23 Novartis jobs in the United Kingdom

Global Clinical Project Manager - Vendor Management Expert - Novartis Dedicated (home-based in Eu...

London, London IQVIA

Posted 13 days ago

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Job Description

**Global Clinical Project Manager - Vendor Management Expert - Single Sponsor (Novartis)**
Are you an experienced Vendor Management professional looking to make an impact in global clinical trials?
We are seeking a **Global Clinical Project Manager - Vendor Management Expert** to join our **Single Sponsor Department** , dedicated exclusively to **Novartis** . In this role, you 'll become an expert in **Vendor Management** for global clinical trials across all phases (Phase I-IV), ensuring seamless execution from study start-up through close-out.
**What We're Looking For**
To excel in this role, you should bring:
+ **Global Clinical Project Management experience**
+ **Strong Vendor Management expertise:** Central lab, eCOA, IRT, ECG, Imaging, Ancillaries and/or Patient Recruitment & Retention with experience in global clinical trials. (must have experience managing at least 2 of these vendors)
+ **Deep understanding of clinical operations processes** and vendor service categories.
+ **Excellent project management skills** to drive efficiency and collaboration
+ **Strong communication and influencing abilities** to partner effectively across functions.
+ **Proven ability to manage risk and performance issues** in a fast-paced environment
**What You'll Do**
As a **Global Clinical Project Manager - Vendor Management Expert** , you will be responsible for ensuring vendor deliverables are met with **quality and efficiency** at the trial level. Your key responsibilities include:
+ **Vendor Oversight & Coordination** - Manage vendor activities across the study lifecycle, ensuring timely and high-quality deliverables.
+ **Study Start-Up Support** - Oversee vendor deliverables during study initiation, ensuring smooth onboarding and activation.
+ **Risk & Performance Management** - Track vendor performance, identify risks, and escalate issues as needed.
+ **Site Readiness & Activation** - Drive vendor activities to support site activations and ensure study milestones are met.
+ **Study Close-Out** - Coordinate vendor deliverables that support Database Lock and study closure.
**What You'll Deliver**
+ **Vendor service excellence at the study level**
+ **Vendor onboarding and performance tracking**
+ **KPI (Key Performance Indicator) and KQI (Key Quality Indicator) dashboards to monitor vendor effectiveness**
+ **Site readiness monitoring and documentation**
+ **Risk mapping with contingency planning**
+ **Vendor cost control and oversight**
**Please note this role is not eligible for the UK visa sponsorship.**
This is an exciting opportunity to play a **critical role in global clinical trials** , ensuring vendor excellence and operational success. If you're ready to take on a **high-impact role** with a leading sponsor, we'd love to hear from you!
IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more at is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create connections that accelerate the development and commercialization of innovative medical treatments. Everything we do is part of a journey to improve patient outcomes and population health worldwide.
To get there, we seek out diverse talent with curious minds and a relentless commitment to innovation and impact. No matter your role, everyone at IQVIA contributes to our shared goal of helping customers improve the lives of patients everywhere. Thank you for your interest in growing your career with us.
EEO Minorities/Females/Protected Veterans/Disabled
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Global Clinical Project Manager - Vendor Management Expert - Novartis Dedicated (home-based in Eu...

