective collaboration and knowledge dissemination. Experience with protein purification, structural biology techniques, and drug screening platforms would be a significant asset.
This hybrid position offers an exciting opportunity to contribute to life-changing medicines within a collaborative and intellectually stimulating environment. We offer a competitive salary, comprehensive benefits, and significant opportunities for professional growth and career advancement. Join a team that is passionate about science and dedicated to improving human health.
Principal Scientist - Drug Discovery
Posted today
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Job Description
Key Responsibilities:
- Design and lead complex research projects focused on identifying and validating new drug targets.
- Develop and implement cutting-edge experimental strategies and assays.
- Analyze and interpret complex experimental data, drawing insightful conclusions.
- Manage and mentor a team of research scientists, fostering a collaborative and productive research environment.
- Contribute to the strategic direction of the drug discovery pipeline.
- Collaborate effectively with cross-functional teams, including chemistry, pharmacology, and toxicology.
- Prepare scientific reports, presentations, and publications.
- Stay abreast of the latest scientific advancements and emerging technologies in the field.
- Manage external collaborations and partnerships.
- Ensure compliance with all laboratory safety regulations and company policies.
Qualifications:
- PhD in Molecular Biology, Biochemistry, Pharmacology, or a related field.
- Minimum of 8 years of post-doctoral and industry experience in drug discovery.
- Proven track record of successfully identifying and validating drug targets.
- Expertise in various experimental techniques and assay development.
- Strong understanding of disease mechanisms and therapeutic intervention strategies.
- Demonstrated leadership and team management skills.
- Excellent data analysis, interpretation, and problem-solving abilities.
- Strong written and verbal communication skills, including presentation experience.
- Experience with data analysis software and bioinformatics tools.
- Ability to work effectively both independently and as part of a hybrid team.
Principal Scientist - Drug Discovery
Posted today
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Job Description
Responsibilities:
- Lead and manage multiple drug discovery projects from concept to early development stages.
- Design and implement innovative experimental strategies to identify and validate novel drug targets.
- Oversee the execution of high-throughput screening (HTS), hit-to-lead, and lead optimization campaigns.
- Develop and implement robust biochemical and cellular assays to evaluate compound efficacy and mechanism of action.
- Analyze and interpret complex experimental data, drawing insightful conclusions and making strategic recommendations.
- Mentor and guide a team of research scientists, fostering scientific rigor and professional development in a remote setting.
- Collaborate effectively with cross-functional teams, including medicinal chemistry, DMPK, and toxicology.
- Stay abreast of the latest scientific advancements and emerging technologies in drug discovery.
- Contribute to the company's intellectual property portfolio through patent filings and publications.
- Communicate research findings and project updates clearly and concisely to senior management and external partners.
- Ph.D. in Molecular Biology, Biochemistry, Pharmacology, or a related life science discipline.
- A minimum of 8 years of post-doctoral research experience in drug discovery within the pharmaceutical or biotechnology industry.
- Demonstrated expertise in at least one major therapeutic area (e.g., oncology, immunology, neuroscience).
- Proven track record of successfully leading drug discovery projects and delivering key milestones.
- Extensive experience with assay development, screening technologies, and compound evaluation.
- Strong understanding of medicinal chemistry principles and drug development processes.
- Excellent leadership, communication, and presentation skills, crucial for remote team collaboration.
- Proficiency in data analysis software and scientific literature databases.
- Ability to work independently, manage complex projects, and thrive in a fast-paced, innovative research environment.
Principal Drug Discovery Chemist
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Job Description
Responsibilities:
- Lead the design and synthesis of novel chemical entities for therapeutic targets, employing state-of-the-art synthetic organic chemistry techniques.
- Develop and optimize synthetic routes for complex molecules, ensuring scalability and efficiency.
- Collaborate with biologists and other scientists to define structure-activity relationships (SAR) and structure-property relationships (SPR).
- Propose and manage synthetic strategies for lead optimization programs, aiming to improve potency, selectivity, and pharmacokinetic profiles.
- Utilize computational chemistry tools and techniques to guide molecular design and predict properties.
- Work closely with DMPK, toxicology, and pharmacology teams to advance compounds through preclinical development.
