3 Molecular Biology jobs in the United Kingdom

Lead Biophysicist - Protein Interaction Studies

Nottingham, East Midlands WhatJobs

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Job Description

full-time
Our client, a cutting-edge biotechnology research firm located in Nottingham , is seeking an experienced Lead Biophysicist to spearhead innovative research in protein-ligand interactions. This hybrid role offers a blend of on-site laboratory work and remote analysis, providing flexibility while ensuring critical experimental progress. The successful candidate will lead a team of researchers, design and execute complex biophysical experiments, and contribute to the development of novel therapeutic agents. You will be responsible for developing and validating new biophysical assays, utilizing techniques such as Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), Differential Scanning Fluorimetry (DSF), and microscale thermophoresis (MST). The Lead Biophysicist will play a crucial role in characterizing the binding kinetics and thermodynamics of protein targets and small molecules, providing critical data to support drug discovery programs. This requires a PhD in Biophysics, Biochemistry, or a closely related field, coupled with at least 7 years of post-doctoral or industry experience in biophysical characterization. Demonstrated expertise in multiple biophysical techniques and a strong understanding of protein chemistry and structural biology are essential. You should have a proven track record of successfully leading research projects, publishing findings in peer-reviewed journals, and mentoring junior scientists. Excellent analytical, problem-solving, and communication skills are paramount, as you will be expected to present complex data to cross-functional teams and contribute to scientific strategy. This is an exceptional opportunity to join a highly collaborative environment and make significant contributions to life-saving scientific advancements. Responsibilities:
  • Lead and manage a team of biophysicists and technicians.
  • Design, optimize, and execute biophysical experiments to study molecular interactions.
  • Utilize a range of biophysical techniques including SPR, ITC, DSF, and MST.
  • Analyze and interpret complex experimental data, drawing meaningful conclusions.
  • Develop and validate new assay methodologies for protein characterization.
  • Contribute to the company's drug discovery pipeline by characterizing target-ligand binding.
  • Collaborate with medicinal chemists, structural biologists, and other research teams.
  • Prepare scientific reports, presentations, and manuscripts for publication.
  • Mentor junior staff and provide technical guidance.
  • Stay current with the latest advancements in biophysics and related fields.
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Scientist - Molecular Biology

Cambridge, Eastern Nuclera

Posted 18 days ago

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Job Description

Permanent

Nuclera is a venture-backed biotech company headquartered in Cambridge, UK with significant operations in Boston, USA. Nuclera’s mission is to accelerate discovery by enabling rapid, easy access to functional proteins essential for drug discovery research. Our eProtein Discovery™ benchtop system accelerates protein expression and purification optimization in research labs.

This is a lab-based role within a group central to Nuclera’s technology development program that will be conducted in close collaboration with colleagues from other groups in the company. A key aspect of this role will be to support development and optimization of new capabilities of our platform.

The role would suit a candidate with excellent communication and organization skills, with a drive for working in a fast-paced biotech environment and a track record of execution and teamwork. Experience in molecular biology, protein expression and characterisation is essential. 

This role will be based in the Cambridge, UK site and is on-site in the lab. 

About the role

  • Design, execute, and troubleshoot PCR, DNA assembly and protein expression with guidance from senior members of the group.
  • Able to work on multiple  projects in parallel.
  • Actively engage in scientific discussion within the group and across groups to contribute to robust product development.
  • Follow SOPs to independently execute and analyze experiments
  • Report results in a timely manner and maintain good laboratory practices.

Requirements

Essential:

  • MSc or PhD in Molecular Biology, Biochemistry, or a related field,
  • 2–4 years of relevant industry experience for MSc graduates, or at least 1 year of industry experience for PhD holders.
  • Track record of delivering robust data and high-quality results within tight timelines
  • Solid understanding of recombinant DNA technology and extensive experience with gene expression in prokaryotic systems
  • Experience with common molecular biology techniques, including PCR, DNA assembly using PCR and Gibson assembly, gene cloning and agarose gel electrophoresis
  • Extensive experience of nucleic acid manipulation (DNA and RNA) for assay and application development (e.g. NGS library prep, NGS application development, synthetic biology applications or expression construct design)
  • Proficiency with DNA analysis software such as SnapGene/Benchling/Vector NTI.
  • Experience with common protein expression and purification techniques, including affinity purification, SDS-PAGE gel electrophoresis, protein quantification
  • A collaborative team player with a positive can-do attitude
  • Strong problem solving capabilities, clear communication and presentation skills
  • Self-motivated interest in Nuclera’s technology.

