21 Drug Safety jobs in the United Kingdom

Our client is seeking a highly experienced and dedicated Lead Drug Safety Physician to join their fully remote global pharmacovigilance team. This critical role focuses on ensuring the safe and effective use of pharmaceutical products throughout their lifecycle. You will be responsible for leading signal detection and risk management activities, providing expert medical input into safety assessments, and contributing to regulatory submissions. As a remote-first professional, you will leverage cutting-edge technology to collaborate with global teams, analyze adverse event data, and develop robust safety strategies. Your expertise will be vital in identifying, evaluating, and mitigating potential risks associated with our client's portfolio of innovative medicines. This role offers the unique opportunity to shape pharmacovigilance practices from a remote location, contributing to patient safety on a global scale.

Responsibilities:

• Lead the medical assessment of safety data from various sources, including spontaneous reports, clinical trials, and literature.
• Oversee the signal detection and risk management processes for assigned products.
• Provide medical expertise for the preparation of Periodic Safety Update Reports (PSURs), Risk Management Plans (RMPs), and other regulatory documents.
• Collaborate with regulatory affairs, clinical development, and other internal departments on safety-related matters.
• Act as a medical point of contact for health authorities regarding drug safety issues.
• Contribute to the development and implementation of pharmacovigilance strategies and SOPs.
• Mentor and provide medical guidance to other members of the safety team.
• Participate in safety reviews of clinical trial protocols and investigator brochures.
• Ensure compliance with global regulatory requirements for pharmacovigilance.

Qualifications:

• Medical Doctor (MD) or equivalent medical degree.
• Extensive experience (8+ years) in pharmacovigilance, drug safety, or clinical development within the pharmaceutical industry.
• Strong understanding of regulatory requirements in major markets (e.g., FDA, EMA).
• Proven experience in signal detection, risk assessment, and benefit-risk evaluation.
• Excellent medical judgment and analytical skills.
• Exceptional communication, presentation, and interpersonal skills.
• Demonstrated leadership capabilities and experience managing complex projects.
• Ability to work autonomously and effectively in a remote, global team environment.
• Proficiency in pharmacovigilance databases and reporting systems.
• Board certification in a relevant medical specialty is a plus.

This is an exceptional opportunity for a seasoned Drug Safety Physician to exert significant influence on patient safety and product stewardship, working entirely remotely from **Coventry, West Midlands, UK**, or any other UK-based location.

Our client, a globally recognized pharmaceutical leader, is seeking a highly experienced Senior Drug Safety Scientist to join their Pharmacovigilance team. This pivotal role is entirely remote, offering the flexibility to work from home across the UK while contributing to the safety monitoring of critical medicines. You will be responsible for ensuring the robust safety surveillance of pharmaceutical products, from clinical development through to post-marketing, and safeguarding patient well-being.

Responsibilities:

• Perform comprehensive case processing and medical assessment of adverse event reports, ensuring compliance with regulatory requirements and company procedures.
• Contribute to the preparation and maintenance of periodic safety update reports (PSURs), development safety update reports (DSURs), and risk management plans (RMPs).
• Conduct signal detection and evaluation activities, identifying potential safety concerns and recommending appropriate actions.
• Collaborate with cross-functional teams, including clinical development, regulatory affairs, and medical affairs, on safety-related matters.
• Interpret safety data and provide expert input into clinical trial protocols, Investigator's Brochures, and informed consent forms.
• Serve as a subject matter expert on drug safety regulations and guidelines in various global markets.
• Contribute to the development and implementation of pharmacovigilance strategies and processes.
• Participate in regulatory authority inspections and internal audits.
• Mentor and provide guidance to junior safety scientists and case processing personnel.
• Stay current with evolving regulatory landscapes and scientific literature related to drug safety.

Qualifications:

• Medical degree (MD, DO, MBBS) or equivalent healthcare professional qualification (e.g., PhD in a relevant life science field with significant safety experience).
• Minimum of 6 years of direct experience in drug safety and pharmacovigilance within the pharmaceutical industry.
• In-depth knowledge of global pharmacovigilance regulations (e.g., FDA, EMA guidelines) and reporting requirements.
• Experience with safety databases (e.g., Argus, ARISg) and case processing.
• Proficiency in signal detection and management methodologies.
• Strong medical assessment and analytical skills, with the ability to critically evaluate safety data.
• Excellent written and verbal communication skills, with the ability to present complex information effectively.
• Proven ability to work independently and manage multiple priorities in a remote setting.
• Strong collaboration and interpersonal skills.
• Experience with risk management planning and execution.

