304 Senior Principal Scientist jobs in the United Kingdom

• Title: Principal Scientist, Non-Clinical PKPD
• Pay: £35.20 p/h
• Contract: 12 months
• Location: Slough

SRG are working with a global biopharmaceutical leader who are seeking a Principal Scientist PKPD to join the team.

Role description:

The Non-Clinical PKPD group sits within the recently formed Quantitative Clinical Pharmacology function of the Early Clinical Development and Translational Sciences Department. Our goal is to use integrated quantitative approaches; as an essential strategic driver from target to market; to bring differentiated solutions to patients. We are driving the quantitative integrated strategy of pharmacokinetics and pharmacology (e.g. PKPD, Systems modelling, clinical pharmacology/pharmacometrics) together with DMPK activities throughout the entirety of the lifetime of projects, from target identification through to life cycle management. We operate and collaborate closely with colleagues across Early Clinical Development & Translational Sciences, which, as a department, is responsible for providing strategy and support in bioanalysis, immunogenicity, safety, pathology, and regulatory activities.

Role and Responsibilities:

• Participate in the development of non-clinical PKPD and GLP toxicokinetics studies. Lead the non-clinical PKPD strategy. Participate in protocol designs and writing by providing scientific support and input into regulatory study designs and protocols.

• Work collaboratively with the project teams representatives (e.g. Non-Clinical Safety, Bioanalysis, Clinical Pharmacology) and with the CROs, to ensure high quality data is generated.

• Work under GLP compliance to deliver data packages that meet regulatory standards.

• Effective communicate with the relevant team members to understand requirements and provide updates to ensure projects timelines are met.

• Analyse and communicate to different stakeholders the results of interim and final PKPD/toxicokinetic data analysis in a timely manner.

• Deliver PKPD study reports and integrated summaries of the studies and participate in regulatory submission documents.

• Facilitate the advancement of drug candidates by building a thorough knowledge of the drug pharmacology and PKPD.

• Represent the interests of the department internally and externally and contribute to enhancing the scientific reputation.

Skills and experience:

• PhD/MSc/BSc relevant discipline (quantitative pharmacology; pharmacokinetics /pharmacodynamics; DMPK, etc.) with more than 5 years hands on experience in PKPD data analysis within a pharma company or CRO environment.

• Good understanding of pharmacology and pharmacologic processes related to disease and drug mechanisms.

• Demonstrated experience in developing and executing effective non-clinical PKPD studies, and in delivering high-quality data packages for regulatory submissions.

• Experience working in a matrix environment, to help design and set non-clinical PKPD study protocols, and analyse, interpret, and report PKPD results including GLP toxicokinetics studies.

• Hands-on experience in delivering high quality pre-clinical PKPD data analysis. Proficiency in the use of Phoenix- WinNonlin for PKPD analysis is essential. Use of other modelling and simulation packages and tools, such as Berkeley Madonna and/or R would be advantageous.

• Able to handle several projects at any given time, to work successfully in project teams, and to communicate clearly to a variety of audiences.

• Good written and verbal communication skills, and ability to communicate study results and produce high standard reports that meet regulatory submission standards. Record of publications and other external scientific contributions relevant to PKPD will be a plus.

Proclinical is seeking a Principal Scientist PKPD to join a dynamic team in the oncology and pharmaceutical space. This role focuses on driving non-clinical pharmacokinetics and pharmacodynamics (PKPD) strategies, supporting early clinical development, and contributing to regulatory submissions. You will collaborate with cross-functional teams to deliver high-quality data packages and play a key role in advancing drug candidates.

Responsibilities:

• Develop and lead non-clinical PKPD and GLP toxicokinetics study strategies.
• Design and write protocols for regulatory studies, providing scientific input.
• Collaborate with project teams and CROs to ensure high-quality data generation.
• Work under GLP compliance to deliver regulatory-standard data packages.
• Communicate interim and final PKPD-toxicokinetic data analysis results to stakeholders.
• Deliver comprehensive PKPD study reports and contribute to submission documents.
• Build a thorough understanding of drug pharmacology and PKPD to facilitate candidate advancement.
• Represent the department internally and externally, enhancing its scientific reputation.

Key Skills and Requirements:

• MSc/PhD in a relevant field
• Background in quantitative pharmacology, pharmacokinetics/pharmacodynamics, or DMPK
• 3+ years hands-on experience in PKPD data analysis within a pharma or CRO environment.
• Strong understanding of pharmacology and drug mechanisms related to disease.
• Proven ability to design, execute, and analyze non-clinical PKPD studies, including GLP toxicokinetics.
• Proficiency in Phoenix WinNonlin for PKPD analysis (Essential)
• Familiarity with tools like Berkeley Madonna or R is a plus.
• Excellent communication skills, with the ability to produce high-standard reports for regulatory submissions.
• Experience working in matrix environments and managing multiple projects simultaneously.
• A record of publications or external scientific contributions in PKPD is advantageous.