- Analyze and interpret complex spectroscopic and analytical data (NMR, MS, HPLC, etc.).
- Stay current with the latest advancements in synthetic methodology, medicinal chemistry, and drug discovery.
- Publish research findings in peer-reviewed journals and present at scientific conferences.
- Mentor and guide junior chemists, fostering scientific excellence and innovation.
- Contribute to intellectual property generation through patent filings.
- Ensure a high level of safety in the laboratory and adherence to all regulatory guidelines.
- Manage external collaborations with CROs and academic institutions as needed.
- PhD in Organic Chemistry, Medicinal Chemistry, or a closely related field.
- Minimum of 8 years of post-doctoral or industry experience in drug discovery, with a strong track record of successful lead optimization and candidate nomination.
- Extensive expertise in synthetic organic chemistry, including modern methodologies and strategies for complex molecule synthesis.
- Deep understanding of medicinal chemistry principles, SAR, and drug properties.
- Experience with hit-to-lead and lead optimization campaigns.
- Proficiency in using analytical techniques (NMR, MS, HPLC, etc.) for compound characterization.
- Familiarity with computational chemistry tools (e.g., Schrödinger, MOE) is a significant advantage.
- Excellent problem-solving skills and creativity in chemical synthesis.
- Strong written and verbal communication skills, with the ability to present complex scientific information effectively.
- Proven ability to work independently and lead research projects in a remote setting.
Senior Research Scientist - Drug Discovery
Posted today
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Key Responsibilities:
- Design, execute, and interpret complex experiments to investigate disease mechanisms and identify potential drug targets.
- Develop and optimize biological assays for target validation and compound screening.
- Utilize cutting-edge techniques in molecular biology, cell biology, and biochemistry.
- Analyze and interpret large datasets, employing statistical methods and bioinformatics tools where appropriate.
- Lead independent research projects, manage timelines, and report findings effectively.
- Collaborate closely with internal teams (e.g., medicinal chemistry, DMPK) and external partners to advance drug discovery programs.
- Contribute to the writing of research proposals, reports, patents, and scientific publications.
- Stay current with the latest scientific literature and technological advancements in relevant therapeutic areas.
- Mentor and guide junior research staff, fostering a collaborative and innovative research environment.
- Ensure all laboratory activities are conducted in compliance with safety regulations and ethical guidelines.
Qualifications:
- PhD in Molecular Biology, Pharmacology, Biochemistry, or a closely related discipline.
- Minimum of 5 years of postdoctoral and/or industry experience in drug discovery research.
- Proven expertise in a relevant therapeutic area (e.g., oncology, immunology, neuroscience).
- Hands-on experience with a variety of molecular and cellular biology techniques.
- Proficiency in data analysis software and statistical analysis.
- Excellent problem-solving skills and critical thinking abilities.
- Strong scientific communication skills, both written and verbal, with a publication record.
- Demonstrated ability to manage projects and work effectively in a team-oriented, fast-paced environment.
- Experience with high-throughput screening (HTS) and assay development is highly advantageous.
- Must be able to work on-site in Oxford, Oxfordshire, UK for laboratory-based activities, with flexibility for remote work for data analysis and reporting.
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Principal Research Scientist - Drug Discovery
Posted today
Job Viewed
Job Description
Key Responsibilities:
- Lead the design and execution of innovative drug discovery programs, from target identification to lead optimisation.
- Manage and mentor a team of research scientists, providing scientific direction and fostering a collaborative research environment.
- Develop and implement novel experimental strategies and methodologies to address complex biological challenges.
- Interpret experimental data, draw robust conclusions, and communicate findings effectively to internal stakeholders and scientific forums.
- Collaborate closely with medicinal chemists, biologists, pharmacologists, and other R&D teams to achieve project goals.
- Contribute to the strategic direction of the drug discovery portfolio and identify new research opportunities.
- Prepare high-quality scientific reports, publications, and patent applications.
- Ensure compliance with all relevant laboratory safety regulations and ethical guidelines.
- Stay abreast of the latest scientific advancements, technologies, and trends in the relevant therapeutic area and drug discovery.
- Drive the advancement of drug candidates through preclinical development stages.