Reading, South East IQVIA

Posted 13 days ago

Job Viewed

Tap Again To Close

Job Description

**Global Clinical Project Manager - Vendor Management Expert - Single Sponsor (Novartis)**
Are you an experienced Vendor Management professional looking to make an impact in global clinical trials?
We are seeking a **Global Clinical Project Manager - Vendor Management Expert** to join our **Single Sponsor Department** , dedicated exclusively to **Novartis** . In this role, you 'll become an expert in **Vendor Management** for global clinical trials across all phases (Phase I-IV), ensuring seamless execution from study start-up through close-out.
**What We're Looking For**
To excel in this role, you should bring:
+ **Global Clinical Project Management experience**
+ **Strong Vendor Management expertise:** Central lab, eCOA, IRT, ECG, Imaging, Ancillaries and/or Patient Recruitment & Retention with experience in global clinical trials. (must have experience managing at least 2 of these vendors)
+ **Deep understanding of clinical operations processes** and vendor service categories.
+ **Excellent project management skills** to drive efficiency and collaboration
+ **Strong communication and influencing abilities** to partner effectively across functions.
+ **Proven ability to manage risk and performance issues** in a fast-paced environment
**What You'll Do**
As a **Global Clinical Project Manager - Vendor Management Expert** , you will be responsible for ensuring vendor deliverables are met with **quality and efficiency** at the trial level. Your key responsibilities include:
+ **Vendor Oversight & Coordination** - Manage vendor activities across the study lifecycle, ensuring timely and high-quality deliverables.
+ **Study Start-Up Support** - Oversee vendor deliverables during study initiation, ensuring smooth onboarding and activation.
+ **Risk & Performance Management** - Track vendor performance, identify risks, and escalate issues as needed.
+ **Site Readiness & Activation** - Drive vendor activities to support site activations and ensure study milestones are met.
+ **Study Close-Out** - Coordinate vendor deliverables that support Database Lock and study closure.
**What You'll Deliver**
+ **Vendor service excellence at the study level**
+ **Vendor onboarding and performance tracking**
+ **KPI (Key Performance Indicator) and KQI (Key Quality Indicator) dashboards to monitor vendor effectiveness**
+ **Site readiness monitoring and documentation**
+ **Risk mapping with contingency planning**
+ **Vendor cost control and oversight**
**Please note this role is not eligible for the UK visa sponsorship.**
This is an exciting opportunity to play a **critical role in global clinical trials** , ensuring vendor excellence and operational success. If you're ready to take on a **high-impact role** with a leading sponsor, we'd love to hear from you!
IQVIA is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create intelligent connections to accelerate the development and commercialization of innovative medical treatments to help improve patient outcomes and population health worldwide. Learn more at is a leading global provider of clinical research services, commercial insights and healthcare intelligence to the life sciences and healthcare industries. We create connections that accelerate the development and commercialization of innovative medical treatments. Everything we do is part of a journey to improve patient outcomes and population health worldwide.
To get there, we seek out diverse talent with curious minds and a relentless commitment to innovation and impact. No matter your role, everyone at IQVIA contributes to our shared goal of helping customers improve the lives of patients everywhere. Thank you for your interest in growing your career with us.
EEO Minorities/Females/Protected Veterans/Disabled
This advertiser has chosen not to accept applicants from your region.

Senior Formulation Scientist - Drug Development

BS1 6GU Bristol, South West £55000 Annually WhatJobs

Posted 10 days ago

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Job Description

full-time
Our client is seeking a highly motivated and experienced Senior Formulation Scientist to join their dynamic drug development team in Bristol, South West England, UK . This role is pivotal in the progression of novel therapeutic candidates from early-stage research through to clinical trials and eventual market launch. You will be responsible for the design, development, and optimization of various pharmaceutical dosage forms, including oral solids, injectables, and topicals.

Key responsibilities include:
  • Leading the formulation development of new chemical entities (NCEs) and existing drug products.
  • Designing and executing experiments to investigate drug solubility, stability, bioavailability, and release profiles.
  • Utilizing a range of analytical techniques (e.g., HPLC, GC, dissolution testing, DSC, TGA) to characterize formulations and raw materials.
  • Troubleshooting formulation challenges and proposing innovative solutions.
  • Preparing detailed scientific reports, development protocols, and contributing to regulatory submission documents.
  • Collaborating effectively with cross-functional teams, including analytical development, process chemistry, manufacturing, and regulatory affairs.
  • Mentoring junior scientists and contributing to the technical development of the team.
  • Staying abreast of the latest scientific literature, industry trends, and regulatory guidelines related to pharmaceutical formulation.
  • Ensuring all work is conducted in compliance with Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) standards.

The ideal candidate will possess a Ph.D. or a Master's degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related discipline, with a minimum of 5 years of hands-on experience in pharmaceutical formulation development. A strong understanding of physical pharmacy principles, drug delivery technologies, and regulatory requirements is essential. Excellent problem-solving skills, strong written and verbal communication abilities, and the capacity to work independently and as part of a team are crucial. Experience with lyophilization or complex parenteral formulations would be a significant advantage. This hybrid role offers a fantastic opportunity to make a tangible impact on patient lives while advancing your career in a leading pharmaceutical research environment.
This advertiser has chosen not to accept applicants from your region.