This is an exceptional opportunity for a seasoned professional to make a significant impact on patient safety from a fully remote location. You will be part of a highly respected global team committed to excellence in pharmacovigilance. The role is aligned with the strategic goals for the London, England, UK area, but is entirely remote.

Our client, a groundbreaking pharmaceutical company at the forefront of medical innovation, is seeking a highly experienced Senior Formulation Scientist to join their dynamic research and development team. This is a fully remote position, offering an exceptional opportunity to contribute to the development of novel drug delivery systems and pharmaceutical products from your home laboratory or approved remote workspace. You will play a critical role in designing, optimizing, and characterizing drug formulations to meet stringent efficacy, safety, and regulatory standards.

Responsibilities:

• Lead the design, development, and optimization of innovative drug formulations (e.g., oral solid dosage forms, injectables, topical applications) for various therapeutic areas.
• Conduct pre-formulation studies to understand drug-excipient compatibility, physicochemical properties, and stability.
• Develop and validate analytical methods for characterizing formulations and assessing drug release profiles.
• Oversee formulation scale-up activities, ensuring successful technology transfer from lab to pilot and manufacturing scales.
• Prepare comprehensive technical documentation, including formulation development reports, analytical method validation reports, and regulatory submission documents.
• Collaborate closely with cross-functional teams, including analytical chemistry, process development, quality assurance, and regulatory affairs.
• Troubleshoot formulation challenges and implement robust solutions to ensure product quality and performance.
• Stay abreast of the latest advancements in pharmaceutical formulation science, drug delivery technologies, and relevant regulatory guidelines.
• Mentor and guide junior scientists, fostering a culture of scientific excellence and continuous learning.
• Manage external contract research organizations (CROs) for specific formulation development activities, ensuring project timelines and deliverables are met.

Qualifications:

• PhD or Master's degree in Pharmaceutical Sciences, Pharmaceutics, Chemical Engineering, or a related discipline.
• Minimum of 7 years of hands-on experience in pharmaceutical formulation development, with a proven track record in bringing drug products from concept to clinical trial stages.
• In-depth knowledge of various drug delivery systems and formulation techniques.
• Proficiency in relevant analytical techniques (e.g., HPLC, GC, DSC, XRPD) for formulation characterization.
• Strong understanding of pharmaceutical manufacturing processes and GMP requirements.
• Experience with regulatory guidelines (e.g., ICH, FDA, EMA) pertaining to drug development.
• Excellent problem-solving skills, with a keen attention to detail and the ability to interpret complex data.
• Exceptional written and verbal communication skills, with the ability to effectively present scientific findings.
• Proven ability to work independently and manage multiple projects in a remote research environment.
• Experience with statistical analysis software and design of experiments (DoE) is advantageous.

This is a fully remote role, offering significant flexibility. You will be an integral part of our research hub in Oxford, Oxfordshire, UK , but your day-to-day work will be conducted remotely. We are looking for a passionate and innovative scientist eager to make a tangible impact on patient lives through advanced pharmaceutical development.

Our client, a leading pharmaceutical company dedicated to advancing healthcare through innovative drug development, is seeking an experienced and highly skilled Principal Formulation Scientist to join their dynamic R&D team in Nottingham, Nottinghamshire, UK . This critical role will involve leading the development of novel drug delivery systems and innovative formulations for a diverse pipeline of pharmaceutical products. You will be at the forefront of designing, optimizing, and scaling up formulations, ensuring product efficacy, stability, and bioavailability. The ideal candidate will possess a deep understanding of pharmaceutical sciences, particularly in pre-formulation, formulation development, and manufacturing processes. Responsibilities include conducting pre-formulation studies, designing and executing experiments for solid dosage forms, sterile injectables, or other relevant delivery routes, and characterizing formulation performance. You will lead the troubleshooting of formulation challenges and provide expert scientific guidance to project teams. The Principal Formulation Scientist will play a key role in the transition of formulations from laboratory scale to clinical manufacturing and beyond. Collaboration with cross-functional teams, including analytical development, DMPK, regulatory affairs, and manufacturing, is essential. You will also contribute to the scientific strategy of the formulation department, stay abreast of emerging technologies, and potentially mentor junior scientists. A strong publication record and experience with intellectual property development are desirable. This hybrid role offers a blend of essential lab-based work and remote strategic planning and analysis, providing a balanced and productive work environment. This is an excellent opportunity to contribute to life-changing medicines within a supportive and scientifically driven organization in Nottingham .
Qualifications:

• Ph.D. in Pharmaceutical Sciences, Pharmaceutics, Chemistry, or a related field
• Minimum of 7 years of progressive experience in pharmaceutical formulation development
• Proven expertise in developing various dosage forms (e.g., oral solids, injectables, topical)
• Strong understanding of pre-formulation, excipient selection, and drug-excipient compatibility
• Hands-on experience with formulation characterization techniques (e.g., DSC, TGA, XRPD, dissolution)
• Experience with pilot-scale formulation manufacturing and technology transfer
• Knowledge of GMP guidelines and regulatory requirements for drug development
• Excellent problem-solving, analytical, and critical thinking skills
• Strong project management and organizational abilities
• Effective communication and interpersonal skills for cross-functional collaboration
• Ability to mentor junior scientists and contribute to scientific strategy
• Experience with specific therapeutic areas is a plus

Our client, a leading pharmaceutical company dedicated to advancing healthcare solutions, is seeking a skilled and innovative Pharmaceutical Formulation Scientist to join their research and development team in Milton Keynes, Buckinghamshire, UK . This role is pivotal in the early-stage development of novel drug formulations, contributing to the creation of effective and patient-centric medicines. The ideal candidate will possess a strong background in pharmaceutical sciences, with hands-on experience in formulation development and characterization. Responsibilities will include:

• Designing, developing, and optimizing oral solid dosage forms (tablets, capsules) and potentially other dosage forms.
• Conducting pre-formulation studies to understand the physicochemical properties of active pharmaceutical ingredients (APIs) and excipients.
• Evaluating and selecting appropriate excipients to achieve desired drug release profiles and stability.
• Utilizing various laboratory techniques for formulation preparation and characterization (e.g., particle size analysis, dissolution testing, differential scanning calorimetry).
• Developing and validating analytical methods for drug product testing.
• Conducting stability studies to assess the shelf-life and performance of formulations under various conditions.
• Troubleshooting formulation challenges and proposing innovative solutions.
• Collaborating with analytical development, process development, and regulatory affairs teams.
• Documenting experimental procedures, results, and reports in accordance with company standards and regulatory guidelines.
• Staying current with scientific literature and industry trends in pharmaceutical formulation and drug delivery.

The successful candidate will hold a Bachelor's or Master's degree in Pharmacy, Pharmaceutical Sciences, Chemistry, or a related discipline. A minimum of 3-5 years of relevant experience in pharmaceutical formulation development within the industry is required. Hands-on experience with common formulation equipment and analytical instrumentation is essential. Knowledge of regulatory guidelines related to drug product development (e.g., ICH) is highly desirable. Excellent problem-solving, critical thinking, and organizational skills are necessary. Strong written and verbal communication abilities are important for effective collaboration within the R&D team. This role offers a competitive salary, comprehensive benefits, and the opportunity to contribute to the development of impactful medicines within our client's state-of-the-art facilities in Milton Keynes, Buckinghamshire, UK , with a hybrid working model.

Our client, a leading innovator in pharmaceutical research and development, is seeking a highly skilled and motivated Senior Formulation Scientist to join their dynamic team. This is an exciting opportunity to contribute to the development of cutting-edge therapeutic agents from pre-clinical stages through to clinical trials. The role will involve extensive laboratory work, data analysis, and collaboration with cross-functional teams.