If you are having difficulty in applying or if you have any questions, please contact Joshua Bye at

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• Lead and direct research projects focused on the design, synthesis, characterization, and application of novel biomaterials.
• Develop and validate new experimental methodologies and analytical techniques.
• Supervise and mentor a team of research scientists and technicians, fostering scientific rigor and collaboration.
• Manage research budgets and resources effectively, ensuring project milestones are met.
• Publish research findings in high-impact peer-reviewed journals and present at international conferences.
• Collaborate with external academic institutions and industry partners to advance research objectives.
• Ensure strict adherence to laboratory safety protocols and regulatory guidelines.
• Contribute to the strategic direction of the R&D department, identifying new research opportunities.
• Translate research findings into potential product development pathways.
• Maintain comprehensive and accurate laboratory records and reports.

• PhD in Materials Science, Biomedical Engineering, Chemistry, or a related field.
• Minimum of 10 years of post-doctoral research experience in biomaterials science, with a strong publication record.
• Demonstrated expertise in material characterization techniques (e.g., SEM, TEM, XPS, FTIR, DSC, TGA).
• Proven experience in designing and synthesizing novel polymeric, ceramic, or composite biomaterials.
• In-depth understanding of cell-material interactions, biocompatibility, and biodegradation.
• Strong leadership, project management, and team-building skills.
• Excellent analytical, critical thinking, and problem-solving abilities.
• Exceptional written and verbal communication skills, with a talent for scientific writing.
• Experience in securing research grants is a significant advantage.
• Ability to work effectively in a collaborative laboratory setting.

Job Description CK Group are recruiting for a Principal Scientist PKPD to join a global pharmaceutical company on a contract basis initially for 12 months.

Salary:
£35.20 Per hour (PAYE) / £47.92 (Umbrella) - flexible for experienced candidates.

Principal Scientist PKPD Role:
Participate in the development of non-clinical PKPD and GLP toxicokinetics studies. Lead the non-clinical PKPD strategy. Participate in protocol designs and writing by providing scientific support and input into regulatory study designs and protocols.
Work collaboratively with the project teams representatives (e.g. Non-Clinical Safety, Bioanalysis, Clinical Pharmacology) and with the CROs, to ensure high quality data is generated.
Deliver PKPD study reports and integrated summaries of the studies and participate in regulatory submission documents.
Facilitate the advancement of drug candidates by building a thorough knowledge of the drug pharmacology and PKPD.
Work collaboratively with the project teams representatives (e.g. Non-Clinical Safety, Bioanalysis, Clinical Pharmacology) and with the CROs, to ensure high quality data is generated

Your Background :
Experience working in a matrix environment, to help design and set non-clinical PKPD study protocols, and analyze, interpret, and report PKPD results including GLP toxicokinetics studies.
PhD/MSc/BSc relevant discipline (quantitative pharmacology; pharmacokinetics /pharmacodynamics; DMPK, etc.) with more than 5 years hands on experience in PKPD data analysis within a pharma company or CRO environment.
Good understanding of pharmacology and pharmacologic processes related to disease and drug mechanisms.
Hands-on experience in delivering high quality pre-clinical PKPD data analysis. Proficiency in the use of Phoenix- WinNonlin for PKPD analysis is essential. Use of other modelling and simulation packages and tools, such as Berkeley Madonna and/or R would be advantageous.
Good written and verbal communication skills, and ability to communicate study results and produce high standard reports that meet regulatory submission standards. Record of publications and other external scientific contributions relevant to PKPD will be a plus.

Company:
Our client is a is a global biopharmaceutical company focused on creating value for people living with severe diseases in immunology and neurology now and into the future.

Location:
This role is based at our client’s site in Slough.

Apply:
For more information, or to apply for this Principal Scientist PKPD, please contact the Key Accounts Team on or email Please quote reference 151 364.
It is essential that applicants hold entitlement to work in the UK
Please note: This role may be subject to a satisfactory basic Disclosure and Barring Service (DBS) check.

INDKA

• Designing, executing, and interpreting complex experiments in drug discovery and development.
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• Analyzing and presenting complex scientific data to internal teams and external stakeholders.
• Collaborating with cross-functional teams, including chemistry, biology, and clinical development.
• Contributing to the preparation of scientific publications, patents, and regulatory submissions.
• Managing external collaborations with academic institutions and CROs.
• Keeping abreast of the latest scientific literature, technologies, and trends in pharmaceutical research.
• Ensuring compliance with all laboratory safety regulations and ethical guidelines.
• Contributing to strategic planning and decision-making within the R&D department.