Senior Formulation Scientist (Drug Development)

LE1 7RW Leicester, East Midlands £55000 Annually WhatJobs

Posted 12 days ago

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Job Description

full-time
Our client, a leading pharmaceutical company, is seeking an accomplished Senior Formulation Scientist to join their cutting-edge research and development department based in Leicester, Leicestershire . This is a crucial laboratory-based role focused on developing innovative drug formulations that enhance therapeutic efficacy and patient compliance. You will be instrumental in the entire lifecycle of formulation development, from early-stage concept to late-stage clinical support.

Responsibilities:
  • Design and execute experiments to develop novel drug formulations (e.g., oral solid dosage forms, injectables, topical preparations) for small molecules and biologics.
  • Investigate and optimize pre-formulation properties, including solubility, stability, and compatibility studies.
  • Develop and validate analytical methods for characterizing drug substances and drug products.
  • Conduct stability studies according to ICH guidelines and interpret results to establish shelf-life.
  • Prepare formulation development reports, present findings at internal meetings, and contribute to regulatory submissions.
  • Collaborate with cross-functional teams, including analytical development, process development, regulatory affairs, and manufacturing.
  • Troubleshoot formulation-related issues encountered during development and scale-up.
  • Stay abreast of scientific literature, emerging technologies, and industry best practices in pharmaceutical formulation.
  • Supervise and mentor junior scientists and technicians within the formulation team.
  • Ensure all laboratory activities are conducted in compliance with GMP and safety regulations.
  • Participate in technology transfer activities to manufacturing sites.
Qualifications:
  • Ph.D. or Master's degree in Pharmaceutics, Chemistry, Pharmaceutical Sciences, or a related discipline.
  • Minimum of 5-7 years of progressive experience in pharmaceutical formulation development.
  • Hands-on experience with a variety of dosage forms and formulation techniques.
  • Strong understanding of physical chemistry, materials science, and drug delivery principles.
  • Proficiency in analytical techniques such as HPLC, DSC, TGA, XRPD, and microscopy.
  • Experience with formulation development software and statistical analysis tools.
  • Excellent problem-solving, analytical, and critical thinking skills.
  • Strong written and verbal communication skills, with the ability to effectively present technical information.
  • Ability to work effectively in a fast-paced, collaborative laboratory environment.
  • Knowledge of regulatory requirements (e.g., FDA, EMA) related to drug development and manufacturing.
This is an exciting opportunity for a seasoned formulation scientist to contribute to the development of life-changing medicines within a renowned pharmaceutical organisation located in Leicester, Leicestershire .
This advertiser has chosen not to accept applicants from your region.

Principal Formulation Scientist (Drug Development)

CB2 1DR Cambridge, Eastern £90000 Annually WhatJobs

Posted 14 days ago

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Job Description

full-time
Our client, a pioneering biopharmaceutical company based in the vibrant scientific hub of **Cambridge**, is seeking an exceptional Principal Formulation Scientist to lead innovative drug development initiatives. This is a fully remote, high-impact role offering the chance to work at the forefront of pharmaceutical research and development from your preferred location. You will be responsible for the design, development, and optimization of novel drug delivery systems and formulations, driving projects from early-stage concept through to preclinical and clinical evaluation. This position requires deep scientific expertise, a rigorous experimental approach, and a strategic vision for advancing therapeutic solutions.

Responsibilities:
  • Lead the formulation development of complex pharmaceutical products, including small molecules, biologics, and advanced therapies.
  • Design and execute experimental strategies to optimize drug solubility, stability, bioavailability, and release profiles.
  • Utilize a range of characterization techniques (e.g., HPLC, DLS, DSC, SEM) to assess formulation performance.
  • Develop and validate analytical methods for formulation analysis.
  • Manage and mentor a team of formulation scientists and technicians.
  • Collaborate closely with cross-functional teams including medicinal chemistry, process development, DMPK, and clinical operations.
  • Interpret experimental data, troubleshoot formulation challenges, and propose innovative solutions.
  • Prepare comprehensive technical reports, protocols, and regulatory submission documents.
  • Stay abreast of scientific literature, emerging technologies, and industry trends in formulation science.
  • Contribute to the strategic direction of the R&D pipeline and intellectual property development.