Key Responsibilities:

• Design, develop, and optimize novel drug delivery systems and formulations for various routes of administration (e.g., oral, injectable, topical).
• Conduct pre-formulation studies, including API characterization, solubility enhancement, and stability assessment.
• Perform compatibility studies and develop analytical methods for drug substance and drug product characterization.
• Utilize a range of formulation technologies and equipment, including granulation, coating, lyophilization, and sterile manufacturing processes.
• Execute experiments meticulously, document all findings accurately in laboratory notebooks and reports, and present results to project teams and management.
• Troubleshoot formulation challenges and propose innovative solutions.
• Collaborate closely with analytical chemists, process engineers, and clinical development teams to ensure successful project progression.
• Stay abreast of the latest scientific literature, regulatory guidelines, and industry trends in pharmaceutical formulation.
• Contribute to the preparation of regulatory submission documents (e.g., IND, NDA).

Qualifications and Experience:

• PhD or MSc in Pharmaceutical Sciences, Chemistry, Chemical Engineering, or a related field.
• Minimum of 5 years of relevant experience in pharmaceutical formulation development, preferably within an R&D setting.
• Proven track record in developing various dosage forms, with a strong understanding of formulation science principles.
• Hands-on experience with laboratory equipment for formulation development and characterization.
• Proficiency in relevant analytical techniques (e.g., HPLC, GC, DSC, TGA, XRPD).
• Excellent understanding of Good Manufacturing Practice (GMP) and regulatory requirements.
• Strong problem-solving skills, attention to detail, and ability to work independently and as part of a team.
• Effective communication and interpersonal skills.

This role is based in Leicester, Leicestershire, UK and offers a hybrid working model, balancing in-office collaboration with remote flexibility. Join us and make a tangible impact on patient lives through groundbreaking pharmaceutical innovations.

Our client, a leading pharmaceutical innovator, is seeking a highly accomplished Principal Clinical Research Scientist to spearhead critical oncology drug development programs. This role requires a deep scientific understanding of cancer biology, extensive experience in clinical trial design and execution, and a passion for bringing life-changing therapies to patients. You will collaborate with world-class researchers and clinicians to advance novel treatments from early-stage research through to regulatory submission.

Responsibilities:

• Lead the scientific strategy and design of Phase I-III clinical trials for novel oncology therapeutics.
• Oversee the development of clinical protocols, investigator brochures, and other essential study documents.
• Provide scientific and clinical expertise to cross-functional teams, including clinical operations, data management, regulatory affairs, and biomarker development.
• Analyze and interpret complex clinical trial data, translating findings into strategic recommendations for drug development.
• Prepare high-quality scientific publications, abstracts, and presentations for key medical conferences and journals.
• Engage with key opinion leaders (KOLs) in oncology to gather insights and foster collaboration.
• Contribute to regulatory submissions (e.g., IND, NDA) by preparing relevant clinical sections.
• Stay abreast of the latest advancements in oncology research, emerging therapeutic modalities, and competitive landscape.
• Mentor and guide junior scientists and clinical development professionals.
• Ensure all clinical research activities comply with GCP, regulatory guidelines, and company policies.

Qualifications:

• Ph.D. or M.D. in a relevant life sciences discipline (e.g., Oncology, Immunology, Molecular Biology).
• Minimum of 10 years of experience in clinical drug development, with a strong focus on oncology.
• Demonstrated success in designing and leading complex clinical trials.
• Expertise in cancer biology, tumor microenvironment, and current therapeutic strategies.
• In-depth knowledge of GCP, regulatory requirements, and clinical trial methodologies.
• Proven ability to analyze and interpret clinical data effectively.
• Excellent scientific writing and communication skills, with a track record of publications and presentations.
• Strong leadership capabilities and experience working in a matrixed environment.
• Ability to travel to Glasgow, Scotland, UK as required for key meetings and site visits.
• Experience with immuno-oncology and targeted therapies is highly desirable.

This is a key role within our client's innovative pipeline, offering the chance to shape the future of cancer treatment.