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• Develop and optimize novel experimental techniques and protocols in areas such as gene editing, genomics, proteomics, and cell-based assays.
• Lead independent research projects from conception through to publication, ensuring scientific rigor and innovation.
• Analyze and interpret large datasets using advanced bioinformatics tools and statistical methods.
• Supervise, mentor, and train junior research staff, post-doctoral fellows, and students.
• Write high-impact grant proposals to secure external funding for research projects.
• Prepare manuscripts for publication in peer-reviewed journals and present research findings at international conferences.
• Collaborate with internal and external research groups to foster interdisciplinary projects.
• Manage laboratory resources, including equipment, supplies, and budget.
• Ensure compliance with all relevant safety regulations and ethical guidelines in laboratory practices.

• Ph.D. in Molecular Biology, Biochemistry, Genetics, or a closely related field.
• Minimum of 10 years of post-doctoral research experience, with a strong track record of independent research and publications.
• Demonstrated expertise in a broad range of molecular biology techniques, including PCR, qPCR, Western Blotting, cloning, cell culture, and microscopy.
• Proven experience with advanced genomic/transcriptomic analysis platforms (e.g., next-generation sequencing) and associated bioinformatics tools.
• Experience in leading research teams and mentoring junior scientists.
• A strong history of securing research funding through competitive grant applications.
• Excellent written and verbal communication skills, with the ability to clearly articulate complex scientific concepts.
• Strong analytical, critical thinking, and problem-solving abilities.
• Ability to work collaboratively in a team environment and foster a positive research culture.
• Experience with CRISPR/Cas9 technology or other gene editing tools is highly desirable.

• Lead independent research projects focused on the design, construction, and characterization of novel biomolecular systems.
• Develop and implement advanced experimental techniques in molecular biology, protein engineering, and high-throughput screening.
• Analyze and interpret complex biological data using sophisticated computational and statistical methods.
• Publish research findings in high-impact peer-reviewed journals and present at international conferences.
• Collaborate with interdisciplinary teams to translate research findings into potential therapeutic or industrial applications.
• Mentor junior scientists and research associates, providing guidance and technical expertise.
• Contribute to the strategic direction of the company's R&D pipeline and technology platforms.
• Ensure compliance with laboratory safety protocols and best practices.
• Explore and propose new research avenues and collaborations.
• Contribute to intellectual property generation through patent applications.

• Ph.D. in Biomolecular Engineering, Synthetic Biology, Biochemistry, Chemical Engineering, or a related field.
• Minimum of 8 years of post-doctoral research experience with a strong publication record in relevant areas.
• Demonstrated expertise in designing and engineering biological molecules and pathways.
• Proficiency in molecular cloning, protein expression and purification, and assay development.
• Experience with computational biology tools and bioinformatics analysis.
• Strong understanding of experimental design and statistical analysis.
• Excellent leadership, communication, and problem-solving skills, suitable for a remote work environment.
• Proven ability to manage research projects and mentor junior team members.
• Experience with high-throughput experimentation and automation is a plus.

• Lead and design innovative drug discovery projects, from target identification through to lead optimization.
• Develop and implement cutting-edge scientific strategies and experimental approaches to address key research questions.
• Manage and mentor a team of research scientists, fostering a collaborative and high-performing research environment.
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• Present research findings at internal and external scientific conferences.
• Manage external research collaborations and CROs to achieve project milestones.
• Contribute to the strategic planning and intellectual property portfolio of the R&D division.
• Ensure adherence to all laboratory safety standards and ethical guidelines.
• Evaluate and implement new technologies to enhance drug discovery capabilities.

• PhD in Pharmacology, Molecular Biology, Biochemistry, or a related life sciences discipline.
• Minimum of 8-10 years of relevant experience in the pharmaceutical or biotechnology industry, with a strong track record in drug discovery and development.
• Demonstrated expertise in target validation, assay development, hit identification, and lead optimization.
• Proven experience in managing research projects and leading scientific teams.
• In-depth knowledge of one or more therapeutic areas (e.g., oncology, immunology, CNS disorders).
• Excellent understanding of modern drug discovery methodologies and technologies.
• Strong publication record and presentation experience.
• Exceptional analytical, critical thinking, and problem-solving skills.
• Outstanding written and verbal communication skills, with the ability to articulate complex scientific concepts.
• Ability to work independently and drive projects forward in a remote, fast-paced environment.
• Experience with small molecule or biologic drug discovery is required.