Qualifications:
  • Ph.D. in Pharmaceutical Sciences, Chemical Engineering, Materials Science, or a related discipline.
  • Minimum of 8 years of progressive experience in pharmaceutical formulation development within the biotech or pharmaceutical industry.
  • Demonstrated expertise in a variety of dosage forms (e.g., oral, injectable, topical) and delivery technologies.
  • In-depth understanding of drug substance properties and their impact on formulation.
  • Proficiency with common laboratory equipment and analytical instrumentation used in formulation science.
  • Strong project management skills and experience leading R&D projects.
  • Excellent written and verbal communication skills, with a proven ability to present complex scientific information.
  • Experience with preclinical and/or early-phase clinical studies is highly advantageous.
  • Ability to work independently and as part of a distributed, global team.
  • A strong publication record or patent contributions is a plus.

This is a unique opportunity to join a dynamic research organization and contribute significantly to the development of life-changing medicines. If you are a visionary scientist passionate about pushing the boundaries of pharmaceutical formulation, we invite you to apply for this exciting remote role.
This advertiser has chosen not to accept applicants from your region.

Senior Formulation Scientist - Drug Development

L3 4AD Liverpool, North West £70000 Annually WhatJobs

Posted 16 days ago

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Job Description

full-time
Our client is seeking an accomplished Senior Formulation Scientist to join their innovative pharmaceutical research and development team based in **Liverpool, Merseyside, UK**. This critical role involves leading the design, development, and optimization of novel drug formulations, from early-stage research through to clinical trial supply. You will be instrumental in translating scientific concepts into viable drug products, addressing complex formulation challenges, and ensuring regulatory compliance. The ideal candidate possesses extensive experience in pharmaceutical formulation, a strong understanding of drug delivery systems, and a proven ability to lead projects and mentor junior scientists.

Key Responsibilities:
  • Lead the formulation development of new drug candidates, including small molecules and biologics.
  • Design and execute experiments to characterize drug substances and excipients.
  • Develop and optimize dosage forms (e.g., oral solids, injectables, topical).
  • Investigate and resolve formulation-related issues encountered during development.
  • Develop and validate analytical methods for formulation characterization.
  • Conduct stability studies and interpret results to define shelf-life.
  • Prepare comprehensive formulation development reports and regulatory submission documents.
  • Collaborate closely with analytical development, DMPK, and manufacturing teams.
  • Stay current with scientific literature, industry trends, and regulatory guidelines.
  • Mentor and guide junior formulation scientists, fostering a culture of scientific excellence.

Qualifications:
  • A Ph.D. or Master's degree in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related field.
  • A minimum of 5-7 years of experience in pharmaceutical formulation development.
  • In-depth knowledge of various dosage forms, drug delivery technologies, and excipient functionalities.
  • Experience with pre-formulation studies, solubility enhancement techniques, and analytical characterization.
  • Proficiency in experimental design and statistical analysis.
  • Strong understanding of regulatory requirements (e.g., ICH guidelines).
  • Excellent problem-solving, organizational, and project management skills.
  • Effective written and verbal communication abilities, with experience presenting to cross-functional teams and stakeholders.
  • Demonstrated leadership potential and experience mentoring team members.

This hybrid role offers a balanced approach to work, combining essential in-lab activities with the flexibility to work remotely. You will be part of a dynamic and collaborative environment at the forefront of pharmaceutical innovation, contributing directly to the development of life-changing medicines. Our client offers a competitive compensation package, excellent benefits, and significant opportunities for professional growth and career advancement within the pharmaceutical industry.
This advertiser has chosen not to accept applicants from your region.

Lead Formulation Scientist, Drug Development

L1 8JQ Liverpool, North West £75000 Annually WhatJobs

Posted 16 days ago

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full-time
Our client is seeking an experienced and visionary Lead Formulation Scientist to drive innovation within their Pharmaceutical division in **Liverpool, Merseyside, UK**. This hybrid role combines essential on-site laboratory work with flexible remote responsibilities. You will be instrumental in the design, development, and optimization of novel drug delivery systems and formulations, from early-stage research through to clinical development and commercialization. This position requires a deep understanding of pharmaceutical sciences, material science, and drug product manufacturing processes. You will lead a team of scientists, manage projects, and collaborate with cross-functional teams to advance pipeline assets.