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**Job Description**
At Thermo Fisher Scientific, you'll discover meaningful work that makes a positive impact on a global scale. Join our colleagues in bringing our Mission to life - enabling our customers to make the world healthier, cleaner and safer. We provide our teams with the resources needed to achieve individual career goals while taking science a step beyond through research, development and delivery of life-changing therapies. With clinical trials conducted in 100+ countries and ongoing development of novel frameworks for clinical research through our PPD clinical research portfolio, our work spans laboratory, digital and decentralized clinical trial services. Your determination to deliver quality and accuracy will improve health outcomes that people and communities depend on - now and in the future.
**The PPD FSP Solution:**
PPD's Functional Service Provider division partner with and serve as an extension of our PPD team, supporting our customers key functions. We cover customer needs on every level, allowing them to do more with less, with an uncompromising commitment to quality. We deploy the same top-tier talent in ALL engagement models. Exceptionally trained, rigorously supported and technologically empowered to help customers manage capacity and set programs up for success.
Joining within our PPD FSP functional area, allows you to join the renowned PPD CRO and still gain invaluable client dedicated experience.
_Our client, a global mid-sized biotech company, focuses on developing innovative treatments for patients with autoimmune diseases. This fast-growing, international organization has a strong scientific foundation. If you're looking for a place where your work, in partnership with others, can have real impact-and where you're encouraged challenge yourself and contribute to breakthrough solutions , the_ **_A_** **_ssociate Director, Drug Development_** _role could be a great fit._
**Discover Impactful Work:**
The Associate Director within Drug Development will oversee high-level plans and progress for asset development, from pre-clinical stages to commercial launch. This role involves close collaboration with various stakeholders to ensure timely availability of documents and alignment with corporate strategy. Act as primary point of contact when concerning integrated cross-functional project planning and status. They closely collaborate with stakeholders who own, contribute to, and/or manage the project and the impact of decisions and changing circumstances. This to drive timely availability of documents as planned.
**A day in the Life:**
_Project Lead responsibilities:_
+ Serves as the primary contact between the sponsor and the organization at the project level.
+ On projects where the scope requires, ensures clear delineation in responsibilities and communication pathways for secondary project leads (such as lead in a specific region, lead for a specific vendor(s) or subset of delivery).
+ Drives and owns the overall delivery of the cross-functional project (time, cost, quality).
+ Ensures financial stewardship at a project level by demonstrating an intimate understanding of the contract, resource alignment to budget, management of Out of Scope activity, drive the Con Mod process/negotiations and team execution to timelines.
+ Establishes, communicates and manages customer expectations to achieve optimal delivery during the project.
+ Drives Risk Identification and Issue Resolution at project level (RBQM/RESOLVE).
+ Ensures project team compliance with organization policies, SOPs, ICH- GCP, regulatory and project specific requirements
_Oversight Director responsibilities:_
+ Accountable for strategic indication or client-specific portfolio management within a Therapeutic Unit.
+ Expertly navigates the need to dive in/dive out of situations while ensuring the Project Lead remains empowered .
+ Provokes critical thinking in Project Lead related to execution of delivery, financial negotiations and prioritization.
+ Provides insight into proposal strategy in prep for bid defense.
+ Works with Therapeutic Unit Head in development of business growth strategies.
+ Maintains awareness and engages as appropriate in the Con Mod process.
+ Communicates with People Manager(s) to support the development of the employee providing expertise and perspective related to client needs, indication and therapeutic knowledge.
_People Manager responsibilities:_
+ Accountable for the career development and performance management of a group of project delivery direct reports in line with The Core People Manager Expectations at the organization.
+ Partners with project team leadership and key stakeholders (i.e OD, SLT, BPL, DevOps, functional leadership) to ensure areas of development, training needs and coaching are aligned through routine and active engagement.
+ Provides coaching, soft skill and technical skill development to grow our Project Delivery talent.
+ Provides support/direction to direct report(s) with regards to knowledge of organization systems, processes and tools within Project Delivery.
+ Liaises with Resourcing Leads, TU Leadership and other key stakeholders to advocate for direct report(s), ensuring appropriate project assignment(s) and balance between career development and business needs.
+ Fosters collaboration and connections amongst peers.
+ Cultivates high quality relationships with each direct report to create a trusting environment.
+ Participates in Initiatives to foster talent development.
**Keys to Success:**
+ Advanced degree (Master or PhD) in a health-related discipline or equivalent experience.
+ At least 10 years of drug development experience across different disease areas.
+ At least 5 years of program management experience in the pharmaceutical or biotech industry.
**Knowledge, Skills, Abilities**
+ Strong leadership, communication, and collaborative skills.
+ Proven ability to mediate conflict and manage change.
+ Advanced project management skills and experience with MS Project.
+ PMP certification is an advantage.
+ Fluent in English (verbal and written).
+ Experience in Regulatory Affairs and/or Clinical Development is a plus.
PPD values the health and wellbeing of our employees. We support and encourage individuals to create a healthy and balanced environment where they can thrive. Below is listed the working environment/requirements for this role:
+ Able to communicate, receive, and understand information and ideas with diverse groups of people in a comprehensible and reasonable manner.
+ Able to work upright and stationary for typical working hours.
+ Ability to use and learn standard office equipment and technology with proficiency.
+ May have exposure to potentially hazardous elements typically found in healthcare or laboratory environments.
+ Able to perform successfully under pressure while prioritizing and handling multiple projects or activities.
+ May require travel. (Recruiter will provide more details.)
Our Mission is to enable our customers to make the world healthier, cleaner and safer. Watch as our colleagues explain 5 reasons to work with us. As one team of 100,000+ colleagues, we share a common set of values - Integrity, Intensity, Innovation and Involvement - working together to accelerate research, solve complex scientific challenges, drive technological innovation and support patients in need. #StartYourStory with PPD, part of Thermo Fisher Scientific, where diverse experiences, backgrounds and perspectives are valued.
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Our client, a pioneering biotechnology company at the forefront of therapeutic innovation, is seeking a highly accomplished Principal Scientist to lead critical research initiatives within their Drug Discovery & Development division. Based in Milton Keynes, Buckinghamshire, UK , this role is integral to advancing novel treatment modalities from early-stage research through to preclinical development. The successful candidate will bring a wealth of scientific expertise, a proven track record in research leadership, and a passion for translating scientific breakthroughs into life-changing medicines. This is a lab-based role requiring hands-on involvement and direct oversight of research activities.