- Ph.D. in Pharmacology, Molecular Biology, Biochemistry, Medicinal Chemistry, or a related life science discipline.
- Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong focus on drug discovery.
- Demonstrated success in leading drug discovery projects and managing scientific teams.
- Extensive experience in one or more key areas of drug discovery (e.g., target validation, assay development, hit-to-lead optimisation, structure-based drug design).
- Proven track record of scientific innovation, publications in peer-reviewed journals, and/or patent filings.
- Excellent understanding of drug development processes and regulatory pathways.
- Exceptional analytical, problem-solving, and critical thinking skills.
- Outstanding communication, presentation, and interpersonal skills, with the ability to influence and inspire.
- Experience working effectively in a remote, collaborative scientific setting.
Principal Research Scientist - Drug Discovery
Posted today
Job Viewed
Job Description
Key Responsibilities:
- Lead and manage multiple drug discovery projects, from target identification through to preclinical candidate selection.
- Design and execute innovative research strategies and experimental plans to validate novel therapeutic targets and pathways.
- Develop and optimize small molecule or biologic drug discovery programs.
- Supervise and mentor a team of research scientists and technicians, fostering a collaborative and high-performance environment.
- Conduct in-depth data analysis, interpret experimental results, and draw robust conclusions.
- Prepare high-quality research reports, scientific publications, and presentations for internal and external audiences.
- Contribute to the company's intellectual property strategy by identifying and patenting new discoveries.
- Collaborate effectively with cross-functional teams, including medicinal chemistry, biology, DMPK, and toxicology.
- Manage external research collaborations with academic institutions and contract research organizations (CROs).
- Stay abreast of the latest scientific advancements and emerging technologies in relevant therapeutic areas.
- Contribute to the strategic direction of the research and development pipeline.
- Ph.D. in Pharmacology, Molecular Biology, Biochemistry, or a related life science discipline.
- Minimum of 8-10 years of post-doctoral or industry experience in drug discovery.
- Proven expertise in one or more therapeutic areas such as oncology, immunology, neuroscience, or infectious diseases.
- Demonstrated success in leading research projects and managing scientific teams.
- Hands-on experience with a range of drug discovery techniques (e.g., target validation, assay development, screening, hit-to-lead optimization).
- Strong understanding of medicinal chemistry, pharmacokinetics, and pharmacodynamics (PK/PD).
- Excellent analytical, problem-solving, and critical thinking skills.
- Outstanding written and verbal communication skills, with a strong publication record.
- Experience in managing CROs and academic collaborations is advantageous.
Principal Scientist, Drug Discovery (Remote)
Posted today
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Job Description
Key Responsibilities:
- Design and lead innovative drug discovery projects aimed at identifying and optimising novel therapeutic agents.
- Develop and implement cutting-edge experimental strategies and methodologies.
- Expertly analyse complex biological and chemical data, drawing insightful conclusions.
- Collaborate effectively with internal cross-functional teams (e.g., biology, DMPK, toxicology) and external partners.
- Mentor and guide junior scientists, fostering a collaborative and high-performing research environment.
- Contribute to the development of scientific strategy and pipeline planning.
- Author high-quality manuscripts for peer-reviewed publications and present findings at scientific conferences.
- Ensure compliance with all relevant ethical, safety, and regulatory guidelines.
- Manage project timelines, resources, and budgets effectively.
- Stay abreast of the latest scientific advancements and technological innovations in drug discovery.
- PhD in Medicinal Chemistry, Pharmacology, Biochemistry, or a closely related field.
- A minimum of 8-10 years of progressive experience in drug discovery within the pharmaceutical or biotechnology industry.
- Demonstrated success in leading drug discovery projects and delivering candidate molecules.
- Strong expertise in one or more therapeutic areas and relevant disease biology.
- Excellent understanding of ADMET properties and their optimisation.
- Proficiency with relevant scientific software and data analysis tools.
- Exceptional problem-solving, critical thinking, and strategic planning skills.
- Outstanding written and verbal communication skills, with a proven ability to publish and present research.
- Demonstrated leadership and mentorship capabilities.
- Ability to work independently and collaboratively in a fully remote setting, demonstrating excellent self-management.