Key Responsibilities:
  • Lead the formulation development of new chemical entities and complex drug products (e.g., injectables, oral solids, biologics).
  • Design and execute experimental studies to evaluate drug solubility, stability, bioavailability, and manufacturability.
  • Develop and optimize formulation strategies to achieve desired therapeutic profiles and patient compliance.
  • Characterize drug product performance using a range of analytical techniques.
  • Oversee technology transfer activities to manufacturing sites and support process validation.
  • Manage project timelines, resources, and budgets, ensuring timely delivery of milestones.
  • Mentor and guide junior formulation scientists, fostering a culture of scientific excellence and innovation.
  • Collaborate closely with preclinical, clinical, regulatory, and manufacturing teams.
  • Author and review technical reports, protocols, and regulatory submission documents.
  • Stay current with industry trends, new technologies, and regulatory guidelines in pharmaceutical formulation.
The ideal candidate will possess a Ph.D. in Pharmaceutical Sciences, Chemical Engineering, Materials Science, or a related discipline, with a minimum of 7 years of relevant industry experience. Demonstrated success in leading formulation development projects and a strong understanding of GMP principles are essential. Expertise in various dosage forms, particularly parenteral and oral drug delivery, is required. Excellent problem-solving, critical thinking, and communication skills are crucial for success in this role. Experience with statistical analysis and design of experiments (DoE) is highly desirable. Join a leading pharmaceutical company in **Liverpool, Merseyside, UK**, and make a significant impact on the future of medicine.
This advertiser has chosen not to accept applicants from your region.
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Principal Formulation Scientist - Drug Development

SR1 2AY Sunderland, North East £70000 Annually WhatJobs

Posted 18 days ago

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Job Description

full-time
Our client, a cutting-edge pharmaceutical research and development company, is seeking a highly experienced Principal Formulation Scientist to join their fully remote R&D team. This senior role is instrumental in driving the innovation and development of novel drug delivery systems and pharmaceutical formulations. You will lead the scientific direction for formulation development projects, from early-stage concept through to pre-clinical and clinical readiness, contributing significantly to the company's pipeline.

Key Responsibilities:
  • Lead the design, development, and optimization of complex pharmaceutical formulations (e.g., oral solid dosage, parenteral, topical) for new chemical entities and existing drug products.
  • Develop and execute comprehensive experimental plans to assess formulation performance, stability, and manufacturability.
  • Provide strategic scientific leadership and technical guidance to a team of formulation scientists and technicians.
  • Troubleshoot formulation challenges and identify innovative solutions to overcome development hurdles.
  • Conduct in-depth literature reviews and stay current with emerging technologies and scientific advancements in pharmaceutics and drug delivery.
  • Prepare and review detailed technical reports, study protocols, and regulatory submission documents (e.g., IND, NDA).
  • Collaborate effectively with cross-functional teams, including analytical development, process chemistry, DMPK, and clinical operations, in a remote setting.
  • Present scientific findings and project updates to internal stakeholders and external partners.
  • Contribute to the intellectual property strategy through patent filings and publications.
  • Ensure all activities are conducted in compliance with GMP, GLP, and other relevant regulatory guidelines.

The ideal candidate will possess a Ph.D. or Master's degree in Pharmaceutics, Pharmaceutical Sciences, Chemistry, or a related discipline, with a minimum of 8 years of progressive experience in pharmaceutical formulation development. A deep understanding of formulation science principles, excipient functionality, and various drug delivery technologies is crucial. Proven experience in leading complex R&D projects and mentoring scientific staff is required. Excellent communication, problem-solving, and organizational skills are essential for success in this remote-first environment. Proficiency in relevant laboratory techniques and analytical methods is expected. This position, though located conceptually near Sunderland, Tyne and Wear, UK , operates entirely remotely.
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Senior Formulation Scientist - Drug Development (Remote)

NR1 2AB Norwich, Eastern £70000 Annually WhatJobs

Posted 11 days ago

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full-time
Our client, a pioneering pharmaceutical company at the forefront of medical innovation, is seeking a highly skilled Senior Formulation Scientist to join their fully remote drug development team. This role is integral to the design, development, and optimisation of novel drug delivery systems and pharmaceutical formulations. You will work independently and collaboratively with a distributed team of experts to advance candidate drugs from pre-clinical stages through to clinical trials and beyond.