Key Responsibilities:

• Design, execute, and interpret complex experiments to drive drug discovery programmes forward.
• Lead and mentor a team of talented research scientists and technicians, fostering a culture of scientific excellence and collaboration.
• Develop and validate novel assays and technologies to support drug discovery efforts.
• Identify and evaluate promising therapeutic targets and lead compounds.
• Oversee preclinical studies, including in vitro and in vivo models, to assess compound efficacy and safety.
• Collaborate effectively with cross-functional teams, including chemistry, pharmacology, toxicology, and translational science.
• Author high-quality scientific reports, manuscripts, and patent applications.
• Present research findings at internal meetings and external scientific conferences.
• Manage external collaborations with academic institutions and contract research organizations (CROs).
• Contribute to strategic planning for the R&D pipeline and portfolio management.
• Ensure compliance with all relevant laboratory safety regulations and best practices.
• Stay abreast of the latest scientific advancements and competitive landscape in relevant therapeutic areas.

Required Qualifications and Expertise:

• Ph.D. in Pharmacology, Molecular Biology, Biochemistry, Immunology, or a related life science discipline.
• Minimum of 10 years of post-doctoral research experience in the pharmaceutical or biotechnology industry, with a strong focus on drug discovery.
• Demonstrated leadership experience in managing scientific teams and projects.
• Deep expertise in (Specific therapeutic area relevant to fictional company, e.g., oncology, infectious diseases, neuroscience) and associated drug discovery methodologies.
• Proficiency in a wide range of in vitro and in vivo experimental techniques.
• Proven ability to design and execute complex research strategies and troubleshoot effectively.
• Excellent analytical, problem-solving, and critical thinking skills.
• Exceptional written and verbal communication skills, with a track record of publications and presentations.
• Experience with biostatistics and data analysis software.
• Strong project management skills and the ability to manage multiple priorities.
• A passion for scientific innovation and a commitment to developing novel therapeutics.

This is an exceptional opportunity for a distinguished scientist to make a significant impact on the future of medicine. Join a world-class research team and contribute to the development of groundbreaking therapies.