Desirable:

  • Previous working experience in the pharmaceutical, CRO, and/or biotechnology industry would be advantageous.
  • Understanding the principles of cell-free protein synthesis technologies
  • Expression and purification of antibodies in E.coli/mammalian cells.
  • Some knowledge of protein assays, characterisation and functional properties (e.g. solubility, aggregation properties, activity)

Benefits

What we offer:

In addition to competitive salaries, we offer a range of benefits including:

  • Company bonus scheme of 5%
  • Share option incentive scheme 
  • Life insurance 
  • Private medical insurance and cash plan 
  • 25 days' annual leave + Bank Holidays 
  • Enhanced employer's pension contributions 
  • Enhanced maternity and paternity Leave 
  • Investment in professional development and learning 
  • Fresh fruit, tea, coffee, and snacks in the office 
  • Organised summer events for staff
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Senior Scientist I Molecular Biology

Entrust Resource Solutions

Posted 1 day ago

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Job Description

full time
Senior Scientist - Molecular Biology
Growing Industrial Biotechnology Business
Edinburgh
£34,000 - 36,000 plus benefits

ERS are very pleased to offer a new role with one of our established clients in the industrial biotechnology and sustainability community. Members of The Industrial Biotechnology Innovation Centre, they conduct contract manufacturing and research services for the betterment of environmental sustainability and human health.
  
They are recruiting for a Senior Molecular Biologist with an interest in developing your career within this space. Working with a fast paced, growing organisation, you will conduct projects on behalf of global biotech clients. No day will be the same as the last and you'll be surrounded by a supportive and high performing team. Ideally, you will have a PhD or Masters in a relevant subject plus 2 + years industry experience.
  
Key Requirements: -
  • A PhD MSc in Molecular Biology/Industrial Biotechnology/ Microbiology (or similar subject)
  • Experience in mammalian cell line development is essential
  • Knowledge and practical experience in molecular biology techniques
  • Genetic cloning experience
  • Experience in working under a QMS (GMP, GLP)
  
Why Apply?
  • Salary DOE, plus performance bonus and benefits package
  • This company are making a real difference and are doing well at it!
  • They offer a structured career progression pathway so you'll always know where you stand and where you're going next
This advertiser has chosen not to accept applicants from your region.

Senior Scientist I Molecular Biology

Entrust Resource Solutions

Posted 1 day ago

Job Viewed

Tap Again To Close

Job Description

permanent
Senior Scientist - Molecular Biology
Growing Industrial Biotechnology Business
Edinburgh
£34,000 - 36,000 plus benefits

ERS are very pleased to offer a new role with one of our established clients in the industrial biotechnology and sustainability community. Members of The Industrial Biotechnology Innovation Centre, they conduct contract manufacturing and research services for the betterment of environmental sustainability and human health.
  
They are recruiting for a Senior Molecular Biologist with an interest in developing your career within this space. Working with a fast paced, growing organisation, you will conduct projects on behalf of global biotech clients. No day will be the same as the last and you'll be surrounded by a supportive and high performing team. Ideally, you will have a PhD or Masters in a relevant subject plus 2 + years industry experience.
  
Key Requirements: -
  • A PhD MSc in Molecular Biology/Industrial Biotechnology/ Microbiology (or similar subject)
  • Experience in mammalian cell line development is essential
  • Knowledge and practical experience in molecular biology techniques
  • Genetic cloning experience
  • Experience in working under a QMS (GMP, GLP)
  
Why Apply?
  • Salary DOE, plus performance bonus and benefits package
  • This company are making a real difference and are doing well at it!
  • They offer a structured career progression pathway so you'll always know where you stand and where you're going next
This advertiser has chosen not to accept applicants from your region.
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