The Senior Formulation Scientist will be responsible for developing robust and scalable formulations for various routes of administration, including oral, parenteral, and topical delivery. This involves selecting appropriate excipients, conducting pre-formulation studies, and optimising formulation parameters to achieve desired physicochemical properties, bioavailability, and stability. You will design and execute experimental plans, analyse data using statistical methods, and interpret results to make informed decisions. A key aspect of this role is troubleshooting formulation challenges and proposing innovative solutions. The Senior Formulation Scientist will prepare detailed documentation, including formulation development reports, protocols, and relevant sections for regulatory submissions (e.g., IND, NDA). You will stay abreast of the latest advancements in formulation science, drug delivery technologies, and regulatory guidelines. As a remote position, excellent self-management, communication, and collaboration skills are essential. You will be expected to actively participate in virtual team meetings, present findings effectively, and contribute to a dynamic, science-driven culture. This role requires a deep understanding of pharmaceutics, material science, and analytical techniques commonly used in drug development. The ability to work autonomously while contributing to team goals is critical for success.
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Principal Research Scientist - AI in Drug Development

B1 2AA Birmingham, West Midlands £75000 Annually WhatJobs

Posted 15 days ago

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full-time
We are at the forefront of innovation and seeking a distinguished Principal Research Scientist to lead our initiatives in applying Artificial Intelligence (AI) and Machine Learning (ML) to drug development. This fully remote role is a unique opportunity to shape the future of pharmaceutical research by integrating cutting-edge computational approaches with biological and chemical data. You will guide research strategies, mentor a team of scientists, and collaborate with industry leaders to accelerate the discovery and development of life-saving medicines. As a remote-first organization, we foster an environment of innovation, collaboration, and impact.

Responsibilities:
  • Lead the design and implementation of AI/ML models and algorithms for various stages of drug discovery and development (e.g., target identification, hit identification, lead optimization, clinical trial design).
  • Develop and execute research roadmaps, setting ambitious yet achievable scientific goals.
  • Analyze large, complex biological, chemical, and clinical datasets to extract meaningful insights.
  • Collaborate with domain experts (biologists, chemists, clinicians) to translate complex problems into AI/ML solutions.
  • Mentor and guide a team of data scientists and research scientists, fostering their technical and scientific growth.
  • Stay abreast of the latest advancements in AI/ML, computational biology, cheminformatics, and drug discovery.
  • Develop and present research findings to internal stakeholders, leadership, and at external scientific forums.
  • Contribute to the intellectual property strategy through patent applications and publications.
  • Ensure the ethical and responsible application of AI/ML in drug development.
  • Evaluate and integrate new technologies and tools to enhance research capabilities.
  • Manage research projects, timelines, and resources effectively in a remote setting.
Qualifications:
  • Ph.D. in Computer Science, Data Science, Computational Biology, Cheminformatics, Bioinformatics, or a related quantitative field.
  • Minimum of 8+ years of relevant research experience in AI/ML, with a significant focus on pharmaceutical or life sciences applications.
  • Demonstrated expertise in developing and deploying machine learning models for predictive tasks in drug discovery (e.g., QSAR, molecular property prediction, generative models).
  • Proficiency in programming languages such as Python and R, and familiarity with AI/ML frameworks (e.g., TensorFlow, PyTorch).
  • Experience working with large-scale biological, chemical, and clinical datasets.
  • Strong understanding of drug discovery processes and relevant scientific disciplines.
  • Excellent leadership, communication, and interpersonal skills, with the ability to influence and collaborate across diverse teams.
  • Proven track record of scientific innovation, publications, and/or patents.
  • Ability to work autonomously and lead research efforts in a remote environment.
This impactful, fully remote position is associated with our hub in **Birmingham, West Midlands, UK**, offering flexibility and global reach.
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